PE20000241A1 - Composicion farmaceutica de proteinas erizo y empleo del mismo - Google Patents
Composicion farmaceutica de proteinas erizo y empleo del mismoInfo
- Publication number
- PE20000241A1 PE20000241A1 PE1999000072A PE00007299A PE20000241A1 PE 20000241 A1 PE20000241 A1 PE 20000241A1 PE 1999000072 A PE1999000072 A PE 1999000072A PE 00007299 A PE00007299 A PE 00007299A PE 20000241 A1 PE20000241 A1 PE 20000241A1
- Authority
- PE
- Peru
- Prior art keywords
- contain
- protein
- support
- pharmaceutical composition
- erizo
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000003693 Hedgehog Proteins Human genes 0.000 title 1
- 108090000031 Hedgehog Proteins Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 229920002674 hyaluronan Polymers 0.000 abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 229920000936 Agarose Polymers 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 241000027355 Ferocactus setispinus Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229920001586 anionic polysaccharide Polymers 0.000 abstract 1
- 150000004836 anionic polysaccharides Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000013020 embryo development Effects 0.000 abstract 1
- 229910052816 inorganic phosphate Inorganic materials 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Biological Depolymerization Polymers (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UNA PROTEINA ERIZO (HEDGEHOG) UNIDA A UN SOPORTE HIDROFILICO BIOCOMPATIBLE Y BIODEGRADABLE, UTILIZANDOSE DE 0,1 mg/ml A 100 mg/ml. EL SOPORTE ES UN POLIMERO QUE SE CARACTERIZA a)POR SER UN ANION A CAUSA DE INTERACCIONES IONICAS; b)NO DESNATURALIZAR LA PROTEINA; c)CONTENER DE 0,1 A 2 IONES POR MONOMERO EN CONDICIONES NEUTRAS; d)CONTENER CARGAS EN FORMA DE GRUPOS DE CARACTER ACIDO; e)PESO MOLECULAR DE 50 000 DALTON; f)NO CONTENER AGAROSA. EL SOPORTE SE COMPONE DE UNA MATRIZ ORGANICA DE SOPORTE HIDROFILICO (ACIDO HIALURONICO) O UN POLISACARIDO ANIONICO O ACIDO HIALURONICO O DE UN FOSFATO INORGANICO INSOLUBLE. LA COMPOSICION SE CARACTERIZA POR EL pH DE 4-10; Y ADICIONALMENTE PUEDE CONTENER ARGININA O IONES ARGINILO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LA PROTEINA ERIZO ES RESPONSABLE DE LA FORMACION DE ESTRUCTURAS EN LA EMBRIOGENESIS Y SE LIBERA EN FORMA LOCAL EN HUESOS Y CARTILAGOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98101893 | 1998-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000241A1 true PE20000241A1 (es) | 2000-04-08 |
Family
ID=8231349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000072A PE20000241A1 (es) | 1998-02-04 | 1999-02-01 | Composicion farmaceutica de proteinas erizo y empleo del mismo |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR014530A1 (es) |
| BR (1) | BR9900523A (es) |
| HR (1) | HRP990036A2 (es) |
| ID (1) | ID22356A (es) |
| PE (1) | PE20000241A1 (es) |
| PL (1) | PL331201A1 (es) |
| TR (1) | TR199900197A2 (es) |
| ZA (1) | ZA99887B (es) |
-
1999
- 1999-02-01 PE PE1999000072A patent/PE20000241A1/es not_active Application Discontinuation
- 1999-02-02 TR TR1999/00197A patent/TR199900197A2/xx unknown
- 1999-02-02 ID IDP990071D patent/ID22356A/id unknown
- 1999-02-02 AR ARP990100423 patent/AR014530A1/es unknown
- 1999-02-03 PL PL33120199A patent/PL331201A1/xx unknown
- 1999-02-03 HR HRP990036 patent/HRP990036A2/hr not_active Application Discontinuation
- 1999-02-03 BR BR9900523-9A patent/BR9900523A/pt not_active IP Right Cessation
- 1999-02-04 ZA ZA9900887A patent/ZA99887B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL331201A1 (en) | 1999-08-16 |
| ZA99887B (en) | 1999-08-04 |
| HRP990036A2 (en) | 1999-08-31 |
| BR9900523A (pt) | 2000-05-02 |
| AR014530A1 (es) | 2001-02-28 |
| TR199900197A2 (xx) | 1999-08-23 |
| ID22356A (id) | 1999-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |