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PE20001297A1 - Antibioticos cetolidos carbamato y carbazato - Google Patents

Antibioticos cetolidos carbamato y carbazato

Info

Publication number
PE20001297A1
PE20001297A1 PE1999001153A PE00115399A PE20001297A1 PE 20001297 A1 PE20001297 A1 PE 20001297A1 PE 1999001153 A PE1999001153 A PE 1999001153A PE 00115399 A PE00115399 A PE 00115399A PE 20001297 A1 PE20001297 A1 PE 20001297A1
Authority
PE
Peru
Prior art keywords
compounds
formula
cetolides
carbazate
carbamate
Prior art date
Application number
PE1999001153A
Other languages
English (en)
Inventor
Yong-Jin Wu
Takushi Kaneko
Wei-Guo Su
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20001297A1 publication Critical patent/PE20001297A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A MACROLIDOS DE FORMULA I, DONDE: X1 ES O, CR13R14, NR4; X2 ES =O, =NOR1; R1 ES H, METILO, ETILO; R2 ES C(R7)(R8)C(R9)(R10)C(R11)(R12)(HETEROCICLO DE 4-10 MIEMBROS), ENTRE OTROS; R3 ES HALO, CIANO, NITRO, TRIFLUOROMETILO, TRIFLUOROMETOXI, AZIDO, -C(O)R5, -C(O)OR5, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6; R6 ES H, -C(O)(ALQUILO C1-C6); R7, R8, R9, R10, R11, R12, R13, R14 SON H, HALO, ALQUILO C1-C6 CON LA CONDICION: CUANDO X1 ES CR13R14 Y R2 ES C(R7)(R8)C(R9)(R10)C(R11)(R12)(HETEROCICLO DE 4-10 MIEMBROS), AL MENOS UNO DE R7, R8. R9, R10, R11, R12, R13, R14 ES HALO O ALQUILO C1-C6; CUANDO X1 ES NR4 Y R2 ES C(R7)(R8)C(R9)(R10)C(R11)(R12)(HETEROCICLO DE 4-10 MIEMBROS), AL MENOS UNO DE R7, R8, R9 R10, R11, R12 ES HALO, ALQUILO C1-C6; ENTRE OTROS; R15 ES ALQUILO C1-C6; R16 ES H, ALQUILO C1-C10. SON COMPUESTOS PREFERIDOS: 11-DESOXI-5-O-DESOXAMINIL-11-(3,3-DIMETIL-3-(4-PIRIDIN-3-IL-IMIDAZOL-1-IL-PROPIL))HIDRAZO-6-O-METIL-3-OXOERITRONOLIDA A, 11,12-CARBAMATO, 9-E-(O-METIL)OXIMA; 11-DESOXI-5-O-DESOXAMINIL-11-(3(R)-METIL-3-(4-PIRIDIN-3-IL-IMIDAZOL-1-IL-PROPIL))HIDRAZO-6-O-METIL-3-OXOERITRONOLIDA A, 11,12-CARBAMATO, 9-E-(O-METIL)OXIMA, ENTRE OTROS. LOS MACROLIDOS SON AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS
PE1999001153A 1998-12-10 1999-11-15 Antibioticos cetolidos carbamato y carbazato PE20001297A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11172898P 1998-12-10 1998-12-10

Publications (1)

Publication Number Publication Date
PE20001297A1 true PE20001297A1 (es) 2000-12-04

Family

ID=22340138

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001153A PE20001297A1 (es) 1998-12-10 1999-11-15 Antibioticos cetolidos carbamato y carbazato

Country Status (13)

Country Link
US (1) US6664238B1 (es)
EP (1) EP1137654A1 (es)
AT (1) ATE344269T1 (es)
AU (1) AU6484199A (es)
DE (1) DE69933897T2 (es)
ES (1) ES2273964T3 (es)
GT (1) GT199900208A (es)
MA (1) MA26711A1 (es)
PA (1) PA8486401A1 (es)
PE (1) PE20001297A1 (es)
TN (1) TNSN99227A1 (es)
TR (1) TR200102129T2 (es)
WO (1) WO2000034297A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE298761T1 (de) 1998-09-22 2005-07-15 Pfizer Prod Inc Carbamat- und carbazatketolidantibiotika
ATE256694T1 (de) * 1999-01-27 2004-01-15 Pfizer Prod Inc Ketolid-antibiotika
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
NZ515027A (en) 1999-04-16 2004-01-30 Kosan Biosciences Inc Erythromycin derivatives as antibiotics
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
EP1171447A2 (en) 1999-04-16 2002-01-16 Ortho-McNeil Pharmaceutical, Inc. Ketolide antibacterials
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
US7419962B2 (en) * 2004-12-07 2008-09-02 Enanta Pharmaceuticals, Inc. 3,6-bicyclolides
EP2233493A1 (en) * 2004-12-21 2010-09-29 Pfizer Products Inc. Macrolides
CN1318441C (zh) * 2005-04-25 2007-05-30 中国医学科学院医药生物技术研究所 大环内酯类抗生素的酮内酯化合物及其制备方法和用途
US20090005325A1 (en) * 2005-11-23 2009-01-01 Biswajit Bas Ketolide Derivatives as Antibacterial Agents
WO2009055557A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
DK2358379T3 (en) 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
JP5711352B2 (ja) 2010-03-22 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライドの結晶形、およびその使用
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
CN114437154B (zh) * 2022-01-30 2024-03-01 北京理工大学 一种含有喹诺酮的酮内酯衍生物及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
IL114589A (en) 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE19626036A1 (de) 1996-06-28 1998-01-02 Whitaker Corp Optischer Steckverbinder
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
HUP0000198A3 (en) 1996-11-27 2000-09-28 Taisho Pharmaceutical Co Ltd Erythromycin a derivatives
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FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
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JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
ATE344269T1 (de) 2006-11-15
DE69933897T2 (de) 2007-03-15
WO2000034297A1 (en) 2000-06-15
DE69933897D1 (de) 2006-12-14
EP1137654A1 (en) 2001-10-04
ES2273964T3 (es) 2007-05-16
TR200102129T2 (tr) 2002-01-21
US6664238B1 (en) 2003-12-16
TNSN99227A1 (fr) 2005-11-10
MA26711A1 (fr) 2004-12-20
GT199900208A (es) 2001-05-31
AU6484199A (en) 2000-06-26
PA8486401A1 (es) 2003-01-24

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