LU86966A1 - Orales therapeutisches system mit systemischer wirkung - Google Patents

Orales therapeutisches system mit systemischer wirkung Download PDF

Info

Publication number: LU86966A1
Authority: LU; Luxembourg
Prior art keywords: core; carbamazepine; therapeutic system; cellulose; water
Prior art date: 1986-08-07

Application number

LU86966A

Other languages

German (de)

English (en)

Inventor

Satish Chandra Khanna

Theresa Ruettimann

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-07

Filing date

1987-08-05

Publication date

1989-03-08

1987-08-05 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1989-03-08 Publication of LU86966A1 publication Critical patent/LU86966A1/fr

Links

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WOOJRPBCEMEHLS-UHFFFAOYSA-N acetic acid;butane-1-sulfonic acid Chemical compound CC(O)=O.CCCCS(O)(=O)=O WOOJRPBCEMEHLS-UHFFFAOYSA-N 0.000 description 1
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CBICCXFXCXELAR-UHFFFAOYSA-N acetic acid;ethyl hydrogen carbonate Chemical compound CC(O)=O.CCOC(O)=O CBICCXFXCXELAR-UHFFFAOYSA-N 0.000 description 1
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GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
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229920006217 cellulose acetate butyrate Polymers 0.000 description 1
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239000011248 coating agent Substances 0.000 description 1
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239000008120 corn starch Substances 0.000 description 1
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125000004122 cyclic group Chemical group 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
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150000002170 ethers Chemical class 0.000 description 1
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239000000945 filler Substances 0.000 description 1
238000011049 filling Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
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235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
SSILHZFTFWOUJR-UHFFFAOYSA-N hexadecane-1-sulfonic acid Chemical compound CCCCCCCCCCCCCCCCS(O)(=O)=O SSILHZFTFWOUJR-UHFFFAOYSA-N 0.000 description 1
150000002402 hexoses Chemical class 0.000 description 1
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230000002401 inhibitory effect Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000004922 lacquer Substances 0.000 description 1
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KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Inorganic materials [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 1
INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
NOQOJKIYCAQVMC-UHFFFAOYSA-L magnesium;2-dodecoxyethyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOCCOS([O-])(=O)=O.CCCCCCCCCCCCOCCOS([O-])(=O)=O NOQOJKIYCAQVMC-UHFFFAOYSA-L 0.000 description 1
ANGQSOHCVRDFPI-UHFFFAOYSA-L magnesium;dodecane-1-sulfonate Chemical compound [Mg+2].CCCCCCCCCCCCS([O-])(=O)=O.CCCCCCCCCCCCS([O-])(=O)=O ANGQSOHCVRDFPI-UHFFFAOYSA-L 0.000 description 1
HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
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BDRTVPCFKSUHCJ-UHFFFAOYSA-N molecular hydrogen;potassium Chemical compound [K].[H][H] BDRTVPCFKSUHCJ-UHFFFAOYSA-N 0.000 description 1
238000000465 moulding Methods 0.000 description 1
PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
CACRRXGTWZXOAU-UHFFFAOYSA-N octadecane-1-sulfonic acid Chemical compound CCCCCCCCCCCCCCCCCCS(O)(=O)=O CACRRXGTWZXOAU-UHFFFAOYSA-N 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000002357 osmotic agent Substances 0.000 description 1
150000002972 pentoses Chemical class 0.000 description 1
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229920000747 poly(lactic acid) Chemical class 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
229940085678 polyethylene glycol 8000 Drugs 0.000 description 1
235000019446 polyethylene glycol 8000 Nutrition 0.000 description 1
229920000151 polyglycol Chemical class 0.000 description 1
239000010695 polyglycol Chemical class 0.000 description 1
239000004626 polylactic acid Chemical class 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
229910052939 potassium sulfate Inorganic materials 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
230000004044 response Effects 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
235000010378 sodium ascorbate Nutrition 0.000 description 1
PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
229960005055 sodium ascorbate Drugs 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
229950005425 sodium myristyl sulfate Drugs 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
229940035044 sorbitan monolaurate Drugs 0.000 description 1
229950004959 sorbitan oleate Drugs 0.000 description 1
229950003429 sorbitan palmitate Drugs 0.000 description 1
229950011392 sorbitan stearate Drugs 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
239000001589 sorbitan tristearate Substances 0.000 description 1
235000011078 sorbitan tristearate Nutrition 0.000 description 1
229960004129 sorbitan tristearate Drugs 0.000 description 1
239000007921 spray Substances 0.000 description 1
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235000019698 starch Nutrition 0.000 description 1
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OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 description 1
MYOWBHNETUSQPA-UHFFFAOYSA-N tetradecane-1-sulfonic acid Chemical compound CCCCCCCCCCCCCCS(O)(=O)=O MYOWBHNETUSQPA-UHFFFAOYSA-N 0.000 description 1
150000004043 trisaccharides Chemical class 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

LU86966A 1986-08-07 1987-08-05 Orales therapeutisches system mit systemischer wirkung LU86966A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH3172/86A CH668187A5 (de)	1986-08-07	1986-08-07	Therapeutisches system mit systemischer wirkung.
CH317286		1986-08-07

Publications (1)

Publication Number	Publication Date
LU86966A1 true LU86966A1 (fr)	1989-03-08

Family

ID=4250176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86966A LU86966A1 (fr)	1986-08-07	1987-08-05	Orales therapeutisches system mit systemischer wirkung

Country Status (30)

Country	Link
US (1)	US4857336A (fr)
JP (1)	JP2592460B2 (fr)
KR (1)	KR950006219B1 (fr)
AT (1)	AT397344B (fr)
AU (1)	AU597403B2 (fr)
BE (1)	BE1000235A3 (fr)
CA (1)	CA1302267C (fr)
CH (1)	CH668187A5 (fr)
DD (1)	DD285718A5 (fr)
DE (1)	DE3725824C2 (fr)
DK (1)	DK175497B1 (fr)
ES (1)	ES2007100A6 (fr)
FI (1)	FI86143C (fr)
FR (1)	FR2602425B1 (fr)
GB (1)	GB2193632B (fr)
GR (1)	GR871234B (fr)
HK (1)	HK33793A (fr)
HU (1)	HU206978B (fr)
IE (1)	IE59718B1 (fr)
IL (1)	IL83386A (fr)
IT (1)	IT1215618B (fr)
LU (1)	LU86966A1 (fr)
MY (1)	MY100767A (fr)
NL (1)	NL194780C (fr)
NO (1)	NO173726C (fr)
NZ (1)	NZ221347A (fr)
PH (1)	PH25090A (fr)
PT (1)	PT85489B (fr)
SE (1)	SE502590C2 (fr)
ZA (1)	ZA875804B (fr)

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US5108756A (en) *	1989-01-12	1992-04-28	Pfizer Inc.	Dispensing devices powered by lyotropic liquid crystals
EP0408496A3 (en) *	1989-07-12	1992-07-01	Ciba-Geigy Ag	Solid dosage form for pharmaceutical substances
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US5800832A (en) *	1996-10-18	1998-09-01	Virotex Corporation	Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5980942A (en) *	1997-01-23	1999-11-09	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Zero-order sustained release matrix tablet formulations of carbamazepine
US6296873B1 (en)	1997-01-23	2001-10-02	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Zero-order sustained release delivery system for carbamazephine derivatives
CO4920215A1 (es) *	1997-02-14	2000-05-29	Novartis Ag	Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones
US20020022056A1 (en)	1997-02-14	2002-02-21	Burkhard Schlutermann	Oxacarbazepine film-coated tablets
AU731693B2 (en)	1997-09-25	2001-04-05	Bayer Intellectual Property Gmbh	Drug formulation having controlled release of active compound
US6099859A (en)	1998-03-20	2000-08-08	Andrx Pharmaceuticals, Inc.	Controlled release oral tablet having a unitary core
EP1079813B1 (fr) *	1998-04-29	2005-02-09	Virotex Corporation	Dispositif porteur pharmaceutique pour l'administration de composes pharmaceutiques aux surfaces muqueuses
US6706283B1 (en) *	1999-02-10	2004-03-16	Pfizer Inc	Controlled release by extrusion of solid amorphous dispersions of drugs
BRPI0206432A2 (pt) *	2001-01-12	2016-10-25	Sun Pharmaceutical Ind Ltd	métodos para administrar dois ou mais agentes terapêuticos ativos e para tratar diabetes melito ou sintomas associados com diabetes melito em um humano e sistema de liberação espaçada de medicamento
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WO2002080887A2 (fr) *	2001-04-10	2002-10-17	Sun Pharmaceutical Industries Limited	Composition a liberation par impulsion reglee dans le temps
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1986
- 1986-08-07 CH CH3172/86A patent/CH668187A5/de not_active IP Right Cessation
1987
- 1987-07-24 GB GB8717643A patent/GB2193632B/en not_active Expired - Lifetime
- 1987-07-29 US US07/079,055 patent/US4857336A/en not_active Ceased
- 1987-07-30 IL IL83386A patent/IL83386A/xx not_active IP Right Cessation
- 1987-08-03 SE SE8703034A patent/SE502590C2/sv not_active IP Right Cessation
- 1987-08-04 DE DE3725824A patent/DE3725824C2/de not_active Expired - Lifetime
- 1987-08-04 GR GR871234A patent/GR871234B/el unknown
- 1987-08-05 LU LU86966A patent/LU86966A1/fr unknown
- 1987-08-05 NZ NZ221347A patent/NZ221347A/xx unknown
- 1987-08-05 DD DD87305733A patent/DD285718A5/de not_active IP Right Cessation
- 1987-08-05 FI FI873409A patent/FI86143C/fi not_active IP Right Cessation
- 1987-08-05 FR FR878711131A patent/FR2602425B1/fr not_active Expired - Lifetime
- 1987-08-05 IT IT8748270A patent/IT1215618B/it active
- 1987-08-05 CA CA000543746A patent/CA1302267C/fr not_active Expired - Lifetime
- 1987-08-05 PH PH35631A patent/PH25090A/en unknown
- 1987-08-05 PT PT85489A patent/PT85489B/pt unknown
- 1987-08-06 NL NL8701857A patent/NL194780C/nl not_active IP Right Cessation
- 1987-08-06 IE IE211087A patent/IE59718B1/en not_active IP Right Cessation
- 1987-08-06 AU AU76617/87A patent/AU597403B2/en not_active Expired
- 1987-08-06 NO NO873298A patent/NO173726C/no not_active IP Right Cessation
- 1987-08-06 ZA ZA875804A patent/ZA875804B/xx unknown
- 1987-08-06 JP JP62195407A patent/JP2592460B2/ja not_active Expired - Lifetime
- 1987-08-06 DK DK198704107A patent/DK175497B1/da not_active IP Right Cessation
- 1987-08-06 MY MYPI87001227A patent/MY100767A/en unknown
- 1987-08-06 AT AT0199387A patent/AT397344B/de not_active IP Right Cessation
- 1987-08-06 HU HU873590A patent/HU206978B/hu unknown
- 1987-08-06 BE BE8700868A patent/BE1000235A3/fr not_active IP Right Cessation
- 1987-08-07 ES ES8702339A patent/ES2007100A6/es not_active Expired
- 1987-08-07 KR KR1019870008652A patent/KR950006219B1/ko not_active Expired - Lifetime
1993
- 1993-04-08 HK HK337/93A patent/HK33793A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE872110L (en)	1988-02-07
FI873409A0 (fi)	1987-08-05
NZ221347A (en)	1989-12-21
FI86143C (fi)	1992-07-27
HK33793A (en)	1993-04-16
PT85489A (en)	1987-09-01
HUT44930A (en)	1988-05-30
ES2007100A6 (es)	1989-06-01
HU206978B (en)	1993-03-01
DK410787A (da)	1988-02-08
AU7661787A (en)	1988-02-11
NO873298D0 (no)	1987-08-06
FR2602425A1 (fr)	1988-02-12
US4857336A (en)	1989-08-15
PT85489B (pt)	1990-06-29
CH668187A5 (de)	1988-12-15
SE8703034L (sv)	1988-02-08
IE59718B1 (en)	1994-03-23
ZA875804B (en)	1988-02-08
DK175497B1 (da)	2004-11-15
FI86143B (fi)	1992-04-15
NO173726B (no)	1993-10-18
DK410787D0 (da)	1987-08-06
DE3725824C2 (de)	1998-12-17
IL83386A0 (en)	1987-12-31
KR880002511A (ko)	1988-05-09
GR871234B (en)	1987-12-08
NO873298L (no)	1988-02-08
DD285718A5 (de)	1991-01-03
KR950006219B1 (ko)	1995-06-12
SE8703034D0 (sv)	1987-08-03
SE502590C2 (sv)	1995-11-20
CA1302267C (fr)	1992-06-02
JPS6344525A (ja)	1988-02-25
AU597403B2 (en)	1990-05-31
ATA199387A (de)	1993-08-15
IL83386A (en)	1992-01-15
NL194780B (nl)	2002-11-01
DE3725824A1 (de)	1988-02-11
PH25090A (en)	1991-02-19
AT397344B (de)	1994-03-25
MY100767A (en)	1991-02-14
FR2602425B1 (fr)	1990-09-14
FI873409A7 (fi)	1988-02-08
JP2592460B2 (ja)	1997-03-19
NL8701857A (nl)	1988-03-01
IT1215618B (it)	1990-02-22
NL194780C (nl)	2003-03-04
GB2193632A (en)	1988-02-17
NO173726C (no)	1994-01-26
BE1000235A3 (fr)	1988-09-20
IT8748270A0 (it)	1987-08-05
GB2193632B (en)	1990-04-25
GB8717643D0 (en)	1987-09-03

Publication	Publication Date	Title
AT397344B (de)	1994-03-25	Verfahren zur herstellung eines oralen therapeutischen systems für carbamazepin
EP0277092B1 (fr)	1992-01-29	Système thérapeutique pour médicaments peu solubles
EP0339506B1 (fr)	1992-05-13	Système osmotique oral avec adhésion améliorée de la membrane au noyau
EP1024793B1 (fr)	2002-01-16	Systeme osmotique de liberation de medicament
DE60038698T2 (de)	2009-05-07	Hydrogel-gesteuerte dosierungsform
DE69909801T2 (de)	2004-06-03	Oral verabreichtes system zur zeitlich und räumlich gesteuerten arzneistoffabgabe
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DE19681389B3 (de)	2015-12-10	Dosierungsform, umfassend Oxybutynin
DE69927708T2 (de)	2006-07-06	Dosierungsformen, die poröse partikel enthalten
DE69720995T2 (de)	2003-11-13	Granulate für die vorbereitung von schnellzerfallende und schnelllösendezubereitungen mit hohem anteil an wirkstoff
DE69520036T2 (de)	2001-06-21	Verfahren zur herstellung von festen pharmazeutischen dosierungsformen hydrophobischen substanzen
DE69910803T2 (de)	2004-06-17	Fentanylzusammensetzung zur behandlung von akutem schmerz
DE60123384T2 (de)	2007-08-02	Dosierungsform des typs "hülle und kern" mit einer wirkstofffreisetzung, die sich der nullten ordnung annähert
DE60101581T2 (de)	2004-09-16	Tablettenform zur gastrischen zurückhaltungssteigerung wasserquellfähiger mit kontrollierter freisetzung oraler dosierungsformen
DE69720055T2 (de)	2003-09-11	Verabreichungsform zur abgabe von steigenden wirkstoffdosen
DE69427466T2 (de)	2002-04-25	Bisacodyl dosierungsform
DE69627170T2 (de)	2004-03-04	Nichtwässrige abführmittel für den kolon
DE69709101T2 (de)	2002-04-25	Therapie mittels gleichförmiger arzneistoffverabreichung
DE60019334T2 (de)	2005-09-08	Antivirale arznei
EP2497465A2 (fr)	2012-09-12	Système de rétention gastrique avec corps alginate
DE19530575A1 (de)	1997-02-20	Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz
DE3909520A1 (de)	1989-10-05	Feste, schnell zerfallende darreichungsformen
DE69414863T2 (de)	1999-04-22	Behälter, der ein hydrophober arzneimittel enthält
EP0765158B1 (fr)	1998-11-04	Excipient destine a la liberation controlee de principes actifs dans le tractus gastro-intestinal avec passage retarde dans le pylore
DE60034142T2 (de)	2007-12-13	Darreichungsform mit einer inneren Membran, einer Verdrängungszusammentzung und einer äußeren semipermeablen Membran

Legal Events

Date	Code	Title	Description
1987-08-05	DT	Application date
1991-06-19	TA	Annual fee