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PE20010202A1 - AROMATIC SULFOHYDROXAMIC ACID AS A METALOPROTEASE INHIBITOR - Google Patents

AROMATIC SULFOHYDROXAMIC ACID AS A METALOPROTEASE INHIBITOR

Info

Publication number
PE20010202A1
PE20010202A1 PE2000000455A PE0004552000A PE20010202A1 PE 20010202 A1 PE20010202 A1 PE 20010202A1 PE 2000000455 A PE2000000455 A PE 2000000455A PE 0004552000 A PE0004552000 A PE 0004552000A PE 20010202 A1 PE20010202 A1 PE 20010202A1
Authority
PE
Peru
Prior art keywords
aryl
aromatic
alkyl
metaloprotease
inhibitor
Prior art date
Application number
PE2000000455A
Other languages
Spanish (es)
Inventor
Thomas E Barta
Daniel P Becker
Louis J Bedell
Terri L Boehm
Gary A Decrescenzo
Yvette M Fobian
John N Freskos
Daniel P Getman
Joseph J Mcdonald
Susan C Howard
Stephen A Kolodziej
Madeleine Hui Li
Deborah A Mischke
Joseph G Rico
Nathan W Stehle
L Hockerman Susan
Michael B Tollefson
William F Vernier
Clara I Villamil
Jeffery N Carroll
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PE20010202A1 publication Critical patent/PE20010202A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DEL ACIDO SULFONHIDROXAMIXO AROMATICO DE FORMULA I, DONDE: R1 Y R2 FORMAN UN ANILLO DE 5-8 RAMIFICACIONES CON 2-3 O, S, N; R3 ES ARILO, HETEROARILO OPCIONALMENTE SUSTITUIDO CON CICLOALQUILO, HETEROCICLOALQUILO, ARILO, ARALQUILO, CIANO, TRIFLUOROMETOXI, HALO, NITRO, ENTRE OTROS; UN COMPUESTO II; DONDE R14 ES UN CATION, CWR15; W ES O, S; R15 ES ALQUILO C1-C6, ARILO, ALCOXI C1-C6, ENTRE OTROS; m, n Y p SON 1-2; m+n+p=1-4; UNO DE X, Y, Z ES CO, NR6, O, S, SO, NSO2R7, EL RESTO SON CR8R9, CR10R11; X Y Z, Z E Y JUNTOS SON UNA MITAD DE NR6CO, NR6SO, OCO, ENTRE OTROS, EL RESTO SON CR8R9, ENTRE OTROS; n ES CERO; X, Y, Z JUNTOS SON UNA MITAD DE R6-N-CO-NR6`, -N(R6)-CR12R12'-NR6', ENTRE OTROS; R6 Y R6' SON FORMIL, ALQUILSULFONICO C1-C6, ALCOXICARBONIL C1-C6-ALQUIL C1-C6, ENTRE OTROS; R12 YR12' SON ALQUIL C1-C6, ARILO, HETEROARILO, HETEROALQUIL, ENTRE OTROS. LOS COMPUESTOS SON INHIBIDORES DE METALOPROTEINASAS DE LA MATRIZREFERS TO AROMATIC SULFONHYDROXAMIXO ACID COMPOUNDS OF FORMULA I, WHERE: R1 AND R2 FORM A RING OF 5-8 BRANCHES WITH 2-3 O, S, N; R3 IS ARYL, HETEROARILO OPTIONALLY SUBSTITUTED WITH CYCLOALKYL, HETEROCYCLOALKYL, ARYL, ARALKYL, CYANE, TRIFLUOROMETOXY, HALO, NITRO, AMONG OTHERS; A COMPOUND II; WHERE R14 IS A CATION, CWR15; W IS O, S; R15 IS C1-C6 ALKYL, ARYL, C1-C6 ALCOXY, AMONG OTHERS; m, n AND p ARE 1-2; m + n + p = 1-4; ONE OF X, Y, Z IS CO, NR6, O, S, SO, NSO2R7, THE REST ARE CR8R9, CR10R11; X AND Z, Z E AND TOGETHER ARE A HALF OF NR6CO, NR6SO, OCO, AMONG OTHERS, THE REST ARE CR8R9, AMONG OTHERS; n IS ZERO; X, Y, Z TOGETHER ARE A HALF OF R6-N-CO-NR6`, -N (R6) -CR12R12'-NR6 ', AMONG OTHERS; R6 AND R6 'ARE FORMIL, C1-C6 ALKYLSULPHONIC, C1-C6 ALCOXYCARBONYL C1-C6 ALKYL, AMONG OTHERS; R12 AND R12 'ARE C1-C6 ALKYL, ARYL, HETEROARYL, HETEROALKYL, AMONG OTHERS. THE COMPOUNDS ARE INHIBITORS OF METALOPROTEINASES IN THE MATRIX

PE2000000455A 1999-05-14 2000-05-15 AROMATIC SULFOHYDROXAMIC ACID AS A METALOPROTEASE INHIBITOR PE20010202A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31183799A 1999-05-14 1999-05-14

Publications (1)

Publication Number Publication Date
PE20010202A1 true PE20010202A1 (en) 2001-02-19

Family

ID=27757522

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000455A PE20010202A1 (en) 1999-05-14 2000-05-15 AROMATIC SULFOHYDROXAMIC ACID AS A METALOPROTEASE INHIBITOR

Country Status (5)

Country Link
AR (1) AR035547A1 (en)
CO (1) CO5251417A1 (en)
PE (1) PE20010202A1 (en)
UY (1) UY26145A1 (en)
ZA (1) ZA200109006B (en)

Also Published As

Publication number Publication date
UY26145A1 (en) 2000-12-29
ZA200109006B (en) 2002-12-02
AR035547A1 (en) 2004-06-16
CO5251417A1 (en) 2003-02-28

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