[go: up one dir, main page]

PE20010627A1 - COMPOSITIONS THAT HAVE IMPROVED STABILITY - Google Patents

COMPOSITIONS THAT HAVE IMPROVED STABILITY

Info

Publication number
PE20010627A1
PE20010627A1 PE2000001034A PE0010342000A PE20010627A1 PE 20010627 A1 PE20010627 A1 PE 20010627A1 PE 2000001034 A PE2000001034 A PE 2000001034A PE 0010342000 A PE0010342000 A PE 0010342000A PE 20010627 A1 PE20010627 A1 PE 20010627A1
Authority
PE
Peru
Prior art keywords
active
improved stability
agent
active agent
ionized
Prior art date
Application number
PE2000001034A
Other languages
Spanish (es)
Inventor
Jayant Eknath Khanolkar
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/467,333 external-priority patent/US20020082307A1/en
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20010627A1 publication Critical patent/PE20010627A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

SE REFIERE A UNA COMPOSICION LIQUIDA ORAL QUE TIENE ESTABILIDAD MEJORADA QUE COMPRENDE a)UN AGENTE ACTIVO DE PESO MOLECULAR INFERIOR A 500 g/MOL, COMO ANTITUSIVOS, ANTIHISTAMINICOS, DESCONGESTIONANTES, EXPECTORANTES, MUCOLITICOS, ANALGESICOS, AGENTES ANTIPIRETICOS, SEDANTES; b)UN DISOLVENTE ANHIDRO HIDROFILO, MISCIBLE EN AGUA COMO PROPILENGLICOL, ETANOL, CARBONATO DE PROPILENO, ENTRE OTROS; c)DE 0,005% A 1% DE UN AGENTE QUELANTE COMO SALES DISODICAS, CALCICAS DEL ACIDO ETILENDIAMINOACETICO, EDTA TETRASODICA, ACIDO CITRICO, ENTRE OTROS, QUE SE ENCUENTRA EN UNA FASE DIFERENTE DE LA FASE DEL ACTIVO, QUE TIENE UNA ESTABILIDAD MEJORADA; d)DE 0,0050% A 1% DE UN AGENTE DE REDUCCION COMO SALES BISULFITO, SODICAS, POTASICAS, DITIOERITRIOL, TIOUREA, ENTRE OTROS CON UN POTENCIAL DE ELECTRODO E° SUPERIOR A -0,119V, EL AGENTE QUELANTE Y DE REDUCCION SON ACTIVOS A UN pH DE 5 A 12, EN COMPOSICIONES DISOLVENTES ACUOSAS Y NO ACUOSAS; EL AGENTE ACTIVO EN SU FORMA NO IONIZADA TIENE UNA SOLUBILIDAD A TEMPERATURA AMBIENTE IGUAL O SUPERIOR A 0,75%; EL AGENTE ACTIVO ES CAPAZ DE SER IONIZADO EN DISOLVENTE ACUOSO, TIENE UN COEFICIENTE DE PARTICION DE OCTANOL:AGUA CUANDO ESTA EN LA FORMA NO IONIZADA DE 100. LA COMPOSICION PUEDE SER UTIL PARA TRATAR ENFERMEDADES RESPIRATORIAS UTILIZANDO NO MAS DE 3mlIT REFERS TO AN ORAL LIQUID COMPOSITION THAT HAS IMPROVED STABILITY, INCLUDING a) AN ACTIVE AGENT OF MOLECULAR WEIGHT LESS THAN 500 g / MOL, AS ANTITUSSIVES, ANTIHISTAMINES, DECONGESTANTS, EXPECTORANTS, ANTI-AGENTS, ANTI-CHOLYTICS; b) A HYDROPHYL ANHYDRO SOLVENT, MISCIBLE IN WATER SUCH AS PROPYLENE GLYCOL, ETHANOL, PROPYLENE CARBONATE, AMONG OTHERS; c) FROM 0.005% TO 1% OF A CHELATING AGENT SUCH AS DISODIC SALTS, ETHYLENDIAMINOACETIC ACID CALCICES, TETRASODIUM EDTA, CITRIC ACID, AMONG OTHERS, WHICH IS IN A DIFFERENT PHASE FROM THE ACTIVE PHASE, WHICH HAS IMPROVED STABILITY; d) FROM 0.0050% TO 1% OF A REDUCING AGENT SUCH AS BISULPHITE, SODIUM, POTASSIUM SALTS, DITIOERITHRIOL, THIOUREA, AMONG OTHERS WITH A POTENTIAL OF ELECTRODE E ° GREATER THAN -0.119V, THE CHELATING AND REDUCING AGENT ARE ACTIVE AT A pH OF 5 TO 12, IN AQUEOUS AND NON-AQUEOUS SOLVENT COMPOSITIONS; THE ACTIVE AGENT IN ITS NON-IONIZED FORM HAS A SOLUBILITY AT AMBIENT TEMPERATURE EQUAL TO OR GREATER THAN 0.75%; THE ACTIVE AGENT IS CAPABLE OF BEING IONIZED IN AQUEOUS SOLVENT, IT HAS A PARTITION COEFFICIENT OF OCTANOL: WATER WHEN IT IS IN THE NON-IONIZED FORM OF 100. THE COMPOSITION MAY BE USEFUL TO TREAT RESPIRATORY DISEASES USING NO MORE THAN 3ml

PE2000001034A 1999-09-29 2000-09-29 COMPOSITIONS THAT HAVE IMPROVED STABILITY PE20010627A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15654099P 1999-09-29 1999-09-29
US09/467,333 US20020082307A1 (en) 1999-01-11 1999-12-20 Compositions having improved stability
US17928900P 2000-01-31 2000-01-31

Publications (1)

Publication Number Publication Date
PE20010627A1 true PE20010627A1 (en) 2001-06-14

Family

ID=27387886

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001034A PE20010627A1 (en) 1999-09-29 2000-09-29 COMPOSITIONS THAT HAVE IMPROVED STABILITY

Country Status (12)

Country Link
EP (1) EP1216044A1 (en)
JP (1) JP2003510279A (en)
CN (1) CN1211085C (en)
AU (1) AU770376B2 (en)
BR (1) BR0014441A (en)
CA (1) CA2385990A1 (en)
CO (1) CO5210868A1 (en)
CZ (1) CZ2002947A3 (en)
HU (1) HUP0202797A3 (en)
MX (1) MXPA02003312A (en)
PE (1) PE20010627A1 (en)
WO (1) WO2001022967A1 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ530889A (en) * 2001-07-31 2005-03-24 Wyeth Corp Use of sucralose as a sweetening agent combined with pH modulation of chemical formulations generates enhanced taste-masking effects
US7138133B2 (en) * 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
US20050249802A1 (en) * 2004-05-06 2005-11-10 The Procter & Gamble Company Softgel encapsulated pharmaceutical compositions comprising concentrated active ingredients
TWI489984B (en) * 2006-08-04 2015-07-01 Wyeth Corp Formulations for parenteral delivery of compounds and uses thereof
JP6076962B2 (en) * 2011-04-01 2017-02-08 フロリダ大学 リサーチファウンデーション インコーポレイティッド Heat-sensitive mucoadhesive or skin-adhesive penetration enhancers for local delivery of therapeutic agents
US9303038B2 (en) 2011-09-06 2016-04-05 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological diseases
WO2013167990A1 (en) 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of depression
US9642915B2 (en) 2012-05-07 2017-05-09 Cellix Bio Private Limited Compositions and methods for the treatment of neuromuscular disorders and neurodegenerative diseases
CA2872975A1 (en) 2012-05-07 2013-11-14 Cellixbio Private Limited Compositions and methods for the treatment of neurological disorders
US9522884B2 (en) 2012-05-08 2016-12-20 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic disorders
US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
WO2013167992A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of inflammatory disorders
US9309233B2 (en) 2012-05-08 2016-04-12 Cellix Bio Private Limited Compositions and methods for the treatment of blood clotting disorders
US9403857B2 (en) 2012-05-10 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
WO2013167997A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
US9273061B2 (en) 2012-05-10 2016-03-01 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
WO2013168015A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of asthma and allergy
WO2013168012A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
WO2013167999A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurologic diseases
US9346742B2 (en) 2012-05-10 2016-05-24 Cellix Bio Private Limited Compositions and methods for the treatment of fibromyalgia pain
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US9573927B2 (en) 2012-05-10 2017-02-21 Cellix Bio Private Limited Compositions and methods for the treatment of severe pain
WO2013168001A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
US9499526B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
EP2852570B1 (en) 2012-05-23 2020-04-22 Cellixbio Private Limited Composition for the treatment of inflammatory bowel disease
CN104603097A (en) 2012-05-23 2015-05-06 塞利克斯比奥私人有限公司 Compositions and methods for the treatment of multiple sclerosis
WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
CA2873104A1 (en) 2012-05-23 2013-11-28 Cellixbio Private Limited Compositions and methods for the treatment of mucositis
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
US9187427B2 (en) 2012-08-03 2015-11-17 Cellix Bio Private Limited N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
CN104364231A (en) 2012-09-08 2015-02-18 塞利克斯比奥私人有限公司 Compositions and methods for treatment of inflammation and lipid disorders
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
EP3004049B1 (en) 2013-06-04 2018-09-05 Cellixbio Private Limited Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
EP3240779B1 (en) 2014-09-26 2020-10-28 Cellixbio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
WO2016051420A1 (en) 2014-09-29 2016-04-07 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
EP3212626B1 (en) 2014-10-27 2018-11-07 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
SG11201705524SA (en) 2015-01-06 2017-08-30 Cellix Bio Private Ltd Compositions and methods for the treatment of inflammation and pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100898A (en) * 1990-01-25 1992-03-31 Richardson-Vicks Inc. Antitussive liquid compositions containing dyclonine
JPH07506839A (en) * 1992-12-04 1995-07-27 メイヤー・ファーマシューティカル・ラボラトリース・インコーポレーテッド Sprayable analgesic compositions and methods of use thereof
JP2946015B2 (en) * 1994-03-10 1999-09-06 小林化工株式会社 Stable antiviral infusion injection
US6461622B2 (en) * 1994-09-07 2002-10-08 Johnson & Johnson Consumer Companies, Inc. Topical compositions
JPH10101581A (en) * 1996-09-26 1998-04-21 Taisho Pharmaceut Co Ltd Bromhexine hydrochloride stabilized preparation and stabilization method
IT1303684B1 (en) * 1998-10-30 2001-02-23 Chiesi Farma Spa FORMULATIONS OF APOMORPHINE IN SOLUTION STABLE OVER TIME.

Also Published As

Publication number Publication date
MXPA02003312A (en) 2002-10-04
AU770376B2 (en) 2004-02-19
CN1211085C (en) 2005-07-20
CN1376065A (en) 2002-10-23
CZ2002947A3 (en) 2002-08-14
HUP0202797A3 (en) 2004-05-28
HUP0202797A2 (en) 2003-01-28
CO5210868A1 (en) 2002-10-30
CA2385990A1 (en) 2001-04-05
EP1216044A1 (en) 2002-06-26
JP2003510279A (en) 2003-03-18
BR0014441A (en) 2002-06-11
AU7986500A (en) 2001-04-30
WO2001022967A1 (en) 2001-04-05

Similar Documents

Publication Publication Date Title
PE20010627A1 (en) COMPOSITIONS THAT HAVE IMPROVED STABILITY
PE20001415A1 (en) COMPOSITIONS THAT HAVE ENHANCED SUPPLY OF ASSETS
PE20071310A1 (en) LIQUID PHENYLEPHRINE FORMULATIONS
JP2005510538A5 (en)
AR031450A1 (en) ORAL COMPOSITIONS THAT HAVE IMPROVED AESTHETICAL CHARACTERISTICS OF THE CONSUMER
AR092470A1 (en) ADALIMUMAB STABLE WATERPROOF FORMULATIONS
PT594314E (en) COMPOSITION AND METHOD FOR DEVELOPING EXTENSIONAL VISCOSITY IN CLEANING COMPOSITIONS
AR049084A1 (en) PERSONAL CARE COMPOSITIONS AND CONCENTRATES FOR THEIR DEVELOPMENT
PE20120023A1 (en) PHARMACEUTICAL FORMULATION FOR AEROSOLS WITH TWO OR MORE ACTIVE PRINCIPLES AND AT LEAST ONE SURFACE-ACTIVE SUBSTANCE
ES2037866T3 (en) A DEODORATING COMPOSITION IN THE FORM OF GEL.
CY1114631T1 (en) PHARMACEUTICAL FORMS OF ECHINOCANDIN Containing surfactants that form a micelle
TW200603835A (en) Mild, moisturizing cleansing compositions
UY24246A1 (en) TROPIC VEHICLES CONTAINING SOLUBILIZED AND STABILIZED AZELAIC ACID
CY1113933T1 (en) CLEANING CLEANERS
BRPI0412059A (en) Method for preparing controlled release formulation
CA2468606A1 (en) Dentifrice compositions comprising a stable low water phase comprising polyphosphate, ionic active ingredients and binder system
BR0008405A (en) Factor viii composition formulated without the addition of albumin, use of a factor viii composition, and method of lyophilizing an aqueous pharmaceutical formulation
AR073793A1 (en) PHARMACEUTICAL FORMULATION LIQUID CONTAINING PARACETAMOL. EXCIPIENT LIQUID
JP2011256125A (en) Dentifrice composition
AR041021A1 (en) TOPICAL COMPOSITION
BR112016004427B1 (en) toothpaste composition
CL2009001680A1 (en) Agrochemical compositions comprising a) metconazole or a salt thereof and b) a straight or branched chain aliphatic carboxylic acid, saturated or unsaturated and where the molar ratio of (b) to (a) is greater than 1
ATE554792T1 (en) STABLE GROWTH HORMONE LIQUID FORMULATION
PE20001397A1 (en) COMPOSITIONS THAT HAVE IMPROVED STABILITY
PE20070437A1 (en) AQUEOUS FORMULATION hFSH

Legal Events

Date Code Title Description
FC Refusal