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PE20000049A1 - Nuevos macrolidos - Google Patents

Nuevos macrolidos

Info

Publication number
PE20000049A1
PE20000049A1 PE1998001287A PE00128798A PE20000049A1 PE 20000049 A1 PE20000049 A1 PE 20000049A1 PE 1998001287 A PE1998001287 A PE 1998001287A PE 00128798 A PE00128798 A PE 00128798A PE 20000049 A1 PE20000049 A1 PE 20000049A1
Authority
PE
Peru
Prior art keywords
alkyl
group
alkinyl
alkenyl
members
Prior art date
Application number
PE1998001287A
Other languages
English (en)
Inventor
John Philip Dirlam
Arthur Hamish Alastair Irvine Mc
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20000049A1 publication Critical patent/PE20000049A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE A NUEVOS ANALOGOS DE ERITROMICINA Y AZALIDAS DE FORMULA I; Y ES H, ALQUILO C1-C10, ALQUENILO C2-C10, ENTRE OTROS; R1 ES ALQUILO, ALQUENILO, ALQUINILO, ALCOXIALQUILO, FENILO OPCIONALMENTE SUSTITUIDO, GRUPO a, -CH2R24, ENTRE OTROS; X ES O, S, -CH2-; a, b, c, d SON 0-2; a+b+c+d¾5; R24 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R2 ES H u OH; R3 ES H, OH u OCH3; R4 ES H, -COR9, COOR9, CONR9R10, UN GRUPO PROTECTOR DE OH; R5 ES -SR8, -(CH2)nCOR8, ALQUILO C1-C10, ENTRE OTROS; n ES 0-1; R8 ES H, ALQUILO C1-C10, ALQUENILO C2-C10, ENTRE OTROS; CUANDO R8 ES -CH2NR8R15, R8 Y R15 FORMAN JUNTOS UN ANILLO MONO O POLICICLICO DE 4 A 10 MIEMBROS, HETEROCICLO DE 5-10 MIEMBROS, ENTRE OTROS; R18 ES OH, R19 ES ALQUILO C1-C10, ALQUENILO C2-C10, ALQUINILO C2-C10, ENTRE OTROS; O R18 Y R19 FORMAN JUNTOS UN ANILLO OXAZOLILO; R20 ES H, UN GRUPO b. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DEL COMPUESTO I Y COMPUESTOS INTERMEDIOS. EL COMPUESTO I PUEDE SER UTIL PARA TRATAR UNA INFECCION BACTERIANA O INFECCION PROTOZOARIA Y OTRAS APLICACIONES COMO CANCER, ATEROSCLEROSIS, REDUCCION DE LA MOTILIDAD GASTRICA
PE1998001287A 1998-01-02 1998-12-28 Nuevos macrolidos PE20000049A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7034398P 1998-01-02 1998-01-02

Publications (1)

Publication Number Publication Date
PE20000049A1 true PE20000049A1 (es) 2000-02-07

Family

ID=22094723

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001287A PE20000049A1 (es) 1998-01-02 1998-12-28 Nuevos macrolidos

Country Status (34)

Country Link
US (2) US6472371B1 (es)
EP (1) EP1044207A1 (es)
JP (1) JP2002500230A (es)
KR (1) KR100352809B1 (es)
CN (1) CN1284081A (es)
AP (1) AP9801420A0 (es)
AR (4) AR014948A1 (es)
AU (1) AU756409B2 (es)
BG (1) BG104644A (es)
BR (1) BR9814601A (es)
CA (1) CA2316919C (es)
CO (1) CO4970821A1 (es)
CZ (1) CZ20002458A3 (es)
DZ (1) DZ2698A1 (es)
EA (1) EA200000594A1 (es)
GT (1) GT199800206A (es)
HR (1) HRP20000442A2 (es)
HU (1) HUP0100420A3 (es)
IL (1) IL137024A0 (es)
IS (1) IS5528A (es)
MA (1) MA24729A1 (es)
NO (1) NO20003347L (es)
NZ (1) NZ504986A (es)
OA (1) OA11438A (es)
PA (1) PA8465301A1 (es)
PE (1) PE20000049A1 (es)
PL (1) PL341642A1 (es)
SK (1) SK9782000A3 (es)
TN (1) TNSN98238A1 (es)
TW (1) TW520374B (es)
UY (2) UY25330A1 (es)
WO (1) WO1999035156A1 (es)
YU (1) YU41500A (es)
ZA (1) ZA9811939B (es)

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AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
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US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
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EP1811841B1 (en) * 2004-11-19 2009-10-28 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
HRP20100253T1 (hr) 2004-12-21 2010-06-30 Pfizer Products Inc. Makrolidi
US20060281695A1 (en) * 2005-06-09 2006-12-14 Schering-Plough Animal Health Corporation Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
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TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
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TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
CN102686570A (zh) 2009-08-05 2012-09-19 杜邦公司 介离子杀虫剂
MX2012013758A (es) 2010-05-27 2013-01-24 Du Pont Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida.
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
JPWO2012105562A1 (ja) * 2011-01-31 2014-07-03 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規マクロライド誘導体
WO2012177668A1 (en) 2011-06-20 2012-12-27 E. I. Du Pont De Nemours And Company Heterocyclic compounds for treating helminth infections
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
TW201326128A (zh) 2011-11-28 2013-07-01 Du Pont 磺醯胺驅蟲劑
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物

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Also Published As

Publication number Publication date
ZA9811939B (en) 2000-06-30
DZ2698A1 (fr) 2003-03-29
NO20003347D0 (no) 2000-06-27
TNSN98238A1 (fr) 2005-03-15
WO1999035156A1 (en) 1999-07-15
IS5528A (is) 2000-06-09
AU1444799A (en) 1999-07-26
BG104644A (en) 2001-01-31
AR020851A2 (es) 2002-05-29
NO20003347L (no) 2000-08-28
AR019787A2 (es) 2002-03-13
CN1284081A (zh) 2001-02-14
AR020551A2 (es) 2002-05-15
CZ20002458A3 (cs) 2001-10-17
UY25330A1 (es) 2000-12-29
PA8465301A1 (es) 2000-09-29
US7015203B2 (en) 2006-03-21
UY25574A1 (es) 1999-09-27
US20040092459A1 (en) 2004-05-13
MA24729A1 (fr) 1999-07-01
BR9814601A (pt) 2000-10-17
NZ504986A (en) 2003-03-28
TW520374B (en) 2003-02-11
EP1044207A1 (en) 2000-10-18
YU41500A (sh) 2003-02-28
GT199800206A (es) 2000-06-21
US6472371B1 (en) 2002-10-29
JP2002500230A (ja) 2002-01-08
SK9782000A3 (en) 2001-12-03
HRP20000442A2 (en) 2001-04-30
OA11438A (en) 2004-04-30
CO4970821A1 (es) 2000-11-07
IL137024A0 (en) 2001-06-14
KR20010024818A (ko) 2001-03-26
AR014948A1 (es) 2001-04-11
HUP0100420A2 (hu) 2001-07-30
AU756409B2 (en) 2003-01-09
HUP0100420A3 (en) 2003-07-28
WO1999035156B1 (en) 1999-10-21
KR100352809B1 (ko) 2002-11-01
CA2316919A1 (en) 1999-07-15
EA200000594A1 (ru) 2001-04-23
CA2316919C (en) 2004-10-26
PL341642A1 (en) 2001-04-23
AP9801420A0 (en) 1998-12-31

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