PE20010701A1 - Combinaciones oncoliticas para el tratamiento del cancer - Google Patents
Combinaciones oncoliticas para el tratamiento del cancerInfo
- Publication number
- PE20010701A1 PE20010701A1 PE2000001206A PE0012062000A PE20010701A1 PE 20010701 A1 PE20010701 A1 PE 20010701A1 PE 2000001206 A PE2000001206 A PE 2000001206A PE 0012062000 A PE0012062000 A PE 0012062000A PE 20010701 A1 PE20010701 A1 PE 20010701A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- cancer
- carcinoma
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000001531 bladder carcinoma Diseases 0.000 abstract 1
- 201000008275 breast carcinoma Diseases 0.000 abstract 1
- 201000010989 colorectal carcinoma Diseases 0.000 abstract 1
- 201000005619 esophageal carcinoma Diseases 0.000 abstract 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 abstract 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)UN ANTAGONISTA DE LEUCOTRIENO (LTB4) DE FORMULA I, X ES UN HETEROCICLO DE 5 MIEMBROS CON 1-4 HETEROATOMOS, BICICLO; Y ES UN ENLACE O UN GRUPO DIVALENTE CON 1-9 ATOMOS; Y2, Y3 SON CH2, O, S,; Z ES UN GRUPO ACIDICO; R1 ES ALQUILO C1-C6, ARILO, CICLOALQUILO C2-C10, ENTRE OTROS; R2 ES H, HALOGENO, HALOALQUILO C1-C10, ALCOXI C1-C10, ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO C1-C10, ARILO, ENTRE OTROS; R4 ES ALQUILO C1-C4, CICLOALQUILO C3-C4, CH2(1-7)(CICLOALQUILO C3-C4), ENTRE OTROS; M ES 0-6; UN COMPUESTO PREFERIDO ES 2-[2-PROPIL-3-[3-[2-ETIL-5-HIDROXI-4-(4-FLUOROFENIL)FENOXI]PROPOXI]FENOXI ACIDO BENZOICO Y b)UN AGENTE ANTICANCEROSO 2`,2'-DIFLUORONUCLEOSIDO DE FORMULA II, DONDE R1 ES H, -COR5; R2 ES UN GRUPO a, b; X ES N, CR4; R3 ES H, ALQUILO C1-C4, COR5; R4 ES H, ALQUILO C1-C4, AMINO, Br, ENTRE OTROS; R5 ES H, ALQUILO C1-C4; UN COMPUESTO PREFERIDO ES GEMCITABINA HCl, 2'-DEOXI-2',2'-DIFLUOROCITIDINA MONOCLORHIDRATO (ß-ISOMERO). LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DEL CANCER, CARCINOMA DE MAMA, CARCINOMA DE VEJIGA, CARCINOMA COLORECTAL, CARCINOMA ESOFAGICO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16478699P | 1999-11-11 | 1999-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010701A1 true PE20010701A1 (es) | 2001-07-07 |
Family
ID=22596085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001206A PE20010701A1 (es) | 1999-11-11 | 2000-11-10 | Combinaciones oncoliticas para el tratamiento del cancer |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1231938A2 (es) |
| JP (1) | JP2003513916A (es) |
| KR (1) | KR20020069512A (es) |
| CN (1) | CN1390139A (es) |
| AR (1) | AR032432A1 (es) |
| AU (1) | AU778829B2 (es) |
| BR (1) | BR0015490A (es) |
| CA (1) | CA2391416A1 (es) |
| CZ (1) | CZ20021551A3 (es) |
| EA (1) | EA200200545A1 (es) |
| HK (1) | HK1050132A1 (es) |
| HU (1) | HUP0204449A3 (es) |
| IL (1) | IL148579A0 (es) |
| MX (1) | MXPA02004733A (es) |
| NO (1) | NO20022245L (es) |
| NZ (1) | NZ517667A (es) |
| PE (1) | PE20010701A1 (es) |
| PL (1) | PL355172A1 (es) |
| SK (1) | SK6492002A3 (es) |
| TR (1) | TR200201245T2 (es) |
| WO (1) | WO2001034137A2 (es) |
| ZA (1) | ZA200202822B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6797723B1 (en) | 1999-11-11 | 2004-09-28 | Eli Lilly And Company | Heterocycle substituted diphenyl leukotriene antagonists |
| AU1916601A (en) * | 1999-11-11 | 2001-06-06 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| WO2001034197A2 (en) * | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| JP2001247459A (ja) | 2000-03-03 | 2001-09-11 | Oakland Uniservices Ltd | 癌の組み合わせ療法 |
| EP1326605A4 (en) * | 2000-05-09 | 2004-03-17 | Univ Creighton | USE OF INHIBITORS OF THE BINDING OF LEUKOTRIEN B4 TO LEUKOTRIEN B4 RECEPTOR TO INHIBIT PROLIFERATION AND INDUCTION OF APOPTOSE IN CANCER CELLS |
| AU2001282717A1 (en) | 2000-07-28 | 2002-02-13 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2386836B (en) | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2394658A (en) | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
| ATE515494T1 (de) | 2004-05-05 | 2011-07-15 | High Point Pharmaceuticals Llc | Neue verbindungen, deren herstellung und verwendung |
| DE602005024384D1 (de) | 2004-05-05 | 2010-12-09 | High Point Pharmaceuticals Llc | Neue verbindungen, ihre herstellung und verwendung |
| CN1302782C (zh) * | 2005-01-17 | 2007-03-07 | 北京京卫燕康药物研究所有限公司 | 盐酸吉西他滨溶液型注射剂 |
| WO2007003581A1 (en) | 2005-06-30 | 2007-01-11 | Novo Nordisk A/S | Phenoxy acetic acids as ppar delta activators |
| US7943613B2 (en) | 2005-12-22 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
| CA2645719A1 (en) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Compounds that modulate ppar activity, their preparation and use |
| US8044236B2 (en) | 2006-10-12 | 2011-10-25 | Institute Of Medicinal Molecular Design, Inc. | Carboxilic acid derivatives |
| US8633245B2 (en) | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
| WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| BR112015009751A2 (pt) | 2012-10-31 | 2017-07-11 | Bayer Cropscience Ag | novos compostos heterocíclicos como pesticidas |
| CN103319466B (zh) * | 2013-07-04 | 2016-03-16 | 郑州大学 | 含香豆素母核的1,2,3-三唑-氨基二硫代甲酸酯化合物、制备方法及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
-
2000
- 2000-11-09 PL PL00355172A patent/PL355172A1/xx not_active Application Discontinuation
- 2000-11-09 MX MXPA02004733A patent/MXPA02004733A/es not_active Application Discontinuation
- 2000-11-09 TR TR2002/01245T patent/TR200201245T2/xx unknown
- 2000-11-09 IL IL14857900A patent/IL148579A0/xx unknown
- 2000-11-09 BR BR0015490-3A patent/BR0015490A/pt not_active IP Right Cessation
- 2000-11-09 JP JP2001536137A patent/JP2003513916A/ja not_active Withdrawn
- 2000-11-09 EA EA200200545A patent/EA200200545A1/ru unknown
- 2000-11-09 WO PCT/US2000/031039 patent/WO2001034137A2/en not_active Ceased
- 2000-11-09 SK SK649-2002A patent/SK6492002A3/sk unknown
- 2000-11-09 NZ NZ517667A patent/NZ517667A/en unknown
- 2000-11-09 EP EP00978535A patent/EP1231938A2/en not_active Withdrawn
- 2000-11-09 KR KR1020027006027A patent/KR20020069512A/ko not_active Withdrawn
- 2000-11-09 CZ CZ20021551A patent/CZ20021551A3/cs unknown
- 2000-11-09 AU AU15990/01A patent/AU778829B2/en not_active Ceased
- 2000-11-09 CN CN00815579A patent/CN1390139A/zh active Pending
- 2000-11-09 CA CA002391416A patent/CA2391416A1/en not_active Abandoned
- 2000-11-09 HK HK03100750.7A patent/HK1050132A1/zh unknown
- 2000-11-09 HU HU0204449A patent/HUP0204449A3/hu unknown
- 2000-11-10 PE PE2000001206A patent/PE20010701A1/es not_active Application Discontinuation
- 2000-11-10 AR ARP000105955A patent/AR032432A1/es unknown
-
2002
- 2002-04-10 ZA ZA200202822A patent/ZA200202822B/xx unknown
- 2002-05-10 NO NO20022245A patent/NO20022245L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20022245L (no) | 2002-07-09 |
| NO20022245D0 (no) | 2002-05-10 |
| TR200201245T2 (tr) | 2004-08-23 |
| WO2001034137A2 (en) | 2001-05-17 |
| NZ517667A (en) | 2004-05-28 |
| ZA200202822B (en) | 2003-09-23 |
| EA200200545A1 (ru) | 2002-12-26 |
| MXPA02004733A (es) | 2002-08-30 |
| AR032432A1 (es) | 2003-11-12 |
| KR20020069512A (ko) | 2002-09-04 |
| EP1231938A2 (en) | 2002-08-21 |
| WO2001034137A3 (en) | 2002-02-14 |
| HUP0204449A3 (en) | 2006-02-28 |
| HUP0204449A2 (hu) | 2003-04-28 |
| JP2003513916A (ja) | 2003-04-15 |
| CA2391416A1 (en) | 2001-05-17 |
| CN1390139A (zh) | 2003-01-08 |
| AU1599001A (en) | 2001-06-06 |
| HK1050132A1 (zh) | 2003-06-13 |
| SK6492002A3 (en) | 2003-09-11 |
| PL355172A1 (en) | 2004-04-05 |
| BR0015490A (pt) | 2002-07-09 |
| CZ20021551A3 (cs) | 2003-02-12 |
| AU778829B2 (en) | 2004-12-23 |
| IL148579A0 (en) | 2002-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |