PE20010041A1 - DERIVATIVES OF 1-AMINOETHYLINDOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents
DERIVATIVES OF 1-AMINOETHYLINDOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICSInfo
- Publication number
- PE20010041A1 PE20010041A1 PE2000000344A PE0003442000A PE20010041A1 PE 20010041 A1 PE20010041 A1 PE 20010041A1 PE 2000000344 A PE2000000344 A PE 2000000344A PE 0003442000 A PE0003442000 A PE 0003442000A PE 20010041 A1 PE20010041 A1 PE 20010041A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aminoethylindol
- derivatives
- fluoroalkyl
- hydroxyethyl
- Prior art date
Links
- QUERAHCHJWZYJF-UHFFFAOYSA-N 1-(1h-indol-2-yl)ethanamine Chemical class C1=CC=C2NC(C(N)C)=CC2=C1 QUERAHCHJWZYJF-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 206010066218 Stress Urinary Incontinence Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 201000002282 venous insufficiency Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE 1-AMINOETILINDOL DE FORMULA I, DONDE: A ES H, HALOGENO, HIDROXI; B Y D SON H, ALQUILO C1-C3; R1 ES H, ALQUILO C1-C4, FLUOROALQUILO C1-C2, PERFLUOROALQUILO C1-C2; R2 ES H, HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C6, FLUOROALQUILO C1-C2, PERFLUOROALQUILO, FENILO; R3 Y R4 SON H, HALOGENO, ALQUILO C1-C6; R5 Y R6 SON H, ALQUILO C1-C6, FLUOROALQUILO C1-C2; R5 Y R6 JUNTOS SON ALQUILENO C2-C7. SON COMPUESTOS PREFERIDOS 2-METILINDOL-4-(1-DIETILAMINO-2-HIDROXIETIL)INDOL, 1(N)-METIL-2-ETILINDOL-4-(1-DIETILAMINO-2-HIDROXIETIL)INDOL, 1(N)-METIL-2-FENIL-4-(1-DIETILAMINO-2-HIDROXIETIL)INDOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS DERIVADOS DE 1-AMINOETILINDOL DE FORMULA I TIENEN ACCION CONTRACTIL SOBRE LOS MUSCULOS LISOS URETRALES Y ARTERIALES Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE INCONTINENCIA URINARIA DE ESFUERZO, INSUFICIENCIA VENOSA, MIGRANA, TRASTORNOS GASTROINTESTINALESREFERS TO 1-AMINOETHYLINDOL DERIVATIVES OF FORMULA I, WHERE: A IS H, HALOGEN, HYDROXY; B AND D ARE H, C1-C3 ALKYL; R1 IS H, C1-C4 ALKYL, C1-C2 FLUOROALKYL, C1-C2 PERFLUOROALKYL; R2 IS H, HALOGEN, C1-C6 ALKYL, C3-C6 CYCLOALKYL, C1-C2 FLUOROALKYL, PERFLUOROALKYL, PHENYL; R3 AND R4 ARE H, HALOGEN, C1-C6 ALKYL; R5 AND R6 ARE H, C1-C6 ALKYL, C1-C2 FLUOROALKYL; R5 AND R6 TOGETHER ARE C2-C7 ALKYLENE. PREFERRED COMPOUNDS ARE 2-METHYLINDOL-4- (1-DIETHYLINDOL-2-HYDROXYETHYL) INDOL, 1 (N) -METHYL-2-ETHYLINDOL-4- (1-DIETHYLINDLE-2-HYDROXYETHYL) INDOLE, 1 (N) -METIL -2-PHENYL-4- (1-DIETHYLAMINE-2-HYDROXYETHYL) INDOL, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE 1-AMINOETHYLINDOL DERIVATIVES OF FORMULA I HAVE CONTRACTILE ACTION ON THE URETHRAL AND ARTERIAL SMOOTH MUSCLES AND MAY BE USEFUL FOR THE TREATMENT OF URINARY STRESS INCONTINENCE, VENOUS INSUFFICIENCY, MIGRANE, GASTROESTINAL DISORDERS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9904577A FR2792316B1 (en) | 1999-04-13 | 1999-04-13 | 1-AMINOETHYLINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010041A1 true PE20010041A1 (en) | 2001-04-12 |
Family
ID=9544316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000344A PE20010041A1 (en) | 1999-04-13 | 2000-04-13 | DERIVATIVES OF 1-AMINOETHYLINDOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR023451A1 (en) |
| AU (1) | AU3971400A (en) |
| CO (1) | CO5180549A1 (en) |
| FR (1) | FR2792316B1 (en) |
| PE (1) | PE20010041A1 (en) |
| UY (1) | UY26102A1 (en) |
| WO (1) | WO2000061554A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077405A1 (en) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | DERIVATIVES OF INDOL INHIBITORS OF HSP90, COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME FOR THE TREATMENT OF CANCER |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2752839B1 (en) * | 1996-08-29 | 1998-10-09 | Synthelabo | BENZOFURANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| FR2752840A1 (en) * | 1996-08-29 | 1998-03-06 | Synthelabo | 7-Amino ethyl benzothiophene derivatives |
-
1999
- 1999-04-13 FR FR9904577A patent/FR2792316B1/en not_active Expired - Fee Related
-
2000
- 2000-04-10 UY UY26102A patent/UY26102A1/en not_active Application Discontinuation
- 2000-04-11 WO PCT/FR2000/000922 patent/WO2000061554A1/en not_active Ceased
- 2000-04-11 AU AU39714/00A patent/AU3971400A/en not_active Abandoned
- 2000-04-11 CO CO00026489A patent/CO5180549A1/en not_active Application Discontinuation
- 2000-04-12 AR ARP000101669A patent/AR023451A1/en unknown
- 2000-04-13 PE PE2000000344A patent/PE20010041A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR023451A1 (en) | 2002-09-04 |
| UY26102A1 (en) | 2000-10-31 |
| AU3971400A (en) | 2000-11-14 |
| FR2792316A1 (en) | 2000-10-20 |
| FR2792316B1 (en) | 2001-06-22 |
| WO2000061554A1 (en) | 2000-10-19 |
| CO5180549A1 (en) | 2002-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |