PE20001647A1 - Derivados de 3-amino-3-arilpropano-1-ol y procedimiento de preparacion de los mismos - Google Patents
Derivados de 3-amino-3-arilpropano-1-ol y procedimiento de preparacion de los mismosInfo
- Publication number
- PE20001647A1 PE20001647A1 PE2000000296A PE0002962000A PE20001647A1 PE 20001647 A1 PE20001647 A1 PE 20001647A1 PE 2000000296 A PE2000000296 A PE 2000000296A PE 0002962000 A PE0002962000 A PE 0002962000A PE 20001647 A1 PE20001647 A1 PE 20001647A1
- Authority
- PE
- Peru
- Prior art keywords
- cyclohexyl
- benzyl
- phenyl
- alkyl
- disease
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- 108090000312 Calcium Channels Proteins 0.000 abstract 1
- 102000003922 Calcium Channels Human genes 0.000 abstract 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- RVCDIGZZCIKTFM-UHFFFAOYSA-N [2-[dimethylamino(phenyl)methyl]cyclohexyl] 4-(trifluoromethyl)benzoate Chemical compound C=1C=CC=CC=1C(N(C)C)C1CCCCC1OC(=O)C1=CC=C(C(F)(F)F)C=C1 RVCDIGZZCIKTFM-UHFFFAOYSA-N 0.000 abstract 1
- OAWCOYRQLKELDG-UHFFFAOYSA-N [2-[dimethylamino(phenyl)methyl]cyclohexyl] 4-methoxybenzoate Chemical compound C1=CC(OC)=CC=C1C(=O)OC1C(C(N(C)C)C=2C=CC=CC=2)CCCC1 OAWCOYRQLKELDG-UHFFFAOYSA-N 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000027939 micturition Effects 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE 3-AMINO-3-ARILPROPAN-1-OL DE FORMULA I, DONDE R1 Y R2 SON ALQUILO C1-C6 O FORMAN JUNTOS UN CICLO (CH2)(2-6) OPCIONALMENTE BENZOCONDENSADO O FENILSUSTITUIDO; R3 ES H, METILO; R4 Y R5 SON ALQUILO C1-C6, CICLOALQUILO C3-C6, FENILO, BENCILO, O JUNTOS FORMAN UN CICLO (CH2)(3-6), CH2CH2OCH2CH2; A ES ARILO OPCIONALMENTE CON HETEROATOMOS EN EL SISTEMA CICLICO; X ES BENCILO O BENZOILO SUSTITUIDO CON R12, R13, R14; R12, R13 Y R14 SON H, F, Cl, Br, CHF2, CF3, OR11, SR11, ENTRE OTROS; R11 ES H, ALQUILO C1-C6, FENILO, BENCILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS DIMETIL-{[2-(2-METILBENCILOXI)CICLOHEXIL]FENIL-METIL}AMINA; 4-TRIFLUORO-METILBENZOATO DE [2-(DIMETILAMINOFENILMETIL)CICLOHEXILO]; 4-METOXI-BENZOATO DE [2-(DIMETILAMINOFENILMETIL)CICLOHEXILO], ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I TIENE AFINIDAD CON EL PUNTO DE LIGADURA 2 DEL CANAL DE SODIO, PUNTO DE LIGADURA DE BENZODIAZEPINA DEL CANAL DE CALCIO DE TIPO L Y PUEDE SER UTIL PARA EL TRATAMIENTO DEL DOLOR NEUROPATICO, CRONICO, ENFERMEDADES CARDIOVASCULARES, INCONTINENCIA URINARIA, DIARREA, PRURITO, DEPENDENCIA DEL ALCOHOL, DEPENDENCIA DE DROGAS, INFLAMACIONES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19915602A DE19915602A1 (de) | 1999-04-07 | 1999-04-07 | 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001647A1 true PE20001647A1 (es) | 2001-01-20 |
Family
ID=7903731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000296A PE20001647A1 (es) | 1999-04-07 | 2000-04-04 | Derivados de 3-amino-3-arilpropano-1-ol y procedimiento de preparacion de los mismos |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6288278B1 (es) |
| EP (1) | EP1043306B1 (es) |
| JP (1) | JP2000327643A (es) |
| KR (1) | KR100686475B1 (es) |
| CN (1) | CN1147461C (es) |
| AR (1) | AR023374A1 (es) |
| AT (1) | ATE263138T1 (es) |
| AU (1) | AU777873B2 (es) |
| BR (1) | BR0008681A (es) |
| CA (1) | CA2303721A1 (es) |
| CO (1) | CO5170510A1 (es) |
| DE (2) | DE19915602A1 (es) |
| DK (1) | DK1043306T3 (es) |
| ES (1) | ES2218016T3 (es) |
| HU (1) | HUP0001397A2 (es) |
| IL (1) | IL135452A (es) |
| NO (1) | NO325029B1 (es) |
| NZ (1) | NZ503397A (es) |
| PE (1) | PE20001647A1 (es) |
| PL (1) | PL339487A1 (es) |
| PT (1) | PT1043306E (es) |
| SI (1) | SI1043306T1 (es) |
| SK (1) | SK4952000A3 (es) |
| UA (1) | UA70307C2 (es) |
| ZA (1) | ZA200001747B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
| DE10108307A1 (de) * | 2001-02-21 | 2002-08-29 | Gruenenthal Gmbh | Substituierte Propan-1,3-diamin-Derivate |
| US6897319B2 (en) * | 2001-12-27 | 2005-05-24 | Ortho-Mcneil Pharmaceutical, Inc. | Useful aroyl pyrrole heteroaryl methanones and methanols |
| DE10213051B4 (de) * | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
| DE102005033732B4 (de) | 2005-05-27 | 2014-02-13 | Grünenthal GmbH | Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017637A (en) * | 1973-03-26 | 1977-04-12 | American Home Products Corporation | Benzylamine analgesics |
| US3937818A (en) * | 1974-03-27 | 1976-02-10 | American Home Products Corporation | Benzylamine narcotic antagonists |
| US3975436A (en) * | 1974-03-27 | 1976-08-17 | American Home Products Corporation | Benzylamine narcotic antagonists |
| US4143158A (en) * | 1978-03-24 | 1979-03-06 | American Home Products Corporation | Inhibition of prolactin release by an opiate antagonist |
| CZ285637B6 (cs) * | 1992-10-26 | 1999-10-13 | Gödecke Aktiengesellschaft | Tilidindihydrogenortofosfát, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje |
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
-
1999
- 1999-04-07 DE DE19915602A patent/DE19915602A1/de not_active Ceased
-
2000
- 2000-03-04 AT AT00104740T patent/ATE263138T1/de active
- 2000-03-04 ES ES00104740T patent/ES2218016T3/es not_active Expired - Lifetime
- 2000-03-04 DK DK00104740T patent/DK1043306T3/da active
- 2000-03-04 EP EP00104740A patent/EP1043306B1/de not_active Expired - Lifetime
- 2000-03-04 DE DE50005841T patent/DE50005841D1/de not_active Expired - Lifetime
- 2000-03-04 PT PT00104740T patent/PT1043306E/pt unknown
- 2000-03-04 SI SI200030414T patent/SI1043306T1/xx unknown
- 2000-03-14 NZ NZ503397A patent/NZ503397A/en unknown
- 2000-04-03 AR ARP000101521A patent/AR023374A1/es not_active Application Discontinuation
- 2000-04-04 IL IL13545200A patent/IL135452A/en not_active IP Right Cessation
- 2000-04-04 UA UA2000041927A patent/UA70307C2/uk unknown
- 2000-04-04 PE PE2000000296A patent/PE20001647A1/es not_active Application Discontinuation
- 2000-04-05 BR BR0008681-9A patent/BR0008681A/pt not_active IP Right Cessation
- 2000-04-05 CO CO00024764A patent/CO5170510A1/es not_active Application Discontinuation
- 2000-04-05 CA CA002303721A patent/CA2303721A1/en not_active Abandoned
- 2000-04-05 HU HU0001397A patent/HUP0001397A2/hu unknown
- 2000-04-06 NO NO20001782A patent/NO325029B1/no not_active IP Right Cessation
- 2000-04-06 PL PL00339487A patent/PL339487A1/xx unknown
- 2000-04-06 ZA ZA200001747A patent/ZA200001747B/xx unknown
- 2000-04-06 AU AU26450/00A patent/AU777873B2/en not_active Ceased
- 2000-04-06 CN CNB001049801A patent/CN1147461C/zh not_active Expired - Fee Related
- 2000-04-06 SK SK495-2000A patent/SK4952000A3/sk unknown
- 2000-04-06 JP JP2000105260A patent/JP2000327643A/ja active Pending
- 2000-04-06 KR KR1020000017864A patent/KR100686475B1/ko not_active Expired - Fee Related
- 2000-04-07 US US09/545,519 patent/US6288278B1/en not_active Ceased
-
2003
- 2003-09-11 US US10/659,680 patent/USRE39530E1/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |