LV13641B - Immunostimulatory oligonucleotide multimers - Google Patents

Immunostimulatory oligonucleotide multimers Download PDF

Info

Publication number: LV13641B
Authority: LV; Latvia
Prior art keywords: tcg; immunomer; oligonucleotide according; deoxy; immunostimulatory
Prior art date: 2004-06-15

Application number

LVP-07-03A

Other languages

English (en)

Inventor

Sudhir Agrawal

Ekambar Kandimalla

Dong Yu

Original Assignee

Idera Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-15

Filing date

2007-01-15

Publication date

2008-07-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35600219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV13641(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-01-15 Application filed by Idera Pharmaceuticals Inc filed Critical Idera Pharmaceuticals Inc

2008-07-20 Publication of LV13641B publication Critical patent/LV13641B/en

Links

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LVP-07-03A 2004-06-15 2007-01-15 Immunostimulatory oligonucleotide multimers LV13641B (en)

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US57998504P	2004-06-15	2004-06-15
US59936204P	2004-08-06	2004-08-06

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US (4)	US20060014713A1 (fr)
EP (2)	EP2901856B1 (fr)
JP (1)	JP4942646B2 (fr)
KR (1)	KR20070028537A (fr)
AU (1)	AU2005257938B2 (fr)
BR (1)	BRPI0512110A (fr)
CA (1)	CA2570786C (fr)
EE (1)	EE200700003A (fr)
ES (1)	ES2645158T3 (fr)
HR (1)	HRP20070012A2 (fr)
HU (1)	HUE036894T2 (fr)
IL (1)	IL179973A0 (fr)
LV (1)	LV13641B (fr)
MA (1)	MA28976B1 (fr)
MX (1)	MXPA06014915A (fr)
NO (1)	NO20070263L (fr)
NZ (1)	NZ552522A (fr)
RU (1)	RU2007101039A (fr)
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Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6207646B1 (en) *	1994-07-15	2001-03-27	University Of Iowa Research Foundation	Immunostimulatory nucleic acid molecules
US20030026782A1 (en) *	1995-02-07	2003-02-06	Arthur M. Krieg	Immunomodulatory oligonucleotides
JP4663113B2 (ja) *	1997-09-05	2011-03-30	ザリージェンツオブザユニバーシティオブカリフォルニア	抗原刺激顆粒球媒介炎症を予防または軽減するための免疫刺激オリゴヌクレオチドの使用
US20030022854A1 (en)	1998-06-25	2003-01-30	Dow Steven W.	Vaccines using nucleic acid-lipid complexes
US6693086B1 (en) *	1998-06-25	2004-02-17	National Jewish Medical And Research Center	Systemic immune activation method using nucleic acid-lipid complexes
KR100917101B1 (ko) *	2000-08-04	2009-09-15	도요 보세키 가부시키가이샤	플렉시블 금속적층체 및 그 제조방법
AU2001294750C1 (en) *	2000-09-26	2008-09-18	Idera Pharmaceuticals, Inc.	Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
US7785610B2 (en) *	2001-06-21	2010-08-31	Dynavax Technologies Corporation	Chimeric immunomodulatory compounds and methods of using the same—III
ES2487645T3 (es) *	2001-06-21	2014-08-22	Dynavax Technologies Corporation	Compuestos inmunomoduladores quiméricos y métodos de uso de los mismos
US7276489B2 (en) *	2002-10-24	2007-10-02	Idera Pharmaceuticals, Inc.	Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
AR040996A1 (es) *	2002-08-19	2005-04-27	Coley Pharm Group Inc	Acidos nucleicos inmunoestimuladores
US8158768B2 (en) *	2002-12-23	2012-04-17	Dynavax Technologies Corporation	Immunostimulatory sequence oligonucleotides and methods of using the same
MXPA05007652A (es) *	2003-01-16	2006-02-22	Hybridon Inc	Modulacion de propiedades inmunoestimulantes de compuestos basados en oligonucleotido mediante la utilizacion de dinucleotidos inmunoestimulantes modificados.
US7354907B2 (en) *	2003-02-07	2008-04-08	Idera Pharmaceuticals, Inc.	Short immunomodulatory oligonucleotides
MXPA05012421A (es) *	2003-05-16	2006-02-22	Hybridon Inc	Tratamiento sinergistico de cancer usando inmunomeros junto con agentes quimioterapeuticos.
AU2004252505B2 (en) *	2003-06-11	2010-10-28	Idera Pharmaceuticals, Inc.	Stabilized immunomodulatory oligonucleotides
US20050013812A1 (en) *	2003-07-14	2005-01-20	Dow Steven W.	Vaccines using pattern recognition receptor-ligand:lipid complexes
JP2007531699A (ja) *	2003-07-15	2007-11-08	イデラファーマシューティカルズインコーポレイテッド	免疫刺激性オリゴヌクレオチドおよび／またはイムノマー化合物をサイトカインおよび／または化学療法剤または放射線療法と組み合わせて用いる、免疫系の相乗的刺激
JP4989225B2 (ja) *	2003-09-25	2012-08-01	コーリーファーマシューティカルグループ，インコーポレイテッド	核酸親油性接合体
NZ546275A (en)	2003-10-30	2009-05-31	Coley Pharm Gmbh	C-class oligonucleotides analogs with enhanced immunostimulatory potency
US20080113929A1 (en) *	2004-06-08	2008-05-15	Coley Pharmaceutical Gmbh	Abasic Oligonucleotide as Carrier Platform for Antigen and Immunostimulatory Agonist and Antagonist
RU2007101039A (ru) *	2004-06-15	2008-07-20	Айдера Фармасьютикалз	Иммуностимулирующие олигонуклеотидные мультимеры
US7427405B2 (en) *	2004-06-15	2008-09-23	Idera Pharmaceuticals, Inc.	Immunostimulatory oligonucleotide multimers
MY159370A (en) *	2004-10-20	2016-12-30	Coley Pharm Group Inc	Semi-soft-class immunostimulatory oligonucleotides
AU2006216493A1 (en) *	2005-02-24	2006-08-31	Coley Pharmaceutical Gmbh	Immunostimulatory oligonucleotides
DK2269622T3 (en)	2005-07-01	2014-03-24	Index Pharmaceuticals Ab	CPG OLIGONUCLEOTIDES USED TO INCREASE STEROID ACTIVITY OF A STEROID DEPENDENT PATIENT
EP2179737B1 (fr)	2005-07-01	2013-08-14	Index Pharmaceuticals AB	Modulation de la réponse aux steroides
US8895522B2 (en)	2005-10-28	2014-11-25	Index Pharmaceuticals Ab	Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
US7470674B2 (en) *	2005-11-07	2008-12-30	Idera Pharmaceuticals, Inc.	Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
PT2405002E (pt) *	2006-02-15	2015-01-05	Adiutide Pharmaceuticals Gmbh	Composições e métodos para formulações de oligonucleotídeos
CN101517082B (zh)	2006-09-27	2014-01-22	科勒制药有限责任公司	具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物
KR20100053598A (ko) *	2007-08-01	2010-05-20	이데라 파마슈티칼즈, 인코포레이티드	Ｔｌｒ９의 신규한 합성 효능제
CN105126072B (zh)	2009-03-25	2020-05-15	德克萨斯大学系统董事会	用于刺激哺乳动物对病原体的先天免疫抵抗力的组合物
GB201021867D0 (en)	2010-12-23	2011-02-02	Mologen Ag	Non-coding immunomodulatory DNA construct
US9260719B2 (en) *	2013-01-08	2016-02-16	Idera Pharmaceuticals, Inc.	Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
EP3024936B1 (fr)	2013-07-25	2019-09-04	Exicure, Inc.	Constructions à partir d'acides nucléiques sphériques utilisées en tant qu'agents immunostimulants à des fins prophylactiques et thérapeutiques
EP3095461A4 (fr)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité
WO2015108046A1 (fr)	2014-01-15	2015-07-23	株式会社新日本科学	Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique
US10149905B2 (en)	2014-01-15	2018-12-11	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
AU2015269412B2 (en)	2014-06-04	2020-03-12	Exicure Operating Company	Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
US10286065B2 (en)	2014-09-19	2019-05-14	Board Of Regents, The University Of Texas System	Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
JP6991857B2 (ja) *	2014-10-10	2022-01-13	イデラファーマシューティカルズインコーポレイテッド	Ｔｌｒ９アゴニストをチェックポイント阻害剤と共に用いるがんの治療
US11213593B2 (en)	2014-11-21	2022-01-04	Northwestern University	Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
LU92821B1 (en)	2015-09-09	2017-03-20	Mologen Ag	Combination comprising immunostimulatory oligonucleotides
GB2542425A (en)	2015-09-21	2017-03-22	Mologen Ag	Means for the treatment of HIV
WO2018039629A2 (fr)	2016-08-25	2018-03-01	Northwestern University	Acides nucléiques sphériques micellaires obtenus à partir de matrices thermosensibles sans trace
JP7200093B2 (ja)	2016-09-15	2023-01-06	アイデラ・ファーマシューティカルズ，インコーポレーテッド	がん治療用ｔｌｒ９アゴニストを用いた免疫調節
WO2018201090A1 (fr)	2017-04-28	2018-11-01	Exicure, Inc.	Synthèse d'acides nucléiques sphériques à l'aide de fractions lipophiles
WO2018209270A1 (fr)	2017-05-11	2018-11-15	Northwestern University	Thérapie cellulaire adoptive utilisant des acides nucléiques sphériques (sna)
MX2022011155A (es) *	2020-03-09	2023-01-04	Dynavax Tech Corp	Inmunización activa de refuerzo contra tétanos, difteria y tosferina.
CA3174927A1 (fr) *	2020-03-09	2021-09-16	Dynavax Technologies Corporation	Vaccins contre le zona comprenant un agoniste de tlr9

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5149797A (en) *	1990-02-15	1992-09-22	The Worcester Foundation For Experimental Biology	Method of site-specific alteration of rna and production of encoded polypeptides
US6346614B1 (en)	1992-07-23	2002-02-12	Hybridon, Inc.	Hybrid oligonucleotide phosphorothioates
US5652355A (en)	1992-07-23	1997-07-29	Worcester Foundation For Experimental Biology	Hybrid oligonucleotide phosphorothioates
TW244371B (fr)	1992-07-23	1995-04-01	Tri Clover Inc
US5912332A (en)	1996-07-26	1999-06-15	Hybridon, Inc.	Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides
US20020028784A1 (en) *	2000-03-10	2002-03-07	Nest Gary Van	Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences
AU2001294750C1 (en) *	2000-09-26	2008-09-18	Idera Pharmaceuticals, Inc.	Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
KR100881923B1 (ko) *	2000-12-27	2009-02-04	다이나박스 테크놀로지 코퍼레이션	면역자극 폴리뉴클레오티드 및 그것의 사용 방법
ES2487645T3 (es)	2001-06-21	2014-08-22	Dynavax Technologies Corporation	Compuestos inmunomoduladores quiméricos y métodos de uso de los mismos
WO2003035836A2 (fr) *	2001-10-24	2003-05-01	Hybridon Inc.	Modulation des proprietes immunostimulantes de composes a base d'oligonucleotides par presentation optimale d'extremites 5'
US7276489B2 (en) *	2002-10-24	2007-10-02	Idera Pharmaceuticals, Inc.	Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
WO2004058159A2 (fr) *	2002-12-23	2004-07-15	Dynavax Technologies Corporation	Composes immunomodulateurs ramifies et leur procedes d'utilisation
MXPA05007652A (es)	2003-01-16	2006-02-22	Hybridon Inc	Modulacion de propiedades inmunoestimulantes de compuestos basados en oligonucleotido mediante la utilizacion de dinucleotidos inmunoestimulantes modificados.
US7354907B2 (en) *	2003-02-07	2008-04-08	Idera Pharmaceuticals, Inc.	Short immunomodulatory oligonucleotides
AU2004252505B2 (en) *	2003-06-11	2010-10-28	Idera Pharmaceuticals, Inc.	Stabilized immunomodulatory oligonucleotides
US20050004579A1 (en)	2003-06-27	2005-01-06	Schneider M. Bret	Computer-assisted manipulation of catheters and guide wires
JP2007531699A (ja) *	2003-07-15	2007-11-08	イデラファーマシューティカルズインコーポレイテッド	免疫刺激性オリゴヌクレオチドおよび／またはイムノマー化合物をサイトカインおよび／または化学療法剤または放射線療法と組み合わせて用いる、免疫系の相乗的刺激
RU2007101039A (ru) *	2004-06-15	2008-07-20	Айдера Фармасьютикалз	Иммуностимулирующие олигонуклеотидные мультимеры
US7427405B2 (en) *	2004-06-15	2008-09-23	Idera Pharmaceuticals, Inc.	Immunostimulatory oligonucleotide multimers

2005
- 2005-06-15 RU RU2007101039/15A patent/RU2007101039A/ru not_active Application Discontinuation
- 2005-06-15 NZ NZ552522A patent/NZ552522A/en unknown
- 2005-06-15 BR BRPI0512110-8A patent/BRPI0512110A/pt not_active IP Right Cessation
- 2005-06-15 EE EEP200700003A patent/EE200700003A/xx unknown
- 2005-06-15 US US11/153,054 patent/US20060014713A1/en not_active Abandoned
- 2005-06-15 HU HUE15153954A patent/HUE036894T2/hu unknown
- 2005-06-15 CA CA2570786A patent/CA2570786C/fr not_active Expired - Lifetime
- 2005-06-15 JP JP2007516632A patent/JP4942646B2/ja not_active Expired - Fee Related
- 2005-06-15 EP EP15153954.1A patent/EP2901856B1/fr not_active Expired - Lifetime
- 2005-06-15 KR KR1020077000993A patent/KR20070028537A/ko not_active Withdrawn
- 2005-06-15 MX MXPA06014915A patent/MXPA06014915A/es active IP Right Grant
- 2005-06-15 WO PCT/US2005/020911 patent/WO2006002038A2/fr not_active Ceased
- 2005-06-15 AU AU2005257938A patent/AU2005257938B2/en not_active Ceased
- 2005-06-15 HR HR20070012A patent/HRP20070012A2/xx not_active Application Discontinuation
- 2005-06-15 EP EP05760552A patent/EP1765417A4/fr not_active Withdrawn
- 2005-06-15 ES ES15153954.1T patent/ES2645158T3/es not_active Expired - Lifetime
- 2005-09-22 US US11/234,396 patent/US7405285B2/en not_active Expired - Fee Related
2006
- 2006-12-11 IL IL179973A patent/IL179973A0/en unknown
- 2006-12-29 MA MA29600A patent/MA28976B1/fr unknown
2007
- 2007-01-15 NO NO20070263A patent/NO20070263L/no not_active Application Discontinuation
- 2007-01-15 LV LVP-07-03A patent/LV13641B/en unknown
- 2007-10-23 US US11/876,913 patent/US20080193437A1/en not_active Abandoned
2009
- 2009-09-23 US US12/565,151 patent/US8420615B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP2901856B1 (fr)	2017-08-09
AU2005257938A1 (en)	2006-01-05
US7405285B2 (en)	2008-07-29
HRP20070012A2 (hr)	2007-10-31
BRPI0512110A (pt)	2007-10-23
US8420615B2 (en)	2013-04-16
NZ552522A (en)	2009-04-30
MA28976B1 (fr)	2007-11-01
NO20070263L (no)	2007-03-09
EP2901856A1 (fr)	2015-08-05
HUE036894T2 (hu)	2018-08-28
CA2570786A1 (fr)	2006-01-05
MXPA06014915A (es)	2007-08-20
EE200700003A (et)	2007-06-15
US20070179103A1 (en)	2007-08-02
RU2007101039A (ru)	2008-07-20
US20060014713A1 (en)	2006-01-19
EP1765417A2 (fr)	2007-03-28
HK1211179A1 (en)	2016-05-20
EP1765417A4 (fr)	2009-03-25
ES2645158T3 (es)	2017-12-04
JP4942646B2 (ja)	2012-05-30
CA2570786C (fr)	2013-05-28
AU2005257938B2 (en)	2010-11-11
US20080193437A1 (en)	2008-08-14
US20100166736A1 (en)	2010-07-01
WO2006002038A3 (fr)	2008-07-17
WO2006002038A2 (fr)	2006-01-05
JP2008502688A (ja)	2008-01-31
IL179973A0 (en)	2007-05-15
KR20070028537A (ko)	2007-03-12

Publication	Publication Date	Title
AU2005257938B2 (en)	2010-11-11	Immunostimulatory oligonucleotide multimers
US7566702B2 (en)	2009-07-28	Immunostimulatory oligonucleotide multimers
US8946175B1 (en)	2015-02-03	Stabilized immunomodulatory oligonucleotides
JP2007500018A6 (ja)	2007-05-10	安定化免疫調節オリゴヌクレオチド
JP2007530449A (ja)	2007-11-01	小オリゴヌクレオチドに基づく化合物による免疫刺激特性の調節
CA2512934A1 (fr)	2004-08-26	Oligonucleotides immunomodulateurs courts
CN101426370A (zh)	2009-05-06	免疫刺激性寡核苷酸多聚体
HK1211179B (en)	2018-07-06	Immunostimulatory oligonucleotide multimers
MXPA06006506A (en)	2006-12-13	Modulation of immunostimulatory properties by small oligonucleotide-based compounds