LU86875A1 - Utilisation de l'activateur tissulaire du plasminogene,son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association - Google Patents

Utilisation de l'activateur tissulaire du plasminogene,son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association Download PDF

Info

Publication number: LU86875A1
Authority: LU; Luxembourg
Prior art keywords: gly; ser; leu; arg; cys
Prior art date: 1986-05-12

Application number

LU86875A

Other languages

English (en)

French (fr)

Inventor

Henry Berger Jr

Crist John Frangakis

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-12

Filing date

1987-05-11

Publication date

1988-01-20

1986-05-12 Priority claimed from US06/862,057 external-priority patent/US4976959A/en

1987-05-11 Application filed by Wellcome Found filed Critical Wellcome Found

1988-01-20 Publication of LU86875A1 publication Critical patent/LU86875A1/fr

Links

102000019197 Superoxide Dismutase Human genes 0.000 title claims abstract description 55
108010012715 Superoxide dismutase Proteins 0.000 title claims abstract description 55
239000008194 pharmaceutical composition Substances 0.000 title claims description 10
102000013566 Plasminogen Human genes 0.000 title claims description 7
108010051456 Plasminogen Proteins 0.000 title claims description 7
239000012190 activator Substances 0.000 title claims description 6
229940032362 superoxide dismutase Drugs 0.000 title 1
230000006378 damage Effects 0.000 claims abstract description 17
108090000373 Tissue Plasminogen Activator Proteins 0.000 claims abstract description 14
102000003978 Tissue Plasminogen Activator Human genes 0.000 claims abstract description 14
229960000187 tissue plasminogen activator Drugs 0.000 claims abstract description 14
239000003814 drug Substances 0.000 claims abstract description 10
238000004519 manufacturing process Methods 0.000 claims abstract description 6
230000002107 myocardial effect Effects 0.000 claims abstract description 4
150000001413 amino acids Chemical group 0.000 claims description 18
238000003973 irrigation Methods 0.000 claims description 17
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 14
229910052802 copper Inorganic materials 0.000 claims description 14
239000010949 copper Substances 0.000 claims description 14
241000124008 Mammalia Species 0.000 claims description 13
208000007536 Thrombosis Diseases 0.000 claims description 12
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 12
241000283690 Bos taurus Species 0.000 claims description 10
230000002401 inhibitory effect Effects 0.000 claims description 10
229910052725 zinc Inorganic materials 0.000 claims description 10
239000011701 zinc Substances 0.000 claims description 10
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 4
229930182817 methionine Natural products 0.000 claims description 4
PUUYVMYCMIWHFE-BQBZGAKWSA-N Gly-Ala-Arg Chemical compound NCC(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N PUUYVMYCMIWHFE-BQBZGAKWSA-N 0.000 claims description 3
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 3
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 3
229920001184 polypeptide Polymers 0.000 claims description 3
108090000765 processed proteins & peptides Proteins 0.000 claims description 3
102000004196 processed proteins & peptides Human genes 0.000 claims description 3
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims description 3
239000004474 valine Substances 0.000 claims description 3
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
229940012957 plasmin Drugs 0.000 claims description 2
108010050848 glycylleucine Proteins 0.000 claims 3
YNQMEIJEWSHOEO-SRVKXCTJSA-N Asn-Tyr-Cys Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CC(=O)N)N)O YNQMEIJEWSHOEO-SRVKXCTJSA-N 0.000 claims 2
KTTCQQNRRLCIBC-GHCJXIJMSA-N Asp-Ile-Ala Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O KTTCQQNRRLCIBC-GHCJXIJMSA-N 0.000 claims 2
MJJIHRWNWSQTOI-VEVYYDQMSA-N Asp-Thr-Arg Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O MJJIHRWNWSQTOI-VEVYYDQMSA-N 0.000 claims 2
LTUVYLVIZHJCOQ-KKUMJFAQSA-N Glu-Arg-Phe Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O LTUVYLVIZHJCOQ-KKUMJFAQSA-N 0.000 claims 2
HAXARWKYFIIHKD-ZKWXMUAHSA-N Gly-Ile-Ser Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(O)=O HAXARWKYFIIHKD-ZKWXMUAHSA-N 0.000 claims 2
IUKIDFVOUHZRAK-QWRGUYRKSA-N Gly-Lys-His Chemical compound NCCCC[C@H](NC(=O)CN)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 IUKIDFVOUHZRAK-QWRGUYRKSA-N 0.000 claims 2
HYIFFZAQXPUEAU-QWRGUYRKSA-N Leu-Gly-Leu Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC(C)C HYIFFZAQXPUEAU-QWRGUYRKSA-N 0.000 claims 2
XMBSYZWANAQXEV-UHFFFAOYSA-N N-alpha-L-glutamyl-L-phenylalanine Natural products OC(=O)CCC(N)C(=O)NC(C(O)=O)CC1=CC=CC=C1 XMBSYZWANAQXEV-UHFFFAOYSA-N 0.000 claims 2
108010047495 alanylglycine Proteins 0.000 claims 2
ZXJZGWOMAFPSJH-DCAQKATOSA-N (2S)-1-[2-[[2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]acetyl]pyrrolidine-2-carboxylic acid Chemical compound [H]NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(O)=O ZXJZGWOMAFPSJH-DCAQKATOSA-N 0.000 claims 1
WQVFQXXBNHHPLX-ZKWXMUAHSA-N Ala-Ala-His Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O WQVFQXXBNHHPLX-ZKWXMUAHSA-N 0.000 claims 1
LGQPPBQRUBVTIF-JBDRJPRFSA-N Ala-Ala-Ile Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O LGQPPBQRUBVTIF-JBDRJPRFSA-N 0.000 claims 1
NXSFUECZFORGOG-CIUDSAMLSA-N Ala-Asn-Leu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O NXSFUECZFORGOG-CIUDSAMLSA-N 0.000 claims 1
ZIWWTZWAKYBUOB-CIUDSAMLSA-N Ala-Asp-Leu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O ZIWWTZWAKYBUOB-CIUDSAMLSA-N 0.000 claims 1
NYDBKUNVSALYPX-NAKRPEOUSA-N Ala-Ile-Arg Chemical compound C[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(O)=O)CCCN=C(N)N NYDBKUNVSALYPX-NAKRPEOUSA-N 0.000 claims 1
RGQCNKIDEQJEBT-CQDKDKBSSA-N Ala-Leu-Tyr Chemical compound C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 RGQCNKIDEQJEBT-CQDKDKBSSA-N 0.000 claims 1
QKHWNPQNOHEFST-VZFHVOOUSA-N Ala-Thr-Cys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](C)N)O QKHWNPQNOHEFST-VZFHVOOUSA-N 0.000 claims 1
GHNDBBVSWOWYII-LPEHRKFASA-N Arg-Asn-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCN=C(N)N)N)C(=O)O GHNDBBVSWOWYII-LPEHRKFASA-N 0.000 claims 1
OZNSCVPYWZRQPY-CIUDSAMLSA-N Arg-Asp-Glu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O OZNSCVPYWZRQPY-CIUDSAMLSA-N 0.000 claims 1
DQNLFLGFZAUIOW-FXQIFTODSA-N Arg-Cys-Ala Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(O)=O DQNLFLGFZAUIOW-FXQIFTODSA-N 0.000 claims 1
BBYTXXRNSFUOOX-IHRRRGAJSA-N Arg-Cys-Phe Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O BBYTXXRNSFUOOX-IHRRRGAJSA-N 0.000 claims 1
KRQSPVKUISQQFS-FJXKBIBVSA-N Arg-Gly-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N KRQSPVKUISQQFS-FJXKBIBVSA-N 0.000 claims 1
UZGFHWIJWPUPOH-IHRRRGAJSA-N Arg-Leu-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)N UZGFHWIJWPUPOH-IHRRRGAJSA-N 0.000 claims 1
OVQJAKFLFTZDNC-GUBZILKMSA-N Arg-Pro-Asp Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(O)=O OVQJAKFLFTZDNC-GUBZILKMSA-N 0.000 claims 1
AMIQZQAAYGYKOP-FXQIFTODSA-N Arg-Ser-Asn Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O AMIQZQAAYGYKOP-FXQIFTODSA-N 0.000 claims 1
ULBHWNVWSCJLCO-NHCYSSNCSA-N Arg-Val-Glu Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CCCN=C(N)N ULBHWNVWSCJLCO-NHCYSSNCSA-N 0.000 claims 1
GMRGSBAMMMVDGG-GUBZILKMSA-N Asn-Arg-Arg Chemical compound C(C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC(=O)N)N)CN=C(N)N GMRGSBAMMMVDGG-GUBZILKMSA-N 0.000 claims 1
GOVUDFOGXOONFT-VEVYYDQMSA-N Asn-Arg-Thr Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O GOVUDFOGXOONFT-VEVYYDQMSA-N 0.000 claims 1
ICDDSTLEMLGSTB-GUBZILKMSA-N Asn-Met-Arg Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O ICDDSTLEMLGSTB-GUBZILKMSA-N 0.000 claims 1
AEZCCDMZZJOGII-DCAQKATOSA-N Asn-Met-Leu Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(O)=O AEZCCDMZZJOGII-DCAQKATOSA-N 0.000 claims 1
GMUOCGCDOYYWPD-FXQIFTODSA-N Asn-Pro-Ser Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O GMUOCGCDOYYWPD-FXQIFTODSA-N 0.000 claims 1
VWADICJNCPFKJS-ZLUOBGJFSA-N Asn-Ser-Asp Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(O)=O VWADICJNCPFKJS-ZLUOBGJFSA-N 0.000 claims 1
SNYCNNPOFYBCEK-ZLUOBGJFSA-N Asn-Ser-Ser Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O SNYCNNPOFYBCEK-ZLUOBGJFSA-N 0.000 claims 1
ZLGKHJHFYSRUBH-FXQIFTODSA-N Asp-Arg-Asp Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O ZLGKHJHFYSRUBH-FXQIFTODSA-N 0.000 claims 1
MGSVBZIBCCKGCY-ZLUOBGJFSA-N Asp-Ser-Ser Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O MGSVBZIBCCKGCY-ZLUOBGJFSA-N 0.000 claims 1
QPDUWAUSSWGJSB-NGZCFLSTSA-N Asp-Val-Pro Chemical compound CC(C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CC(=O)O)N QPDUWAUSSWGJSB-NGZCFLSTSA-N 0.000 claims 1
AEJSNWMRPXAKCW-WHFBIAKZSA-N Cys-Ala-Gly Chemical compound SC[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O AEJSNWMRPXAKCW-WHFBIAKZSA-N 0.000 claims 1
CPTUXCUWQIBZIF-ZLUOBGJFSA-N Cys-Asn-Ser Chemical compound SC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(O)=O CPTUXCUWQIBZIF-ZLUOBGJFSA-N 0.000 claims 1
CFQVGYWKSLKWFX-KBIXCLLPSA-N Cys-Glu-Ile Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O CFQVGYWKSLKWFX-KBIXCLLPSA-N 0.000 claims 1
KABHAOSDMIYXTR-GUBZILKMSA-N Cys-Glu-Leu Chemical compound CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)N KABHAOSDMIYXTR-GUBZILKMSA-N 0.000 claims 1
WAJDEKCJRKGRPG-CIUDSAMLSA-N Cys-His-Ser Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CS)N WAJDEKCJRKGRPG-CIUDSAMLSA-N 0.000 claims 1
HBHMVBGGHDMPBF-GARJFASQSA-N Cys-Leu-Pro Chemical compound CC(C)C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CS)N HBHMVBGGHDMPBF-GARJFASQSA-N 0.000 claims 1
MBRWOKXNHTUJMB-CIUDSAMLSA-N Cys-Pro-Glu Chemical compound [H]N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O MBRWOKXNHTUJMB-CIUDSAMLSA-N 0.000 claims 1
DQBRIEGWTLXALA-GQGQLFGLSA-N Cys-Trp-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CS)N DQBRIEGWTLXALA-GQGQLFGLSA-N 0.000 claims 1
HPZAJRPYUIHDIN-BZSNNMDCSA-N Cys-Tyr-Phe Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CS)N HPZAJRPYUIHDIN-BZSNNMDCSA-N 0.000 claims 1
ZOMMHASZJQRLFS-IHRRRGAJSA-N Cys-Tyr-Val Chemical compound CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CS)N ZOMMHASZJQRLFS-IHRRRGAJSA-N 0.000 claims 1
BPDVTFBJZNBHEU-HGNGGELXSA-N Glu-Ala-His Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 BPDVTFBJZNBHEU-HGNGGELXSA-N 0.000 claims 1
ITYRYNUZHPNCIK-GUBZILKMSA-N Glu-Ala-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O ITYRYNUZHPNCIK-GUBZILKMSA-N 0.000 claims 1
UENPHLAAKDPZQY-XKBZYTNZSA-N Glu-Cys-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)N)O UENPHLAAKDPZQY-XKBZYTNZSA-N 0.000 claims 1
UQHGAYSULGRWRG-WHFBIAKZSA-N Glu-Ser Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CO)C(O)=O UQHGAYSULGRWRG-WHFBIAKZSA-N 0.000 claims 1
QOOFKCCZZWTCEP-AVGNSLFASA-N Glu-Tyr-Cys Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O QOOFKCCZZWTCEP-AVGNSLFASA-N 0.000 claims 1
LJPIRKICOISLKN-WHFBIAKZSA-N Gly-Ala-Ser Chemical compound NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O LJPIRKICOISLKN-WHFBIAKZSA-N 0.000 claims 1
MXXXVOYFNVJHMA-IUCAKERBSA-N Gly-Arg-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CN MXXXVOYFNVJHMA-IUCAKERBSA-N 0.000 claims 1
DTPOVRRYXPJJAZ-FJXKBIBVSA-N Gly-Arg-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CCCN=C(N)N DTPOVRRYXPJJAZ-FJXKBIBVSA-N 0.000 claims 1
GGEJHJIXRBTJPD-BYPYZUCNSA-N Gly-Asn-Gly Chemical compound NCC(=O)N[C@@H](CC(N)=O)C(=O)NCC(O)=O GGEJHJIXRBTJPD-BYPYZUCNSA-N 0.000 claims 1
DUYYPIRFTLOAJQ-YUMQZZPRSA-N Gly-Asn-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)CN DUYYPIRFTLOAJQ-YUMQZZPRSA-N 0.000 claims 1
CEXINUGNTZFNRY-BYPYZUCNSA-N Gly-Cys-Gly Chemical compound [NH3+]CC(=O)N[C@@H](CS)C(=O)NCC([O-])=O CEXINUGNTZFNRY-BYPYZUCNSA-N 0.000 claims 1
UQJNXZSSGQIPIQ-FBCQKBJTSA-N Gly-Gly-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)CNC(=O)CN UQJNXZSSGQIPIQ-FBCQKBJTSA-N 0.000 claims 1
UESJMAMHDLEHGM-NHCYSSNCSA-N Gly-Ile-Leu Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O UESJMAMHDLEHGM-NHCYSSNCSA-N 0.000 claims 1
IKAIKUBBJHFNBZ-LURJTMIESA-N Gly-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)CN IKAIKUBBJHFNBZ-LURJTMIESA-N 0.000 claims 1
VLIJYPMATZSOLL-YUMQZZPRSA-N Gly-Lys-Cys Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)CN VLIJYPMATZSOLL-YUMQZZPRSA-N 0.000 claims 1
CVFOYJJOZYYEPE-KBPBESRZSA-N Gly-Lys-Tyr Chemical compound [H]NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O CVFOYJJOZYYEPE-KBPBESRZSA-N 0.000 claims 1
WMGHDYWNHNLGBV-ONGXEEELSA-N Gly-Phe-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CN)CC1=CC=CC=C1 WMGHDYWNHNLGBV-ONGXEEELSA-N 0.000 claims 1
IZVICCORZOSGPT-JSGCOSHPSA-N Gly-Val-Tyr Chemical compound [H]NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O IZVICCORZOSGPT-JSGCOSHPSA-N 0.000 claims 1
PDSUIXMZYNURGI-AVGNSLFASA-N His-Arg-Arg Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC1=CN=CN1 PDSUIXMZYNURGI-AVGNSLFASA-N 0.000 claims 1
VOEGKUNRHYKYSU-XVYDVKMFSA-N His-Asp-Ala Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(O)=O VOEGKUNRHYKYSU-XVYDVKMFSA-N 0.000 claims 1
YAALVYQFVJNXIV-KKUMJFAQSA-N His-Leu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CN=CN1 YAALVYQFVJNXIV-KKUMJFAQSA-N 0.000 claims 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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LU86875A 1986-05-12 1987-05-11 Utilisation de l'activateur tissulaire du plasminogene,son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association LU86875A1 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US86204686A	1986-05-12	1986-05-12
US06/862,057 US4976959A (en)	1986-05-12	1986-05-12	T-PA and SOD in limiting tissue damage
US86205786		1986-05-12
US86204686		1986-05-12

Publications (1)

Publication Number	Publication Date
LU86875A1 true LU86875A1 (fr)	1988-01-20

Family

ID=27127662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86875A LU86875A1 (fr)	1986-05-12	1987-05-11	Utilisation de l'activateur tissulaire du plasminogene,son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association

Country Status (13)

Country	Link
JP (1)	JPH0680015B2 (da)
AU (1)	AU600724B2 (da)
BE (1)	BE1001425A4 (da)
CH (1)	CH672989A5 (da)
DE (1)	DE3715662A1 (da)
DK (1)	DK237187A (da)
FR (1)	FR2600895B1 (da)
GB (1)	GB2194886B (da)
IE (1)	IE59895B1 (da)
LU (1)	LU86875A1 (da)
NL (1)	NL8701113A (da)
NZ (1)	NZ220260A (da)
SE (1)	SE8701921L (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0780784B2 (ja) *	1987-10-23	1995-08-30	宇部興産株式会社	微小循環障害に基づく心筋虚血傷害治療薬
NZ230808A (en) *	1988-10-24	1993-04-28	Squibb & Sons Inc	Pharmaceutical compositions and combinations containing an angiotensin-converting enzyme inhibitor and a thrombolytic agent
DE4038563A1 (de) *	1990-12-04	1992-06-11	Gruenenthal Gmbh	Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
US5520912A (en) *	1993-07-02	1996-05-28	Immuno Aktiengesellschaft	Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
DE19518625C2 (de) *	1995-05-24	1997-08-07	Buescher Pebueso Beton	Verfahren zum Abdichten von Betonrohren und ein für die Durchführung des Verfahrens geeignetes Betonrohr
US6844315B2 (en)	1998-05-20	2005-01-18	Erasmus Universiteit Rotterdam	Immunoregulator
US8680059B2 (en)	1998-05-20	2014-03-25	Biotempt B.V.	Oligopeptide acetate and formulations thereof
US7175679B2 (en)	2001-03-29	2007-02-13	Biotempt B.V.	Oligopeptide treatment of NF-κB mediated inflammation
US20030220258A1 (en)	2001-12-21	2003-11-27	Robbert Benner	Treatment of ischemic events
EP1138692A1 (en)	2000-03-29	2001-10-04	Erasmus Universiteit Rotterdam	Fragments of human chorionic gonadotropin (hcg) as immunoregulator
US6921751B1 (en)	1998-05-20	2005-07-26	Erasmus Universiteit Rotterdam	Immunoregulator
EP1300418A1 (en)	2001-10-04	2003-04-09	Erasmus Universiteit Rotterdam	Gene regulation by oligopeptides
US7358330B2 (en)	2001-03-29	2008-04-15	Biotempt B.V.	Immunoregulatory compositions
USRE43279E1 (en)	2000-03-29	2012-03-27	Biotemp B.V.	Compositions capable of reducing elevated blood urea concentration
US7576174B2 (en)	2000-03-29	2009-08-18	Biotempt B.V.	Compositions capable of reducing elevated blood urea concentration
US7560433B2 (en)	2001-12-21	2009-07-14	Biotempt B.V.	Treatment of multiple sclerosis (MS)
US7786084B2 (en)	2001-12-21	2010-08-31	Biotempt B.V.	Treatment of burns
US7501391B2 (en)	2001-12-21	2009-03-10	Biotempt B.V.	Treatment of transplant survival
US7517529B2 (en)	2003-04-08	2009-04-14	Biotempt B.V.	Treatment of type I diabetes
CN101217971B (zh)	2005-07-05	2011-11-09	比奥滕普特公司	肿瘤的治疗
EP1864692A1 (en)	2006-06-07	2007-12-12	Biotempt B.V.	Use of peptides for the control of radiation injury
WO2011013668A1 (ja) *	2009-07-27	2011-02-03	国立大学法人新潟大学	虚血性イベントの治療用医薬品組成物
US8652476B2 (en)	2009-07-27	2014-02-18	Niigata University	Pharmaceutical composition for treating ischemic events
US10617756B2 (en)	2017-01-05	2020-04-14	Shimojani, LLC	Drug regimen for treatment of cerebral ischemia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8003402A (nl) *	1980-06-11	1982-01-04	Leuven Res & Dev Vzw	Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
EP0112122B1 (en) *	1982-12-14	1991-08-28	South African Inventions Development Corporation	Plasminogen activator
JPS59196824A (ja) *	1983-04-21	1984-11-08	Kowa Co	吸着防止剤
US4929444A (en) *	1985-05-28	1990-05-29	Burroughs Wellcome Co.	Low pH pharmaceutical formulation containing t-PA
CA1297008C (en) *	1985-05-28	1992-03-10	Michael D. Johnston	Aqueous parenteral solution of tissue-plasminogen activator
WO1987006831A1 (en) *	1986-05-15	1987-11-19	Emory University	Composition and method for treating a thrombus and embolus

1987
- 1987-05-11 GB GB8711058A patent/GB2194886B/en not_active Expired - Fee Related
- 1987-05-11 AU AU72704/87A patent/AU600724B2/en not_active Ceased
- 1987-05-11 DK DK237187A patent/DK237187A/da not_active Application Discontinuation
- 1987-05-11 BE BE8700510A patent/BE1001425A4/fr not_active IP Right Cessation
- 1987-05-11 IE IE121087A patent/IE59895B1/en not_active IP Right Cessation
- 1987-05-11 FR FR8706551A patent/FR2600895B1/fr not_active Expired - Lifetime
- 1987-05-11 NZ NZ220260A patent/NZ220260A/xx unknown
- 1987-05-11 SE SE8701921A patent/SE8701921L/xx unknown
- 1987-05-11 JP JP62114386A patent/JPH0680015B2/ja not_active Expired - Lifetime
- 1987-05-11 DE DE19873715662 patent/DE3715662A1/de active Granted
- 1987-05-11 LU LU86875A patent/LU86875A1/fr unknown
- 1987-05-11 CH CH1788/87A patent/CH672989A5/de not_active IP Right Cessation
- 1987-05-11 NL NL8701113A patent/NL8701113A/nl not_active Application Discontinuation

Also Published As

Publication number	Publication date
CH672989A5 (da)	1990-01-31
FR2600895A1 (fr)	1988-01-08
NL8701113A (nl)	1987-12-01
IE871210L (en)	1987-11-12
BE1001425A4 (fr)	1989-10-31
FR2600895B1 (fr)	1993-12-24
GB2194886B (en)	1990-04-25
AU600724B2 (en)	1990-08-23
SE8701921L (sv)	1987-11-13
GB2194886A (en)	1988-03-23
JPH0680015B2 (ja)	1994-10-12
DK237187D0 (da)	1987-05-11
DK237187A (da)	1987-11-13
AU7270487A (en)	1987-11-19
SE8701921D0 (sv)	1987-05-11
NZ220260A (en)	1990-07-26
DE3715662A1 (de)	1987-11-19
GB8711058D0 (en)	1987-06-17
IE59895B1 (en)	1994-04-20
JPS6322026A (ja)	1988-01-29

Publication	Publication Date	Title
BE1001425A4 (fr)	1989-10-31	Utilisation de l'activateur tissulaire du plasminogene, son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association.
AU607303B2 (en)	1991-02-28	Composition of anticoagulants
EP0115974B1 (fr)	1988-09-07	Préparation à activité collagénolytique ayant une activité élevée et compositions pharmaceutiques la contenant
FR2593393A1 (fr)	1987-07-31	Solution aqueuse a usage parenteral d'activateur tissulaire du plasminogene, procede pour la preparer et recipient obture la contenant
LU86444A1 (fr)	1986-12-05	Nouvelle compostion d'activateur tissulaire du plasminogene
HU224826B1 (en)	2006-02-28	Activated protein c formulations
FR2591485A1 (fr)	1987-06-19	Compositions stabilisees contenant l'activateur du plasminogene du tissu humain.
US4976959A (en)	1990-12-11	T-PA and SOD in limiting tissue damage
EP2268267B1 (en)	2017-06-14	Dry transglutaminase composition
US20110053851A1 (en)	2011-03-03	Haemostasis-modulating compositions and uses therefor
JPH0273022A (ja)	1990-03-13	組織プラスミノーゲン活性化因子を用いた薬学的製剤
FR2634125A1 (fr)	1990-01-19	Composition pharmaceutique a base de superoxyde dismutase
TW200529870A (en)	2005-09-16	Therapeutic use of factor XI
CA1282002C (en)	1991-03-26	Pharmaceutical composition comprising t-pa and oxypurinol
JP3227673B2 (ja)	2001-11-12	膵炎予防治療薬
FR2605225A1 (fr)	1988-04-22	Compositions pharmaceutiques a base d'urokinase
FR2495634A1 (fr)	1982-06-11	Enzyme nouvelle et utilisable en therapeutique
JPH05368B2 (da)	1993-01-05
JPH09143092A (ja)	1997-06-03	心筋梗塞予防治療剤
HK1081109B (en)	2007-09-07	Cardioprotective therapies based on enzymatic elimination of lipid peroxides by allene oxide synthase
HK1081109A1 (en)	2006-05-12	Cardioprotective therapies based on enzymatic elimination of lipid peroxides by allene oxide synthase
FR2538702A1 (fr)	1984-07-06	Preparation a activite collagenolytique ayant une activite elevee et compositions phamaceutiques la contenant

Legal Events

Date	Code	Title	Description
1987-05-11	DT	Application date
1991-06-13	TA	Annual fee