PE20000945A1 - Compuesto de maleimida disustituida y su uso farmaceutico - Google Patents
Compuesto de maleimida disustituida y su uso farmaceuticoInfo
- Publication number
- PE20000945A1 PE20000945A1 PE1999000774A PE00077499A PE20000945A1 PE 20000945 A1 PE20000945 A1 PE 20000945A1 PE 1999000774 A PE1999000774 A PE 1999000774A PE 00077499 A PE00077499 A PE 00077499A PE 20000945 A1 PE20000945 A1 PE 20000945A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- disustituted
- maleimide compound
- diona
- Prior art date
Links
- -1 MALEIMIDE COMPOUND Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- DXGTUUQHTDOFFQ-UHFFFAOYSA-N [N].C1=CC=C2NC=CC2=C1 Chemical compound [N].C1=CC=C2NC=CC2=C1 DXGTUUQHTDOFFQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE MALEIMIDA DISUSTITUIDA DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C6; R2 ES ARILO C6-C18, CICLOALQUILO C3-C8, HETEROCICLO DE 5-12 MIEMBROS CON 1-4 O, S, N; R3, R5, R6, R7 Y R8 SON H, OH, HALOGENO, AMINO, ALQUILO C1-C6, ALCOXI C1-C6; R4 ES W; O R4 Y R3 JUNTOS FORMAN *-(CH2)p-C(W)(W`)-(CH2)q-, *-(CH2)p-C(W')(W)-CH=CH-, O R4 Y R5 SON *-(CH2)p-C(W')(W)-(CH2)r-O-; W ES -(CH2)l-(Y)m-(CH2)n-Z; Y ES CR9R9', NR10, O, S, CONH, ENTRE OTROS; R9 Y R9' SON H, OH, ALQUILO C1-C6, ALCOXI C1-C6, ALQUILTIO C1-C6, ALQUILAMINO C1-C6, DIALQUILAMINO C1-C6, HETEROCICLO DE 5-12 MIEMBROS, ENTRE OTROS; Z ES H, OH, HALOGENO, ALCOXI C1-C6, ALCOXICARBONIL C1-C6, NR11R12, AMIDINA, ENTRE OTROS; R10, R11 Y R12 SON H, ALQUILO C1-C6; l ES 0-4; m ES 0-1; n ES 0-4; W' ES H, W, -(CH2)l-(Y)m-(CH2)n-Z; p, q r SON 0-4; * ES EL ENLACE AL NITROGENO DEL INDOL. SON COMPUESTOS PREFERIDOS 3-(1H-INDO-3-LIL)-4-[(3-METOXIFENIL)AMINO]-1H-PIRROL-2,5-DIONA, 3-(1H-INDO-3-LIL)-4-(FENILAMINO)-1H-PIRROL-2,5-DIONA, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR SELECTIVO DE ß ISOZIMA DE CINASA PROTEICA C POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE COMPLICACIONES DIABETICAS COMO RETINOPATIA, NEFROPATIA, CARDIOMIOPATIA, NEUROPATIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21507098 | 1998-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000945A1 true PE20000945A1 (es) | 2000-09-25 |
Family
ID=16666269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000774A PE20000945A1 (es) | 1998-07-30 | 1999-08-02 | Compuesto de maleimida disustituida y su uso farmaceutico |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1120414A1 (es) |
| KR (1) | KR20010085305A (es) |
| CN (1) | CN1320123A (es) |
| AU (1) | AU4929999A (es) |
| BR (1) | BR9912612A (es) |
| CA (1) | CA2338866A1 (es) |
| HU (1) | HUP0103381A3 (es) |
| ID (1) | ID27510A (es) |
| IL (1) | IL141080A0 (es) |
| NO (1) | NO20010487L (es) |
| PE (1) | PE20000945A1 (es) |
| WO (1) | WO2000006564A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6719520B2 (en) | 1998-10-08 | 2004-04-13 | Smithkline Beecham Corporation | Method and compounds |
| ATE284387T1 (de) * | 1998-10-08 | 2004-12-15 | Smithkline Beecham Plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
| EP1224932A4 (en) * | 1999-08-20 | 2002-10-16 | Sagami Chem Res | ACTIVE SUBSTANCES TO INHIBIT CELL DEATH |
| GB0008264D0 (en) * | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
| CA2431166A1 (en) | 2000-12-08 | 2002-06-13 | Ortho-Mcneil Pharmaceutical, Inc. | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
| BR0212676A (pt) * | 2001-09-21 | 2006-05-23 | Upjohn Co | compostos terapêuticos ligantes de 5-ht, composições farmacêuticas compreendendo tais compostos e seus usos |
| PE20040079A1 (es) | 2002-04-03 | 2004-04-19 | Novartis Ag | Derivados de indolilmaleimida |
| CN1671694A (zh) | 2002-06-05 | 2005-09-21 | 詹森药业有限公司 | 作为激酶抑制剂的二吲哚基－顺丁烯二酰亚胺衍生物 |
| WO2003103663A2 (en) | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| EA200600032A1 (ru) | 2003-06-13 | 2006-06-30 | Янссен Фармацевтика Н.В. | Замещённые производные индазолил (индолил) малеимида в качестве ингибиторов киназ |
| GB0316232D0 (en) | 2003-07-11 | 2003-08-13 | Astrazeneca Ab | Therapeutic agents |
| US7608626B2 (en) | 2004-11-01 | 2009-10-27 | Wyeth | Substituted indolizines and derivatives as CNS agents |
| RS51826B (sr) * | 2005-02-09 | 2012-02-29 | Arqule Inc. | Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera |
| EP2392574B1 (en) | 2007-06-22 | 2013-12-18 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| AU2008268613A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| CA2690799C (en) * | 2007-06-22 | 2015-06-16 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| CN101671329B (zh) * | 2009-06-17 | 2012-11-07 | 东华大学 | 3-氨基醇取代的吲哚马来酰亚胺化合物、其制备和应用 |
| CN102344443A (zh) * | 2011-07-15 | 2012-02-08 | 南开大学 | 点击化学合成开环马来酰亚胺类化合物及其在治疗疾病中的应用 |
| WO2013029043A1 (en) * | 2011-08-25 | 2013-02-28 | Reaction Biology Corp. | Selective kinase inhibitors |
| CN112574163B (zh) * | 2021-01-29 | 2023-04-07 | 山西省肿瘤研究所 | 巴西苏木素类天然产物(+)-Brazilin的合成方法 |
| WO2025165835A1 (en) * | 2024-01-31 | 2025-08-07 | Ensem Therapeutics, Inc. | Anilino tricyclic compounds, and compositions and methods thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
-
1999
- 1999-07-28 HU HU0103381A patent/HUP0103381A3/hu unknown
- 1999-07-28 BR BR9912612-5A patent/BR9912612A/pt not_active Application Discontinuation
- 1999-07-28 CN CN99811577A patent/CN1320123A/zh active Pending
- 1999-07-28 IL IL14108099A patent/IL141080A0/xx unknown
- 1999-07-28 WO PCT/JP1999/004085 patent/WO2000006564A1/ja not_active Ceased
- 1999-07-28 CA CA002338866A patent/CA2338866A1/en not_active Abandoned
- 1999-07-28 EP EP99933165A patent/EP1120414A1/en not_active Withdrawn
- 1999-07-28 AU AU49299/99A patent/AU4929999A/en not_active Abandoned
- 1999-07-28 ID IDW20010409A patent/ID27510A/id unknown
- 1999-07-28 KR KR1020017001124A patent/KR20010085305A/ko not_active Ceased
- 1999-08-02 PE PE1999000774A patent/PE20000945A1/es not_active Application Discontinuation
-
2001
- 2001-01-29 NO NO20010487A patent/NO20010487L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2338866A1 (en) | 2000-02-10 |
| BR9912612A (pt) | 2001-11-20 |
| EP1120414A1 (en) | 2001-08-01 |
| AU4929999A (en) | 2000-02-21 |
| ID27510A (id) | 2001-04-12 |
| CN1320123A (zh) | 2001-10-31 |
| NO20010487L (no) | 2001-03-28 |
| NO20010487D0 (no) | 2001-01-29 |
| IL141080A0 (en) | 2002-02-10 |
| WO2000006564A1 (en) | 2000-02-10 |
| HUP0103381A3 (en) | 2002-07-29 |
| KR20010085305A (ko) | 2001-09-07 |
| HUP0103381A2 (hu) | 2002-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |