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PE120899A1 - Derivados de d-homo-9,10-seco-colesta-23-in-3,25-diol - Google Patents

Derivados de d-homo-9,10-seco-colesta-23-in-3,25-diol

Info

Publication number
PE120899A1
PE120899A1 PE1998000971A PE00097198A PE120899A1 PE 120899 A1 PE120899 A1 PE 120899A1 PE 1998000971 A PE1998000971 A PE 1998000971A PE 00097198 A PE00097198 A PE 00097198A PE 120899 A1 PE120899 A1 PE 120899A1
Authority
PE
Peru
Prior art keywords
homo
diol
derivatives
colesta
seco
Prior art date
Application number
PE1998000971A
Other languages
English (en)
Inventor
Marc Muller
Wolfgang Pirson
Pierre Barbier
Peter Mohr
Franz Bauer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE120899A1 publication Critical patent/PE120899A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DERIVADOS DE D-HOMO-9,10-SECOCOLESTA-23-IN-3,25-DIOL DE FORMULA I, DONDE; C(R,R) ES CH2 o C=CH2, R1 ES H, F, OH; R2 Y R3 SON ALQUILO C1-C4, CF3; O C(R2,R3) ES CICLOALQUILO C3-C6. UN COMPUESTO PREFERIDO ES (5Z,7E)-(1S,3R)-1,26,26,26,27,27,27-HEPTAFLUORO-D-HOMO-9,10-SECOCOLESTA-5,7,10(19),17-TETRAEN-23-IN-3,25-DIOL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS QUE DEPENDEN DE LA VITAMINA D TALES COMO PSORIASIS, LEUCEMIA, ACNE, DERMATITIS SEBORREICA, OSTEOPOROSIS, ESCLEROSIS MULTIPLE
PE1998000971A 1997-10-17 1998-10-14 Derivados de d-homo-9,10-seco-colesta-23-in-3,25-diol PE120899A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97118036 1997-10-17

Publications (1)

Publication Number Publication Date
PE120899A1 true PE120899A1 (es) 1999-12-02

Family

ID=8227488

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000971A PE120899A1 (es) 1997-10-17 1998-10-14 Derivados de d-homo-9,10-seco-colesta-23-in-3,25-diol

Country Status (8)

Country Link
US (1) US5919986A (es)
AR (1) AR017339A1 (es)
AU (1) AU9750398A (es)
CO (1) CO4970801A1 (es)
MA (1) MA26554A1 (es)
PE (1) PE120899A1 (es)
WO (1) WO1999020605A1 (es)
ZA (1) ZA989431B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA008072B1 (ru) * 2001-12-03 2007-02-27 Новацея, Инк. Фармацевтические составы, содержащие соединения активного витамина d
US20050101576A1 (en) * 2003-11-06 2005-05-12 Novacea, Inc. Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
ZA200510025B (en) * 2003-06-11 2007-03-28 Novacea Inc Pharmaceutical compositions comprising active vitamin D compounds
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
PT3095447T (pt) 2006-02-03 2022-01-24 Opko Renal Llc Tratamento da insuficiência e deficiência de vitamina d com 25-hidroxivitamina d2 e 25-hidroxivitamina d3
SI2037936T1 (sl) 2006-06-21 2014-11-28 Opko Renal, Llc Postopek zdravljenja in prepreäśevanja sekundarnega hiperparatiroidizma
SI2481400T1 (sl) 2007-04-25 2014-11-28 Opko IP Holdings II, Inc. Nadzorovano oralno sproščanje sestavkov, ki vsebujejo spojino vitamina D in voskasti nosilec
EP2148684B1 (en) 2007-04-25 2013-01-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
CN102341110B (zh) * 2009-01-27 2017-04-12 博格有限责任公司 用于减轻与化疗有关的副作用的维生素d3及其类似物
CN105663146B (zh) 2009-08-14 2020-09-11 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
LT2552484T (lt) 2010-03-29 2020-04-27 Opko Ireland Global Holdings, Ltd. Būdai ir kompozicijos, skirti paratiroidų lygiams sumažinti
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
SG11201509715UA (en) 2013-05-29 2015-12-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
MY198547A (en) 2016-03-28 2023-09-04 Opko Ireland Global Holdings Ltd Methods of vitamin d treatment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
CN1103755C (zh) * 1993-07-09 2003-03-26 桑拉米克斯实验公司 维生素ｄ的新型结构类似物
US5384314B1 (en) * 1994-03-11 1997-08-05 Hoffmann La Roche 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
PT771789E (pt) * 1995-10-30 2000-05-31 Hoffmann La Roche 1 alfa 26-di-hidroxi-d-homo-vitamina d3
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol

Also Published As

Publication number Publication date
AU9750398A (en) 1999-05-10
AR017339A1 (es) 2001-09-05
US5919986A (en) 1999-07-06
MA26554A1 (fr) 2004-12-20
ZA989431B (en) 1999-04-19
WO1999020605A1 (en) 1999-04-29
CO4970801A1 (es) 2000-11-07

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