LU102656B1 - Liquid food supplement for immune stimulation, process for its production and use - Google Patents

Abstract

The invention relates to a liquid food supplement for immune stimulation, which has the following ingredients: - terpene hydrocarbons from a cypress plant (Cupressaceae) boiled in water, - gentiobiosis and/or bitter substances, in particular gentianopicrin and/or amarogentin, from subterranean components of a gentian plant (Gentianaceae) boiled in water . The inventors have found through experiments on 30 people who were undergoing chemotherapy for cancer that a drinkable infusion beverage containing the herbal substances according to claim 1 advantageously stimulates the immune system, whereby a rapid recovery of the patients could be brought about.

Description

a rile see an sx wa LU102656 N 8 Mert Description: ProSecur GmbH, 60329 Frankfurt (Germany) "Liquid food supplement for use in immune stimulation, method for its production and use" The invention relates to a liquid food supplement for use in immune stimulation, the following contains: - terpene hydrocarbons from juniper (Juniperus communis) boiled in water, - gentiobiosis and/or bitter substances, in particular gentianopicrin and/or amarogentin, from subterranean components of yellow gentian (Gentiana lutea) boiled in water. The invention also relates to a method for producing such a food supplement and its use.

ı5 DE 69837474 T2 discloses a composition that can be used to treat viral diseases such as HIV or herpes. The composition includes a nutrient and a botanical extract obtained from Gentiana or Juniperus.

DE 10 2006 006 532 A1 discloses a pharmaceutical composition based on microtablets, which is particularly easy to dose and of which at least one microtablet can contain juniper (Juniperus) or gentian (Gentiana lutea).

EP 0621 777 B1 describes a production process for active substance pellets, in which lipophilic substances can be added without the addition of emulsifiers. One of these substances is juniper oil.

EP 1 236 466 A1 discloses a bioadhesive, antiviral composition which can adhere to oral mucosal tissue and which has a natural substance such as juniper berry oil or gentian from the Gentianaceae plant family for treating fungal infections.

WO 2018/083115 A1 discloses a herbal antimicrobial composition which has dried Juniperus communis or Gentiana lutea as ingredients. Page 1/6

EP 1 228 769 A1 discloses a regenerative drug for natural infection-immunological therapy which LU102656 contains a plant extract from juniper, gentian or pine in addition to a microorganism component.

None of the known compositions causes a stimulation of a person's immune system through purely vegetable substances. It is not known from any of the known compositions that these can be produced by boiling plant components in water in the manner of an infusion beverage.

AU 2015249035 A1 describes a composition for the treatment of liver diseases. This composition contains, inter alia, an extract from a plant of the genus Juniperus and an extract from a plant of the genus Gentiana. The examples of this reference show different proportions of the components of the compositions.

CN 105 456 616, CN 104 173 965 and CN 104 888 060 each describe traditional Chinese medicinal compositions containing plants of the genera Gentiana and Juniperus.

The object of the invention is to create a natural and drinkable food supplement whose ingredients stimulate the immune system. Furthermore, the invention is based on the object of creating a food supplement that can be used as a support, ie as a supplement to drug therapy. According to the invention, the object is achieved in that the food supplement contains essential oils from mountain pine (Pinus Mugo).

Yellow Gentian (Gentiana Lutea) is readily available worldwide. The essential oils of the mountain pine, from which mountain pine oil can be obtained by steam distillation, are known for internal use in catarrhs.

The inventors found through tests on 30 people who were undergoing chemotherapy for cancer that a potable infusion beverage containing the herbal substances according to claim 1 advantageously stimulates the immune system, thereby bringing about a rapid recovery of the patients could become. In some cases, recovery was twice as fast as predicted by physicians and as would have been expected without the dietary supplement of the present invention.

Page 2/6

Surprisingly, the effect of this mixture went far beyond the sum of the individual healing LU102656 effects for which cypress plants such as the common juniper (Juniperus communis) or the yellow gentian (Gentiana lutea) are known. It is assumed that an interaction of these two components triggers an immune reaction that supports chemotherapy, ie the body's self-healing powers are activated. Because the plants or at least parts of them are boiled in water, simple production is possible. The inventors have found that it does not matter whether the plants or their parts are dried or freshly cut.

It is conceivable that the plants or parts thereof are chopped up or used in the form of chaff or pellets. For the preparation, the plants or parts thereof are boiled in water at, for example, ı5 100° C. for 10 to 40 minutes, preferably 30 minutes. After cooling to a temperature of <60° C., the plants or parts thereof are decanted or seven removed. The remaining liquid forms the dietary supplement and can be used warm or cold.

Gentiobiose is a disaccharide, while gentianopicrin and/or amarogentin are bitter substances that are found to a particularly high degree in the subterranean components of yellow gentian, i.e. the roots. These bitter substances can stimulate the production of gastric juice, salivary secretion and bile.

The terpene hydrocarbons, in particular terpene alcohols, preferably terpinen-4-ol, α-pinene and/or β-pinene, are expediently obtained from a fruit, needles and/or scale leaves of the common juniper (Juniperus communis). The essential oil contained in common juniper, especially its fruits, has a high proportion of a-pinene and/or ß-pinene. a-pinene alone is said to have an anti-inflammatory or in vitro antimicrobial effect. At low doses, a-pinene alone has a bronchospasmolytic effect. Terpinen-4-ol has been shown to have an aquaretic effect on its own.

In a further embodiment of the invention, the essential oils of the mountain pine (Pinus Mugo) are obtained by boiling branches, needles and/or cones of the mountain pine in water. Boiling the branches, needles and/or cones ensures that an adequate amount of essential oils is extracted. It is preferable to use needles Page 3/6 and/or branches, which can be in the form of chaff or pellets. The food supplement expediently contains linoleic acid, which is obtained in particular by boiling fruits, branches and/or needles of a pine tree, preferably a pine tree, in water. The pine belongs to the pine genus (Pinus) and the pine family (Pinaceae). Linoleic acid is converted in the human body via the intermediate product a-linolenic acid into dihomogammalinolenic acid and arachidonic acid, with the former being anti-inflammatory and the latter being pro-inflammatory. The inventors assume that the further components of a food supplement according to the invention result in a shift in the conversion of linoleic acid in favor of arachdonic acid, as a result of which a special immune reaction is triggered. This is supported by the fact that people complained about nausea after taking the dietary supplement on the following day, which gave way to a particularly good general physical condition from the ı5 second day after taking it.

In one embodiment of the invention, the food supplement is a decoction, for the production of which solid, in particular dried, parts of plants are boiled in the water and removed after cooling. A simple preparation in the manner of a tea is advantageously possible.

Appropriately, the dietary supplement is purely herbal. Synthetically derived substances are not used, a dietary supplement suitable for vegans is created. In one embodiment of the invention, the vegetable content is between 0.001% by weight and 5% by weight, preferably between 0.002% by weight and 1.0% by weight. These values relate to the weight fraction in the consumable composition after the solid plant matter has been thus removed from the water in which it was cooked. It has been found to be particularly effective when the proportions of the individual plant components are the same and total between 0.05 and 0.25% by weight. The food supplement expediently has terpene hydrocarbons, gentiobiose and/or bitter substances, the essential oils of mountain pine (Pinus Mugo), linoleic acid and a natural resin in the same proportion. The inventors were able to determine the best results in the immune stimulation of patients undergoing chemotherapy with these proportions, LU102656, which were 0.03% by weight per proportion.

In one embodiment of the invention, the food supplement according to the invention consists exclusively of water and the substances from branches, blossoms and/or leaves or

Needles of the yellow gentian (Gentiana Lutea), the common juniper (Juniperus communis), the mountain pine (Pinus Mugo), a pine and the resin of a conifer.

The invention is explained in more detail below using exemplary embodiments.

Example 1—a composition not according to the invention: 600 g of chopped, dried roots of yellow gentian (Gentiana lutea) and 600 g of a chopped mixture of blossoms and branches of common juniper (Juniperus communis) are divided into 2 μl Boiled water at 100°C for 30 min.

After cooking, the liquid is cooled down to 55°C and the botanicals are strained out.

The remaining fluid is given to several chemotherapy patients at a dose of 200 ml per week for 5 consecutive weeks.

Subjectively, after 4 days, a good feeling of well-being appeared, which lasted until the end of the chemotherapy.

This liquid contained 0.025% by weight of terpinen-4-ol and 0.03% by weight of amarogen.

Also 0.04% by weight of a-pinene.

Example 2:

600 g of chopped, dried roots of yellow gentian (Gentiana Lutea), 600 g of a chopped mixture of flowers and branches of common juniper (Juniperus communis) and 600 g of crushed fresh needles and pine cones of mountain pine (Pinus Mugo). into 2 | Boiled water at 100°C for 25 min.

After cooking, the liquid is cooled down to 55 °C and the plant substances are strained out.

The remaining fluid is given to several chemotherapy patients at a dose of 200 ml per week for 5 consecutive weeks.

Subjectively, after 4 days, a good feeling of well-being appeared, which lasted until the end of the chemotherapy.

This liquid contained 0.022% by weight of terpinen-4-ol, 0.037% by weight of amarogen and 0.029% by weight of mountain pine oil.

Also 0.036% by weight of a-pinene.

Page 5/6

Example 3: LU102656 600 g of fresh yellow gentian (Gentiana Lutea) roots, 600 g of a chopped mixture of flowers and branches of common juniper (Juniperus communis), 600 g of crushed fresh needles and pine cones of mountain pine (Pinus Mugo) and 500 g of dried fruit and needles of a pine in 2 | Boiled water at 100 °C for 35 min. After cooking, the liquid is cooled down to 55 °C and the plant matter is strained out. The remaining fluid is given to several chemotherapy patients at a dose of 200 ml per week for 5 consecutive weeks. Subjectively, after 3 days, a good feeling of well-being appeared, which lasted until the end of the chemotherapy. This liquid contained 0.025% by weight terpinen-4-ol, 0.033% by weight amarogen, 0.027% by weight mountain pine oil and 0.031% by weight linosic acid.

Example 4: 800 g of a mixture of dried flowers and roots of yellow gentian (Gentiana Lutea), 800 g of a chopped mixture of dried flowers and branches of common juniper (Juniperus communis), 700 g of crushed fresh needles and pine cones of mountain pine ( Pinus Mugo), 600 g dried pine fruits and needles and 100 g dried spruce resin in 3 | Boiled water at 100°C for 30 min. After boiling, the liquid is cooled down to 60 °C and the solid parts of the plant are sieved off. The remaining fluid is given to several chemotherapy patients at a dose of 200 ml per week for 5 consecutive weeks. Subjectively, more than half of the users felt well after just 2 days, which lasted until the end of the chemotherapy. Recovery was on average 20% quicker than predicted by treating physicians. This liquid contained 0.03% by weight terpinen-4-ol, 0.03% by weight amarogen, 0.03% by weight mountain pine oil, 0.03% by weight linosic acid and 0.03% by weight -% resin. It goes without saying that all combinations of the compositions shown in Examples 2 to 4 are conceivable. Page 6/6

Claims (13)

Patent claims: LU102656 1. Liquid food supplement for use in stimulating the immune system, containing the following ingredients: - terpene hydrocarbons from juniper (Juniperus communis) boiled in water, - gentiobiosis and/or bitter substances, in particular gentianopicrin and/or amarogentin, from boiled in water underground components of yellow gentian (Gentiana Lutea), characterized in that the food supplement contains essential oils of mountain pine (Pinus Mugo). 2. Dietary supplement according to claim 1, characterized in that the terpene hydrocarbons, in particular terpene alcohols, preferably terpinen-4-ol, α-pinene and/or β-pinene, from a fruit, leaves and/or scaly leaves of common juniper (Juniperus communis) are obtained. 3. Dietary supplement according to claim 1 or 2, characterized in that the essential oils of the mountain pine (Pinus Mugo) are obtained by boiling branches, needles and/or cones of the mountain pine in water. 4. Dietary supplement according to one of Claims 1 to 3, characterized in that the dietary supplement contains linoleic acid, which is obtained in particular by boiling fruits, branches and/or needles of a pine tree, preferably a pine tree, in water. 5. Dietary supplement according to one of claims 1 to 4, characterized in that the dietary supplement has a natural resin, in particular the resin of a coniferous tree. 6. Dietary supplement according to one of claims 1 to 5, page 1/3 characterized in that the dietary supplement is a LU102656 brew, for the production of which solid, in particular dried, parts of plants are boiled in the water and removed after cooling. 7. Dietary supplement according to one of claims 1 to 6, characterized in that the dietary supplement is purely vegetable. 8. Dietary supplement according to one of claims 1 to 7, characterized in that the vegetable content is between 0.001% by weight and 5% by weight, preferably between 0.002% by weight and 1.0% by weight. 9. Dietary supplement according to one of Claims 1 to 8, characterized in that the dietary supplement contains terpene hydrocarbons, gentiobiosis and/or bitter substances, the essential oils of mountain pine (Pinus Mugo), linoleic acid and a natural resin in the same proportion. 10. A process for the manufacture of an aqueous food supplement for use in immunostimulation according to any one of claims 1 to 9, wherein plant parts are boiled in water and, after cooling, are removed by decantation or sieving. 11. The method according to claim 10, characterized in that an equal amount of fruit, branches and/or leaves of common juniper (Juniperus communis) and yellow gentian (Gentiana Lutea) are boiled in the water. 12. The method according to claim 10, characterized in that an equal amount of a fruit, from branches and / or leaves of the common juniper (Juniperus communis), the yellow gentian (Gentiana Lutea), a pine Page 2/3 fer, preferably one pine, and a vegetable resin in which water is boiled LU102656. 13. Use of a liquid dietary supplement according to any one of claims 1 to 9, which can be produced or produced using a method according to any one of claims 10 to 12, for use in stimulating the immune system of a human, in particular a human suffering from a tumor disease. Page 3/3