PE20001397A1 - Composiciones que tienen estabilidad mejorada - Google Patents
Composiciones que tienen estabilidad mejoradaInfo
- Publication number
- PE20001397A1 PE20001397A1 PE2000000018A PE0000182000A PE20001397A1 PE 20001397 A1 PE20001397 A1 PE 20001397A1 PE 2000000018 A PE2000000018 A PE 2000000018A PE 0000182000 A PE0000182000 A PE 0000182000A PE 20001397 A1 PE20001397 A1 PE 20001397A1
- Authority
- PE
- Peru
- Prior art keywords
- water
- solvent
- composition
- active agent
- antihistamines
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 229940125715 antihistaminic agent Drugs 0.000 abstract 2
- 239000000739 antihistaminic agent Substances 0.000 abstract 2
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 229960005015 local anesthetics Drugs 0.000 abstract 1
- HGASFNYMVGEKTF-UHFFFAOYSA-N octan-1-ol;hydrate Chemical compound O.CCCCCCCCO HGASFNYMVGEKTF-UHFFFAOYSA-N 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA COMPOSICION CON ESTABILIDAD MEJORADA QUE COMPRENDE a)UN AGENTE ACTIVO QUE SE CARACTERIZA POR PRESENTARSE EN SU FORMA NO IONIZADA CON UN PORCENTAJE DE VALOR DE SOLUBILIDAD EN EL DISOLVENTE A T° AMBIENTE IGUAL O SUPERIOR A 0,075%, CON UNA DISPERSION MONOMOLECULAR EN EL DISOLVENTE Y AGUA; UN PESO MOLECULAR INFERIOR A 500g POR MOL, SIENDO IONICO EN UN DISOLVENTE ACUOSO, CON UN COEFICIENTE DE PARTICION OCTANOL-AGUA CUANDO ESTA EN LA FORMA IONIZADA, PUEDE SER ANTITUSIVOS, ANTIHISTAMINAS, ANTIHISTAMINAS NO SEDANTES, DESCONGESTIONANTES, EXPECTORANTES, MUCOLITICOS, ANALGESICOS, AGENTES ANTIINFLAMATORIOS, ANTIPIRETICOS, ANESTESICOS LOCALES, b)UN DISOLVENTE PARA SOLUBILIZAR EL AGENTE ACTIVO, COMPRENDE DE 60% A 99,975% EN PESO DE LA COMPOSICION, SIENDO ANHIDRO, HIDROFILO, MISCIBLE EN AGUA; PUDIENDO SER PROPILENGLICOL, ETANOL, POLI(ETILENGLICOL), CARBONATO DE PROPILENO, MONOETILETER DEL DIETILENGLICOL, GLICOFUROL, GLICEROL; c)UN MAXIMO DE 10% DE AGUA PARA MEJORAR LA ESTABILIDAD DEL AGENTE ACTIVO. LA COMPOSICION PUEDE SER UTIL PARA TRATAR LAS ENFERMEDADES RESPIRATORIAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11537899P | 1999-01-11 | 1999-01-11 | |
| US15653999P | 1999-09-29 | 1999-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001397A1 true PE20001397A1 (es) | 2000-12-21 |
Family
ID=26813132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000018A PE20001397A1 (es) | 1999-01-11 | 2000-01-10 | Composiciones que tienen estabilidad mejorada |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20020086878A1 (es) |
| EP (1) | EP1143973A2 (es) |
| JP (1) | JP2002534462A (es) |
| KR (1) | KR20010093256A (es) |
| CN (1) | CN1346270A (es) |
| AU (1) | AU3344900A (es) |
| BR (1) | BR0007428A (es) |
| CA (1) | CA2360358A1 (es) |
| CO (1) | CO5430216A1 (es) |
| CZ (1) | CZ20012493A3 (es) |
| HU (1) | HUP0105279A3 (es) |
| ID (1) | ID30508A (es) |
| NO (1) | NO20013440L (es) |
| PE (1) | PE20001397A1 (es) |
| TR (1) | TR200101929T2 (es) |
| WO (1) | WO2000041692A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003066472A1 (en) | 2002-02-08 | 2003-08-14 | The Procter & Gamble Company | Child resistant sachet |
| US20040028622A1 (en) * | 2002-08-12 | 2004-02-12 | Michael Gurin | Multifunctional flavor systems and method of use |
| PT2218448E (pt) | 2002-12-13 | 2016-01-26 | Durect Corp | Sistema oral de entrega de fármaco que compreende materiais transportadores líquidos de alta viscosidade |
| JP4542743B2 (ja) | 2002-12-26 | 2010-09-15 | Ｋｄｌ株式会社 | ピリドン誘導体の溶液状医薬組成物 |
| US20070048424A1 (en) * | 2005-09-01 | 2007-03-01 | Moza Ashok K | Liquid composition of 2-Isopropyl-N,2,3-trimethylbutyramide and N-Ethyl-p-menthane-3-carboxamide, its preparation method and its applications as a cooling agent and flavor enhancer |
| US20070059417A1 (en) * | 2005-09-15 | 2007-03-15 | Moza Ashok K | Cooling agents as flavor and saltiness enhancers |
| FR2906140B1 (fr) * | 2006-09-22 | 2008-12-05 | Philippe Perovitch | Forme galenique pour l'administration par voie trans-muqueuse de principes actifs |
| FR2910317B1 (fr) * | 2006-12-21 | 2009-02-13 | Philippe Perovitch | Forme galenique pour l'administration par voie transmuqueuse de paracetamol |
| EP2219622A1 (en) * | 2007-12-06 | 2010-08-25 | Durect Corporation | Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| US8518439B2 (en) * | 2008-12-03 | 2013-08-27 | Novartis Ag | Liquid therapeutic composition |
| TW201521769A (zh) | 2013-03-15 | 2015-06-16 | Durect Corp | 具有流變改質劑以減少溶解變異性之組成物 |
| CN109475505A (zh) | 2016-07-06 | 2019-03-15 | 度瑞公司 | 具有药物组成物、屏障层及药物层的口服剂型 |
| US11234897B2 (en) | 2017-03-27 | 2022-02-01 | DXM Pharmaceutical, Inc. | Packaged multi-dose liquid dextromethorphan hydrobromide formulation |
| WO2018183203A1 (en) * | 2017-03-27 | 2018-10-04 | DXM Pharmaceutical, Inc. | Packaged multi-dose liquid drug formulation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5100898A (en) * | 1990-01-25 | 1992-03-31 | Richardson-Vicks Inc. | Antitussive liquid compositions containing dyclonine |
| NZ279443A (en) * | 1994-01-24 | 1998-04-27 | Procter & Gamble | Solubilizing difficultly soluble pharmaceutical agents using a mixture of polyethylene glycol, polyvinylpyrrolidone and propylene glycol |
| US5510389A (en) * | 1994-03-02 | 1996-04-23 | The Procter & Gamble Company | Concentrated acetaminophen solution compositions |
| US5616621A (en) * | 1995-01-30 | 1997-04-01 | American Home Products Corporation | Taste masking liquids |
-
1999
- 1999-12-20 US US09/467,334 patent/US20020086878A1/en not_active Abandoned
-
2000
- 2000-01-10 HU HU0105279A patent/HUP0105279A3/hu unknown
- 2000-01-10 BR BR0007428-4A patent/BR0007428A/pt not_active IP Right Cessation
- 2000-01-10 CA CA002360358A patent/CA2360358A1/en not_active Abandoned
- 2000-01-10 KR KR1020017008797A patent/KR20010093256A/ko not_active Ceased
- 2000-01-10 CN CN00802686A patent/CN1346270A/zh active Pending
- 2000-01-10 EP EP00911569A patent/EP1143973A2/en not_active Withdrawn
- 2000-01-10 WO PCT/US2000/000574 patent/WO2000041692A2/en not_active Ceased
- 2000-01-10 CZ CZ20012493A patent/CZ20012493A3/cs unknown
- 2000-01-10 PE PE2000000018A patent/PE20001397A1/es not_active Application Discontinuation
- 2000-01-10 ID IDW00200101509A patent/ID30508A/id unknown
- 2000-01-10 TR TR2001/01929T patent/TR200101929T2/xx unknown
- 2000-01-10 AU AU33449/00A patent/AU3344900A/en not_active Abandoned
- 2000-01-10 JP JP2000593303A patent/JP2002534462A/ja not_active Abandoned
- 2000-01-11 CO CO00001050A patent/CO5430216A1/es not_active Application Discontinuation
-
2001
- 2001-07-11 NO NO20013440A patent/NO20013440L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0105279A2 (hu) | 2002-05-29 |
| BR0007428A (pt) | 2002-10-15 |
| NO20013440D0 (no) | 2001-07-11 |
| CZ20012493A3 (cs) | 2001-11-14 |
| CA2360358A1 (en) | 2000-07-20 |
| ID30508A (id) | 2001-12-13 |
| NO20013440L (no) | 2001-09-11 |
| TR200101929T2 (tr) | 2001-12-21 |
| WO2000041692A2 (en) | 2000-07-20 |
| AU3344900A (en) | 2000-08-01 |
| US20020086878A1 (en) | 2002-07-04 |
| WO2000041692A3 (en) | 2000-11-30 |
| CO5430216A1 (es) | 2004-06-01 |
| JP2002534462A (ja) | 2002-10-15 |
| KR20010093256A (ko) | 2001-10-27 |
| CN1346270A (zh) | 2002-04-24 |
| HUP0105279A3 (en) | 2003-05-28 |
| EP1143973A2 (en) | 2001-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |