PE20001487A1 - 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocin-10-oles sustituidos con n-(5-fenil-tetrahidrofuranil) metilo y n-(6-fenil-tetrahidropiranil) metilo; procedimientos para prepararlos y su empleo como composiciones farmaceuticas - Google Patents
1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocin-10-oles sustituidos con n-(5-fenil-tetrahidrofuranil) metilo y n-(6-fenil-tetrahidropiranil) metilo; procedimientos para prepararlos y su empleo como composiciones farmaceuticasInfo
- Publication number
- PE20001487A1 PE20001487A1 PE2000000132A PE0001322000A PE20001487A1 PE 20001487 A1 PE20001487 A1 PE 20001487A1 PE 2000000132 A PE2000000132 A PE 2000000132A PE 0001322000 A PE0001322000 A PE 0001322000A PE 20001487 A1 PE20001487 A1 PE 20001487A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- phenyl
- benzazocin
- oles
- hexahydro
- Prior art date
Links
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002490 cerebral effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010048962 Brain oedema Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 1
- 208000006752 brain edema Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 229940125794 sodium channel blocker Drugs 0.000 abstract 1
- 239000003195 sodium channel blocking agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A 1,2,3,4,5,6-HEXAHIDRO-2,6-DIMETANO-3-BENZAZOCIN-10-OLES DE FORMULA I, DONDE R1, R2, R4 Y R5 SON H, METILO, F; n ES1-2; R3 ES H, F, Cl, Br, METILO, ETILO, OH, METOXI; R6 ES H, METILO, ETILO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION CARACTERIZADO PORQUE UN DERIVADO DE NOR-BENZOMORFANO REACCIONA CON UN DERIVADO DE TETRAHIDROFURANO, HEXAHIDROPIRANO Y EL PRODUCTO FINAL SE PURIFICA, SE AISLA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE 0,001% A 5% EN PESO DEL COMPUESTO. EL COMPUESTO ES UN BLOQUEADOR DE LOS CANALES DE SODIO DEPENDIENTE DE VOLTAJE Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS FUNCIONALES CAUSADOS POR SOBREESTIMULACION, ARRITMIAS, ESPASMOS, ISQUEMIA CARDIACA, CEREBRAL, DOLOR, TRASTORNOS NEURODEGENERATIVOS, EPILEPSIA, HIPOGLUCEMIA, HIPOXIA, INOXIA, TRAUMA CEREBRAL, EDEMA CEREBRAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19907874A DE19907874A1 (de) | 1999-02-23 | 1999-02-23 | N-(5-Phenyl-tetrahydrofuranyl)methyl- und N-(6-Phenyl-tetrahydropyranyl)methyl substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001487A1 true PE20001487A1 (es) | 2001-01-18 |
Family
ID=7898638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000132A PE20001487A1 (es) | 1999-02-23 | 2000-02-21 | 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocin-10-oles sustituidos con n-(5-fenil-tetrahidrofuranil) metilo y n-(6-fenil-tetrahidropiranil) metilo; procedimientos para prepararlos y su empleo como composiciones farmaceuticas |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1157020B1 (es) |
| JP (1) | JP2002537393A (es) |
| AR (1) | AR022718A1 (es) |
| AT (1) | ATE224890T1 (es) |
| AU (1) | AU2910900A (es) |
| CA (1) | CA2362697C (es) |
| CO (1) | CO5170499A1 (es) |
| DE (2) | DE19907874A1 (es) |
| DK (1) | DK1157020T3 (es) |
| ES (1) | ES2183786T3 (es) |
| PE (1) | PE20001487A1 (es) |
| PT (1) | PT1157020E (es) |
| UY (1) | UY26022A1 (es) |
| WO (1) | WO2000050421A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19957156A1 (de) * | 1999-11-27 | 2001-05-31 | Boehringer Ingelheim Pharma | Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel |
| US6355652B1 (en) | 1999-11-27 | 2002-03-12 | Boehringer Ingelheim Pharma Kg | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| DE10204276A1 (de) * | 2002-02-02 | 2003-08-07 | Boehringer Ingelheim Pharma | N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel |
| US6683089B2 (en) | 2002-02-02 | 2004-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols |
| AR069545A1 (es) * | 2007-11-16 | 2010-02-03 | Boehringer Ingelheim Pharma | Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y |
| JP7289119B2 (ja) * | 2019-02-15 | 2023-06-09 | 国立大学法人千葉大学 | 光学活性置換テトラヒドロフラン誘導体を合成する方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1575009A (en) * | 1976-06-21 | 1980-09-17 | Acf Chemiefarma Nv | 6,7-benzomorphan derivatives |
| AU524600B2 (en) * | 1976-09-22 | 1982-09-23 | Sterling Drug Inc. | 2,6-methano-3-benzazocines |
| JPS5513253A (en) * | 1978-07-15 | 1980-01-30 | Res Inst For Prod Dev | Cis-3-aralkyl substituted-8-benzoylthio-6,11-dimethyl-2,6- methano-1,2,3,4,5,6-hexahydro-3-benzazocine or its acid addition salt |
| DE3839659A1 (de) * | 1988-11-24 | 1990-05-31 | Boehringer Ingelheim Kg | Verwendung von benzomorphanen zur zytoprotektion |
-
1999
- 1999-02-23 DE DE19907874A patent/DE19907874A1/de not_active Withdrawn
-
2000
- 2000-02-12 AU AU29109/00A patent/AU2910900A/en not_active Abandoned
- 2000-02-12 EP EP00907557A patent/EP1157020B1/de not_active Expired - Lifetime
- 2000-02-12 JP JP2000601001A patent/JP2002537393A/ja active Pending
- 2000-02-12 CA CA002362697A patent/CA2362697C/en not_active Expired - Fee Related
- 2000-02-12 ES ES00907557T patent/ES2183786T3/es not_active Expired - Lifetime
- 2000-02-12 PT PT00907557T patent/PT1157020E/pt unknown
- 2000-02-12 WO PCT/EP2000/001160 patent/WO2000050421A1/de not_active Ceased
- 2000-02-12 DE DE50000560T patent/DE50000560D1/de not_active Expired - Fee Related
- 2000-02-12 AT AT00907557T patent/ATE224890T1/de not_active IP Right Cessation
- 2000-02-12 DK DK00907557T patent/DK1157020T3/da active
- 2000-02-21 PE PE2000000132A patent/PE20001487A1/es not_active Application Discontinuation
- 2000-02-21 UY UY26022A patent/UY26022A1/es unknown
- 2000-02-22 CO CO00012191A patent/CO5170499A1/es not_active Application Discontinuation
- 2000-02-23 AR ARP000100754A patent/AR022718A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR022718A1 (es) | 2002-09-04 |
| CA2362697C (en) | 2008-04-22 |
| EP1157020B1 (de) | 2002-09-25 |
| WO2000050421A1 (de) | 2000-08-31 |
| CA2362697A1 (en) | 2000-08-31 |
| PT1157020E (pt) | 2003-01-31 |
| CO5170499A1 (es) | 2002-06-27 |
| DE19907874A1 (de) | 2000-08-24 |
| DE50000560D1 (de) | 2002-10-31 |
| JP2002537393A (ja) | 2002-11-05 |
| EP1157020A1 (de) | 2001-11-28 |
| ES2183786T3 (es) | 2003-04-01 |
| AU2910900A (en) | 2000-09-14 |
| UY26022A1 (es) | 2000-09-29 |
| ATE224890T1 (de) | 2002-10-15 |
| DK1157020T3 (da) | 2003-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |