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PE20001640A1 - Compuestos dihetero sustituidos como inhibidores de metaloproteasas - Google Patents

Compuestos dihetero sustituidos como inhibidores de metaloproteasas

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Publication number
PE20001640A1
PE20001640A1 PE2000000247A PE0002472000A PE20001640A1 PE 20001640 A1 PE20001640 A1 PE 20001640A1 PE 2000000247 A PE2000000247 A PE 2000000247A PE 0002472000 A PE0002472000 A PE 0002472000A PE 20001640 A1 PE20001640 A1 PE 20001640A1
Authority
PE
Peru
Prior art keywords
alkenyl
alkyl
link
diheter
metaloproteases
Prior art date
Application number
PE2000000247A
Other languages
English (en)
Inventor
Biswanath De
Michael George Natchus
Neil Gregory Almstead
Stanislaw Pikul
Menyan Cheng
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20001640A1 publication Critical patent/PE20001640A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07D285/01—Five-membered rings
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Color Printing (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: X ES OH, NHOH; J ES D-(CR14R14)tR15; D ES O; X ES UN ENLACE, SE UNE A J Y FORMAN UN ANILLO DE 5-9 MIEMBROS; W ES S, O, ENTRE OTROS; R1 ES H, OH, ALCOXI, ENTRE OTROS; R2 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; T ES (CR8R8`)p-A-(CR8''R8''')qR9; p Y q SON 0-4; R8, R8', R8'', R8''' SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R9 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; A ES O, SOr, ENTRE OTROS, r ES 0-2; CUANDO p ES 0; A ES UN ENLACE; R3 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; R4 Y R4' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; R5 ES (CR11R11')sR12; s ES 0-4; R11 Y R11' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; R12 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; J ES D-(CR14R14')tR15; t ES 0-4; D ES O, SOu; u ES 0-2; R6 Y R6' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; R7 ES (CR17R17')vR18; v ES 0-4; R17, R17' Y R18 SON H, ALQUILO, ALQUENILO, ENTRE OTROS; M ES E-(CR19R19')wR20; w ES 0-4; E ES O, SOx, ENTRE OTROS; x ES 0-2; Q ES G'-(CR22R22')yR23; y ES 0-4; G' ES UN ENLACE, O, SO2, ENTRE OTROS; Z ES CICLOALQUILO, HETEROCICLOALQUILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES ACIDO 2-[(4'-METOXI[1,1'-BIFENIL]-4-IL)SULFONIL]AMINO-4-HIDROXI-5-[(2-TIAZOLIL)TIO]-PENTANOICO, ENTRE OTROS. EL COMPUESTO ES UN INHIBIDOR DE METALOPROTEASA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ARTRITIS, CANCER, DESORDEN OCULAR
PE2000000247A 1999-03-03 2000-03-22 Compuestos dihetero sustituidos como inhibidores de metaloproteasas PE20001640A1 (es)

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US12271899P 1999-03-03 1999-03-03

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PE20001640A1 true PE20001640A1 (es) 2001-02-01

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US (2) US6566381B1 (es)
EP (1) EP1165530A2 (es)
JP (1) JP2002538146A (es)
KR (1) KR20010102485A (es)
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2001126719A (ru) * 1999-03-03 2004-02-20 Дзе Проктер Энд Гэмбл Компани (US) Дигетерозамещенные ингибиторы металлопротеазы
US6696456B1 (en) 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
SK5082002A3 (en) * 1999-10-14 2002-10-08 Procter & Gamble Beta disubstituted metalloprotease inhibitors
JP2003528082A (ja) 2000-03-21 2003-09-24 ザ プロクター アンド ギャンブル カンパニー ニフッ化酪酸メタロプロテアーゼ阻害物質
CZ20023180A3 (cs) * 2000-03-21 2003-02-12 The Procter And Gamble Company Metalloproteázové inhibitory zahrnující vedlejší heterocyklický řetězec
AU2001245891A1 (en) 2000-03-21 2001-10-03 The Procter & Gamble Company Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
AU4882101A (en) * 2000-04-28 2001-11-12 Shionogi & Co., Ltd. Mmp-12 inhibitors
WO2002033087A2 (en) * 2000-10-17 2002-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US6645993B2 (en) 2001-03-30 2003-11-11 Warner-Lambert Company 3-heterocyclylpropanohydroxamic acid PCP inhibitors
GB0108097D0 (en) * 2001-03-30 2001-05-23 Pfizer Ltd Compounds
JPWO2003080042A1 (ja) * 2002-03-27 2005-07-21 塩野義製薬株式会社 軟骨細胞外基質分解阻害剤
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
WO2004112796A1 (en) * 2003-06-20 2004-12-29 Alcon, Inc. Treatment of amd with combination of ingredients
BR0318625A (pt) * 2003-12-04 2006-10-31 Wyeth Corp biaril sulfonamidas e métodos para usar as mesmas
ATE411306T1 (de) * 2003-12-04 2008-10-15 Wyeth Corp Biarylsulfonamide als mmp-inhibitoren
US20080119513A1 (en) * 2004-09-06 2008-05-22 Fumihiko Watanabe Sulfonamide Derivative Selectively Inhibiting Mmp-13
WO2010032629A1 (en) 2008-09-19 2010-03-25 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device
WO2017152114A1 (en) * 2016-03-04 2017-09-08 Jeffrey Alan Klein Tumescent contravenom drug delivery
CN108238981A (zh) * 2016-12-23 2018-07-03 宁波爱诺医药科技有限公司 一种lcz-696关键中间体的制备方法
CN114014824B (zh) * 2020-12-09 2023-06-13 上海科技大学 一种杂环化合物的应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1985184U (de) 1965-06-26 1968-05-09 Detlef Schaffer Kolbenmaschine.
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
DE4011172A1 (de) 1990-04-06 1991-10-10 Degussa Verbindungen zur bekaempfung von pflanzenkrankheiten
GB9102635D0 (en) 1991-02-07 1991-03-27 British Bio Technology Compounds
GB9107368D0 (en) 1991-04-08 1991-05-22 Smithkline Beecham Plc Novel compounds
IL98681A (en) 1991-06-30 1997-06-10 Yeda Rehovot And Dev Company L Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives
JPH05125029A (ja) 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
GB9200245D0 (en) 1992-01-07 1992-02-26 British Bio Technology Compounds
US5552419A (en) 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
ES2133785T3 (es) 1994-06-22 1999-09-16 British Biotech Pharm Inhibidores de metaloproteinasas.
US5861510A (en) 1995-04-20 1999-01-19 Pfizer Inc Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors
IL118325A0 (en) * 1995-05-25 1996-10-31 Pont Merck And Pharmaceutical Integrin receptor antagonists and pharmaceutical compositions containing them
KR980009238A (ko) 1995-07-28 1998-04-30 우에노 도시오 설포닐아미노산 유도체
CN1198096A (zh) 1995-08-08 1998-11-04 菲布洛根有限公司 用于治疗与胶原蛋白过量产生有关的疾病的c－蛋白酶抑制剂
IL124559A (en) 1995-12-08 2004-07-25 Agouron Pharma Inhibitors of metalloproteinases, pharmaceutical preparations containing them and their use
US6136834A (en) 1995-12-27 2000-10-24 Ono Pharmaceutical Co., Ltd. Tetrazole compounds and pharmaceutical agents containing such derivative
FR2743562B1 (fr) 1996-01-11 1998-04-03 Sanofi Sa Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant
EP0950656B1 (en) * 1996-01-23 2007-04-11 Shionogi & Co., Ltd. Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
TW448172B (en) 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
EP0915086A4 (en) 1996-05-24 2001-01-17 Ono Pharmaceutical Co PHENYLSULFONAMIDE DERIVATIVES
US5861861A (en) 1996-06-28 1999-01-19 Microchip Technology Incorporated Microcontroller chip with integrated LCD control module and switched capacitor driver circuit
BR9712792A (pt) 1996-08-28 1999-12-14 Procter & Gamble Inibidores de metaloprotease bidentada.
EP0927161B1 (en) 1996-08-28 2002-10-16 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
TR199900429T2 (xx) 1996-08-28 1999-05-21 The Procter & Gamble Company Spirosiklik metaloproteaz inhibit�rleri.
CZ62699A3 (cs) 1996-08-28 1999-07-14 The Procter & Gamble Company Heterocyklické inhibitory metaloproteinas
DK0925287T3 (da) 1996-08-28 2003-05-12 Procter & Gamble Heterocykliske metalloproteaseinhibitorer
ATE227274T1 (de) 1996-08-28 2002-11-15 Procter & Gamble 1,3-diheterozyklische metalloprotease inhibitoren
ATE212619T1 (de) 1996-10-22 2002-02-15 Upjohn Co Alpha-amino sulfonyl hydroxamsäure als matrix metalloproteinase inhibitoren
AU720615B2 (en) 1997-01-17 2000-06-08 Pharmacia & Upjohn Company Bis-sulfonomides hydroxamic acids as MMP inhibitors
JPH10204054A (ja) 1997-01-21 1998-08-04 Ono Pharmaceut Co Ltd フェニルスルホンアミド誘導体
ATE248812T1 (de) 1997-02-03 2003-09-15 Pfizer Prod Inc Arylsulfonylhydroxamsäurederivate
GB9706255D0 (en) 1997-03-26 1997-05-14 Smithkline Beecham Plc Novel compounds
NZ338082A (en) 1997-04-01 2000-06-23 Agouron Pharma Metalloproteinase and Tumor Necrosis Factor-alpha convertase inhibitors, pharmaceutical compositions and their use in treating disease mediated by metalloproteinase activity.
US5756545A (en) * 1997-04-21 1998-05-26 Warner-Lambert Company Biphenysulfonamide matrix metal alloproteinase inhibitors
WO1998050348A1 (en) 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
DE19719621A1 (de) 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren
DK0877019T3 (da) 1997-05-09 2002-04-08 Hoechst Ag Substituerede diaminocarboxylsyrer
BR9810841A (pt) * 1997-07-31 2001-07-10 Procter & Gamble Inibidores de metaloprotease alicìclicos
AU751701B2 (en) * 1997-12-23 2002-08-22 Warner-Lambert Company Ace inhibitor-MMP inhibitor combinations
CA2318145C (en) 1998-02-04 2009-10-27 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
JPH11246527A (ja) * 1998-03-02 1999-09-14 Shionogi & Co Ltd Ｍｍｐ−８阻害剤
CA2327290A1 (en) 1998-04-03 1999-10-14 Sankyo Company Limited Sulfonamide derivatives
EP0967201A1 (en) * 1998-05-20 1999-12-29 Roche Diagnostics GmbH Pharmaceutical agents containing sulfonamids as matrix metalloproteinase inhibitors
JP2002532440A (ja) * 1998-12-18 2002-10-02 デュポン ファーマシューティカルズ カンパニー ビトロネクチン受容体拮抗剤薬剤
RU2001126719A (ru) * 1999-03-03 2004-02-20 Дзе Проктер Энд Гэмбл Компани (US) Дигетерозамещенные ингибиторы металлопротеазы

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