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LT4159204T - Nauja farmacinė kompozicija - Google Patents

Nauja farmacinė kompozicija

Info

Publication number
LT4159204T
LT4159204T LTEP22209104.3T LT22209104T LT4159204T LT 4159204 T LT4159204 T LT 4159204T LT 22209104 T LT22209104 T LT 22209104T LT 4159204 T LT4159204 T LT 4159204T
Authority
LT
Lithuania
Prior art keywords
pharmaceutical composition
novel pharmaceutical
novel
composition
pharmaceutical
Prior art date
Application number
LTEP22209104.3T
Other languages
English (en)
Inventor
Douglas DEMARINI
Ngocdiep T. Le
Francisco HENRIQUEZ
Lihong Wang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46314827&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4159204(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of LT4159204T publication Critical patent/LT4159204T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2813Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTEP22209104.3T 2010-12-20 2011-12-20 Nauja farmacinė kompozicija LT4159204T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061424967P 2010-12-20 2010-12-20

Publications (1)

Publication Number Publication Date
LT4159204T true LT4159204T (lt) 2024-05-10

Family

ID=46314827

Family Applications (3)

Application Number Title Priority Date Filing Date
LTEP22209104.3T LT4159204T (lt) 2010-12-20 2011-12-20 Nauja farmacinė kompozicija
LTEP11849974.8T LT2654736T (lt) 2010-12-20 2011-12-20 Nauja farmacinė kompozicija
LTEP22209107.6T LT4159205T (lt) 2010-12-20 2011-12-20 Nauja farmacinė kompozicija

Family Applications After (2)

Application Number Title Priority Date Filing Date
LTEP11849974.8T LT2654736T (lt) 2010-12-20 2011-12-20 Nauja farmacinė kompozicija
LTEP22209107.6T LT4159205T (lt) 2010-12-20 2011-12-20 Nauja farmacinė kompozicija

Country Status (38)

Country Link
US (5) US8580304B2 (lt)
EP (4) EP2654736B1 (lt)
JP (2) JP6126014B2 (lt)
KR (1) KR101911109B1 (lt)
CN (1) CN103998041B (lt)
AR (2) AR084102A1 (lt)
AU (1) AU2011349422B2 (lt)
BR (1) BR112013015602B1 (lt)
CA (1) CA2822701C (lt)
CL (1) CL2013001779A1 (lt)
CR (1) CR20130352A (lt)
CY (1) CY1123376T1 (lt)
DK (3) DK4159205T3 (lt)
DO (1) DOP2013000138A (lt)
EA (1) EA025198B1 (lt)
ES (3) ES2985024T3 (lt)
FI (2) FI4159204T3 (lt)
HR (3) HRP20240563T1 (lt)
HU (3) HUE066525T2 (lt)
IL (1) IL226855A (lt)
JO (1) JO3594B1 (lt)
LT (3) LT4159204T (lt)
MA (1) MA34883B1 (lt)
MX (1) MX2013007073A (lt)
MY (1) MY170501A (lt)
NZ (1) NZ612157A (lt)
PE (1) PE20140040A1 (lt)
PH (1) PH12013501209A1 (lt)
PL (3) PL4159205T3 (lt)
PT (3) PT4159205T (lt)
RS (2) RS65497B1 (lt)
SG (1) SG191054A1 (lt)
SI (3) SI4159205T1 (lt)
TW (1) TWI505828B (lt)
UA (1) UA113158C2 (lt)
UY (1) UY33818A (lt)
WO (1) WO2012088033A2 (lt)
ZA (1) ZA201304189B (lt)

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TWI505828B (zh) 2010-12-20 2015-11-01 葛蘭素史克智慧財產(第二)有限公司 新穎醫藥組成物
KR20240146112A (ko) 2012-08-17 2024-10-07 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
SG11201503688SA (en) * 2012-11-30 2015-06-29 Glaxosmithkline Llc Novel pharmaceutical composition
WO2015019125A1 (en) * 2013-08-05 2015-02-12 Societe De Developpement Et De Recherche Industrielle Molecular targets for the treatment of wounds, in particular chronic wounds
CN103819471A (zh) * 2013-11-25 2014-05-28 镇江圣安医药有限公司 吡啶并(4,3-d)嘧啶-1(2H)-基苯基乙酰胺的衍生物及其应用
CN104918937B (zh) * 2013-12-06 2016-09-14 杭州普晒医药科技有限公司 曲美替尼及其溶剂化物的晶型、其制备方法、含有它们的药物组合物及其用途
EP2913048A1 (en) 2014-02-27 2015-09-02 ratiopharm GmbH Pharmaceutical composition comprising trametinib
WO2016126012A1 (en) * 2015-02-05 2016-08-11 Boryung Pharmaceutical Co., Ltd Tablet and method of preparing the same
KR101545268B1 (ko) 2015-02-05 2015-08-20 보령제약 주식회사 정제 및 이의 제조방법
US20170020880A1 (en) * 2015-07-22 2017-01-26 Hetero Research Foundation Pharmaceutical compositions of trametinib
CN116172869A (zh) * 2016-08-10 2023-05-30 豪夫迈·罗氏有限公司 包含Akt蛋白激酶抑制剂的药物组合物
RU2627692C1 (ru) 2016-10-10 2017-08-10 Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") N-{ 3-[3-циклопропил-5-(2-фторо-4-иодофениламино)-6,8-диметил-2,4,7-триоксо-3,4,6,7-тетрагидро-2Н-пиридо[4,3-d]пиримидин-1-ил]-фенил} -циклопропанкарбоксамида диметилсульфоксида сольват в качестве ингибитора МЕК1/2
CN108778281B (zh) * 2016-11-25 2021-09-03 江苏恒瑞医药股份有限公司 一种吡啶酮类衍生物药物组合物及其制备方法
TWI798218B (zh) 2017-05-02 2023-04-11 瑞士商諾華公司 組合療法
MX2021013817A (es) 2019-05-13 2021-12-14 Novartis Ag Nuevas formas cristalinas de n-(3-(2-(2-hidroxietoxi)-6-morfolinop iridin-4-il)-4-metilfenil)-2-(trifluorometil)isonicotinamida como inhibidores de raf para el tratamiento del cancer.
MX2022000492A (es) * 2019-07-11 2022-07-04 Praxis Prec Medicines Inc Formulaciones de moduladores de canal de calcio tipo t y metodos de uso de estos.
EP4007585A4 (en) 2019-08-02 2023-11-08 OneHealthCompany, Inc. TREATMENT OF CANINE CANCERS
RU2749719C1 (ru) * 2020-10-08 2021-06-16 Нестерук Владимир Викторович Препарат для лечения анемии, связанной с хроническим заболеванием почек, и способ его получения
WO2023105286A1 (en) 2021-12-06 2023-06-15 My Personal Therapeutics Ltd A combination treatment for cancer
WO2024171019A1 (en) * 2023-02-13 2024-08-22 Alembic Pharmaceuticals Limited Pharmaceutical composition of trametinib and process of preparation thereof
WO2025132408A2 (en) 2023-12-21 2025-06-26 Synthon B.V. Solvates of trametinib

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Also Published As

Publication number Publication date
IL226855A (en) 2017-04-30
PH12013501209A1 (en) 2013-07-29
SI4159205T1 (sl) 2024-06-28
TW201249441A (en) 2012-12-16
DK4159205T3 (da) 2024-05-13
AR084102A1 (es) 2013-04-24
EP2654736A4 (en) 2015-04-22
RS65497B1 (sr) 2024-06-28
SG191054A1 (en) 2013-08-30
US20140154316A1 (en) 2014-06-05
SI2654736T1 (sl) 2020-10-30
HUE066525T2 (hu) 2024-08-28
FI4159204T3 (fi) 2024-04-22
DK2654736T3 (da) 2020-09-14
US9155706B2 (en) 2015-10-13
US8580304B2 (en) 2013-11-12
ES2985024T3 (es) 2024-11-04
AR122185A2 (es) 2022-08-24
PL2654736T3 (pl) 2020-12-14
NZ612157A (en) 2015-05-29
AU2011349422A1 (en) 2013-05-02
CN103998041A (zh) 2014-08-20
SI4159204T1 (sl) 2024-06-28
EP3808343A1 (en) 2021-04-21
US20130266649A1 (en) 2013-10-10
EP2654736A2 (en) 2013-10-30
US9399021B2 (en) 2016-07-26
ZA201304189B (en) 2014-02-26
DK4159204T3 (da) 2024-05-21
EP2654736B1 (en) 2020-07-01
CN103998041B (zh) 2016-08-17
CY1123376T1 (el) 2021-12-31
KR20130130028A (ko) 2013-11-29
UY33818A (es) 2012-07-31
EP4159204A1 (en) 2023-04-05
JO3594B1 (ar) 2020-07-05
PT4159204T (pt) 2024-05-07
CA2822701A1 (en) 2012-06-28
KR101911109B1 (ko) 2018-10-23
PT2654736T (pt) 2020-09-24
MA34883B1 (fr) 2014-02-01
WO2012088033A3 (en) 2014-03-13
HUE050788T2 (hu) 2021-01-28
US9271941B2 (en) 2016-03-01
PL4159204T3 (pl) 2024-07-01
HRP20240564T1 (hr) 2024-09-27
JP6126014B2 (ja) 2017-05-10
HRP20201409T1 (hr) 2020-11-27
LT4159205T (lt) 2024-05-10
LT2654736T (lt) 2020-09-25
UA113158C2 (xx) 2016-12-26
AU2011349422B2 (en) 2015-12-10
BR112013015602B1 (pt) 2022-03-03
JP2017137299A (ja) 2017-08-10
EA201390913A1 (ru) 2014-04-30
CR20130352A (es) 2013-12-18
RS65496B1 (sr) 2024-06-28
US20120183613A1 (en) 2012-07-19
MX2013007073A (es) 2013-09-26
EP4159205A1 (en) 2023-04-05
TWI505828B (zh) 2015-11-01
EP4159205B1 (en) 2024-02-14
MY170501A (en) 2019-08-08
EA025198B1 (ru) 2016-11-30
HRP20240563T1 (hr) 2024-08-16
CA2822701C (en) 2018-10-23
DOP2013000138A (es) 2013-11-30
HUE066526T2 (hu) 2024-08-28
WO2012088033A2 (en) 2012-06-28
FI4159205T3 (fi) 2024-04-23
EP4159204B1 (en) 2024-02-14
BR112013015602A2 (pt) 2017-02-21
ES2982775T3 (es) 2024-10-17
ES2820536T3 (es) 2021-04-21
PL4159205T3 (pl) 2024-06-24
US20140037726A1 (en) 2014-02-06
US20140099365A1 (en) 2014-04-10
PE20140040A1 (es) 2014-02-26
PT4159205T (pt) 2024-05-08
JP2014510704A (ja) 2014-05-01
CL2013001779A1 (es) 2014-06-27

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