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PE20010236A1 - Compuestos n-ciclopentilo como moduladores de la actividad de los receptores de quimiocina - Google Patents

Compuestos n-ciclopentilo como moduladores de la actividad de los receptores de quimiocina

Info

Publication number
PE20010236A1
PE20010236A1 PE2000000576A PE0005762000A PE20010236A1 PE 20010236 A1 PE20010236 A1 PE 20010236A1 PE 2000000576 A PE2000000576 A PE 2000000576A PE 0005762000 A PE0005762000 A PE 0005762000A PE 20010236 A1 PE20010236 A1 PE 20010236A1
Authority
PE
Peru
Prior art keywords
modulators
compounds
activity
cyclopentilo
chemokine receptors
Prior art date
Application number
PE2000000576A
Other languages
English (en)
Inventor
E Paul E Paul
Kerry A Hilfiker
Kevin T Chapman
Sander G Mills
Shrenik K Shah
Dong-Ming Shen
Bryan Oates
Dooseop Kim
Ravi N Guthikonda
Jennifer L Loebach
Malcolm Maccoss
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20010236A1 publication Critical patent/PE20010236A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE N-CICLOPENTILO DE FORMULA I, DONDE X ES ALQUILO C0-C6-Y-ALQUILO C0-C6, ALQUENILO C2-C10, ALQUINILO C2-C10 SUSTITUIDO CON HALO, OH, -O-ALQUILO C1-C3, TRIFLUOROMETILO; Y ES O, SO2, NR10, NR10-S02, ENTRE OTROS; R10 ES H, ALQUILO C1-C6, BENCILO, FENILO, ENTRE OTROS; R1 ES CO2H, NO2, TETRAZOLILO, HIDROXISOXAZOL, SO2NH-(ALQUILO C0-C3)-R9; R9 ES H, ALQUILO C1-C6, CICLOALQUILO C5-C6, ENTRE OTROS; R3 ES FENILO, HETEROCICLO SUSTITUIDO CON HALO, TRIFLUOROMETILO, HIDROXI, ALQUILO C1-C3, ENTRE OTROS; R4, R5, R6 SON H, ALQUILO C1-C10, CICLOALQUILO C3-C8, ALQUENILO C2-C10, ALQUINILO C2-C10, FENILO, ENTRE OTROS; R7 ES H, ALQUILO C1-C6, OH, HALO; R8 ES H, CICLOALQUILO C3-C8, FENILO, NAFTILO, BIFENILO, OPCIONALMENTE SUSTITUIDO CON R12; O R8 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON 1-5 R13; -O-ALQUILO C1-C6, CF3, CHF2, CH2F, NO2, CO2R9, NR9R10, ENTRE OTROS; R12 ES HALO, CIANO, OH, ENTRE OTROS; R13 ES HALO, CIANO, OH, ENTRE OTROS; n ES 1-4; x ES 0-2; y ES 0-2. LOS DERIVADOS DE N-CICLOPENTILO SON MODULADORES DE LA ACTIVIDAD DE LOS RECEPTORES DE QUIMIOCINA CCR-5, CCR-3 Y PUEDEN SER UTILES PARA LA PREVENCION DE LA INFECCION POR VIH, TRASTORNOS Y ENFERMEDADES INFLAMATORIAS E INMUNOREGULADORAS, ENFERMEDADES ALERGICAS COMO RINITIS, DERMATITIS, CONJUNTIVITIS
PE2000000576A 1999-06-11 2000-06-09 Compuestos n-ciclopentilo como moduladores de la actividad de los receptores de quimiocina PE20010236A1 (es)

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US13888699P 1999-06-11 1999-06-11
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GB0108876D0 (en) * 2001-04-09 2001-05-30 Novartis Ag Organic Compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
AU2003207646C1 (en) * 2002-01-22 2008-09-18 Vanderbilt University Treating stress response with chemokine receptor CCR5 modulators
US7393844B2 (en) * 2003-03-18 2008-07-01 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
MX2010005631A (es) * 2007-11-23 2010-06-02 Leo Pharma As Nuevos compuestos de hidrocarburo ciclicos para el tratamiento de enfermedades.
EP2588445A1 (en) * 2010-06-30 2013-05-08 Leo Pharma A/S New polymorphic form of a calcimimetic compound
WO2012000499A1 (en) * 2010-06-30 2012-01-05 Leo Pharma A/S New polymorphic form of a calcimimetic compound

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AU5522498A (en) * 1996-12-13 1998-07-03 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
CA2278309A1 (en) * 1997-01-21 1998-07-23 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
EP1003514A4 (en) * 1997-07-25 2000-10-11 Merck & Co Inc CYCLIC AMINE MODULATORS OF CHEMOKIN RECEPTORS
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US6140349A (en) * 1998-02-02 2000-10-31 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

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CA2382880A1 (en) 2000-12-21
EP1192133A1 (en) 2002-04-03
DE60031676T2 (de) 2007-08-30
AU772321B2 (en) 2004-04-22
ES2274793T3 (es) 2007-06-01
AU5472600A (en) 2001-01-02
WO2000076972A1 (en) 2000-12-21
JP4688381B2 (ja) 2011-05-25
CA2382880C (en) 2008-10-14
JP2003502315A (ja) 2003-01-21
CO5180558A1 (es) 2002-07-30

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