PE20000352A1 - STREPTOMYCES AVERMITILIS GENE DIRECTING THE AVERMECTIN RATIO B2: B1 - Google Patents
STREPTOMYCES AVERMITILIS GENE DIRECTING THE AVERMECTIN RATIO B2: B1Info
- Publication number
- PE20000352A1 PE20000352A1 PE1999000099A PE00009999A PE20000352A1 PE 20000352 A1 PE20000352 A1 PE 20000352A1 PE 1999000099 A PE1999000099 A PE 1999000099A PE 00009999 A PE00009999 A PE 00009999A PE 20000352 A1 PE20000352 A1 PE 20000352A1
- Authority
- PE
- Peru
- Prior art keywords
- avec
- avermitilis
- avermectins
- refers
- sequence
- Prior art date
Links
- 241001468227 Streptomyces avermitilis Species 0.000 title abstract 5
- 239000005660 Abamectin Substances 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 241001136792 Alle Species 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 229940009098 aspartate Drugs 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 108010042660 rRNA (adenosine-O-2'-)methyltransferase Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REFIERE A UN POLINUCLEOTIDO AISLADO QUE COMPRENDE a)ORF COMPLETA DE aveC DE S. AVERMITILIS O QUE CARECE DE LA ORF COMPLETA DE aveC SEGUIDA DE LA ORF DE aveC; O EL PRODUCTO GENICO AveC DE S AVERMITILIS DEL PLASMIDO pSE186 O SECUENCIAS DE NUCLEOTIDOS QUE FLANQUEAN EL GEN avec EN S. AVERMITILIS; b)OLIGONUCLEOTIDO QUE SE HIBRIDIZA CON EL POLINUCLEOTIDO O EL COMPLEMENTO DE DICHA SECUENCIA; c)UNA O MAS MUTACIONES DE S. AVERMITILIS EN LAS QUE SE HA INACTIVADO EL ALELO DE aveC DE TIPO SILVESTRE Y QUE PRODUCE UNA DIFERENTE CANTIDAD DE AVERMECTINAS DE CLASES 2:1 DE CICLOHEXIL B2:CICLOHEXIL B1 AVERMECTINAS SUSTITUYENDOSE EN LA POSICION 138 SERINA POR TREONINA, EN LA POSICION 139 ALANINA POR TREONINA, EN LA POSICION 55 SERINA POR ASPARTATO; d)UN PROMOTOR FUERTE COMO ermE DE SACCHAROPOLYSPORA ERYTHRAEA; e)UN ALELO DE aveC INACTIVADO MEDIANTE DELECION DE PstI/SphI DE 640 PARES DE BASES. TAMBIEN SE REFIERE A UN VECTOR RECOMBINANTE QUE COMPRENDE UNA SECUENCIA DE NUCLEOTIDOS IGUAL U HOMOLOGA A LA SECUENCIA DE AveC S AVERMITILIS, ADEMAS CODIFICA ELEMENTOS REGULADORES, MARCADOR SELECTIVO; Y A CELULAS HOSPEDADORAS. TAMBIEN SE REFIERE A UN METODO PARA PRODUCIR UN PRODUCTO GENICO AveC RECOMBINANTE; UN PROCEDIMIENTO PARA IDENTIFICAR MUTACIONES Y PARA PRODUCIR NUEVAS CEPAS DE S. AVERMITILIS. LAS AVERMECTINAS TIENEN ACTIVIDAD ANTIHELMINTICAREFERS TO AN ISOLATED POLYNUCLEOTIDE THAT INCLUDES a) A COMPLETE ORF OF aveC DE S. AVERMITILIS OR THAT LACKS THE COMPLETE ORF OF aveC FOLLOWED BY THE ORF OF aveC; OR THE GENE PRODUCT AveC OF S AVERMITILIS FROM PLASMID pSE186 OR SEQUENCES OF NUCLEOTIDES THAT FLANK THE GENE avec IN S. AVERMITILIS; b) OLIGONUCLEOTIDE THAT HYBRIDIZES WITH THE POLYNUCLEOTIDE OR THE COMPLEMENT OF SAID SEQUENCE; c) ONE OR MORE MUTATIONS OF S. AVERMITILIS IN WHICH THE WILD-TYPE aveC ALLEL HAS BEEN INACTIVATED AND WHICH PRODUCES A DIFFERENT AMOUNT OF CLASS 2: 1 AVERMECTINS OF CYCLOHEXIL B2: CYCLOHEXIL B1 AVERMECTINS BEING SUBSTITUTED IN THE POSITION OF BEING 138 TREONINE, AT POSITION 139 ALANINE BY THREONINE, AT POSITION 55 SERINE BY ASPARTATE; d) A STRONG PROMOTER AS SACCHAROPOLYSPORA ERYTHRAEA ermE; e) ONE ALLE OF aveC INACTIVATED THROUGH PstI / SphI DELETION OF 640 BASE PAIRS. IT ALSO REFERS TO A RECOMBINANT VECTOR THAT INCLUDES A SEQUENCE OF NUCLEOTIDES EQUAL OR HOMOLOGATED TO THE SEQUENCE OF AveC S AVERMITILIS, IN ADDITION IT CODES REGULATORY ELEMENTS, SELECTIVE MARKER; AND TO HOST CELLS. IT ALSO REFERS TO A METHOD TO PRODUCE A RECOMBINANT AveC GENIC PRODUCT; A PROCEDURE FOR IDENTIFYING MUTATIONS AND FOR PRODUCING NEW STRAINS OF S. AVERMITILIS. THE AVERMECTINS HAVE ANTIHELMINE ACTIVITY
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7463698P | 1998-02-13 | 1998-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000352A1 true PE20000352A1 (en) | 2000-05-16 |
Family
ID=22120706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000099A PE20000352A1 (en) | 1998-02-13 | 1999-02-08 | STREPTOMYCES AVERMITILIS GENE DIRECTING THE AVERMECTIN RATIO B2: B1 |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1053335A1 (en) |
| JP (2) | JP2002503473A (en) |
| KR (3) | KR100499214B1 (en) |
| CN (2) | CN1297485A (en) |
| AP (1) | AP9901463A0 (en) |
| AR (1) | AR018085A1 (en) |
| AU (1) | AU752343C (en) |
| BG (1) | BG64911B1 (en) |
| BR (1) | BR9907893A (en) |
| CA (2) | CA2320031A1 (en) |
| CO (1) | CO5070698A1 (en) |
| DZ (1) | DZ2720A1 (en) |
| EA (1) | EA003905B1 (en) |
| GT (1) | GT199900014A (en) |
| HN (1) | HN1999000008A (en) |
| HR (1) | HRP20000539A2 (en) |
| HU (1) | HUP0100784A3 (en) |
| IL (2) | IL137610A0 (en) |
| IS (1) | IS5567A (en) |
| MA (1) | MA24760A1 (en) |
| NO (1) | NO20004044L (en) |
| NZ (2) | NZ505676A (en) |
| OA (1) | OA11449A (en) |
| PA (1) | PA8467601A1 (en) |
| PE (1) | PE20000352A1 (en) |
| PL (1) | PL194270B1 (en) |
| SK (1) | SK11722000A3 (en) |
| TN (1) | TNSN99017A1 (en) |
| TW (1) | TW585910B (en) |
| WO (1) | WO1999041389A1 (en) |
| YU (1) | YU50900A (en) |
| ZA (1) | ZA991138B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ505676A (en) * | 1998-02-13 | 2003-02-28 | Pfizer Prod Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| DE60031126T2 (en) | 1999-08-12 | 2007-02-08 | Pfizer Products Inc., Groton | STREPTOMYCES AVERMITILIS GEN FOR REGULATING THE RELATIONSHIP BETWEEN THE B2: B1 AVERMECTINS |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| SI1476539T1 (en) * | 2002-02-12 | 2009-06-30 | Pfizer Prod Inc | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| CN107338210B (en) * | 2017-09-05 | 2021-08-17 | 天津科技大学 | A kind of Streptomyces avermitilis synthetic medium and preparation method of fermentation broth thereof |
| CN111269296B (en) * | 2020-03-06 | 2021-11-05 | 山东大学 | nLsA protein, structural gene thereof and application thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (en) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (en) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| ATE89604T1 (en) * | 1987-10-23 | 1993-06-15 | Pfizer | PROCESS FOR THE PREPARATION OF AGLYCONES OF AVERMECTIN AND CULTURES CONTAINING THEM. |
| JPH0747171B2 (en) * | 1988-09-20 | 1995-05-24 | 株式会社東芝 | Rolling mill setting method and device |
| EP0391594B1 (en) * | 1989-03-31 | 1995-10-18 | Merck & Co. Inc. | Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| JP2888586B2 (en) * | 1990-03-05 | 1999-05-10 | 社団法人北里研究所 | Microorganism for selective production of specific components of avermectin and its selective production method |
| FI942725A7 (en) * | 1993-12-16 | 1995-06-17 | Pfizer | Genes encoding the branched-chain alpha-keto acid dehydrogenase complex from Streptomyces avermitilis |
| NZ505676A (en) * | 1998-02-13 | 2003-02-28 | Pfizer Prod Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
-
1999
- 1999-01-25 NZ NZ505676A patent/NZ505676A/en unknown
- 1999-01-25 BR BR9907893-7A patent/BR9907893A/en not_active Application Discontinuation
- 1999-01-25 IL IL13761099A patent/IL137610A0/en unknown
- 1999-01-25 CN CN99805027A patent/CN1297485A/en active Pending
- 1999-01-25 WO PCT/IB1999/000130 patent/WO1999041389A1/en not_active Ceased
- 1999-01-25 CN CNA2004100054154A patent/CN1521180A/en active Pending
- 1999-01-25 KR KR10-2000-7008870A patent/KR100499214B1/en not_active Expired - Fee Related
- 1999-01-25 KR KR10-2004-7015691A patent/KR20040099389A/en not_active Ceased
- 1999-01-25 CA CA002320031A patent/CA2320031A1/en not_active Abandoned
- 1999-01-25 AU AU18878/99A patent/AU752343C/en not_active Ceased
- 1999-01-25 PL PL99342468A patent/PL194270B1/en not_active IP Right Cessation
- 1999-01-25 HU HU0100784A patent/HUP0100784A3/en not_active Application Discontinuation
- 1999-01-25 KR KR10-2004-7008310A patent/KR20040053390A/en not_active Ceased
- 1999-01-25 CA CA002521289A patent/CA2521289A1/en not_active Abandoned
- 1999-01-25 NZ NZ518657A patent/NZ518657A/en unknown
- 1999-01-25 SK SK1172-2000A patent/SK11722000A3/en unknown
- 1999-01-25 YU YU50900A patent/YU50900A/en unknown
- 1999-01-25 EA EA200000758A patent/EA003905B1/en not_active IP Right Cessation
- 1999-01-25 EP EP99900270A patent/EP1053335A1/en not_active Withdrawn
- 1999-01-25 HR HR20000539A patent/HRP20000539A2/en not_active Application Discontinuation
- 1999-01-25 JP JP2000531570A patent/JP2002503473A/en active Pending
- 1999-01-26 PA PA19998467601A patent/PA8467601A1/en unknown
- 1999-02-01 GT GT199900014A patent/GT199900014A/en unknown
- 1999-02-05 HN HN1991000008A patent/HN1999000008A/en unknown
- 1999-02-08 PE PE1999000099A patent/PE20000352A1/en not_active Application Discontinuation
- 1999-02-09 TW TW088102005A patent/TW585910B/en active
- 1999-02-10 MA MA25460A patent/MA24760A1/en unknown
- 1999-02-10 TN TNTNSN99017A patent/TNSN99017A1/en unknown
- 1999-02-10 DZ DZ990021A patent/DZ2720A1/en active
- 1999-02-11 AR ARP990100571A patent/AR018085A1/en unknown
- 1999-02-11 AP APAP/P/1999/001463A patent/AP9901463A0/en unknown
- 1999-02-12 CO CO99008652A patent/CO5070698A1/en unknown
- 1999-02-12 ZA ZA9901138A patent/ZA991138B/en unknown
-
2000
- 2000-07-20 IS IS5567A patent/IS5567A/en unknown
- 2000-08-04 OA OA1200000217A patent/OA11449A/en unknown
- 2000-08-11 NO NO20004044A patent/NO20004044L/en not_active Application Discontinuation
- 2000-09-12 BG BG104759A patent/BG64911B1/en unknown
-
2004
- 2004-04-27 JP JP2004130624A patent/JP4011036B2/en not_active Expired - Fee Related
-
2007
- 2007-05-31 IL IL183596A patent/IL183596A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |