LU86004A1 - ANALGESIC AND ANTI-INFLAMMATORY COMPOSITION FOR THE TREATMENT OF ARTHROSIS - Google Patents

Description

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The present invention relates to an optionally injectable antibiotic composition, consisting of a synergistic mixture of an Oxytetracycline compound and another constituent.

It is intended, in human and possibly veterinary medicine, to cure osteoarthritis and all degenerative lesions of the joints, as well as synovitis and particularly inflammations of the meniscus of the knee.

Arthrosis lesions are chronic inflammations of the joints due to a proliferation of underlying bone tissue.

The most frequent localizations of arthritis lesions are the intervertebral, coxo-femoral joints, knees and certain joints of the hand and foot.

The main symptom is pain. It is calmed by rest but exacerbated by movement. At the initial stage, osteoarthritis leads to a limitation of * movements and crunches to mobilization. It thus shows painful joints when pressed.

; At an advanced stage, we notice swellings and even irreversible deformations of the joints.

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The medical treatment of osteoarthritis mainly involves the administration of analgesic medications and the prescription of anti-inflammatory drugs.

Among others, corticosteroids are undoubtedly effective and immediately relieve acute pain, but they also have serious drawbacks. In fact, they involve infectious risks çpi reident pa ^ Æbis necessary a combination of antibiotics and digestive, renal and neurological risks, because of their great toxicity.

The present invention aims to treat osteoarthritis without having the drawbacks of corticosteroid therapy. It relates to a medicinal composition, allows a basic, early and prolonged treatment of osteoarthritis and prevents any recurrence.

This drug composition can be administered in its dosage form, orally or parenterally. It relates to a synergistic mixture of an antibiotic of the oxytetracycline type and of another constituent, essentially characterized in that this other constituent is a vitamin A-D complex.

According to a feature of the invention, the oxytetracycline and the vitamin A-D complex are mixed in a weight ratio of 0.3 to 3.

The activity of the aforementioned composition is advantageously reinforced by the presence of a complex of B vitamins, containing in particular vitamin '' antineuritis * ', vitamin' 'antidermatosique' 'and vitamin PP ( or B ^) '' antipellagreuse ''.

i 3 Other features and details of the invention will become apparent from the detailed description given above, of a particular dosage form of the invention.

i if Oxytetracycline is an antibiotic compound which is isolated from substances produced by actinomycetes and in particular from Streptomyces rimosus. It was first described in US Patent No. 2,516,080 (Pfizer). It is mainly used as an anti-bacterial against certain infectious diseases. It is administered in particular to combat bacteria from the group of Salmonella and Pseudomonas.

The addition of other antibiotics, of Penicillin G and of colistin sulfate according to Belgian patent N® 505 709 and the Luxembourg patent application Ne 84 786 remarkably broadens the spectra of applicability of oxytetracycline to fight bacillus de Koch and bacteria from the Salmonella and Pseudomonas group, responsible for diseases dangerous to humans and poultry. Note for humans, paratyphoid fever and salmonellous enterocolitis. Oxytetracycline is characterized by an extremely broad spectrum and reduced toxicity.

The present invention widens the field of application of oxytetracycline and extends it to the early and nevertheless radical treatment of diseases and traumas of the joints.

4! The invention is based on the discovery that oxytetracycline or Terramycin exhibits astonishing efficacy against osteoarthritis when it is administered η at the same time as a vitamin complex A-D2 * Excellent results are obtained when the components are mixed in a weight ratio varying from 0.3 to 5.

<j Vitamins A-D ^ are mainly intended to fix calcium.

This synergy of oxytetracycline and a vitamin A-D2 complex is reinforced by the presence of a quantity of a B complex intended to alleviate possible digestive disorders.

The B complex vitamins including vitamins B, j, Bg, PP, Bg, B ^ 2 "pantothenic acid and biotin are part of the composition of different fermental systems that regulate the general metabolism and can quickly restore the normal function of the intestinal flora after a disturbance.

It should therefore be noted that the primary medical indications for each of the constituents described above, taken separately, are completely different from those; of their mixture.

The synergistic composition according to the invention finds its preferred application in the treatment of osteoarthritis. It heals degenerate lesions! ratives of the joints. Its analgesic and anti-inflammatory effects are immediate. It makes it possible to effectively treat synovitis, synovial effusions and other inflammations of the meniscus of the knee, t 5 common in professional footballers.

It provides spectacular results in the treatment of sciatica, rheumatism, decalcification of bones, herniated discs, lumbago, sprains and muscle tears.

The following example of composition is intended to illustrate the new and inventive nature of the drug composition. Neither the precise composition nor the dosage form should be considered a limitation. The following analysis determines the amounts of each of the constituents present in a teaspoon, that is to say 5 ml of the composition according to the invention.

Constituents Quantity per 5 ml 1 / Oxytetracycline hydrochloride 50-150 mg (calculated on the basis of oxytetra-cyclin-base) 2 / Vitamin A. (Ergocalciferol) 50,000-150,000 Ü.I.

3 / Vitamin D2 (Butylated hydroxytoluene) 50,000-150,000 IU

4 / Vitamin (1.5-3 mg thiamine hydrochloride or Aneurine) 5 / Vitamin B2 (Riboflavin) 400-650 pg 6 / Vitamin (Pyridoxine) 200-450 pg 7 / Vitamin B ^ (Cyanocaboiamine) none 8 / Vitamin PP (Nicotinamide) 3-10 mg 9 / Vitamin B ^ (Calcium pantothenate) none 10 / Dexpanthenol 40-80 pg 11 / Biotin none 12 / Magnesium oxide 100-300 pg 13 / Sugar syrup ad 5 mi.

6 EXAMPLE 1

A preferred embodiment has a composition corresponding to the following formula, containing per 5 ml, the following constituents:

Constituents Per teaspoonful of 5 ml 1 / Oxytetracycline hydrochloride 70 mg (calculated on the basis of oxytetra-cyclin-base) 2 / Vitamin A (Ergocalciferol) 115,000 IU.

3 / Vitamin D ^ (Hydroxytoluene-butyl) 115,000 IU

4 / Vitamin B. 2.2 mg (thiamine hydrochloride or Aneurine) 5 / Vitamin B2 (Riboflavin) 530 pg 6 / Vitamin B ^ (Piridoxine) 300 pg 7 / Vitamin B ^ (Cyanocobalamin) none 8 / Vitamin PP (Nicotinamide ) 6 mg 9 / Vitamin (Calcium pantothenate) none 10 / Dexpanthenol 60 pg 11 / Biotin none 12 / Magnesium oxide 175 Pg 13 / Sugar syrup ad 5 ml EXAMPLE 2

Another possible execution formula has a composition corresponding to the following formula, containing per 5 ml the following constituents given in milligrams: 7 * ►

Constituents Per spoonful of 5 king

Oxytetracycline hydrochloride 70 mg

Lives. k 50,000 U.I.

Lives. D2 50,000 U.I.

Lives. B.j 1.425 mg

Lives. B2 0.225 mg

Lives. B6 0.225 mg D-Pantothenol 0.225 mg

Lives. PP 3 mg

Excipient * 3 mg

The mixture of Example 1 is produced by mixing together 100 ml of a 10% solution of injectable oxytetra-cyclin, containing for example 92.6 mg of oxytetracycline hydrochloride per ml of solution, 150 mg of an AD vitamin complex, marketed for example by Pfizer for veterinary use. Then add 100 ml of syrup of vitamin B complexes, as an example of BBCOZYM ^ Roche (syrup) and / or BECOVITAI * (syrup, produced by Cilag NU / SA and approximately 200 ml of a sugar syrup, so as to obtain 650 ml of medicinal composition in the form of a syrup.

The preparation in syrup form at the dosages indicated above is administered orally at the rate of three teaspoons for 3 days. The treatment is continued by taking a teaspoon i for a few days.

Contraindications are determined by hypercalcemia which can lead to kidney blockage.

The composition must be taken under medical supervision.

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i 8 * * * ï-, "It should be noted that, as a variant, each of the constituents can be added in injectable form, in particular the vitamin complex BECOZYM ^ Roche and / or BECOVITAN forte, so as to obtain an oily solution for injection. . This dosage form promotes the assimilation of vitamin and biotin.

Other modifications may be made to the embodiment of the invention. It is obvious that the skilled person can bring many variations in the choice, in particular excipients, supports or diluents. In principle therefore, the invention covers all the synergistic combinations of the invention with the carriers, diluents and excipients usually used in pharmacology. .

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Claims (6)

1. Antibiotic composition comprising, optionally in injectable form, a synergistic mixture of an antibiotic of the oxytetracycline type and of another constituent, characteristic; ; laughed in that this other constituent is a vitamin complex a-d2. 2. Composition according to Claim 1, characterized in that the oxytetracycline and the vitamin complex A-B! 2 are mixed in a weight ratio of 0.3 to 3. 3. Composition according to any one of claims 1 and 2, characterized in that it also comprises a vitamin B complex. 4. Composition according to any one of claims 1 to 3, characterized in that it corresponds to the galenical formula obtained by mixing for 5 ml (1 teaspoonful) the following constituents: · i "i 9" i 10 • w Constituents Quantity per 5 mi 1 / Oxytetracycline hydrochloride 50-150 mg (calculated on the basis of oxytetra- ~ cycline-base) 2 / Vitamin A (Ergocalciferol) 50,000-150. 000 IU 3 / Vitamin D2 (Butylated hydroxytoluene) 50,000-150,000 IU 4 / Vitamin 13 ^ (1 ”hydrochloride 5-3 mg thiamine or Aneurine) 5 / Vitamin B2 (Riboflavin) 400-650 pg o / Vitamin (Pyridoxine) 200 -450 μg 7 / Vitamin B ^ 2 (Cyanocabolamine) none 8 / Vitamin PP (Nicotinamide) 3-10 mg 9 / Vitamin (Calcium pantothenate) none 10 / Dexpanthenol 40-80 pg 11 / Biotin „none 12 / Magnesium oxide 100-300 pg 13 / Sugar syrup ad 5 ml 5. Composition according to claim 4, characterized in that it responds to the following analysis:. 9 1 * 11 "> Constituents Per spoonful to" _____ 5 ml coffee "1 / Oxytetracycline hydrochloride 70 mg 5 (calculated on the basis of oxytetra-cyclin-base) 2 / Vitamin A (Ergocalciferol) 115,000 IU 3 / Vitamin D2 (Hydroxytoluene-butyl) 115,000 IU 4 / Vitamin B. 2.2 mg (thiamine hydrochloride or Aneurine) 5 / Vitamin B2 (Riboflavin) 530 pg b / Vitamin (Piridoxine) 300 μ§ 7 / Vitamin B ^ 2 (Cyanocobalamin ) none 8 / Vitamin PP- \ Nicotinamide) ^ mg 9 / Vitamin B ,. (Calcium pantothenate) none 10 / Dexpanthenol 60 pg 11 / Bistine none 12 / Magnesium oxide 175 ug 13 / Sugar syrup * ad 5 ml 6. Use of a composition according to one of claims 1 to 5, for treating osteoarthritis, synovia, synovial effusion, inflammation of the meniscus of the knee, sciatica, rheumatism, bone decalcifications, herniated discs, lumbago, sprains and muscle tears. •at ; / l