PE17598A1 - QUINOLINS - Google Patents
QUINOLINSInfo
- Publication number
- PE17598A1 PE17598A1 PE1996000810A PE00081096A PE17598A1 PE 17598 A1 PE17598 A1 PE 17598A1 PE 1996000810 A PE1996000810 A PE 1996000810A PE 00081096 A PE00081096 A PE 00081096A PE 17598 A1 PE17598 A1 PE 17598A1
- Authority
- PE
- Peru
- Prior art keywords
- benzo
- alkyl
- quinolins
- reaction
- inhibitors
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- AWBOSXFRPFZLOP-UHFFFAOYSA-N 2,1,3-benzoxadiazole Chemical compound C1=CC=CC2=NON=C21 AWBOSXFRPFZLOP-UHFFFAOYSA-N 0.000 abstract 1
- PWORFEDVDWBHSJ-UHFFFAOYSA-N 2-methylbenzotriazole Chemical compound C1=CC=CC2=NN(C)N=C21 PWORFEDVDWBHSJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "X" ES -O-, -S- o -N(CH3)-; R1 ES HIDROGENO O ALQUILO C1-C4; R2 ES ALQUILO C1-C4 O PIRIDILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE OBTENCION DE (I), QUE COMPRENDE: 1) HACER REACCIONAR UN BENZO[c]TIADIAZOL, BENZO[c]FURAZAN o 2-METIL-2H-BENZO[d]TRIAZOL (SUSTITUIDOS EN LA POSICION 3 o 4 CON Q) CON UNA QUINOLINA (SUSTITUIDA EN LA POSICION 8 CON Q`), EN DONDE: Q Y Q' SON GRUPOS SALIENTES CAPACES DE PARTICIPAR EN UNA REACCION DE ACOPLAMIENTO CRUZADO; Y OPCIONALMENTE, 2) N-ALQUILAR o N-OXIDAR EL COMPUESTO (I). DICHAS QUINOLINAS ACTUAN COMO INHIBIDORES SELECTIVOS DE LA FOSFODIESTERASA IV Y/O INHIBIDORES DE LA LIBERACION DE TNF-O, SIENDO USADOS EN EL TRATAMIENTO DEL ASMA, O DE LAS ENFERMEDADES AUTOINMUNES, ENTRE OTRASTHEY REFER TO COMPOUNDS OF FORMULA (I), WHERE: "X" IS -O-, -S- or -N (CH3) -; R1 IS HYDROGEN OR C1-C4 ALKYL; R2 IS C1-C4 ALKYL OR PIRIDYL. IT ALSO REFERS TO THE PROCEDURE FOR OBTAINING (I), WHICH INCLUDES: 1) REACTION A BENZO [c] TIADIAZOL, BENZO [c] FURAZAN or 2-METHYL-2H-BENZO [d] TRIAZOL (REPLACED IN POSITION 3 or 4 WITH Q) WITH A QUINOLINE (SUBSTITUTED IN POSITION 8 WITH Q`), WHERE: QYQ 'ARE OUTGOING GROUPS ABLE TO PARTICIPATE IN A CROSS-COUPLED REACTION; AND OPTIONALLY, 2) N-RENT or N-OXIDIZE THE COMPOUND (I). SUCH QUINOLINS ACT AS SELECTIVE INHIBITORS OF PHOSPHODIESTERASE IV AND / OR INHIBITORS OF THE RELEASE OF TNF-O, BEING USED IN THE TREATMENT OF ASTHMA, OR OF AUTOIMMUNE DISEASES, AMONG OTHERS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9523267.4A GB9523267D0 (en) | 1995-11-14 | 1995-11-14 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE17598A1 true PE17598A1 (en) | 1998-04-06 |
Family
ID=10783856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1996000810A PE17598A1 (en) | 1995-11-14 | 1996-11-12 | QUINOLINS |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0873338A1 (en) |
| JP (1) | JPH11515000A (en) |
| KR (1) | KR19990067574A (en) |
| CN (1) | CN1202170A (en) |
| AU (1) | AU7570996A (en) |
| BR (1) | BR9611504A (en) |
| CA (1) | CA2235126A1 (en) |
| CO (1) | CO4770973A1 (en) |
| CZ (1) | CZ149498A3 (en) |
| GB (1) | GB9523267D0 (en) |
| HU (1) | HUP9903492A3 (en) |
| MX (1) | MX9803839A (en) |
| PE (1) | PE17598A1 (en) |
| PL (1) | PL326636A1 (en) |
| SK (1) | SK63998A3 (en) |
| TR (1) | TR199800851T2 (en) |
| WO (1) | WO1997018208A1 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU777012B2 (en) | 1999-08-21 | 2004-09-30 | Takeda Gmbh | Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist |
| US20040180900A1 (en) | 2001-05-23 | 2004-09-16 | Masaharu Takigawa | Therapeutic composition for repairing chondropathy |
| KR20040007596A (en) | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | Compositions for promoting healing of bone fracture |
| JP2006522151A (en) | 2003-04-01 | 2006-09-28 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | Phosphodiesterase inhibitors in infertility |
| KR20070026390A (en) | 2004-01-23 | 2007-03-08 | 암젠 인코포레이션 | Compound and how to use |
| JP2006347936A (en) | 2005-06-15 | 2006-12-28 | Bayer Cropscience Ag | Insecticidal benzanilides |
| CA2796826A1 (en) | 2010-05-10 | 2011-11-17 | Gilead Sciences, Inc. | Bifunctional quinoline derivatives |
| UY33373A (en) | 2010-05-10 | 2011-12-30 | Gilead Sciences Inc | ? Bifunctional pyrazolopyridine compounds, their use in therapy and compositions that comprise them ?. |
| CA2888485C (en) | 2012-10-16 | 2021-01-26 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror.gamma.t |
| ME02794B (en) | 2012-10-16 | 2018-01-20 | Janssen Pharmaceutica Nv | METHYLENE-LINED CHINOLINYL MODULATORS OF ROR-GAMMA-T |
| AU2013331493A1 (en) | 2012-10-16 | 2015-04-09 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORyt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| BR112016008215A2 (en) | 2013-10-15 | 2017-09-26 | Janssen Pharmaceutica Nv | roryt alkyl-linked quinolinyl modulators |
| ES2742843T3 (en) | 2013-10-15 | 2020-02-17 | Janssen Pharmaceutica Nv | ROR quinolinyl modulators (gamma) t |
| IL279410B2 (en) * | 2018-06-24 | 2024-03-01 | Adama Agan Ltd | Process for the preparation of quinmerac |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
| US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
-
1995
- 1995-11-14 GB GBGB9523267.4A patent/GB9523267D0/en active Pending
-
1996
- 1996-11-12 PE PE1996000810A patent/PE17598A1/en not_active Application Discontinuation
- 1996-11-13 JP JP9515313A patent/JPH11515000A/en not_active Withdrawn
- 1996-11-13 AU AU75709/96A patent/AU7570996A/en not_active Abandoned
- 1996-11-13 TR TR1998/00851T patent/TR199800851T2/en unknown
- 1996-11-13 HU HU9903492A patent/HUP9903492A3/en unknown
- 1996-11-13 SK SK639-98A patent/SK63998A3/en unknown
- 1996-11-13 CO CO96059775A patent/CO4770973A1/en unknown
- 1996-11-13 BR BR9611504A patent/BR9611504A/en not_active Application Discontinuation
- 1996-11-13 WO PCT/EP1996/004978 patent/WO1997018208A1/en not_active Ceased
- 1996-11-13 PL PL96326636A patent/PL326636A1/en unknown
- 1996-11-13 CZ CZ981494A patent/CZ149498A3/en unknown
- 1996-11-13 CA CA002235126A patent/CA2235126A1/en not_active Abandoned
- 1996-11-13 KR KR1019980703597A patent/KR19990067574A/en not_active Withdrawn
- 1996-11-13 CN CN96198305A patent/CN1202170A/en active Pending
- 1996-11-13 EP EP96938196A patent/EP0873338A1/en not_active Withdrawn
-
1998
- 1998-05-14 MX MX9803839A patent/MX9803839A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9611504A (en) | 1999-03-02 |
| JPH11515000A (en) | 1999-12-21 |
| HUP9903492A3 (en) | 2000-08-28 |
| SK63998A3 (en) | 1998-10-07 |
| CN1202170A (en) | 1998-12-16 |
| CO4770973A1 (en) | 1999-04-30 |
| HUP9903492A2 (en) | 2000-07-28 |
| MX9803839A (en) | 1998-09-30 |
| GB9523267D0 (en) | 1996-01-17 |
| TR199800851T2 (en) | 1998-08-21 |
| CZ149498A3 (en) | 1998-08-12 |
| PL326636A1 (en) | 1998-10-12 |
| CA2235126A1 (en) | 1997-05-22 |
| AU7570996A (en) | 1997-06-05 |
| EP0873338A1 (en) | 1998-10-28 |
| KR19990067574A (en) | 1999-08-25 |
| WO1997018208A1 (en) | 1997-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |