PE20001355A1 - 1,3-diamino-cetonas como inhibidores de proteasas - Google Patents
1,3-diamino-cetonas como inhibidores de proteasasInfo
- Publication number
- PE20001355A1 PE20001355A1 PE1999001311A PE00131199A PE20001355A1 PE 20001355 A1 PE20001355 A1 PE 20001355A1 PE 1999001311 A PE1999001311 A PE 1999001311A PE 00131199 A PE00131199 A PE 00131199A PE 20001355 A1 PE20001355 A1 PE 20001355A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- diamine
- het
- aralkyl
- cycloalkyl
- Prior art date
Links
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- -1 BENZYLOXYCARBONYL Chemical class 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A COMPUESTOS DE 1,3-DIAMINO-CETONAS FORMULA DE I, DONDE: A ES CO, CHOH; R1 ES R4NR`CH(R3)-CO, R5-X-CH(R3)-CO, R3-CH2(CO), R11-CH(R*)-CO; R2 ES H, ALQUILO C1-C6, CICLOALQUIL C3-C6, ALQUILO C0-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6, R9C(O), R9SO2-, R9OC(O)-, R9R12NC(O)-, R7R6N-CH(R8)-Z, ENTRE OTROS; R'' ES H, ALQUILO C1-C6, Ar-ALQUILO C0-C6; R''' ES H, ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6; R3 Y R8 SON H, ALQUENILO C2-C6, ALQUINILO C2-C6, HET, Ar, ALQUILO C1-C6, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, ENTRE OTROS; R5, R9, R10 SON ALQUILO C1-C6, CICLOALQUIL C3-C6 ALQUILO C0-C6, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, ARALQUILO C0-C6; R7 ES H, ALQUILO C1-C6, ARALQUILO C0-C6, ENTRE OTROS; R6 Y R7 JUNTOS FORMAN PIRROLIDINA, PIPERIDINA O MORFOLINA, CADA R' ES H, ALQUILO C1-C6, ARALQUILO C0-C6, HET-ALQUILO C0-C6; R11 ES Ar, R12-R15 SON H, ALQUILO C1-C6, ENTRE OTROS; R* ES H, ALQUILO C1-C6, ENTRE OTROS; Z ES CO, CH2; M ES HC=CH, H2C-CH2, H(OR2)C-C(OR2)H, H(OR2)C-CH2, H(NR2H)C-C(NR2H)H, ENTRE OTROS; X ES CH2, S, O; n ES 1-7. UN COMPUESTO PREFERIDO N-(N-(BENCILOXICARBONIL)-L-LEUCINIL)-4-(R,S)-AMINO-1,2,3,4,7,8-HEXAHIDRO-3-OXO-[2-(N-BENCILOXICARBONIL)-L-LEUCINIL]-AZOCINA, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE PROTEASAS Y PUEDE SER UTIL PARA EL TRATAMIENTO DE OSTEOPOROSIS, PERIODONTITIS, ARTRITIS, GINGIVITIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11414398P | 1998-12-23 | 1998-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001355A1 true PE20001355A1 (es) | 2001-01-28 |
Family
ID=22353596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001311A PE20001355A1 (es) | 1998-12-23 | 1999-12-23 | 1,3-diamino-cetonas como inhibidores de proteasas |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1140897A4 (es) |
| JP (1) | JP2002533452A (es) |
| AR (1) | AR021970A1 (es) |
| AU (1) | AU2713100A (es) |
| CO (1) | CO5180541A1 (es) |
| DZ (1) | DZ2976A1 (es) |
| HK (1) | HK1041690A1 (es) |
| PE (1) | PE20001355A1 (es) |
| WO (1) | WO2000039115A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| AU1474801A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2001034600A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| JP2003513971A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
| CN1416346A (zh) | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
| US6982263B2 (en) | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
| WO2003075853A2 (en) | 2002-03-08 | 2003-09-18 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| EP1796793A4 (en) * | 2004-09-07 | 2009-08-05 | Smithkline Beecham Corp | NEW CONNECTIONS |
| WO2006076575A2 (en) * | 2005-01-13 | 2006-07-20 | Bristol-Myers Squibb Company | Substituted biaryl compounds as factor xia inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2285A1 (fr) * | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
| PE73799A1 (es) * | 1997-05-08 | 1999-10-22 | Smithkline Beecham Corp | Inhibidores de proteasas |
-
1999
- 1999-12-16 CO CO99078651A patent/CO5180541A1/es not_active Application Discontinuation
- 1999-12-21 AR ARP990106647A patent/AR021970A1/es unknown
- 1999-12-21 WO PCT/US1999/030602 patent/WO2000039115A1/en not_active Ceased
- 1999-12-21 JP JP2000591026A patent/JP2002533452A/ja not_active Withdrawn
- 1999-12-21 HK HK02101209.3A patent/HK1041690A1/zh unknown
- 1999-12-21 AU AU27131/00A patent/AU2713100A/en not_active Abandoned
- 1999-12-21 EP EP99968936A patent/EP1140897A4/en not_active Withdrawn
- 1999-12-22 DZ DZ990276A patent/DZ2976A1/xx active
- 1999-12-23 PE PE1999001311A patent/PE20001355A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO5180541A1 (es) | 2002-07-30 |
| AU2713100A (en) | 2000-07-31 |
| WO2000039115A1 (en) | 2000-07-06 |
| EP1140897A1 (en) | 2001-10-10 |
| EP1140897A4 (en) | 2002-04-03 |
| JP2002533452A (ja) | 2002-10-08 |
| HK1041690A1 (zh) | 2002-07-19 |
| DZ2976A1 (fr) | 2004-03-15 |
| AR021970A1 (es) | 2002-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |