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PE20000474A1 - INHIBITORS OF NITRIC OXIDE SYNTHASE - Google Patents

INHIBITORS OF NITRIC OXIDE SYNTHASE

Info

Publication number
PE20000474A1
PE20000474A1 PE1999000395A PE00039599A PE20000474A1 PE 20000474 A1 PE20000474 A1 PE 20000474A1 PE 1999000395 A PE1999000395 A PE 1999000395A PE 00039599 A PE00039599 A PE 00039599A PE 20000474 A1 PE20000474 A1 PE 20000474A1
Authority
PE
Peru
Prior art keywords
inhibitors
alkyl
nitric oxide
oxide synthase
thiahexanoico
Prior art date
Application number
PE1999000395A
Other languages
Spanish (es)
Inventor
Richard Graham Knowles
Wendy Karen Alderton
Christoph Hubertus Ladel
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20000474A1 publication Critical patent/PE20000474A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE AL USO DE INHIBIDORES DE LA OXIDO NITRICO SINTASA DE FORMULA I, DONDE R1 ES UN ALQUILO C1-C6; R2 ES -Q-C(-NH2)-CO2H, GRUPO a; R3 ES -(CH2)nNH2; n ES 0-2; Q ES UN ALQUILENO, ALQUENILENO, ALQUINILENO C3-C6, -(CH2)pX(CH2)q; -(CH2)rA(CH2)s-, p ES 2-3; q ES 1-2; X ES S(O)x; x ES 0-2, O, NR4, r ES 0-2; s ES 0-2; A ES UN ANILLO CARBOCICLICO, HETEROCICLICO DE 3 A 6 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON ALQUILO C1-C6, ALCOXI C1-C6, HIDROXI, HALO, ENTRE OTROS; R4 ES H, ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS ACIDO (R)-2-AMINO-6-(1-IMINOETILAMINO)-4,4-DIOXO-4-TIAHEXANOICO, (S)-[2-(1-IMINOETILAMINO)ETIL]-L-HOMOCISTEINA. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO Y PROFILAXIS DE UNA INFECCION BACTERIANA O VIRAL EN CHOQUE SEPTICOREFERS TO THE USE OF INHIBITORS OF THE NITRIC OXIDE SYNTHASE OF FORMULA I, WHERE R1 IS A C1-C6 ALKYL; R2 IS -Q-C (-NH2) -CO2H, GROUP a; R3 IS - (CH2) nNH2; n IS 0-2; Q IS AN ALKYLENE, ALKENYLENE, C3-C6 ALKYNYLENE, - (CH2) pX (CH2) q; - (CH2) rA (CH2) s-, p ES 2-3; q IS 1-2; X IS S (O) x; x IS 0-2, O, NR4, r IS 0-2; s IS 0-2; A IS A CARBOCYCLIC, HETEROCICLIC RING OF 3 TO 6 MEMBERS OPTIONALLY SUBSTITUTED WITH C1-C6 ALKYL, C1-C6 ALCOXY, HYDROXY, HALO, AMONG OTHERS; R4 IS H, C1-C6 ALKYL. PREFERRED COMPOUNDS ARE (R) -2-AMINO-6- (1-IMINOETHYLAMINE) -4,4-DIOXO-4-THIAHEXANOICO, (S) - [2- (1-IMINOETHYLAMINO) ETHYL] -L-HOMOCISTEIN. COMPOUND I MAY BE USEFUL FOR THE TREATMENT AND PROPHYLAXIS OF A BACTERIAL OR VIRAL INFECTION IN SEPTIC SHOCK

PE1999000395A 1998-05-15 1999-05-12 INHIBITORS OF NITRIC OXIDE SYNTHASE PE20000474A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9810299.9A GB9810299D0 (en) 1998-05-15 1998-05-15 Use of nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
PE20000474A1 true PE20000474A1 (en) 2000-06-06

Family

ID=10832007

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000395A PE20000474A1 (en) 1998-05-15 1999-05-12 INHIBITORS OF NITRIC OXIDE SYNTHASE

Country Status (6)

Country Link
AR (1) AR020587A1 (en)
AU (1) AU4040699A (en)
GB (1) GB9810299D0 (en)
MA (1) MA24854A1 (en)
PE (1) PE20000474A1 (en)
WO (1) WO1999059566A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0031179D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
WO2003097050A2 (en) * 2002-05-16 2003-11-27 Pharmacia Corporation A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CN102202649A (en) 2008-10-07 2011-09-28 Mpex医药有限公司 Fluoroquinolone Aerosol Formulations for Improved Pharmacokinetics
PL2346509T3 (en) 2008-10-07 2021-03-08 Horizon Orphan Llc Inhalation of levofloxacin for reducing lung inflammation
KR20120100904A (en) 2009-09-04 2012-09-12 엠펙스 파마슈티컬즈, 인코포레이티드 Use of aerosolized levofloxacin for treating cystic fibrosis
DE102010055322A1 (en) * 2010-12-21 2012-06-21 Christian-Albrechts-Universität Zu Kiel Antibacterial and antifungal substances

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312835A (en) * 1989-09-13 1994-05-17 Board Of Regents, The University Of Texas System Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension
US5545625A (en) * 1994-12-12 1996-08-13 The Medical College Of Wisconsin Research Foundation, Inc. Preventing conversion of citrulline to argininosuccinate to limit pathological nitric oxide overproduction
GB9425701D0 (en) * 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
MY117948A (en) * 1997-01-13 2004-08-30 Glaxo Group Ltd Nitride oxide synthase inhibitors.
GB9702312D0 (en) * 1997-02-05 1997-03-26 Univ London Method for identifying selective inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
MA24854A1 (en) 1999-12-31
AU4040699A (en) 1999-12-06
GB9810299D0 (en) 1998-07-15
AR020587A1 (en) 2002-05-22
WO1999059566A1 (en) 1999-11-25

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Legal Events

Date Code Title Description
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