[go: up one dir, main page]

LU91867I9 - - Google Patents

Info

Publication number
LU91867I9
LU91867I9 LU91867C LU91867C LU91867I9 LU 91867 I9 LU91867 I9 LU 91867I9 LU 91867 C LU91867 C LU 91867C LU 91867 C LU91867 C LU 91867C LU 91867 I9 LU91867 I9 LU 91867I9
Authority
LU
Luxembourg
Application number
LU91867C
Other versions
LU91867I2 (fr
Inventor
Alan Edward Royce
Tomoyuki Oomura
Madhusudhan Pudipeddi
Colleen Ruegger
Masaki Sasaki
Tokuhiro Tamura
Original Assignee
Novartis Ag
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91867(I9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Mitsubishi Tanabe Pharma Corp filed Critical Novartis Ag
Publication of LU91867I2 publication Critical patent/LU91867I2/fr
Publication of LU91867I9 publication Critical patent/LU91867I9/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
LU91867C 2003-04-08 2011-09-08 Fingolimod et ses dérivés pharmaceutiquement acceptables (GILENYA®) LU91867I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46121503P 2003-04-08 2003-04-08
PCT/EP2004/003656 WO2004089341A1 (fr) 2003-04-08 2004-04-06 Compositions pharmaceutiques solides contenant un agoniste des recepteurs de la s1p et un alcool de sucre

Publications (2)

Publication Number Publication Date
LU91867I2 LU91867I2 (fr) 2011-11-08
LU91867I9 true LU91867I9 (fr) 2019-01-03

Family

ID=32326722

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91867C LU91867I2 (fr) 2003-04-08 2011-09-08 Fingolimod et ses dérivés pharmaceutiquement acceptables (GILENYA®)

Country Status (41)

Country Link
US (11) US20060275357A1 (fr)
EP (5) EP2319502A1 (fr)
JP (3) JP5495467B2 (fr)
KR (3) KR20110005320A (fr)
CN (2) CN101797241B (fr)
AR (3) AR043987A1 (fr)
AT (3) AT501681B1 (fr)
AU (1) AU2004228929B2 (fr)
BE (2) BE1015972A5 (fr)
BR (1) BRPI0409250B8 (fr)
CA (2) CA2521325C (fr)
CL (2) CL2004000745A1 (fr)
CY (3) CY1110260T1 (fr)
DE (4) DE202004021680U1 (fr)
DK (2) DK1613288T3 (fr)
EC (1) ECSP056090A (fr)
ES (3) ES2228282B1 (fr)
FR (2) FR2854073B1 (fr)
GB (1) GB2400318B (fr)
GR (1) GR1005052B (fr)
HR (3) HRP20100601B1 (fr)
HU (2) HUE028247T2 (fr)
IL (3) IL170888A (fr)
IS (2) IS2682B (fr)
IT (1) ITMI20040682A1 (fr)
LU (1) LU91867I2 (fr)
MA (1) MA27729A1 (fr)
MX (1) MXPA05010860A (fr)
MY (1) MY141249A (fr)
NO (4) NO329332B1 (fr)
NZ (3) NZ542622A (fr)
PE (5) PE20150676A1 (fr)
PL (2) PL2316431T3 (fr)
PT (1) PT1613288E (fr)
RU (5) RU2358716C2 (fr)
SG (1) SG175449A1 (fr)
SI (2) SI2316431T1 (fr)
TN (1) TNSN05256A1 (fr)
TW (1) TWI332847B (fr)
WO (1) WO2004089341A1 (fr)
ZA (1) ZA200507394B (fr)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080096972A1 (en) * 2004-07-30 2008-04-24 Thitiwan Buranachokpaisan Compound formulations of 2-amino-1, 3-propanediol compounds
CN1891212B (zh) * 2005-07-07 2010-10-13 马启明 一种口服制剂及其制备方法
PT2295049E (pt) * 2005-09-09 2015-03-02 Novartis Ag Tratamento de doenças auto-imunes
MX2008006090A (es) 2005-11-09 2008-10-23 Proteolix Inc Compuestos para inhibicion de la enzima.
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
RU2450016C2 (ru) 2006-06-19 2012-05-10 Протеоликс, Инк. Пептидные эпоксикетоны для ингибирования протеасомы
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
KR101884047B1 (ko) * 2006-09-26 2018-07-31 노파르티스 아게 Ｓ１ｐ 조정제를 포함하는 제약 조성물
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
EP1923054A1 (fr) * 2006-09-26 2008-05-21 Novartis AG Composition pharmaceutique à désintégration rapide comprenant un agoniste ou modulateur de S1P
EP1923055A1 (fr) * 2006-09-26 2008-05-21 Novartis AG Composition pharmaceutique lyophilisée comprenant un agoniste ou modulateur de S1P
EP1905434A1 (fr) * 2006-09-26 2008-04-02 Novartis AG Compositions organiques comprenant d'un agoniste de S1P recepteur et leur utilisation therapeutique
EP1923058A1 (fr) * 2006-09-26 2008-05-21 Novartis AG Composition pharmaceutique enrobée comprenant un agoniste ou un modulateur de S1P
WO2008124210A1 (fr) * 2007-02-14 2008-10-16 Emory University Procédés et compositions destinés à traiter ou prévenir une infection en utilisant des agents de séquestration des leucocytes
CN104324015B (zh) 2007-03-29 2018-08-28 第一三共株式会社 药物组合物
KR20160086980A (ko) 2007-10-04 2016-07-20 오닉스 세라퓨틱스, 인크. 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
PL2465492T3 (pl) 2007-10-12 2015-11-30 Novartis Ag Mieszaniny zawierające modulatory receptora 1-fosforanu sfingozyny (S1P)
AU2012216630B2 (en) * 2007-10-12 2015-01-22 Novartis Ag Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators
JP5534645B2 (ja) * 2008-01-11 2014-07-02 日医工株式会社 無包装状態において安定性に優れた塩酸サルポグレラート含有経口投与製剤
WO2009099174A1 (fr) 2008-02-07 2009-08-13 Kyorin Pharmaceutical Co., Ltd. Agent thérapeutique ou agent préventif pour maladie inflammatoire des intestins contenant un dérivé d'alcool aminé comme composant actif
HRP20170246T4 (hr) 2008-03-17 2020-02-07 Actelion Pharmaceuticals Ltd. Režim doziranja za selektivni agonist s1p1-receptora
MX2010014223A (es) 2008-06-20 2011-01-21 Novartis Ag Composiciones pediatricas para el tratamiento de esclerosis multiple.
EP2299982B1 (fr) * 2008-06-20 2018-04-04 Merck Patent GmbH Matrice pour comprimé directement compressible et à désintégration rapide
RU2498636C2 (ru) * 2008-09-04 2013-11-20 Карджилл Инкорпорейтед Таблетирование эритрита
MX2011004225A (es) 2008-10-21 2011-06-21 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
AU2009315735B2 (en) 2008-11-11 2013-01-10 Novartis Ag Salts of fingolimod
US8530522B2 (en) * 2008-11-11 2013-09-10 Novartis Ag Organic compounds
AU2013100532B4 (en) * 2008-11-11 2013-11-28 Novartis Ag Crystalline forms of fingolimod HCL
CA2747427C (fr) 2008-12-17 2015-10-13 Daiichi Sankyo Company, Limited Methode de production d'un derive de diamine
JPWO2010082531A1 (ja) 2009-01-13 2012-07-05 第一三共株式会社 活性化血液凝固因子阻害剤
CN102348688B (zh) 2009-03-10 2014-07-09 第一三共株式会社 用于制备二胺衍生物的方法
EP2407450B1 (fr) 2009-03-13 2015-04-22 Daiichi Sankyo Company, Limited Procédé de production d'un dérivé diamine optiquement actif
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
SG176934A1 (en) * 2009-06-18 2012-01-30 Daiichi Sankyo Co Ltd Pharmaceutical composition having improved solubility
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
WO2011060179A1 (fr) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Utilisation de peptides epoxycetones pour la suppression de la metastase
BR112012022060A2 (pt) 2010-03-01 2018-05-08 Onyx Therapeutics Inc composto para a inibição de imunoproteassoma
EP2548556B1 (fr) 2010-03-19 2016-08-10 Daiichi Sankyo Company, Limited Procédé d'amélioration de l'aptitude à se dissoudre d'un anticoagulant
ES2560955T3 (es) 2010-03-19 2016-02-23 Daiichi Sankyo Company, Limited Cristal de derivado de diamina y procedimiento de producción del mismo
US20130095177A1 (en) * 2010-04-22 2013-04-18 Ratiopharm Gmbh Method of preparing an oral dosage form comprising fingolimod
KR101795096B1 (ko) 2010-07-02 2017-12-01 다이이찌 산쿄 가부시키가이샤 광학 활성 디아민 유도체의 염의 제조 방법
EP2646409A4 (fr) 2010-11-25 2015-12-16 Shilpa Medicare Ltd Polymorphes du fingolimode et leurs procédés
HRP20191842T1 (hr) 2011-01-07 2019-12-27 Novartis Ag Formulacije imunosupresiva
US8858991B2 (en) 2011-01-19 2014-10-14 Pathologica Llc Delayed release oral pharmaceutical dosage forms comprising MGBG
AR085749A1 (es) * 2011-04-01 2013-10-23 Novartis Ag Formulaciones
EA028950B1 (ru) 2011-08-01 2018-01-31 Тева Фармасьютикал Индастриз Лтд. Способ получения фармацевтических композиций, содержащих финголимод
JPWO2013022059A1 (ja) 2011-08-10 2015-03-05 第一三共株式会社 ジアミン誘導体含有医薬組成物
WO2013091704A1 (fr) 2011-12-22 2013-06-27 Synthon Bv Composition pharmaceutique comprenant le fingolimod
RU2482842C1 (ru) * 2012-04-26 2013-05-27 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения
RU2506949C1 (ru) * 2012-06-13 2014-02-20 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
WO2014011695A2 (fr) 2012-07-09 2014-01-16 Onyx Therapeutics, Inc. Promédicaments d'inhibiteurs d'époxy cétone protéase peptidique
RU2496486C1 (ru) * 2012-07-11 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение
EP3831372A1 (fr) 2013-01-08 2021-06-09 Pathologica LLC Mitoguazone pour prévenir la rechute ou la progression de la sclérose en plaques
WO2014141298A2 (fr) * 2013-03-11 2014-09-18 Astron Research Limited Composition pharmaceutique stable de fingolimod
US9629834B2 (en) * 2013-04-26 2017-04-25 Kyoto University Medicinal composition for inhibiting formation and/or enlargement of cerebral aneurysm or shrinking same
WO2013190151A1 (fr) * 2013-05-13 2013-12-27 Synthon B.V. Composition pharmaceutique contenant du fingolimod
US20160128951A1 (en) * 2013-07-29 2016-05-12 Aizant Drug Research Solutions Pvt Ltd Pharmaceutical compositions of fingolimod
RU2530626C1 (ru) * 2013-10-21 2014-10-10 Ооо "Валента-Интеллект" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
WO2016026461A1 (fr) * 2014-08-22 2016-02-25 Sunshine Lake Pharma Co., Ltd. Composition solide de fingolimod et préparation associée
WO2016042493A1 (fr) * 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Compositions pharmaceutiques de fingolimod
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
CN107530301A (zh) * 2015-01-20 2018-01-02 汉达医药有限责任公司 稳定的固体芬戈莫德剂型
US20180042895A1 (en) 2015-02-26 2018-02-15 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
RU2577230C1 (ru) * 2015-04-09 2016-03-10 Общество с ограниченной ответственностью "Лонг Шенг Фарма Рус" Способ получения капсул финголимода гидрохлорида
US9690975B2 (en) 2015-05-28 2017-06-27 Axogen Corporation Quantitative structural assay of a nerve graft
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
EP3419607B1 (fr) 2017-03-29 2019-11-20 Deva Holding Anonim Sirketi Formulations stables de fingolimod
GR1009654B (el) 2018-08-31 2019-11-18 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου
DE102018217334A1 (de) * 2018-10-10 2020-04-16 Harbins Ruhr Bioscience, Inc. Sphingoid-Base und/oder Wirkstoff zur Verwendung bei der Prophylaxe und/oder Therapie einer viralen Infektion und/oder viralen Infektionskrankheit oder der Desinfektion, Nahrungsmittel/Nahrungsergänzungsmittel, Futtermittel/Futterergänzungsmittel und Pflanzenschutzmittel
JP7503420B2 (ja) * 2020-05-18 2024-06-20 東和薬品株式会社 フィンゴリモドを含む医薬組成物とその製造方法及び安定化方法
EP4181906A1 (fr) 2020-07-16 2023-05-24 Harbins Ruhr Bioscience, Inc. Composés sphingoïdes à utiliser dans la prophylaxie et/ou la thérapie d'une infection par un coronavirus
JP2024506825A (ja) * 2021-01-28 2024-02-15 プリオセラ エスエーエス Ｓ１ｐ受容体調節剤による処置の方法
AU2021424131A1 (en) * 2021-01-28 2023-07-27 Priothera Limited Methods of treatment with s1p receptor modulators

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7607683A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4110332A (en) * 1977-05-05 1978-08-29 Chevron Research Company 1-Triorganostannyl-3-organothio-4-substituted-1,2,4-delta2 -triazolidin-5-ones
US4559153A (en) 1983-10-25 1985-12-17 Phillips Petroleum Company Metal working lubricant
US5112616A (en) * 1988-11-30 1992-05-12 Schering Corporation Fast dissolving buccal tablet
JP2841857B2 (ja) * 1990-11-29 1998-12-24 田辺製薬株式会社 長期間安定な経口用医薬製剤
JP2579602B2 (ja) 1992-10-21 1997-02-05 吉富製薬株式会社 ２−アミノ−１，３−プロパンジオール化合物および免疫抑制剤
WO1996006068A1 (fr) 1994-08-22 1996-02-29 Yoshitomi Pharmaceutical Industries, Ltd. Compose benzenique et son utilisation medicale
DE69633613T2 (de) 1995-12-28 2006-02-09 Mitsubishi Pharma Corp. 2-amino-2-(2-(4-octylphenyl)ethyl)propan-1,3-diol enthaltendes Arzneimittel zur topischen Anwendung zur Behandlung von Erkrankungen,die durch eine Störung des Immunsystems hervorgerufen werden
JPH11209277A (ja) 1998-01-19 1999-08-03 Yoshitomi Pharmaceut Ind Ltd 医薬組成物
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
JP2002241272A (ja) 1996-07-18 2002-08-28 Mitsubishi Pharma Corp 医薬処方組成物
GB9624038D0 (en) 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
PT990440E (pt) * 1997-02-27 2009-02-05 Novartis Ag Composição farmacêutica compreendendo 2-amino-2-[2-(4-octilfenil)etil]propano-1,3-diol, uma lecitina e um sacárido
PT1319651E (pt) * 1997-04-04 2005-09-30 Mitsubishi Pharma Corp Composto 2-aminopropano-1,3-diol, sua utilizacao farmaceutica e seus intermediarios sinteticos
JPH1180026A (ja) * 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
JP3545595B2 (ja) 1998-04-01 2004-07-21 花王株式会社 スフィンゴ糖脂質の製造法
JP4627356B2 (ja) * 1999-06-30 2011-02-09 昭 松森 ウイルス性心筋炎の予防または治療薬剤
EP1195165A4 (fr) * 1999-07-12 2005-08-10 Ono Pharmaceutical Co Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate
AU2001269503B2 (en) 2000-07-13 2005-02-17 Sankyo Company, Limited Amino alcohol derivatives
CA2421893A1 (fr) * 2000-08-31 2002-03-07 Merck And Co., Inc. Derives de phosphates utilises en tant qu'agents immuno-regulateurs
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
MXPA03008755A (es) 2001-03-26 2004-02-18 Novartis Ag Derivados de 2-amino-propanol.
US7521192B2 (en) 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
US20040235794A1 (en) 2001-09-04 2004-11-25 Shinji Nakade Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller
CA2460640C (fr) 2001-09-27 2011-03-29 Kyorin Pharmaceutical Co., Ltd. Derives d'ether de diaryle, ses sels et agents immunosuppresseur utilisat ces derives
AU2002332289B2 (en) 2001-09-27 2007-05-10 Kyorin Pharmaceutical Co., Ltd. Diaryl sulfide derivative, addition salt thereof, and immunosuppressant
AU2003216054B2 (en) 2002-01-18 2007-01-04 Merck & Co., Inc. Selective S1P1/Edg1 receptor agonists
ATE441654T1 (de) 2002-01-18 2009-09-15 Merck & Co Inc Edg-rezeptoragonisten
CA2473740A1 (fr) 2002-01-18 2003-07-31 David Solow-Cordero Procedes pour traiter des pathologies associees a un recepteur d'edg
WO2003062248A2 (fr) 2002-01-18 2003-07-31 Merck & Co., Inc. N-(benzyl)aminoalkyl carboxylates, phosphinates, phosphonates et tetrazoles en tant qu'agonistes de recepteur edg
MX2007000564A (es) * 2004-07-16 2007-03-30 Kyorin Seiyaku Kk Metodo para utilizar efectivamente medicamentos referentes a la prevencion de efectos secundarios.

Also Published As

Publication number Publication date
MA27729A1 (fr) 2006-01-02
SG175449A1 (en) 2011-11-28
AU2004228929B2 (en) 2008-02-07
US20090203798A1 (en) 2009-08-13
GR20040100121A (el) 2004-12-17
MXPA05010860A (es) 2006-05-25
PE20050396A1 (es) 2005-07-05
TWI332847B (en) 2010-11-11
CN1767819A (zh) 2006-05-03
ES2228282B1 (es) 2006-02-16
ES2556947T3 (es) 2016-01-21
AT501681B1 (de) 2012-04-15
TNSN05256A1 (en) 2007-07-10
JP2011006461A (ja) 2011-01-13
JP2013177404A (ja) 2013-09-09
JP2004307506A (ja) 2004-11-04
AU2004228929A1 (en) 2004-10-21
LU91867I2 (fr) 2011-11-08
EP1613288B1 (fr) 2008-11-19
RU2010146697A (ru) 2012-05-27
GR1005052B (el) 2005-11-30
GB2400318A (en) 2004-10-13
EP2008650A3 (fr) 2011-04-27
HRP20050886B1 (en) 2011-01-31
IS8885A (is) 2010-02-25
GB0407819D0 (en) 2004-05-12
BRPI0409250B8 (pt) 2022-01-18
CN101797241B (zh) 2013-03-27
CY1117071T1 (el) 2017-04-05
CA2707750A1 (fr) 2004-10-21
SI1613288T1 (sl) 2009-04-30
US20130108675A1 (en) 2013-05-02
EP1613288A1 (fr) 2006-01-11
NO329332B1 (no) 2010-09-27
PE20131352A1 (es) 2013-11-14
KR20110005320A (ko) 2011-01-17
BRPI0409250A (pt) 2006-03-28
RU2358716C2 (ru) 2009-06-20
ES2320767T3 (es) 2009-05-28
IL170888A (en) 2010-06-16
CN1767819B (zh) 2010-07-28
US20140011885A1 (en) 2014-01-09
KR20050121712A (ko) 2005-12-27
PE20150676A1 (es) 2015-05-17
NO2011016I1 (no) 2011-09-19
EP2319502A1 (fr) 2011-05-11
GB2400318B (en) 2005-08-10
PE20130200A1 (es) 2013-03-09
NO20131287L (no) 2006-01-09
PE20090743A1 (es) 2009-07-17
RU2475237C2 (ru) 2013-02-20
DK2316431T3 (en) 2016-01-11
NZ592339A (en) 2012-09-28
WO2004089341A1 (fr) 2004-10-21
CY1110260T1 (el) 2014-04-09
ECSP056090A (es) 2006-03-01
RU2475236C2 (ru) 2013-02-20
BE1015972A5 (fr) 2005-12-06
CL2011000450A1 (es) 2011-11-25
AR078781A2 (es) 2011-11-30
SI2316431T1 (sl) 2016-04-29
AT504853A2 (de) 2008-08-15
IE20040246A1 (en) 2004-12-15
DK1613288T3 (da) 2009-03-23
NZ586280A (en) 2011-12-22
US20220031609A1 (en) 2022-02-03
DE122011100047I1 (de) 2011-12-15
DE202004021680U1 (de) 2010-04-22
CA2521325C (fr) 2010-09-14
ES2228282A1 (es) 2005-04-01
IS2682B (is) 2010-10-15
NO2011016I2 (no) 2012-08-27
US20140255497A1 (en) 2014-09-11
HUS1100016I1 (hu) 2016-08-29
IL242037A0 (en) 2015-11-30
IS8114A (is) 2005-11-01
NO20055231L (no) 2006-01-09
PL2316431T3 (pl) 2016-09-30
EP2316431B1 (fr) 2015-09-30
NO20055231D0 (no) 2005-11-07
US20170290787A1 (en) 2017-10-12
CY2011013I2 (el) 2014-04-09
BE2011C030I2 (fr) 2023-03-07
HRP20100600A2 (hr) 2011-03-31
JP5543298B2 (ja) 2014-07-09
HK1071685A1 (en) 2005-07-29
AT501681A1 (de) 2006-10-15
DE102004016947A1 (de) 2004-10-21
HRP20100601A2 (hr) 2011-03-31
IL197578A0 (en) 2011-07-31
DE602004017847D1 (de) 2009-01-02
FR11C0036I1 (fr) 2011-10-14
FR11C0036I2 (fr) 2023-12-29
HRP20050886A2 (en) 2006-11-30
RU2012148593A (ru) 2014-05-20
US20190175527A1 (en) 2019-06-13
CL2004000745A1 (es) 2005-02-11
KR20120101148A (ko) 2012-09-12
CA2521325A1 (fr) 2004-10-21
AR043987A1 (es) 2005-08-17
HRP20100601B1 (hr) 2016-12-02
US8324283B2 (en) 2012-12-04
JP5495467B2 (ja) 2014-05-21
FR2854073B1 (fr) 2008-03-14
RU2005134173A (ru) 2006-09-10
EP2316431A1 (fr) 2011-05-04
FR2854073A1 (fr) 2004-10-29
BRPI0409250B1 (pt) 2017-07-11
HUE028247T2 (en) 2016-12-28
CY2011013I1 (el) 2014-04-09
HK1155647A1 (en) 2012-05-25
HK1091114A1 (en) 2007-01-12
NO334116B1 (no) 2013-12-16
US20200237690A1 (en) 2020-07-30
US20080311188A1 (en) 2008-12-18
PT1613288E (pt) 2009-02-25
ITMI20040682A1 (it) 2004-07-06
US20060275357A1 (en) 2006-12-07
NZ542622A (en) 2009-01-31
ZA200507394B (en) 2007-03-28
MY141249A (en) 2010-03-31
NO335120B1 (no) 2014-09-22
IL197578A (en) 2015-10-29
PL1613288T3 (pl) 2009-07-31
EP2769713A1 (fr) 2014-08-27
RU2010147000A (ru) 2012-08-10
TW200503784A (en) 2005-02-01
KR101367574B1 (ko) 2014-02-25
EP2008650A2 (fr) 2008-12-31
US20110105620A1 (en) 2011-05-05
NO20100250L (no) 2006-01-09
AR078782A2 (es) 2011-11-30
RU2009105403A (ru) 2010-08-27
ATE414508T1 (de) 2008-12-15
CN101797241A (zh) 2010-08-11

Similar Documents

Publication Publication Date Title
BE2013C067I2 (fr)
BE2011C030I2 (fr)
BE2013C034I2 (fr)
JP2004008796A5 (fr)
BE2012C053I2 (fr)
JP2003304446A5 (fr)
JP2004026308A5 (fr)
JP2004005424A5 (fr)
JP2004214046A5 (fr)
JP2004092902A5 (fr)
JP2004048077A5 (fr)
AU2002351829A1 (fr)
AU2002318342A1 (fr)
AU2002348177A1 (fr)
AU2002345911A1 (fr)
AU2002341905A1 (fr)
AU2002341898A1 (fr)
AU2002340206A1 (fr)
AU2002339901A1 (fr)
AU2002337949A1 (fr)
AU2002333044A1 (fr)
AU2002332887A1 (fr)
AU2002331433A1 (fr)
AU2002329412A1 (fr)
AU2002327736A1 (fr)