PE117399A1 - CICATRIZACION DE FRACTURAS UTILIZANDO ANALOGOS DE PTHrP - Google Patents
CICATRIZACION DE FRACTURAS UTILIZANDO ANALOGOS DE PTHrPInfo
- Publication number
- PE117399A1 PE117399A1 PE1998000838A PE00083898A PE117399A1 PE 117399 A1 PE117399 A1 PE 117399A1 PE 1998000838 A PE1998000838 A PE 1998000838A PE 00083898 A PE00083898 A PE 00083898A PE 117399 A1 PE117399 A1 PE 117399A1
- Authority
- PE
- Peru
- Prior art keywords
- pthrp
- positions
- amino acid
- helice
- leu
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE AL USO DE UN ANALOGO POLIPEPTIDICO RELACIONADO CON LA HORMONA PARATIROIDEA (PTHrP) QUE PRESENTA RESIDUOS DE AMINOACIDOS QUE FORMAN UNA HELICE O ANFIPATICA PARA LA PREPARACION DE UN MEDICAMENTO PARA LA CICATRIZACION DE HUESO Y REPARACION DE FRACTURAS DE PREFERENCIA DE HUESO INTRAMEMBRANOSO. LA HELICE O ANFIPATICA PRESENTA LA SIGUIENTE SECUENCIA Glu Leu Leu Glu Xaa Leu Leu Glu Lys Leu, DONDE Xaa ES LISINA O HISTIDINA; O EL ANALOGO DE PTHrP ES UNA SECUENCIA DE 34 AMINOACIDOS. O EL ANALOGO DE PTHrP POSEE AL MENOS DOS RESIDUOS DE AMINOACIDOS UNIDOS A TRAVES DE CADENAS LATERALES UBICADOS EN LAS POSICIONES 13 Y 17 O EN LAS POSICIONES 26 Y 30; O ES UNA FORMA TRUNCADA N-TERMINAL DE 30 A 50 RESIDUOS AMINOACIDOS OPCIONALMENTE SUSTITUIDA EN LAS POSICIONES 5, 13, 17, 19, 26, 30, 32 Y 34; TAMBIEN SE REFIERE AL USO DE UN SEGUNDO AGENTE CICATRIZADOR DE HUESO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5832497P | 1997-09-09 | 1997-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE117399A1 true PE117399A1 (es) | 1999-11-20 |
Family
ID=22016113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000838A PE117399A1 (es) | 1997-09-09 | 1998-09-07 | CICATRIZACION DE FRACTURAS UTILIZANDO ANALOGOS DE PTHrP |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6583114B2 (es) |
| EP (1) | EP1005359B1 (es) |
| JP (1) | JP2002509854A (es) |
| KR (1) | KR100679778B1 (es) |
| CN (1) | CN1210059C (es) |
| AR (1) | AR015435A1 (es) |
| AT (1) | ATE297754T1 (es) |
| AU (1) | AU752925B2 (es) |
| BR (1) | BR9812068A (es) |
| CA (1) | CA2302255C (es) |
| CO (1) | CO4890856A1 (es) |
| CZ (1) | CZ298701B6 (es) |
| DE (1) | DE69830591T2 (es) |
| ES (1) | ES2244090T3 (es) |
| HR (1) | HRP20000109A2 (es) |
| HU (1) | HU226866B1 (es) |
| IL (2) | IL134719A0 (es) |
| MA (1) | MA26545A1 (es) |
| MY (1) | MY121291A (es) |
| NO (1) | NO323740B1 (es) |
| NZ (1) | NZ502970A (es) |
| PE (1) | PE117399A1 (es) |
| PL (1) | PL195703B1 (es) |
| RS (1) | RS49707B (es) |
| RU (1) | RU2224539C2 (es) |
| SA (1) | SA98190565B1 (es) |
| TR (1) | TR200000649T2 (es) |
| TW (1) | TW552139B (es) |
| UY (1) | UY25172A1 (es) |
| WO (1) | WO1999012561A2 (es) |
| ZA (1) | ZA988030B (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1059933T1 (en) * | 1998-08-19 | 2003-04-30 | Eli Lilly & Company | Use of parathyroide hormone consisting of aminoacid sequence 1-34 of human parathyroid hormone for reducing the risk of both vertebral and non vertebral bone fracture |
| EP1769804B1 (en) * | 1998-08-19 | 2012-09-19 | Eli Lilly And Company | hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human |
| US20040033950A1 (en) | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
| DZ2873A1 (fr) | 1998-08-19 | 2003-12-15 | Lilly Co Eli | Procédé pour augmenter la dureté et la rigidité osseuse. |
| CA2245903A1 (en) * | 1998-09-28 | 2000-03-28 | Mcgill University | Use of pex in the treatment of metabolic bone diseases |
| CN1350521A (zh) | 1999-03-05 | 2002-05-22 | 宝洁公司 | C16不饱和的fp选择性前列腺素类似物 |
| US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US6393328B1 (en) * | 2000-05-08 | 2002-05-21 | International Rehabilitative Sciences, Inc. | Multi-functional portable electro-medical device |
| US6675048B2 (en) * | 2000-05-08 | 2004-01-06 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
| US6560487B1 (en) * | 2000-05-08 | 2003-05-06 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
| WO2003059291A2 (en) * | 2002-01-10 | 2003-07-24 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
| WO2005041998A1 (en) | 2003-10-02 | 2005-05-12 | Ali Sadat M | Peptide for promoting healing of fractures |
| CA2584095A1 (en) * | 2004-10-08 | 2006-04-20 | Forbes Medi-Tech (Research) Inc. | Vasoactive intestinal polypeptide pharmaceuticals |
| CA2628945A1 (en) * | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| WO2007133580A2 (en) * | 2006-05-09 | 2007-11-22 | Zelos Therapeutics, Inc. | Use of pth (1-31) and optionally g-csf for hematopoietic stimulation |
| USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| LT2957278T (lt) | 2006-10-03 | 2017-09-11 | Radius Health, Inc. | Stabili kompozicija, apimanti pthrp ir jos panaudojimas |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| JP5564167B2 (ja) * | 2008-05-22 | 2014-07-30 | 日本たばこ産業株式会社 | 苦味マスキング剤及び苦味低減方法 |
| US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8563513B2 (en) | 2009-03-27 | 2013-10-22 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
| JP2013512688A (ja) | 2009-12-07 | 2013-04-18 | ミシガン テクノロジカル ユニバーシティ | クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法 |
| US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| CA2943611A1 (en) | 2014-03-28 | 2015-10-01 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| CN104146961B (zh) * | 2014-07-04 | 2018-02-27 | 深圳职业技术学院 | 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法 |
| CA2984357A1 (en) | 2015-04-29 | 2016-11-03 | Radius Pharmaceuticals, Inc. | Methods for treating cancer |
| US20180161401A1 (en) * | 2015-07-06 | 2018-06-14 | Zheng Xin Dong | Novel Formulations of PTHrP Analogue |
| EP3481414B1 (en) | 2016-04-18 | 2021-11-03 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
| JP7481115B2 (ja) | 2017-01-05 | 2024-05-10 | ラジウス ファーマシューティカルズ，インコーポレイテッド | Ｒａｄ１９０１－２ｈｃｌの多形性形態 |
| US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
| IL279853B2 (en) | 2018-07-04 | 2025-01-01 | Radius Pharmaceuticals Inc | Polymorphic forms of RAD 1901-2HCL |
| CN119390714A (zh) | 2019-02-12 | 2025-02-07 | 雷迪厄斯制药公司 | 方法和化合物 |
| BR112022004462A2 (pt) | 2019-09-12 | 2022-05-31 | Radius Health Inc | Métodos para melhorar a fusão espinhal com abaloparatida |
| CN112646042A (zh) * | 2019-10-10 | 2021-04-13 | 陕西麦科奥特科技有限公司 | 活性多肽化合物 |
| JP2024502334A (ja) * | 2021-01-05 | 2024-01-18 | ラジウス ヘルス，インコーポレイテッド | アバロパラチドを用いた長骨骨折の治療 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3935738A1 (de) * | 1989-10-27 | 1991-05-08 | Forssmann Wolf Georg | Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5821225A (en) * | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
| US5977070A (en) * | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| GB9308033D0 (en) * | 1993-04-19 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| WO1995002610A1 (en) * | 1993-07-13 | 1995-01-26 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| TW273513B (es) * | 1993-10-27 | 1996-04-01 | Chugai Pharmaceutical Co Ltd | |
| JPH08310965A (ja) * | 1995-05-16 | 1996-11-26 | Chugai Pharmaceut Co Ltd | 骨癒合促進剤 |
| US5717062A (en) * | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| US5955574A (en) * | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
| US5723577A (en) * | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
-
1998
- 1998-09-02 CZ CZ20000862A patent/CZ298701B6/cs not_active IP Right Cessation
- 1998-09-02 CN CNB988089696A patent/CN1210059C/zh not_active Expired - Lifetime
- 1998-09-02 PL PL98339449A patent/PL195703B1/pl unknown
- 1998-09-02 EP EP98951341A patent/EP1005359B1/en not_active Expired - Lifetime
- 1998-09-02 DE DE69830591T patent/DE69830591T2/de not_active Expired - Lifetime
- 1998-09-02 AT AT98951341T patent/ATE297754T1/de active
- 1998-09-02 BR BR9812068-9A patent/BR9812068A/pt not_active IP Right Cessation
- 1998-09-02 HU HU0004560A patent/HU226866B1/hu unknown
- 1998-09-02 CA CA2302255A patent/CA2302255C/en not_active Expired - Lifetime
- 1998-09-02 IL IL13471998A patent/IL134719A0/xx unknown
- 1998-09-02 HR HR20000109A patent/HRP20000109A2/hr not_active Application Discontinuation
- 1998-09-02 ZA ZA988030A patent/ZA988030B/xx unknown
- 1998-09-02 TR TR2000/00649T patent/TR200000649T2/xx unknown
- 1998-09-02 KR KR1020007002454A patent/KR100679778B1/ko not_active Expired - Lifetime
- 1998-09-02 RS YUP-127/00A patent/RS49707B/sr unknown
- 1998-09-02 WO PCT/EP1998/005550 patent/WO1999012561A2/en not_active Ceased
- 1998-09-02 RU RU2000109305/15A patent/RU2224539C2/ru active
- 1998-09-02 JP JP2000510458A patent/JP2002509854A/ja active Pending
- 1998-09-02 NZ NZ502970A patent/NZ502970A/en not_active IP Right Cessation
- 1998-09-02 ES ES98951341T patent/ES2244090T3/es not_active Expired - Lifetime
- 1998-09-02 AU AU97406/98A patent/AU752925B2/en not_active Expired
- 1998-09-03 US US09/146,802 patent/US6583114B2/en not_active Expired - Lifetime
- 1998-09-07 MY MYPI98004075A patent/MY121291A/en unknown
- 1998-09-07 TW TW087114825A patent/TW552139B/zh not_active IP Right Cessation
- 1998-09-07 PE PE1998000838A patent/PE117399A1/es not_active Application Discontinuation
- 1998-09-07 UY UY25172A patent/UY25172A1/es not_active Application Discontinuation
- 1998-09-07 AR ARP980104456A patent/AR015435A1/es unknown
- 1998-09-07 CO CO98051174A patent/CO4890856A1/es unknown
- 1998-09-08 MA MA25247A patent/MA26545A1/fr unknown
- 1998-09-21 SA SA98190565A patent/SA98190565B1/ar unknown
-
2000
- 2000-02-24 IL IL134719A patent/IL134719A/en not_active IP Right Cessation
- 2000-03-08 NO NO20001195A patent/NO323740B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal |