PE20010661A1 - Composicion que comprende un inhibidor de lipasas - Google Patents
Composicion que comprende un inhibidor de lipasasInfo
- Publication number
- PE20010661A1 PE20010661A1 PE2000000950A PE0009502000A PE20010661A1 PE 20010661 A1 PE20010661 A1 PE 20010661A1 PE 2000000950 A PE2000000950 A PE 2000000950A PE 0009502000 A PE0009502000 A PE 0009502000A PE 20010661 A1 PE20010661 A1 PE 20010661A1
- Authority
- PE
- Peru
- Prior art keywords
- fatty acid
- refers
- lipase inhibitor
- ester
- acid ester
- Prior art date
Links
- 229940086609 Lipase inhibitor Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 4
- 239000000194 fatty acid Substances 0.000 abstract 4
- 229930195729 fatty acid Natural products 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- -1 POLYOL FATTY ACID ESTER Chemical class 0.000 abstract 3
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 229920005862 polyol Polymers 0.000 abstract 2
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 abstract 2
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N trilaurin Chemical compound CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229920002774 Maltodextrin Polymers 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 abstract 1
- 229960001243 orlistat Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE: a)DE 1% A 50% DE UN INHIBIDOR DE LIPASAS GASTROINTESTINALES TAL COMO ORLISTAT; b)0.5% A 90% EN PESO DE UN ESTER DE ACIDO GRASO DE POLIOLES CON UN PUNTO DE FUSION MAYOR QUE LA TEMPERATURA CORPORAL DE PREFERENCIA GLICEROL, AZUCARES, ESTER GLICERIDO COMO TRIGLICERIDOS (TRILAURIN, TRIMIRISTIN, TRIPALMITIN, TRITEARIN), MONOGLICERIDOS (MONOCAPRIN, MONOLAURIN, MONOMIRISTIN, MOPALMITIN), FOSFOLIPIDOS (LECITINA NO HIDROGENADA, PARCIALMENTE O TOTALMENTE HIDROGENADA). LA FRACCION DE ACIDO GRASO EN EL ESTER DE ACIDO GRASO DE POLIOL TIENEN DOCE O MAS ATOMOS DE CARBONO Y LAS FRACCIONES DE ACIDO GRASO ESTAN SATURADOS; c)UN EXCIPIENTE FARMACEUTICAMENTE ACEPTABLE TAL COMO CARBOHIDRATOS, ALMIDON, MALTODEXTRINAS, CELULOSA, DESINTEGRANTES, TENSIOACTIVOS, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LA COMPOSICION FARMACEUTICA PUEDE SER UTIL PARA CONTROLAR O PREVENIR LA OBESIDAD
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99118179 | 1999-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010661A1 true PE20010661A1 (es) | 2001-06-25 |
Family
ID=8238989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000950A PE20010661A1 (es) | 1999-09-13 | 2000-09-13 | Composicion que comprende un inhibidor de lipasas |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6703369B1 (es) |
| EP (1) | EP1216048B1 (es) |
| JP (1) | JP4217017B2 (es) |
| KR (1) | KR100523879B1 (es) |
| CN (1) | CN1197554C (es) |
| AR (1) | AR025609A1 (es) |
| AT (1) | ATE285783T1 (es) |
| AU (1) | AU769016B2 (es) |
| BR (1) | BRPI0013940B1 (es) |
| CA (1) | CA2383036C (es) |
| CO (1) | CO5210857A1 (es) |
| CZ (1) | CZ301844B6 (es) |
| DE (1) | DE60017156T2 (es) |
| EG (1) | EG24225A (es) |
| ES (1) | ES2233444T3 (es) |
| GC (1) | GC0000259A (es) |
| HK (1) | HK1049798B (es) |
| HR (1) | HRP20020206B1 (es) |
| HU (1) | HU229037B1 (es) |
| IL (2) | IL148570A0 (es) |
| JO (1) | JO2300B1 (es) |
| MA (1) | MA26817A1 (es) |
| ME (1) | MEP90908A (es) |
| MX (1) | MXPA02002662A (es) |
| MY (1) | MY127430A (es) |
| NO (1) | NO328889B1 (es) |
| NZ (1) | NZ517396A (es) |
| PE (1) | PE20010661A1 (es) |
| PL (1) | PL199869B1 (es) |
| PT (1) | PT1216048E (es) |
| RS (1) | RS50373B (es) |
| RU (1) | RU2248218C2 (es) |
| SI (1) | SI1216048T1 (es) |
| TR (1) | TR200200605T2 (es) |
| WO (1) | WO2001019378A2 (es) |
| ZA (1) | ZA200201249B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR025609A1 (es) * | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones lipidas solidas |
| EP1307264B1 (en) * | 2000-07-28 | 2004-10-20 | F. Hoffmann-La Roche Ag | New pharmaceutical composition |
| US20030027786A1 (en) * | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6730319B2 (en) * | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| DE10251963A1 (de) * | 2002-11-08 | 2004-05-19 | Lts Lohmann Therapie-Systeme Ag | Transmucosale pharmazeutische Darreichungsform |
| US8372430B2 (en) * | 2002-12-17 | 2013-02-12 | The Procter & Gamble Company | Compositions, methods, and kits useful for the alleviation of gastrointestinal effects |
| BR0318167A (pt) * | 2003-03-04 | 2006-02-21 | Nostrum Pharmaceuticals Inc | formulação de liberação controlada contendo um material hidrofóbico como o agente de liberação controlada |
| FI20045076L (fi) * | 2004-03-15 | 2005-09-16 | Bioferme Oy | Funktionaalinen elintarvike |
| AU2005297923B2 (en) * | 2004-10-25 | 2010-12-23 | Japan Tobacco Inc. | Solid medicinal preparation improved in solubility and stability and process for producing the same |
| KR100669497B1 (ko) * | 2005-08-17 | 2007-01-16 | 보람제약주식회사 | 안정성과 용출률이 뛰어난 약리학적 조성물 및 그 제조방법 |
| EP1808163A1 (en) * | 2005-12-22 | 2007-07-18 | Teva Pharmaceutical Industries Ltd. | Compressed solid dosage forms with drugs of low solubility and process for making the same |
| WO2007073389A1 (en) * | 2005-12-22 | 2007-06-28 | Teva Pharmaceutical Industries Ltd. | Compressed solid dosage forms with drugs of low solubility and process for making the same |
| US20070148245A1 (en) * | 2005-12-22 | 2007-06-28 | Ilan Zalit | Compressed solid dosage forms with drugs of low solubility and process for making the same |
| KR101252635B1 (ko) | 2006-04-20 | 2013-04-10 | (주)아모레퍼시픽 | 리파아제 저해제 및 친유성 오일흡수제를 포함하는 약학조성물 및 이로부터 제조된 경구 투여용 제제 |
| KR100903504B1 (ko) * | 2007-05-18 | 2009-06-17 | 강태용 | 비라칸사스 열매 추출물질을 포함하는 기능식품 및 체중 감소제 |
| JP2010536798A (ja) * | 2007-08-17 | 2010-12-02 | テバ ファーマシューティカル インダストリーズ リミティド | 難溶性薬物の生体利用率を制御するための方法及び組成物 |
| PL2036575T3 (pl) * | 2007-09-12 | 2011-02-28 | Mader S R L | Kompozycje farmaceutyczne do stosowania doustnie w leczeniu pacjentów dotkniętych otyłością |
| PL216542B1 (pl) | 2008-03-20 | 2014-04-30 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób wytwarzania stabilnej kompozycji orlistatu w postaci kapsułkowanego proszku |
| US8309107B2 (en) | 2008-10-06 | 2012-11-13 | Banner Pharmacaps, Inc. | Stable solutions of orlistat for pharmaceutical dosage forms |
| BRPI0901602B8 (pt) | 2009-04-03 | 2021-05-25 | Ems S/A | formulação farmacêuticas |
| UA107369C2 (en) | 2010-02-01 | 2014-12-25 | Lab Bago S A | Pharmaceutical composition with anti-obesity activity comprising a premixture of pure orlistat and preparation process |
| EP2486805A1 (en) * | 2011-02-11 | 2012-08-15 | Puratos N.V. | An emulsion whippable at room-temperature |
| MY162951A (en) * | 2011-04-14 | 2017-07-31 | J Oil Mills Inc | Palm-based and fractionated oil and fat, oil and fat composition and foods mixed with the same |
| CN102552168B (zh) * | 2012-01-31 | 2013-08-07 | 杭州华东医药集团生物工程研究所有限公司 | 一种含有奥利司他的药物组合物及其制备方法 |
| GB2501535A (en) | 2012-04-26 | 2013-10-30 | Sony Corp | Chrominance Processing in High Efficiency Video Codecs |
| MX363640B (es) * | 2012-05-31 | 2019-03-28 | Repros Therapeutics Inc | Formulaciones y metodos para la administracion vaginal de antiprogestinas. |
| CA2923838A1 (en) * | 2013-10-28 | 2015-05-07 | Nestec S.A. | Monoacylglycerols for use in conjunction with a lipase inhibitor and/or diets low in fat and/or calories |
| CN115105476B (zh) * | 2021-03-23 | 2023-11-14 | 山东新时代药业有限公司 | 一种奥利司他冻干口服制剂及其制备工艺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| FR2710264B1 (fr) * | 1993-09-21 | 1995-12-08 | Rocher Yves Biolog Vegetale | Utilisation pour le traitement des peaux mixtes d'une quantité efficace de substances actives. |
| AU5185398A (en) * | 1996-12-04 | 1998-06-29 | James S Pincott | Process and apparatus for making crumb rubber from scrap tyres |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| YU34199A (sh) | 1997-02-05 | 2002-08-12 | F. Hoffmann-La Roche Ag. | Primena inhibitora gastrointestinalne lipaze |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| DK1105123T3 (da) * | 1998-08-14 | 2004-08-09 | Hoffmann La Roche | Farmaceutiske præparater indeholdende lipase-inhibitorer og chitosan |
| DK1105122T3 (da) | 1998-08-14 | 2005-08-08 | Hoffmann La Roche | Pharmaceutical compositions containing lipase inhibitors |
| AR025609A1 (es) * | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones lipidas solidas |
-
2000
- 2000-09-08 AR ARP000104722A patent/AR025609A1/es active IP Right Grant
- 2000-09-11 ME MEP-909/08A patent/MEP90908A/xx unknown
- 2000-09-11 WO PCT/EP2000/008857 patent/WO2001019378A2/en not_active Ceased
- 2000-09-11 HR HR20020206A patent/HRP20020206B1/xx not_active IP Right Cessation
- 2000-09-11 IL IL14857000A patent/IL148570A0/xx active IP Right Grant
- 2000-09-11 HK HK03101988.9A patent/HK1049798B/zh not_active IP Right Cessation
- 2000-09-11 EP EP00964158A patent/EP1216048B1/en not_active Expired - Lifetime
- 2000-09-11 AT AT00964158T patent/ATE285783T1/de active
- 2000-09-11 JO JO2000156A patent/JO2300B1/en active
- 2000-09-11 DE DE60017156T patent/DE60017156T2/de not_active Expired - Lifetime
- 2000-09-11 MX MXPA02002662A patent/MXPA02002662A/es active IP Right Grant
- 2000-09-11 HU HU0202762A patent/HU229037B1/hu unknown
- 2000-09-11 CN CNB008126798A patent/CN1197554C/zh not_active Expired - Lifetime
- 2000-09-11 RS YUP-136/02A patent/RS50373B/sr unknown
- 2000-09-11 ES ES00964158T patent/ES2233444T3/es not_active Expired - Lifetime
- 2000-09-11 PL PL356154A patent/PL199869B1/pl unknown
- 2000-09-11 KR KR10-2002-7003247A patent/KR100523879B1/ko not_active Expired - Lifetime
- 2000-09-11 JP JP2001523010A patent/JP4217017B2/ja not_active Expired - Lifetime
- 2000-09-11 PT PT00964158T patent/PT1216048E/pt unknown
- 2000-09-11 CA CA002383036A patent/CA2383036C/en not_active Expired - Lifetime
- 2000-09-11 RU RU2002107450/15A patent/RU2248218C2/ru active
- 2000-09-11 SI SI200030589T patent/SI1216048T1/xx unknown
- 2000-09-11 CZ CZ20021277A patent/CZ301844B6/cs not_active IP Right Cessation
- 2000-09-11 AU AU75177/00A patent/AU769016B2/en not_active Expired
- 2000-09-11 NZ NZ517396A patent/NZ517396A/en not_active IP Right Cessation
- 2000-09-11 MY MYPI20004207 patent/MY127430A/en unknown
- 2000-09-11 BR BRPI0013940A patent/BRPI0013940B1/pt not_active IP Right Cessation
- 2000-09-11 TR TR2002/00605T patent/TR200200605T2/xx unknown
- 2000-09-12 CO CO00068855A patent/CO5210857A1/es active IP Right Grant
- 2000-09-12 EG EG20001160A patent/EG24225A/xx active
- 2000-09-13 PE PE2000000950A patent/PE20010661A1/es not_active IP Right Cessation
- 2000-09-13 US US09/660,700 patent/US6703369B1/en not_active Expired - Lifetime
- 2000-09-13 GC GCP2000906 patent/GC0000259A/en active
-
2002
- 2002-02-13 ZA ZA200201249A patent/ZA200201249B/en unknown
- 2002-03-07 IL IL148570A patent/IL148570A/en unknown
- 2002-03-11 MA MA26544A patent/MA26817A1/fr unknown
- 2002-03-12 NO NO20021205A patent/NO328889B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FG | Grant, registration | ||
| MK | Expiration of term |