PE20010134A1 - Uso de agonistas de receptores 5ht1 y un inhibidor de la cox-2 para el tratamiento de la migrana - Google Patents
Uso de agonistas de receptores 5ht1 y un inhibidor de la cox-2 para el tratamiento de la migranaInfo
- Publication number
- PE20010134A1 PE20010134A1 PE2000000434A PE0004342000A PE20010134A1 PE 20010134 A1 PE20010134 A1 PE 20010134A1 PE 2000000434 A PE2000000434 A PE 2000000434A PE 0004342000 A PE0004342000 A PE 0004342000A PE 20010134 A1 PE20010134 A1 PE 20010134A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxycarbonyl
- migrana
- inhibitor
- treatment
- Prior art date
Links
- 102000035038 5-HT1 receptors Human genes 0.000 title abstract 2
- 108091005478 5-HT1 receptors Proteins 0.000 title abstract 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 2
- 239000000018 receptor agonist Substances 0.000 title abstract 2
- 229940044601 receptor agonist Drugs 0.000 title abstract 2
- 229940111134 coxibs Drugs 0.000 title 1
- -1 OXAZOLE COMPOUND Chemical group 0.000 abstract 5
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229960000590 celecoxib Drugs 0.000 abstract 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960002472 eletriptan Drugs 0.000 abstract 1
- OTLDLQZJRFYOJR-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC1=CN=C2[C]1C=C(CCS(=O)(=O)C=1C=CC=CC=1)C=C2 OTLDLQZJRFYOJR-LJQANCHMSA-N 0.000 abstract 1
- 229960005254 naratriptan Drugs 0.000 abstract 1
- AMKVXSZCKVJAGH-UHFFFAOYSA-N naratriptan Chemical compound C12=CC(CCS(=O)(=O)NC)=CC=C2NC=C1C1CCN(C)CC1 AMKVXSZCKVJAGH-UHFFFAOYSA-N 0.000 abstract 1
- 229960000425 rizatriptan Drugs 0.000 abstract 1
- TXHZXHICDBAVJW-UHFFFAOYSA-N rizatriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1CN1C=NC=N1 TXHZXHICDBAVJW-UHFFFAOYSA-N 0.000 abstract 1
- 229960003708 sumatriptan Drugs 0.000 abstract 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 abstract 1
- 229960002004 valdecoxib Drugs 0.000 abstract 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 abstract 1
- 229960001360 zolmitriptan Drugs 0.000 abstract 1
- ULSDMUVEXKOYBU-ZDUSSCGKSA-N zolmitriptan Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1C[C@H]1COC(=O)N1 ULSDMUVEXKOYBU-ZDUSSCGKSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)DE 0.05 A 100 mg/DIA DE UN AGONISTA DE RECEPTORES 5HT1 COMO ELETRIPTAN, RIZATRIPTAN, ZOLMITRIPTAN, SUMATRIPTAN, NARATRIPTAN b)UN COMPUESTO IMIDAZOL SUSTITUIDO CON BENCENO DE FORMULA I, DONDE: R1 ES SULFAMILO; R2 ES HALOALQUILO; R3 ES ALQUILO, ENTRE OTROS; R4 ES ARILO, CICLOALQUILO, CICLOALQUENILO OPCIONALMENTE SUSTITUIDO CON HALO, ALQUILTIO, ALQUILSULFINILO, ENTRE OTROS; o UN COMPUESTO OXAZOL SUSTITUIDO DE FORMULA II, DONDE: R1 ES ALQUILO, CARBOXIALQUILO, ALCOXICARBONILO, AMINOCARBONILO, ALCOXICARBONIL-ALQUILO, CARBOXILO, ALCOXI, HALOALCOXI, ENTRE OTROS; R3 ES CICLOALQUILO, CICLOALQUENILO, ARILO OPCIONALMENTE SUSTITUIDO CON ALQUILO, CIANO, CARBOXILO, ALCOXICARBONILO, HALOALQUILO, HIDROXILO ENTRE OTROS; R4 ES ALQUILO, HIDROXILO, AMINO; UTILIZANDOSE DE 10 A 300 mg/DIA DEL INHIBIDOR DE CICLOOXIGENASA-2 TAL COMO CELECOXIB, VALDECOXIB. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE LA MIGRANA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13430999P | 1999-05-14 | 1999-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010134A1 true PE20010134A1 (es) | 2001-02-28 |
Family
ID=22462766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000434A PE20010134A1 (es) | 1999-05-14 | 2000-05-10 | Uso de agonistas de receptores 5ht1 y un inhibidor de la cox-2 para el tratamiento de la migrana |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1051994A3 (es) |
| JP (1) | JP2000336031A (es) |
| KR (1) | KR20010029717A (es) |
| AU (1) | AU3253800A (es) |
| CA (1) | CA2308824A1 (es) |
| CO (1) | CO5170509A1 (es) |
| HU (1) | HUP0001889A3 (es) |
| IL (1) | IL136024A0 (es) |
| PE (1) | PE20010134A1 (es) |
| ZA (1) | ZA200002343B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2348979A1 (en) * | 1998-11-02 | 2000-05-11 | Merck & Co., Inc. | Method of treating migraines and pharmaceutical compositions |
| GB9929039D0 (en) * | 1999-12-08 | 2000-02-02 | Glaxo Group Ltd | Medicaments |
| NL2000351C2 (nl) | 2005-12-22 | 2007-09-11 | Pfizer Prod Inc | Estrogeen-modulatoren. |
| US10198350B2 (en) | 2011-07-28 | 2019-02-05 | Netlist, Inc. | Memory module having volatile and non-volatile memory subsystems and method of operation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
-
2000
- 2000-05-05 AU AU32538/00A patent/AU3253800A/en not_active Abandoned
- 2000-05-08 IL IL13602400A patent/IL136024A0/xx unknown
- 2000-05-09 EP EP00303890A patent/EP1051994A3/en not_active Withdrawn
- 2000-05-10 PE PE2000000434A patent/PE20010134A1/es not_active Application Discontinuation
- 2000-05-10 CO CO00033396A patent/CO5170509A1/es not_active Application Discontinuation
- 2000-05-12 CA CA002308824A patent/CA2308824A1/en not_active Abandoned
- 2000-05-12 HU HU0001889A patent/HUP0001889A3/hu unknown
- 2000-05-12 JP JP2000140270A patent/JP2000336031A/ja not_active Abandoned
- 2000-05-12 ZA ZA200002343A patent/ZA200002343B/xx unknown
- 2000-05-13 KR KR1020000025597A patent/KR20010029717A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1051994A3 (en) | 2003-01-08 |
| HU0001889D0 (en) | 2000-07-28 |
| CO5170509A1 (es) | 2002-06-27 |
| JP2000336031A (ja) | 2000-12-05 |
| CA2308824A1 (en) | 2000-11-14 |
| HUP0001889A3 (en) | 2003-07-28 |
| HUP0001889A2 (hu) | 2001-05-28 |
| IL136024A0 (en) | 2001-05-20 |
| KR20010029717A (ko) | 2001-04-16 |
| AU3253800A (en) | 2000-11-16 |
| EP1051994A2 (en) | 2000-11-15 |
| ZA200002343B (en) | 2001-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |