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PE20010588A1 - POLYMERIC CONJUGATES INHIBITORS OF PROTEOLYTIC AND LIPOLYTIC ENZYMES - Google Patents

POLYMERIC CONJUGATES INHIBITORS OF PROTEOLYTIC AND LIPOLYTIC ENZYMES

Info

Publication number
PE20010588A1
PE20010588A1 PE2000000930A PE0009302000A PE20010588A1 PE 20010588 A1 PE20010588 A1 PE 20010588A1 PE 2000000930 A PE2000000930 A PE 2000000930A PE 0009302000 A PE0009302000 A PE 0009302000A PE 20010588 A1 PE20010588 A1 PE 20010588A1
Authority
PE
Peru
Prior art keywords
unit
alkyl
mod
alkylene
linked
Prior art date
Application number
PE2000000930A
Other languages
Spanish (es)
Inventor
Scott Edward Osborne
Todd Laurence Underiner
Timothy Bates
Renae Dianna Fossum
Garry Steven Garrett
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20010588A1 publication Critical patent/PE20010588A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

SE REFIERE A UN CONJUGADO POLIMERICO DE FORMULA [[[MOD]-(X)a-C(=O)-(X)a]w-T]x[(L)z-[POLI]]y QUE COMPRENDE UN COMPONENTE POLIMERICO ENLAZADO A UN COMPONENTE INHIBIDOR DE ENZIMAS QUE TIENE UNA UNIDAD DE ACILO, AMBOS COMPONENTES SE ENLAZAN POR MEDIO DE UNA UNIDAD DE ENLACE CAPAZ DE MODULAR LA INTERACCION ENTRE UNA ENZIMA Y EL COMPONENTE INHIBIDOR, AMBOS COMPONENTES PERMANECEN ENLAZADOS DESPUES QUE DICHA UNIDAD DE ACILO INTERACTUA CON DICHA ENZIMA; DONDE [POLI] ES UNA UNIDAD POLIMERICA: R19(OR18)x, ENTRE OTROS; L ES UN ENLACE CO, CONH, CONHCO, ENTRE OTROS, UNA UNIDAD DE ACILO DE FORMULA [MOD](X)aC(X)(X)a, [MOD] ES H, ALQUILO C1-C18, CICLOALQUILO C3-C18, ALQUENILO C2-C18, SE UNE A LA UNIDAD T PARA FORMAR UN ANILLO C1-C5, UN GRUPO a, b; R ES H, ALQUILO C1-C18, CICLOALQUILO C3-C18, ALQUENILO C2-C18, ALQUINILO C2-C18, ARILO C6-C18, HETEROCICLO C2-C18, ALQUILENOARILO -(R1)n-(R2), (CH2)mN(R3)2, ENTRE OTROS; R1 ES ALQUILENO C1-C12, ALQUENILENO C2-C12, R2 ES ARILO C6-C18, n ES 1-16; R3 ES ALQUILO C1-C18, m ES 0-10, ENTRE OTRAS; X ES CH2, NH, O, S, CF2, a ES 0-1, w ES 1-6, x ES 1-50, y ES 1-10, z ES 0-1, R18 ES ALQUILENO C2-C12, FENILENO, ALQUILENOARILENO C7-C12, ENTRE OTROS. EL CONJUGADO POLIMERICO INHIBE LAS ENZIMAS PROTEASA Y LIPASA UTILES EN EL TRATAMIENTO DE SARPULLIDO DE PANALREFERS TO A POLYMER CONJUGATE OF THE FORMULA [[[MOD] - (X) aC (= O) - (X) a] wT] x [(L) z- [POLY]] and THAT INCLUDES A POLYMERIC COMPONENT BOUND TO A ENZYME INHIBITOR COMPONENT THAT HAS AN ACYL UNIT, BOTH COMPONENTS ARE LINKED BY MEANS OF A LINK UNIT CAPABLE OF MODULATING THE INTERACTION BETWEEN AN ENZYME AND THE INHIBITING COMPONENT, BOTH COMPONENTS REMAIN LINKED WITH SAID LINKED THEREFORE; WHERE [POLI] IS A POLYMERIC UNIT: R19 (OR18) x, AMONG OTHERS; L IS A LINK CO, CONH, CONHCO, BETWEEN OTHERS, AN ACILO UNIT OF FORMULA [MOD] (X) aC (X) (X) a, [MOD] IS H, C1-C18 ALKYL, C3-C18 CYCLOALKYL, C2-C18 ALKENYL, IS JOINED TO UNIT T TO FORM A C1-C5 RING, A GROUP a, b; R IS H, C1-C18 ALKYL, C3-C18 CYCLOALKYL, C2-C18 ALKENYL, C2-C18 ALKYL, C6-C18 ARYL, C2-C18 HETEROCYCLE, ALKYLENOARYL - (R1) n- (R2), (CH2) mN ( R3) 2, AMONG OTHERS; R1 IS C1-C12 ALKYLENE, C2-C12 ALKENYLENE, R2 IS C6-C18 ARYL, n IS 1-16; R3 IS C1-C18 ALKYL, m IS 0-10, AMONG OTHERS; X IS CH2, NH, O, S, CF2, a ES 0-1, w ES 1-6, x IS 1-50, y ES 1-10, z IS 0-1, R18 IS C2-C12 ALKYLENE, PHENYLENE , ALKYLENE ARYLENE C7-C12, AMONG OTHERS. THE POLYMER CONJUGATE INHIBITS THE ENZYMES PROTEASE AND LIPASE USEFUL IN THE TREATMENT OF BREAD RASH

PE2000000930A 1999-09-10 2000-09-08 POLYMERIC CONJUGATES INHIBITORS OF PROTEOLYTIC AND LIPOLYTIC ENZYMES PE20010588A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15347399P 1999-09-10 1999-09-10

Publications (1)

Publication Number Publication Date
PE20010588A1 true PE20010588A1 (en) 2001-06-23

Family

ID=22547365

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000930A PE20010588A1 (en) 1999-09-10 2000-09-08 POLYMERIC CONJUGATES INHIBITORS OF PROTEOLYTIC AND LIPOLYTIC ENZYMES

Country Status (6)

Country Link
EP (1) EP1212098A2 (en)
JP (1) JP2003509538A (en)
AR (1) AR023272A1 (en)
AU (1) AU7127000A (en)
PE (1) PE20010588A1 (en)
WO (1) WO2001018181A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5020451B2 (en) * 1999-09-10 2012-09-05 ザ プロクター アンド ギャンブル カンパニー Enzyme inhibitor
RU2324696C2 (en) * 2001-08-30 2008-05-20 Ализайм Терапевтикс Лимитед Thieno-(1,3)-oxazine-4-ons possessing inhibiting activity in respect to lipase
US8907154B2 (en) 2001-10-01 2014-12-09 The Procter & Gamble Company Sanitary napkins with hydrophobic lotions
US20030143186A1 (en) * 2001-11-13 2003-07-31 The Procter & Gamble Company Protease enzyme inhibitors
EA009368B1 (en) * 2001-12-20 2007-12-28 Оси Фармасьютикалз, Инк. Pancreatic lipase inhibitor compounds, their synthesis and use
US9035123B2 (en) 2002-10-01 2015-05-19 The Procter & Gamble Company Absorbent article having a lotioned topsheet
US20050048105A1 (en) * 2003-08-29 2005-03-03 Mcnulty Amy K. Protease inhibitor compositions for prevention and treatment of skin conditions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665070A (en) * 1985-06-25 1987-05-12 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use
DE4342154A1 (en) * 1993-12-10 1995-06-14 Behringwerke Ag Amidinophenylalanine derivatives, process for their preparation, their use and agents containing them as anticoagulants
US6267952B1 (en) * 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
ID28814A (en) * 1998-03-12 2001-07-05 Procter & Gamble UNLIMITED USE OF OBSERVERS THAT HAVE A SKIN CARE COMPOSITION COATED BY ENZIM OBSERVATION
US6066673A (en) * 1998-03-12 2000-05-23 The Procter & Gamble Company Enzyme inhibitors
JP2002505917A (en) * 1998-03-12 2002-02-26 ザ、プロクター、エンド、ギャンブル、カンパニー Protease inhibitors in absorbent articles
JP2003508480A (en) * 1999-09-10 2003-03-04 ザ、プロクター、エンド、ギャンブル、カンパニー Enzyme inhibitors

Also Published As

Publication number Publication date
EP1212098A2 (en) 2002-06-12
AU7127000A (en) 2001-04-10
JP2003509538A (en) 2003-03-11
WO2001018181A2 (en) 2001-03-15
WO2001018181A3 (en) 2001-12-13
AR023272A1 (en) 2002-09-04

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