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PE20011164A1 - Derivados de eteres de pirazol como agentes antiinflamatorios / analgesicos - Google Patents

Derivados de eteres de pirazol como agentes antiinflamatorios / analgesicos

Info

Publication number
PE20011164A1
PE20011164A1 PE2001000213A PE2001000213A PE20011164A1 PE 20011164 A1 PE20011164 A1 PE 20011164A1 PE 2001000213 A PE2001000213 A PE 2001000213A PE 2001000213 A PE2001000213 A PE 2001000213A PE 20011164 A1 PE20011164 A1 PE 20011164A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
pirazole
inflammatory
ethers
Prior art date
Application number
PE2001000213A
Other languages
English (en)
Inventor
Hengmiao Cheng
Subas Man Sakya
Jason Kenneth Dutra
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20011164A1 publication Critical patent/PE20011164A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/24—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms having sulfone or sulfonic acid radicals in the molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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Abstract

SE REFIERE DERIVADOS A ETER,TIOETER, AMINA DE PIRAZOL DE FORMULA I DONDE A ES O, S, SO, SO2, NR4; X ES CR7, N; Y ES CR8, N; R1 ES ALQUILO C1-C6, NH2; R2 ES H, HALOGENO, HIDROXI, MERCAPTO, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R3 ES ALQUILO C1-C6, ARILO C6-C10, CICLOALQUILO C3-C10, HETEROARILO, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, ALQUILSULFONILO C1-C6, ALQUILO C1-C6-C=O, ENTRE OTROS; R5 ES H, HALOGENO, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R6 ES H, HALOGENO, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R7 ES H, HALOGENO, OH, MERCAPTO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R8 ES H, HALOGENO, OH, MERCAPTO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; SON COMPUESTOS PREFERIDOS 2-(5-ISOBUTOXI-3-TRIFLUOROMETILPIRAZOL-1-IL]-5-METANOSULFONILPIRIDINA; 2-[5-(1-ETILPROPOXI)-3-TRIFLUOROMETILPIRAZOL-1-IL]-5-METANOSULFONILPIRIDINA, ENTRE OTROS; LOS COMPUESTOS I INHIBEN LA BIOSINTESIS DE PROSTAGLANDINAS Y PUEDEN SER UTILES PARA TRATAR ARTRITIS, FIEBRE, RESFRIO, DISMENORREA, CALAMBRES MESTRUALES, NEURODEGENERACION, CANCER DE COLON
PE2001000213A 2000-03-03 2001-03-01 Derivados de eteres de pirazol como agentes antiinflamatorios / analgesicos PE20011164A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18686900P 2000-03-03 2000-03-03

Publications (1)

Publication Number Publication Date
PE20011164A1 true PE20011164A1 (es) 2001-11-13

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ID=22686598

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PE2001000213A PE20011164A1 (es) 2000-03-03 2001-03-01 Derivados de eteres de pirazol como agentes antiinflamatorios / analgesicos

Country Status (16)

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US (3) US6878726B2 (es)
EP (1) EP1259504A1 (es)
JP (1) JP2003525288A (es)
AR (1) AR027967A1 (es)
AU (2) AU2001232175B2 (es)
BR (1) BR0108908A (es)
CA (1) CA2401697A1 (es)
CO (1) CO5271651A1 (es)
GT (1) GT200100036A (es)
HN (1) HN2001000037A (es)
MX (1) MXPA02008627A (es)
PA (1) PA8513101A1 (es)
PE (1) PE20011164A1 (es)
TN (1) TNSN01035A1 (es)
WO (1) WO2001064669A1 (es)
ZA (1) ZA200207015B (es)

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US20020058681A1 (en) 2002-05-16
EP1259504A1 (en) 2002-11-27
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CA2401697A1 (en) 2001-09-07
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US6878726B2 (en) 2005-04-12
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US20040259879A1 (en) 2004-12-23
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AU3217501A (en) 2001-09-12

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