LU86349A1 - Nouveaux derives de pyridylmethoxy-et-methylmercaptoanilines,utiles et notamment comme antiasthmatiques,leur fabrication et medicaments les contenant - Google Patents

Nouveaux derives de pyridylmethoxy-et-methylmercaptoanilines,utiles et notamment comme antiasthmatiques,leur fabrication et medicaments les contenant Download PDF

Info

Publication number: LU86349A1
Authority: LU; Luxembourg
Prior art keywords: pyridylmethoxy; compound; formula; aniline; desired compound
Prior art date: 1985-03-08

Application number

LU86349A

Other languages

English (en)

French (fr)

Inventor

Nielsen Ole Bent Tvarmose

Ahnfelt-Ronne Ian

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-08

Filing date

1986-03-07

Publication date

1987-04-02

1985-03-08 Priority claimed from GB858506094A external-priority patent/GB8506094D0/en

1985-10-11 Priority claimed from GB858525153A external-priority patent/GB8525153D0/en

1986-03-07 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

1987-04-02 Publication of LU86349A1 publication Critical patent/LU86349A1/fr

Links

238000004519 manufacturing process Methods 0.000 title claims description 10
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238000000034 method Methods 0.000 claims description 117
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229910052739 hydrogen Inorganic materials 0.000 claims description 24
239000001257 hydrogen Substances 0.000 claims description 24
239000000047 product Substances 0.000 claims description 23
-1 2-quinolylmethoxy Chemical group 0.000 claims description 20
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CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 8
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ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
229960001008 heparin sodium Drugs 0.000 description 1
GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 1
239000005457 ice water Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
210000004969 inflammatory cell Anatomy 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 1
239000002555 ionophore Substances 0.000 description 1
230000000236 ionophoric effect Effects 0.000 description 1
150000002537 isoquinolines Chemical class 0.000 description 1
238000002372 labelling Methods 0.000 description 1
239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 description 1
229960000582 mepyramine Drugs 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
239000003595 mist Substances 0.000 description 1
239000007932 molded tablet Substances 0.000 description 1
210000000214 mouth Anatomy 0.000 description 1
CDGZSMOCDYNULJ-UHFFFAOYSA-N n-(2-chloro-4-hydroxyphenyl)acetamide Chemical compound CC(=O)NC1=CC=C(O)C=C1Cl CDGZSMOCDYNULJ-UHFFFAOYSA-N 0.000 description 1
VOAJIZWMDUSXFK-UHFFFAOYSA-N n-(chloromethyl)aniline Chemical compound ClCNC1=CC=CC=C1 VOAJIZWMDUSXFK-UHFFFAOYSA-N 0.000 description 1
PNFXKYICTMFFJD-UHFFFAOYSA-N n-[4-(pyridin-2-ylmethoxy)phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1OCC1=CC=CC=N1 PNFXKYICTMFFJD-UHFFFAOYSA-N 0.000 description 1
PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 description 1
210000003928 nasal cavity Anatomy 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
210000001331 nose Anatomy 0.000 description 1
239000007764 o/w emulsion Substances 0.000 description 1
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
238000011017 operating method Methods 0.000 description 1
239000002997 ophthalmic solution Substances 0.000 description 1
229940054534 ophthalmic solution Drugs 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
229960005489 paracetamol Drugs 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
229920002866 paraformaldehyde Polymers 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
239000006072 paste Substances 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000001991 pathophysiological effect Effects 0.000 description 1
230000007310 pathophysiology Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
230000035699 permeability Effects 0.000 description 1
238000005502 peroxidation Methods 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
230000000770 proinflammatory effect Effects 0.000 description 1
OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
229960003712 propranolol Drugs 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
238000005057 refrigeration Methods 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
150000003902 salicylic acid esters Chemical class 0.000 description 1
150000003335 secondary amines Chemical group 0.000 description 1
IWOLVLSIZCEOHM-UHFFFAOYSA-M silver;dibenzyl phosphate Chemical compound [Ag+].C=1C=CC=CC=1COP(=O)([O-])OCC1=CC=CC=C1 IWOLVLSIZCEOHM-UHFFFAOYSA-M 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000005507 spraying Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000012258 stirred mixture Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
230000008961 swelling Effects 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
150000005671 trienes Chemical class 0.000 description 1
150000004684 trihydrates Chemical class 0.000 description 1
239000006200 vaporizer Substances 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Quinoline Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

LU86349A 1985-03-08 1986-03-07 Nouveaux derives de pyridylmethoxy-et-methylmercaptoanilines,utiles et notamment comme antiasthmatiques,leur fabrication et medicaments les contenant LU86349A1 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB8506094		1985-03-08
GB858506094A GB8506094D0 (en)	1985-03-08	1985-03-08	Chemical products
GB8525153		1985-10-11
GB858525153A GB8525153D0 (en)	1985-10-11	1985-10-11	Chemical compounds

Publications (1)

Publication Number	Publication Date
LU86349A1 true LU86349A1 (fr)	1987-04-02

Family

ID=26288945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86349A LU86349A1 (fr)	1985-03-08	1986-03-07	Nouveaux derives de pyridylmethoxy-et-methylmercaptoanilines,utiles et notamment comme antiasthmatiques,leur fabrication et medicaments les contenant

Country Status (18)

Country	Link
US (2)	US4826987A (da)
JP (1)	JPH0764813B2 (da)
AU (1)	AU585586B2 (da)
BE (1)	BE904368A (da)
CA (1)	CA1276640C (da)
DE (1)	DE3607382A1 (da)
DK (1)	DK166582B1 (da)
ES (1)	ES8802610A1 (da)
FR (1)	FR2578540B1 (da)
GB (1)	GB2173788B (da)
GR (1)	GR860628B (da)
IE (1)	IE58870B1 (da)
IT (1)	IT1221079B (da)
LU (1)	LU86349A1 (da)
NL (1)	NL8600596A (da)
NZ (1)	NZ215347A (da)
PT (1)	PT82147B (da)
SE (1)	SE463819B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0219308B1 (en) *	1985-10-16	1991-10-23	Merck Frosst Canada Inc.	2-substituted quinolines
DK196688A (da) *	1987-04-28	1988-10-29	Fujisawa Pharmaceutical Co	Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
US4826990A (en) *	1987-09-30	1989-05-02	American Home Products Corporation	2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
GB8728051D0 (en) *	1987-12-01	1988-01-06	Leo Pharm Prod Ltd	Chemical compounds
US4889935A (en) *	1987-12-18	1989-12-26	American Home Products Corporation	Aminoguanidine derivatives
WO1990012006A1 (en) *	1989-04-07	1990-10-18	Pfizer Inc.	Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma, arthritis and related diseases
DE3927369A1 (de) *	1989-08-19	1991-02-21	Bayer Ag	Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe
DE3935139A1 (de) *	1989-10-21	1991-04-25	Bayer Ag	Substituierte (chinolin-2-yl-methoxy)phenyl-thioharnstoffe
US5021576A (en) *	1989-10-27	1991-06-04	American Home Products Corporation	2-Anilino phenylacetic acid derivatives
US5324747A (en) *	1992-07-15	1994-06-28	Hoffmann-La Roche Inc.	N-substituted anilines, inhibitors of phospholipases A2
US5840318A (en) *	1993-05-11	1998-11-24	Immunom Technologies, Inc.	Methods and compositions for modulating immune systems of animals
US7189834B2 (en) *	1993-05-11	2007-03-13	Marshall William E	Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection
US5508408A (en) *	1993-09-10	1996-04-16	Ciba-Geigy Corporation	Quinoline compound
US5795900A (en) *	1995-10-03	1998-08-18	Abbott Laboratories	Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
US5668150A (en) *	1996-07-26	1997-09-16	Abbott Laboratories	Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
EP1051181B1 (en) *	1997-12-31	2004-03-17	The University Of Kansas	Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
HN2001000008A (es)	2000-01-21	2003-12-11	Inc Agouron Pharmaceuticals	Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
GB2431927B (en) *	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) *	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) *	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
TW200920369A (en) *	2007-10-26	2009-05-16	Amira Pharmaceuticals Inc	5-lipoxygenase activating protein (flap) inhibitor
MX2010012814A (es) *	2008-05-23	2010-12-20	Amira Pharmaceuticals Inc	Inhibidor de proteina activadora de 5-lipoxigenasa.
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
TW201215607A (en)	2010-07-02	2012-04-16	Lundbeck & Co As H	Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US31624A (en) *		1861-03-05		Tatting-frame
US2761865A (en) *	1954-07-07	1956-09-04	Hoffmann La Roche	Pyridylalkyl sulfones
US4003906A (en) *	1974-01-22	1977-01-18	The Dow Chemical Company	Substituted pyridinyl methylthio or (methylsulfonyl)benzeneamines
GB2069493B (en) *	1980-02-20	1984-02-29	Wyeth John & Brother Ltd	Pyridine derivatives
GB2069492B (en) *	1980-02-20	1984-02-29	Wyeth John & Brother Ltd	Sulphur compounds
US4567184A (en) *	1982-12-01	1986-01-28	Usv Pharmaceutical Corporation	Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
IE56702B1 (en) *	1982-12-01	1991-11-06	Usv Pharma Corp	Antiinflammatory antiallergic compounds
JPS5988835U (ja) *	1982-12-06	1984-06-15	ホシデン株式会社	スイツチ
US4486593A (en) *	1983-01-19	1984-12-04	The Upjohn Company	2-,3-, or 4-Pyridinylmethylamino arylic acids as thromboxane A2 synthetase and 5-lipoxygenase inhibitors
US4563463A (en) *	1983-03-18	1986-01-07	Usv Pharmaceutical Corp.	2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents
US4554355A (en) *	1984-07-19	1985-11-19	American Home Products Corporation	Heterocyclic compounds as antiallergic agents
US5109009A (en) *	1985-03-08	1992-04-28	Leo Pharmaceutical Products Ltd.	Quinoline and pyridine compounds and inhibition of 5-lipoxygenases therewith

1986
- 1986-02-10 IE IE37086A patent/IE58870B1/en not_active IP Right Cessation
- 1986-02-20 GB GB08604183A patent/GB2173788B/en not_active Expired
- 1986-02-28 US US06/834,542 patent/US4826987A/en not_active Expired - Fee Related
- 1986-02-28 SE SE8600913A patent/SE463819B/sv not_active IP Right Cessation
- 1986-03-03 NZ NZ215347A patent/NZ215347A/xx unknown
- 1986-03-04 DK DK096986A patent/DK166582B1/da not_active IP Right Cessation
- 1986-03-06 IT IT67183/86A patent/IT1221079B/it active
- 1986-03-06 PT PT82147A patent/PT82147B/pt not_active IP Right Cessation
- 1986-03-06 CA CA000503464A patent/CA1276640C/en not_active Expired - Lifetime
- 1986-03-06 GR GR860628A patent/GR860628B/el unknown
- 1986-03-06 DE DE19863607382 patent/DE3607382A1/de not_active Ceased
- 1986-03-07 NL NL8600596A patent/NL8600596A/nl not_active Application Discontinuation
- 1986-03-07 LU LU86349A patent/LU86349A1/fr unknown
- 1986-03-07 FR FR868603268A patent/FR2578540B1/fr not_active Expired - Lifetime
- 1986-03-07 AU AU54444/86A patent/AU585586B2/en not_active Ceased
- 1986-03-07 ES ES552805A patent/ES8802610A1/es not_active Expired
- 1986-03-07 BE BE0/216378A patent/BE904368A/fr not_active IP Right Cessation
- 1986-03-08 JP JP61051286A patent/JPH0764813B2/ja not_active Expired - Lifetime
1990
- 1990-12-31 US US07/633,390 patent/US5157039A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4826987A (en)	1989-05-02
DK166582B1 (da)	1993-06-14
SE8600913L (sv)	1986-09-09
JPS61207374A (ja)	1986-09-13
JPH0764813B2 (ja)	1995-07-12
GB2173788A (en)	1986-10-22
SE8600913D0 (sv)	1986-02-28
SE463819B (sv)	1991-01-28
IE860370L (en)	1986-09-08
AU585586B2 (en)	1989-06-22
GB8604183D0 (en)	1986-03-26
NZ215347A (en)	1990-02-26
IE58870B1 (en)	1993-11-17
PT82147B (pt)	1988-07-29
GB2173788B (en)	1988-08-10
DK96986D0 (da)	1986-03-04
DK96986A (da)	1986-09-09
ES552805A0 (es)	1988-09-16
AU5444486A (en)	1986-09-18
FR2578540A1 (fr)	1986-09-12
BE904368A (fr)	1986-09-08
FR2578540B1 (fr)	1990-11-16
GR860628B (en)	1986-06-26
IT8667183A0 (it)	1986-03-06
ES8802610A1 (es)	1988-09-16
US5157039A (en)	1992-10-20
NL8600596A (nl)	1986-10-01
PT82147A (en)	1986-04-01
CA1276640C (en)	1990-11-20
DE3607382A1 (de)	1986-09-11
IT1221079B (it)	1990-06-21

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CH665632A5 (fr)	1988-05-31	Composes d'aminophenol.
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JP2005527518A (ja)	2005-09-15	新規なカルコン（ｃｈａｌｃｏｎｅ）誘導体とその使用
AU617386B2 (en)	1991-11-28	Substituted quinolines
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WO1994003431A1 (en)	1994-02-17	Isoserine derivatives and their use as leukotriene antagonists
EP0119896A1 (fr)	1984-09-26	Nouveaux dérivés de l'amino-5 dithiole-1,2 one-3, leur préparation et les compositions médicinales qui les contiennent
FR2719047A1 (fr)	1995-10-27	Nouveaux dérivés de benzylamines, leur procédé de fabrication et les compositions pharmaceutiques les renfermant.
EP0169186B1 (fr)	1988-03-23	Nouveaux dérivés de décahydroquinoléinol, leur procédé de préparation et les compositions les contenant
WO2012104538A1 (fr)	2012-08-09	Nouveaux dérivés de 1, 5 - dihydropyrrol - 2 - one utiles pour le traitement paludisme ou d'autres maladies parasitaires et fongiques
JPH05507496A (ja)	1993-10-28	抗高コレステロール血ビス―トリフルオロメチル置換イミダゾリンおよびその誘導体
MC1726A1 (fr)	1986-12-15	Composes bicycliques substitues