PE20000733A1 - Derivados de acridina - Google Patents
Derivados de acridinaInfo
- Publication number
- PE20000733A1 PE20000733A1 PE1999000565A PE00056599A PE20000733A1 PE 20000733 A1 PE20000733 A1 PE 20000733A1 PE 1999000565 A PE1999000565 A PE 1999000565A PE 00056599 A PE00056599 A PE 00056599A PE 20000733 A1 PE20000733 A1 PE 20000733A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- double bond
- ch2nr14r15
- acridine derivatives
- Prior art date
Links
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title abstract 2
- 229940027998 antiseptic and disinfectant acridine derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- JIQNWFBLYKVZFY-UHFFFAOYSA-N methoxycyclohexatriene Chemical class COC1=C[C]=CC=C1 JIQNWFBLYKVZFY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229940127240 opiate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Press Drives And Press Lines (AREA)
Abstract
SE REFIERE A DERIVADOS DE ACRIDINA DE FORMULA I, DONDE: a)R1 ES A, CUANDO R2 ES H, OR12; o R2 Y R3 FORMAN UN DOBLE ENLACE; R3 ES H o R3 Y R2 FORMAN UN DOBLE ENLACE, R4 ES CH2NR14R15; R5, R6 SON H, ALQUILO C1-C6; R7 Y R8 SON H; b)R3 ES A CUANDO R1 ES H o R1 Y R4 FORMAN UN DOBLE ENLACE; R2 ES H, R4 ES H, OR12; o R4 Y R1 o R4 Y R5 FORMAN UN DOBLE ENLACE; R5, R7 Y R8 SON H, o R5 Y R6 FORMAN UN DOBLE ENLACE; R6 ES CH2NR14R15; c)CUANDO R5 ES A; R1, R2, R3, R4 Y R7 SON H, R6 ES H, OR12 o R6 Y R3 o R6 Y R7 FORMAN UN DOBLE ENLACE; R8 ES CH2NR14R15; A ES UN FENIL SUSTITUIDO CON R11; R9 Y R10 SON H, OH, ALCOXI C1-C6, Cl, F, CN, CF3, COOH, CONR17R18, COOR16; R11 ES H, OH, ALCOXI C1-C6, O-CICLOALCOXI C3-C7, O-ARILO, O-HETEROCICLO; R12 ES H, ALQUILO C1-C6, ARILO, COR13; R13 ES ALQUILO C1-C6, ARILO; R14 Y R15 SON ALQUILO C1-C6, ARILO, CICLOALQUILO C3-C7; R16, R17 Y R18 SON ALQUILO C1-C6; X ES N, CUANDO Y ES C o X ES C CUANDO Y ES N. SON COMPUESTOS PREFERIDOS CLORHIDRATO DE RAC-CIS-[3-DIMETILAMINOMETIL-2-(3-METOXI-FENIL)]-1,2,3,4-TETRAHIDRO-ACRIDIN-2-OL, CLORHIDRATO DE RAC-CIS-[4-DIMETILAMINOMETIL-3-(3-METOXI-FENIL)]-1,2,3,4-TETRAHIDRO-ACRIDIN-3-OL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PRESENTA AFINIDAD POR EL Ù-RECEPTOR DE OPIATO POR LO QUE PUEDE SER UTIL COMO ANALGESICO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19830105A DE19830105C1 (de) | 1998-07-06 | 1998-07-06 | Acridinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000733A1 true PE20000733A1 (es) | 2000-08-12 |
Family
ID=7873106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000565A PE20000733A1 (es) | 1998-07-06 | 1999-06-24 | Derivados de acridina |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6077845A (es) |
| EP (2) | EP0970949B1 (es) |
| JP (1) | JP2000026426A (es) |
| KR (1) | KR100601742B1 (es) |
| CN (1) | CN1206221C (es) |
| AR (1) | AR019219A1 (es) |
| AT (1) | ATE247643T1 (es) |
| AU (1) | AU749935B2 (es) |
| BR (1) | BR9903115A (es) |
| CA (1) | CA2276764C (es) |
| CO (1) | CO5080790A1 (es) |
| CZ (1) | CZ296559B6 (es) |
| DE (2) | DE19830105C1 (es) |
| DK (1) | DK0970949T3 (es) |
| ES (1) | ES2205642T3 (es) |
| HU (1) | HU226039B1 (es) |
| IL (1) | IL130801A (es) |
| MY (1) | MY124404A (es) |
| NO (1) | NO312958B1 (es) |
| NZ (1) | NZ336122A (es) |
| PE (1) | PE20000733A1 (es) |
| PL (1) | PL193386B1 (es) |
| PT (1) | PT970949E (es) |
| RU (1) | RU2225399C2 (es) |
| SI (1) | SI0970949T1 (es) |
| SK (1) | SK284234B6 (es) |
| UY (1) | UY25592A1 (es) |
| ZA (1) | ZA994369B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10000311A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Aminomethyl-Phonyl-Cyclohexanonderivate |
| KR100381716B1 (ko) * | 2000-10-09 | 2003-04-26 | 한국화학연구원 | 항암활성을 가지는 아크리딘 유도체 |
| JP5650637B2 (ja) * | 2008-03-27 | 2015-01-07 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | （ヘテロ−）アリール−シクロヘキサン誘導体 |
| CN105315205B (zh) * | 2015-01-19 | 2018-03-23 | 威海惠安康生物科技有限公司 | 一种以邻硝基苯甲醛和环己醇为原料制备吖啶的方法 |
| RU2616247C1 (ru) * | 2016-03-28 | 2017-04-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинский государственный университет имени Коста Левановича Хетагурова" (СОГУ) | Твердая лекарственная форма, обладающая холинопозитивным действием, на основе 9-бутиламино-3,3-диметил-1,2,4-тригидроакридина |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| DE2337474C2 (de) * | 1973-07-24 | 1982-01-21 | Hoechst Ag, 6000 Frankfurt | Chemotherapeutisch wirksame Tetrahydroacridone, Verfahren zu ihrer Herstellung und sie enthaltende Mittel |
| US4851536A (en) * | 1987-05-07 | 1989-07-25 | American Home Products Corporation | Cyclohexylquinolines as inhibitors of interleukin 1 |
| US5210087A (en) * | 1991-02-13 | 1993-05-11 | Hoechst-Roussel Pharmaceuticals Inc. | 9-aminotetrahydroacridines and related compounds |
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| DE19547766A1 (de) * | 1995-12-20 | 1997-06-26 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| DE19755480A1 (de) * | 1997-12-13 | 1999-06-24 | Gruenenthal Gmbh | Substituierte heterocyclische Benzocycloalkene und ihre Verwendung als analgetisch wirksame Substanzen |
-
1998
- 1998-07-06 DE DE19830105A patent/DE19830105C1/de not_active Expired - Fee Related
-
1999
- 1999-06-03 NZ NZ336122A patent/NZ336122A/en unknown
- 1999-06-04 MY MYPI99002260A patent/MY124404A/en unknown
- 1999-06-15 PT PT99111564T patent/PT970949E/pt unknown
- 1999-06-15 EP EP99111564A patent/EP0970949B1/de not_active Expired - Lifetime
- 1999-06-15 DE DE59906645T patent/DE59906645D1/de not_active Expired - Lifetime
- 1999-06-15 EP EP03013144A patent/EP1369417A1/de not_active Withdrawn
- 1999-06-15 ES ES99111564T patent/ES2205642T3/es not_active Expired - Lifetime
- 1999-06-15 DK DK99111564T patent/DK0970949T3/da active
- 1999-06-15 AT AT99111564T patent/ATE247643T1/de not_active IP Right Cessation
- 1999-06-15 SI SI9930393T patent/SI0970949T1/xx unknown
- 1999-06-24 PE PE1999000565A patent/PE20000733A1/es not_active Application Discontinuation
- 1999-06-29 US US09/340,729 patent/US6077845A/en not_active Expired - Fee Related
- 1999-06-30 UY UY25592A patent/UY25592A1/es not_active Application Discontinuation
- 1999-07-02 CZ CZ0240799A patent/CZ296559B6/cs not_active IP Right Cessation
- 1999-07-02 SK SK908-99A patent/SK284234B6/sk not_active IP Right Cessation
- 1999-07-02 CA CA002276764A patent/CA2276764C/en not_active Expired - Fee Related
- 1999-07-02 CO CO99041630A patent/CO5080790A1/es unknown
- 1999-07-02 AR ARP990103231A patent/AR019219A1/es active IP Right Grant
- 1999-07-05 ZA ZA9904369A patent/ZA994369B/xx unknown
- 1999-07-05 RU RU99114454/04A patent/RU2225399C2/ru not_active IP Right Cessation
- 1999-07-05 KR KR1019990026837A patent/KR100601742B1/ko not_active Expired - Fee Related
- 1999-07-05 HU HU9902270A patent/HU226039B1/hu not_active IP Right Cessation
- 1999-07-05 PL PL334180A patent/PL193386B1/pl not_active IP Right Cessation
- 1999-07-05 IL IL130801A patent/IL130801A/en not_active IP Right Cessation
- 1999-07-05 NO NO19993320A patent/NO312958B1/no not_active IP Right Cessation
- 1999-07-05 AU AU37983/99A patent/AU749935B2/en not_active Ceased
- 1999-07-05 CN CNB991101618A patent/CN1206221C/zh not_active Expired - Fee Related
- 1999-07-05 JP JP11190920A patent/JP2000026426A/ja active Pending
- 1999-07-06 BR BR9903115-9A patent/BR9903115A/pt active Search and Examination
-
2000
- 2000-03-30 US US09/538,274 patent/US6274768B1/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |