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LU79685A1 - Procede de preparation de nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et de compositions pharmaceutiques les contenant - Google Patents

Procede de preparation de nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et de compositions pharmaceutiques les contenant

Info

Publication number
LU79685A1
LU79685A1 LU79685A LU79685A LU79685A1 LU 79685 A1 LU79685 A1 LU 79685A1 LU 79685 A LU79685 A LU 79685A LU 79685 A LU79685 A LU 79685A LU 79685 A1 LU79685 A1 LU 79685A1
Authority
LU
Luxembourg
Prior art keywords
dextrogyres
hydantoins
isomers
preparation
new
Prior art date
Application number
LU79685A
Other languages
English (en)
Inventor
R Sarges
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of LU79685A1 publication Critical patent/LU79685A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
LU79685A 1977-05-23 1978-05-22 Procede de preparation de nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et de compositions pharmaceutiques les contenant LU79685A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/799,586 US4130714A (en) 1977-05-23 1977-05-23 Hydantoin therapeutic agents

Publications (1)

Publication Number Publication Date
LU79685A1 true LU79685A1 (fr) 1979-12-06

Family

ID=25176274

Family Applications (1)

Application Number Title Priority Date Filing Date
LU79685A LU79685A1 (fr) 1977-05-23 1978-05-22 Procede de preparation de nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et de compositions pharmaceutiques les contenant

Country Status (37)

Country Link
US (1) US4130714A (fr)
JP (1) JPS6035350B2 (fr)
AR (1) AR219531A1 (fr)
AT (1) AT357170B (fr)
AU (1) AU499518B1 (fr)
BE (1) BE867248A (fr)
CA (1) CA1088073A (fr)
CH (1) CH631455A5 (fr)
CS (1) CS200550B2 (fr)
DD (1) DD137107A5 (fr)
DE (2) DE2821966C2 (fr)
DK (1) DK147941C (fr)
EG (1) EG13691A (fr)
ES (1) ES470070A1 (fr)
FI (1) FI62838C (fr)
FR (1) FR2392024A1 (fr)
GB (1) GB1572688A (fr)
GR (1) GR68694B (fr)
HK (1) HK53981A (fr)
HU (1) HU177718B (fr)
IE (1) IE47273B1 (fr)
IL (1) IL54754A (fr)
IN (1) IN147854B (fr)
IT (1) IT1096306B (fr)
KE (1) KE3168A (fr)
LU (1) LU79685A1 (fr)
MY (1) MY8200156A (fr)
NL (1) NL7804158A (fr)
NO (1) NO150206C (fr)
NZ (1) NZ187334A (fr)
PH (1) PH13828A (fr)
PL (1) PL110460B1 (fr)
PT (1) PT68071B (fr)
SE (1) SE437375B (fr)
SU (1) SU873885A3 (fr)
YU (1) YU40829B (fr)
ZA (1) ZA782919B (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
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CA1088945A (fr) * 1976-10-18 1980-11-04 Pfizer Limited Derives de l'hydantoine utilises comme agents therapeutiques
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4210667A (en) * 1979-04-19 1980-07-01 Pfizer Inc. Pharmaceutical preparations containing coumarin carboxylic acid derivatives
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
US4419521A (en) * 1981-11-12 1983-12-06 Pfizer Inc. 6-Halo-4-chromanamines useful as intermediates to make chiral hydantoins
JPS58124788A (ja) * 1982-01-20 1983-07-25 Eisai Co Ltd 光学活性ヒダントイン誘導体，その製造方法ならびにそれを含有する治療用薬剤
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4436745A (en) 1982-04-15 1984-03-13 Alcon Laboratories, Inc. Method of inhibiting aldose reductase activity
US4438272A (en) 1982-04-15 1984-03-20 Alcon Laboratories, Inc. Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
US4431828A (en) * 1982-11-10 1984-02-14 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil
US4528387A (en) * 1982-11-10 1985-07-09 Pfizer Inc. Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid
US4435578A (en) 1982-11-10 1984-03-06 Pfizer Inc. Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid
US4556670A (en) * 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
EP0159143B1 (fr) * 1984-03-23 1987-12-16 Pfizer Inc. Spiro-indènes et spiro-dihydro-1,2-naphtalènes pour le traitement de complications diabétiques
US4717725A (en) * 1984-04-11 1988-01-05 Alcon Laboratories, Inc. Ophthalmic wound healing with aldose reductase inhibitors
US4600717A (en) * 1984-04-11 1986-07-15 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in ophthalmic wound healing
JPH06772B2 (ja) * 1984-07-09 1994-01-05 鐘淵化学工業株式会社 ３―（４―フルオロフエノキシ）プロピオニトリルを用いる６―フルオロ―４―クロマノンの製造法
US4680306A (en) * 1984-07-20 1987-07-14 Pfizer Inc. Sprio-imidazolones for treatment of diabetes complications
US4656169A (en) * 1984-08-14 1987-04-07 Pfizer Inc. Tetracyclic spiro-hydantoin aldose reductase inhibitors and compositions
ATE37371T1 (de) * 1984-08-20 1988-10-15 Pfizer Verfahren zur herstellung asymmetrischer hydantoine.
US4620019A (en) * 1984-08-23 1986-10-28 Pfizer Inc. S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
US4551542A (en) * 1984-09-26 1985-11-05 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
WO1986007353A1 (fr) 1985-06-14 1986-12-18 Pfizer Inc. Produit intermediaire utilise dans la producton d'hydantoines asymetriques
JPS627654U (fr) * 1985-06-26 1987-01-17
WO1987004344A1 (fr) * 1986-01-17 1987-07-30 Pfizer Inc. Derives de l'acide hydroxyacetique pour le traitement de complications diabetiques
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
WO1988006887A1 (fr) * 1987-03-20 1988-09-22 Alcon Laboratories, Inc. Utilisation d'inhibiteurs de la reductase aldose afin d'augmenter la sensibilite a l'insuline chez des personnes souffrant de diabetes mellitus
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US4952694A (en) * 1988-07-27 1990-08-28 Pfizer Inc. Novel resolution process for racemic spiro-hydantoins
US5006657A (en) * 1988-07-27 1991-04-09 Pfizer Inc. Intermediates in a resolution process for racemic spiro hydantoins
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
WO1992000071A1 (fr) * 1989-02-10 1992-01-09 Washington Research Foundation Agents immunoregulateurs
US4980357A (en) * 1990-03-01 1990-12-25 Pfizer Inc. Azolidinedione derivatives
US5039672A (en) * 1990-04-05 1991-08-13 Pfizer Inc. Heterocyclic compounds as aldose reductase inhibitors
US5236945A (en) * 1990-06-11 1993-08-17 Pfizer Inc. 1H-indazole-3-acetic acids as aldose reductase inhibitors
US5206367A (en) * 1992-02-18 1993-04-27 Pfizer Inc. Preparation of optically active spiro-hydantoins
NZ254550A (en) * 1992-09-28 1997-08-22 Pfizer Use of nitrogen-substituted pyrimidines to prepare medicaments useful for treatment or prevention of diabetic complications
US5521208A (en) * 1993-07-29 1996-05-28 Alcon Laboratories, Inc. Compositions and methods for the treatment of the metabolically impaired and for improved compliance
GEP20022788B (en) * 1997-04-15 2002-09-25 Csir Za Pharmaceutical Compositions Having Appetite Suppressant Activity
GB2355657B (en) * 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
JP2004514700A (ja) 2000-11-30 2004-05-20 ファイザー・プロダクツ・インク Ｇａｂａアゴニスト及びアルドース還元酵素阻害剤の組み合わせ
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
US8158667B2 (en) 2006-08-21 2012-04-17 Kador Peter F Topical treatment of cataracts in dogs
EP2368560A1 (fr) 2007-03-12 2011-09-28 Zadec ApS Extrait de rooibos anti-diabétique
AU2008230949B2 (en) 2007-03-23 2013-05-30 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibitors
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
EP2654749B1 (fr) 2010-12-23 2017-05-10 The Board of Regents of The University of Texas System Méthodes de traitement de copd
UA118035C2 (uk) * 2013-10-07 2018-11-12 Сінгента Партісіпейшнс Аг Гербіцидні сполуки
US12090142B2 (en) 2018-02-22 2024-09-17 Board Of Regents, The University Of Texas System Combination therapy for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683718A (en) * 1952-01-11 1954-07-13 Searle & Co Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
CA1088945A (fr) * 1976-10-18 1980-11-04 Pfizer Limited Derives de l'hydantoine utilises comme agents therapeutiques

Also Published As

Publication number Publication date
CH631455A5 (fr) 1982-08-13
SE437375B (sv) 1985-02-25
GR68694B (fr) 1982-02-01
AR219531A1 (es) 1980-08-29
SE7803626L (sv) 1978-11-24
GB1572688A (en) 1980-07-30
ZA782919B (en) 1979-06-27
IL54754A (en) 1982-04-30
ES470070A1 (es) 1979-01-01
DK147941B (da) 1985-01-14
DE2821966A1 (de) 1978-11-30
IE47273B1 (en) 1984-02-08
CS200550B2 (en) 1980-09-15
FI781613A7 (fi) 1978-11-24
NL7804158A (nl) 1978-11-27
IN147854B (fr) 1980-07-19
IT7823672A0 (it) 1978-05-22
AU499518B1 (en) 1979-04-26
DK226778A (da) 1978-11-24
ATA365378A (de) 1979-11-15
YU116978A (en) 1983-02-28
YU40829B (en) 1986-06-30
FI62838C (fi) 1983-03-10
MY8200156A (en) 1982-12-31
PT68071A (en) 1978-06-01
SU873885A3 (ru) 1981-10-15
FR2392024B1 (fr) 1981-07-24
FR2392024A1 (fr) 1978-12-22
JPS53144575A (en) 1978-12-15
KE3168A (en) 1981-11-06
PL110460B1 (en) 1980-07-31
NO150206C (no) 1984-09-05
CA1088073A (fr) 1980-10-21
DE2858042C2 (de) 1983-11-24
NO150206B (no) 1984-05-28
IT1096306B (it) 1985-08-26
PH13828A (en) 1980-10-07
FI62838B (fi) 1982-11-30
HU177718B (en) 1981-12-28
PL206826A1 (pl) 1979-04-23
IL54754A0 (en) 1978-07-31
IE781015L (en) 1978-11-23
DE2821966C2 (de) 1983-06-01
PT68071B (en) 1979-10-26
NO781769L (no) 1978-11-24
DK147941C (da) 1985-08-26
HK53981A (en) 1981-11-13
JPS6035350B2 (ja) 1985-08-14
DD137107A5 (de) 1979-08-15
US4130714A (en) 1978-12-19
AT357170B (de) 1980-06-25
EG13691A (en) 1982-12-31
NZ187334A (en) 1984-04-27
BE867248A (fr) 1978-11-20

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