LT4008721T - Borono esterio ir rūgšties junginių sintezė - Google Patents

Borono esterio ir rūgšties junginių sintezė

Info

Publication number: LT4008721T
Authority: LT; Lithuania
Prior art keywords: synthesis; acid compounds; boronic ester; boronic; ester
Prior art date: 2004-03-30

Application number

LTEP21197526.3T

Other languages

English (en)

Inventor

Fraser I. Pickersgill

John Bishop

Young Lo

Fang-Ting Chui

Vithalanand R. Kulkarni

Original Assignee

Millennium Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-30

Filing date

2005-03-24

Publication date

2024-03-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34968044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4008721(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-03-24 Application filed by Millennium Pharmaceuticals, Inc. filed Critical Millennium Pharmaceuticals, Inc.

2024-03-25 Publication of LT4008721T publication Critical patent/LT4008721T/lt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Virology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Tropical Medicine & Parasitology (AREA)
Transplantation (AREA)
AIDS & HIV (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)

LTEP21197526.3T 2004-03-30 2005-03-24 Borono esterio ir rūgšties junginių sintezė LT4008721T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US55753504P	2004-03-30	2004-03-30

Publications (1)

Publication Number	Publication Date
LT4008721T true LT4008721T (lt)	2024-03-25

Family

ID=34968044

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEP21197526.3T LT4008721T (lt)	2004-03-30	2005-03-24	Borono esterio ir rūgšties junginių sintezė
LTEP18172486.5T LT3385267T (lt)	2004-03-30	2005-03-24	Borono rūgšties esterio ir rūgšties junginių sintezė

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LTEP18172486.5T LT3385267T (lt)	2004-03-30	2005-03-24	Borono rūgšties esterio ir rūgšties junginių sintezė

Country Status (41)

Country	Link
US (14)	US7714159B2 (lt)
EP (5)	EP2377868A1 (lt)
JP (4)	JP4558039B2 (lt)
KR (1)	KR100939598B1 (lt)
CN (5)	CN111925385B (lt)
AR (3)	AR049374A1 (lt)
AT (1)	ATE521612T1 (lt)
AU (1)	AU2005230930B2 (lt)
BR (1)	BRPI0509587A (lt)
CA (4)	CA2738706C (lt)
CL (2)	CL2010000350A1 (lt)
CR (1)	CR8653A (lt)
CY (3)	CY1112053T1 (lt)
DK (4)	DK3385267T3 (lt)
DO (1)	DOP2011000293A (lt)
EA (1)	EA012927B1 (lt)
EC (1)	ECSP066960A (lt)
ES (4)	ES2371652T3 (lt)
FI (1)	FI4008721T3 (lt)
HK (1)	HK1246300A1 (lt)
HR (4)	HRP20212002T1 (lt)
HU (2)	HUE065769T2 (lt)
IL (3)	IL178250A (lt)
LT (2)	LT4008721T (lt)
ME (1)	ME01975B (lt)
MX (1)	MX367324B (lt)
MY (1)	MY145427A (lt)
NL (3)	NL1028639C2 (lt)
NO (4)	NO338905B1 (lt)
NZ (3)	NZ598172A (lt)
PE (3)	PE20060162A1 (lt)
PL (4)	PL3385267T3 (lt)
PT (4)	PT1756121E (lt)
RS (4)	RS65253B1 (lt)
SG (5)	SG10201600029PA (lt)
SI (4)	SI2377869T1 (lt)
TW (1)	TWI386212B (lt)
UA (1)	UA90108C2 (lt)
UY (3)	UY28830A1 (lt)
WO (1)	WO2005097809A2 (lt)
ZA (1)	ZA200608689B (lt)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6083903A (en) *	1994-10-28	2000-07-04	Leukosite, Inc.	Boronic ester and acid compounds, synthesis and uses
RS65253B1 (sr) *	2004-03-30	2024-03-29	Millennium Pharm Inc	Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline
WO2008075376A1 (en) *	2006-12-18	2008-06-26	Natco Pharma Limited	Polymorphic forms of bortezomib and process for their preparation
WO2009004350A1 (en) *	2007-07-03	2009-01-08	Pliva Hrvatska D.O.O.	Methods for preparing bortezomib and intermediates used in its manufacture
KR20140042933A (ko)	2007-08-06	2014-04-07	밀레니엄 파머슈티컬스 인코퍼레이티드	프로테아좀 억제제
US7442830B1 (en)	2007-08-06	2008-10-28	Millenium Pharmaceuticals, Inc.	Proteasome inhibitors
EA034601B1 (ru) *	2007-08-06	2020-02-25	Милленниум Фармасьютикалз, Инк.	Способ получения бороновых кислот
AU2016253697A1 (en) *	2007-08-06	2016-11-24	Millennium Pharmaceuticals, Inc.	Proteasome inhibitors
US20110118274A1 (en) *	2007-08-23	2011-05-19	Cornell Research Foundation, Inc.	Proteasome inhibitors and their use in treating pathogen infection and cancer
US20100226597A1 (en) *	2007-09-12	2010-09-09	Dr. Reddy's Laboratories Limited	Bortezomib and process for producing same
US7838673B2 (en)	2007-10-16	2010-11-23	Millennium Pharmaceuticals, Inc.	Proteasome inhibitors
EA030685B1 (ru)	2008-06-17	2018-09-28	Милленниум Фармасьютикалз, Инк.	Способ получения соединения боронатного эфира
AR075090A1 (es)	2008-09-29	2011-03-09	Millennium Pharm Inc	Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
AU2013204874B2 (en) *	2008-09-29	2016-11-10	Millennium Pharmaceuticals, Inc.	Derivatives of 1-amino-2-cyclobutylethylboronic acid
EP2238973A1 (en)	2009-04-07	2010-10-13	Cephalon France	Lyophilized preparations of proteasome inhibitors
CN101899062B (zh) *	2009-05-26	2015-04-15	上海威智医药科技有限公司	α-手性硼酸及硼酸酯的合成工艺
EP2270019A1 (en)	2009-06-19	2011-01-05	LEK Pharmaceuticals d.d.	New synthetic route for the preparation of alpha-amino boronic esters
EP2280016A1 (en)	2009-07-27	2011-02-02	LEK Pharmaceuticals d.d.	New synthetic route for the preparation of alpha-amino boronic esters via substituted alk-1-ynes
JP2012530116A (ja)	2009-06-19	2012-11-29	レツク・フアーマシユーテイカルズ・デー・デー	脱ハロゲン化なしにハロゲノアルケンを水素化する方法
EP2516449A1 (en)	2009-12-22	2012-10-31	Cephalon, Inc.	Proteasome inhibitors and processes for their preparation, purification and use
WO2011090940A1 (en)	2010-01-19	2011-07-28	Cerulean Pharma Inc.	Cyclodextrin-based polymers for therapeutic delivery
EP2534159A1 (en)	2010-02-09	2012-12-19	Ranbaxy Laboratories Limited	Process for the preparation of bortezomib
CN101781326B (zh) *	2010-02-11	2013-08-21	福建南方制药股份有限公司	一种制备手性氨基硼酸的中间体及其制备方法
WO2011107912A1 (en)	2010-03-04	2011-09-09	Ranbaxy Laboratories Limited	Polymorphic forms of bortezomib
US8263578B2 (en)	2010-03-18	2012-09-11	Innopharma, Inc.	Stable bortezomib formulations
WO2011116286A2 (en) *	2010-03-18	2011-09-22	Innopharma, Llc	Stable bortezomib formulations
US8513218B2 (en)	2010-03-31	2013-08-20	Millennium Pharmaceuticals, Inc.	Derivatives of 1-amino-2-cyclopropylethylboronic acid
CN101812026B (zh) *	2010-04-12	2013-08-28	亚邦医药股份有限公司	一种硼替佐米的合成方法
EP2571525A4 (en)	2010-05-18	2016-04-27	Cerulean Pharma Inc	Compositions and methods for treating autoimmune and other diseases
EP2627636B1 (en)	2010-10-14	2015-09-02	Synthon BV	Process for making bortezomib and the intermediates for the process
TW201309303A (zh)	2011-03-03	2013-03-01	Cephalon Inc	用於治療狼瘡的蛋白酶體抑制劑
CN102206188B (zh) *	2011-04-08	2013-02-27	苏州二叶制药有限公司	N-(吡嗪-2-基羰基)-l-苯丙氨酸的制备方法
US8497374B2 (en)	2011-05-12	2013-07-30	Scinopharm Taiwan, Ltd.	Process for preparing and purifying bortezomib
CN102268029B (zh) *	2011-05-19	2013-10-09	苏州二叶制药有限公司	化合物（1s,2s,3r,5s）-蒎烷二醇-l-苯丙氨酸-l-亮氨酸硼酸酯的制备
MX2013015308A (es)	2011-06-22	2014-05-20	Cephalon Inc	Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso.
CN102351890B (zh) *	2011-09-30	2014-07-02	重庆泰濠制药有限公司	一种硼替佐米的合成方法
CN102492021B (zh) *	2011-12-13	2013-10-23	重庆泰濠制药有限公司	硼替佐米的制备工艺
JP6129203B2 (ja) *	2011-12-22	2017-05-17	アレストレーディングソシエテアノニム	α−アミノボロン酸誘導体、選択性免疫プロテアソーム阻害剤
CN103374026A (zh) *	2012-04-27	2013-10-30	重庆医药工业研究院有限责任公司	一种硼替佐米中间体的制备方法
CN103450331B (zh) *	2012-06-05	2016-05-25	山东新时代药业有限公司	一种硼替佐米的精制方法
JP2015532915A (ja) *	2012-09-11	2015-11-16	シプラ・リミテッド	ボルテゾミブの製造方法
WO2014072985A1 (en)	2012-11-06	2014-05-15	Natco Pharma Limited	Novel boronic acid derivatives as anti cancer agents
EP2919786A4 (en)	2012-11-16	2016-06-01	Shilpa Medicare Ltd	Crystalline bortezomib process
JP6403219B2 (ja)	2012-12-07	2018-10-10	ベナトルクスファーマシューティカルズ，インク．	ベータ−ラクタマーゼ阻害剤
CN103897027A (zh) *	2012-12-29	2014-07-02	曹亚英	关键中间体晶型，制备方法及其在硼替佐米合成中的运用
CN103897026A (zh) *	2012-12-29	2014-07-02	朱继东	硼替佐米关键中间体的晶型，制备方法及其运用
ES2730013T3 (es)	2013-01-10	2019-11-07	Venatorx Pharmaceuticals Inc	Inhibidores de betalactamasa
ZA201402789B (en)	2013-04-16	2015-11-25	Cipla Ltd	Process for the preparation of bortezomib mannitol ester
CN104211758B (zh) *	2013-05-29	2020-06-12	深圳翰宇药业股份有限公司	一种硼替佐米的制备方法
CN103497233B (zh) *	2013-09-30	2015-04-08	哈药集团技术中心	一种硼替佐米的制备方法
CN103554219A (zh) *	2013-10-01	2014-02-05	昆明贵研药业有限公司	一种制备硼替佐米的方法
KR101691353B1 (ko) *	2013-12-09	2016-12-30	주식회사 경보제약	보르테조밉의 제조방법 및 그의 신규 중간체
EP3102585B1 (en)	2014-02-03	2021-05-19	Ohio State Innovation Foundation	Boronic acid esters and pharmaceutical formulations thereof
UY36132A (es)	2014-05-20	2015-11-30	Millennium Pharm Inc	Métodos para terapia de cáncer
HRP20210693T1 (hr)	2014-06-11	2021-06-11	VenatoRx Pharmaceuticals, Inc.	Inhibitori beta-laktamaze
JP6420629B2 (ja) *	2014-10-30	2018-11-07	ボーグワーナーインコーポレーテッド	チェーンガイドおよびチェーンテンショナアーム
DE102015204151B4 (de) *	2015-03-09	2025-12-24	Adidas Ag	Ball, insbesondere Fußball, und Verfahren zur Herstellung eines Balls
JP6223508B2 (ja) *	2016-06-27	2017-11-01	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	プロテアソーム阻害剤
WO2018027062A1 (en)	2016-08-04	2018-02-08	VenatoRx Pharmaceuticals, Inc.	Boron-containing compounds
WO2018150386A1 (en)	2017-02-17	2018-08-23	Fresenius Kabi Oncology Ltd.	An improved process for the preparation of boronic acid esters
IL301591B1 (en)	2017-03-06	2025-11-01	Venatorx Pharmaceuticals Inc	Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof
WO2018218190A1 (en)	2017-05-26	2018-11-29	VenatoRx Pharmaceuticals, Inc.	Penicillin-binding protein inhibitors
EP3630783A4 (en)	2017-05-26	2021-03-03	Venatorx Pharmaceuticals, Inc.	PENICILLIN-BINDING PROTEIN INHIBITORS
CN109305980B (zh)	2017-07-28	2022-10-11	成都奥璟生物科技有限公司	一种硼酸酯化合物、其合成方法及其用途
EP3676272A4 (en)	2017-09-02	2021-04-21	Sun Pharmaceutical Industries Limited	IXAZOMIB CITRATE PREPARATION PROCESS
EP3802551A4 (en)	2018-05-25	2022-03-02	Venatorx Pharmaceuticals, Inc.	Penicillin-binding protein inhibitors
CN111187336B (zh) *	2018-11-14	2022-05-20	正大天晴药业集团股份有限公司	硼替佐米的精制方法
US11964993B2 (en)	2021-07-03	2024-04-23	Shilpa Pharma Lifesciences Limited	Crystalline bortezomib process
WO2025034812A2 (en)	2023-08-07	2025-02-13	Tae Life Sciences Llc	Trifluoroborate (bf3) compositions for use in boron neutron capture therapy and methods thereof
WO2025080942A1 (en) *	2023-10-13	2025-04-17	The Brigham And Women’S Hospital, Inc.	Proteasome inhibitors and methods of use thereof
CN120248757A (zh) *	2025-05-28	2025-07-04	滁州瑞达新能源材料有限公司	一种自清洁耐候的铝合金光伏组件边框及其制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL31992A (en) *	1968-05-08	1973-07-30	American Cyanamid Co	Synthetic thyrocalcitonins and method of making them
ZA794723B (en) *	1978-09-11	1980-08-27	Univ Miami	Anti-hypertensive agents
US4525309A (en) *	1983-03-15	1985-06-25	Washington State University Research Foundation, Inc.	Lewis acid catalysis of the homologation of boronic esters with haloalkylmetal reagents
US4499082A (en) *	1983-12-05	1985-02-12	E. I. Du Pont De Nemours And Company	α-Aminoboronic acid peptides
US4537773A (en)	1983-12-05	1985-08-27	E. I. Du Pont De Nemours And Company	α-Aminoboronic acid derivatives
ES8603405A1 (es) *	1985-04-22	1985-12-16	Inke Sa	"procedimiento para la obtencion del ester benzilico de 1-(n-(1--etoxicarbonil-3-oxo-fenilpropil)-l-alanil)-l-prolina".
SE8506094D0 (sv) *	1985-12-20	1985-12-20	Astra Laekemedel Ab	New antibacterial agents and intermediates therefor
US4701545A (en) *	1986-02-12	1987-10-20	Washington State University Research Foundation, Inc.	Preparation of α,α-dihaloalkyl boronic esters
US5250720A (en)	1987-06-05	1993-10-05	The Dupont Merck Pharmaceutical Company	Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
US5187157A (en) *	1987-06-05	1993-02-16	Du Pont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
US5242904A (en) *	1987-06-05	1993-09-07	The Dupont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (de)	1987-11-05	1990-08-22	Hoechst Aktiengesellschaft	Renin-Inhibitoren
US5106948A (en) *	1988-05-27	1992-04-21	Mao Foundation For Medical Education And Research	Cytotoxic boronic acid peptide analogs
US6083903A (en) *	1994-10-28	2000-07-04	Leukosite, Inc.	Boronic ester and acid compounds, synthesis and uses
CA2435124A1 (en) *	2001-01-25	2002-08-01	Millennium Pharmaceuticals, Inc.	Formulation of boronic acid compounds
JPWO2003033507A1 (ja)	2001-10-12	2005-02-03	杏林製薬株式会社	ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬
JPWO2003033506A1 (ja) *	2001-10-12	2005-02-03	杏林製薬株式会社	アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬
RS65253B1 (sr) *	2004-03-30	2024-03-29	Millennium Pharm Inc	Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline
WO2009004350A1 (en) *	2007-07-03	2009-01-08	Pliva Hrvatska D.O.O.	Methods for preparing bortezomib and intermediates used in its manufacture
US7838673B2 (en) *	2007-10-16	2010-11-23	Millennium Pharmaceuticals, Inc.	Proteasome inhibitors
JP2012530116A (ja) *	2009-06-19	2012-11-29	レツク・フアーマシユーテイカルズ・デー・デー	脱ハロゲン化なしにハロゲノアルケンを水素化する方法

2005
- 2005-03-24 RS RS20240260A patent/RS65253B1/sr unknown
- 2005-03-24 EP EP11167263A patent/EP2377868A1/en not_active Ceased
- 2005-03-24 CN CN202010514035.2A patent/CN111925385B/zh not_active Expired - Lifetime
- 2005-03-24 HU HUE21197526A patent/HUE065769T2/hu unknown
- 2005-03-24 CN CN201310294873.3A patent/CN103396427B/zh not_active Expired - Lifetime
- 2005-03-24 LT LTEP21197526.3T patent/LT4008721T/lt unknown
- 2005-03-24 SG SG10201600029PA patent/SG10201600029PA/en unknown
- 2005-03-24 ES ES05742865T patent/ES2371652T3/es not_active Expired - Lifetime
- 2005-03-24 PL PL18172486T patent/PL3385267T3/pl unknown
- 2005-03-24 SI SI200531843T patent/SI2377869T1/sl unknown
- 2005-03-24 AU AU2005230930A patent/AU2005230930B2/en not_active Expired
- 2005-03-24 CA CA2738706A patent/CA2738706C/en not_active Expired - Lifetime
- 2005-03-24 CN CN201710810795.6A patent/CN107474062A/zh active Pending
- 2005-03-24 KR KR1020067022780A patent/KR100939598B1/ko not_active Expired - Lifetime
- 2005-03-24 EP EP05742865A patent/EP1756121B1/en not_active Expired - Lifetime
- 2005-03-24 NZ NZ598172A patent/NZ598172A/xx not_active IP Right Cessation
- 2005-03-24 EA EA200601795A patent/EA012927B1/ru unknown
- 2005-03-24 PT PT05742865T patent/PT1756121E/pt unknown
- 2005-03-24 HR HRP20212002TT patent/HRP20212002T1/hr unknown
- 2005-03-24 PT PT111672648T patent/PT2377869E/pt unknown
- 2005-03-24 RS RS20140186A patent/RS53259B/sr unknown
- 2005-03-24 MX MX2014005871A patent/MX367324B/es unknown
- 2005-03-24 DK DK18172486.5T patent/DK3385267T3/da active
- 2005-03-24 PT PT181724865T patent/PT3385267T/pt unknown
- 2005-03-24 PL PL05742865T patent/PL1756121T3/pl unknown
- 2005-03-24 SI SI200532297T patent/SI3385267T1/sl unknown
- 2005-03-24 DK DK21197526.3T patent/DK4008721T3/da active
- 2005-03-24 LT LTEP18172486.5T patent/LT3385267T/lt unknown
- 2005-03-24 PL PL11167264T patent/PL2377869T3/pl unknown
- 2005-03-24 ES ES21197526T patent/ES2974758T3/es not_active Expired - Lifetime
- 2005-03-24 CA CA2560886A patent/CA2560886C/en not_active Expired - Lifetime
- 2005-03-24 CN CN200580017645.5A patent/CN1960996B/zh not_active Expired - Lifetime
- 2005-03-24 PT PT211975263T patent/PT4008721T/pt unknown
- 2005-03-24 UA UAA200611339A patent/UA90108C2/uk unknown
- 2005-03-24 EP EP18172486.5A patent/EP3385267B1/en not_active Expired - Lifetime
- 2005-03-24 SI SI200531401T patent/SI1756121T1/sl unknown
- 2005-03-24 WO PCT/US2005/009774 patent/WO2005097809A2/en not_active Ceased
- 2005-03-24 JP JP2007506261A patent/JP4558039B2/ja not_active Expired - Lifetime
- 2005-03-24 PL PL21197526.3T patent/PL4008721T3/pl unknown
- 2005-03-24 SG SG10201800972PA patent/SG10201800972PA/en unknown
- 2005-03-24 HR HR20110846T patent/HRP20110846T1/hr unknown
- 2005-03-24 NZ NZ586824A patent/NZ586824A/en not_active IP Right Cessation
- 2005-03-24 NZ NZ550522A patent/NZ550522A/en not_active IP Right Cessation
- 2005-03-24 ME MEP-2011-502A patent/ME01975B/me unknown
- 2005-03-24 ES ES18172486T patent/ES2899606T3/es not_active Expired - Lifetime
- 2005-03-24 FI FIEP21197526.3T patent/FI4008721T3/fi active
- 2005-03-24 RS RS20211565A patent/RS62738B1/sr unknown
- 2005-03-24 RS RS20110502A patent/RS51983B/sr unknown
- 2005-03-24 HR HRP20240307TT patent/HRP20240307T3/hr unknown
- 2005-03-24 SI SI200532318T patent/SI4008721T1/sl unknown
- 2005-03-24 CA CA2853272A patent/CA2853272A1/en not_active Abandoned
- 2005-03-24 HU HUE18172486A patent/HUE056859T2/hu unknown
- 2005-03-24 DK DK11167264.8T patent/DK2377869T3/da active
- 2005-03-24 ES ES11167264.8T patent/ES2457593T3/es not_active Expired - Lifetime
- 2005-03-24 US US11/088,667 patent/US7714159B2/en active Active
- 2005-03-24 EP EP11167264.8A patent/EP2377869B1/en not_active Expired - Lifetime
- 2005-03-24 SG SG200902156-9A patent/SG151322A1/en unknown
- 2005-03-24 AT AT05742865T patent/ATE521612T1/de active
- 2005-03-24 MY MYPI20051304A patent/MY145427A/en unknown
- 2005-03-24 DK DK05742865.8T patent/DK1756121T3/da active
- 2005-03-24 BR BRPI0509587-5A patent/BRPI0509587A/pt not_active Application Discontinuation
- 2005-03-24 CA CA2859119A patent/CA2859119A1/en not_active Abandoned
- 2005-03-24 EP EP21197526.3A patent/EP4008721B1/en not_active Expired - Lifetime
- 2005-03-24 SG SG2012049763A patent/SG182999A1/en unknown
- 2005-03-24 CN CN201810192292.1A patent/CN108329337B/zh not_active Expired - Lifetime
- 2005-03-24 SG SG2012049755A patent/SG182998A1/en unknown
- 2005-03-29 PE PE2005000359A patent/PE20060162A1/es not_active Application Discontinuation
- 2005-03-29 PE PE2009001314A patent/PE20110075A1/es active IP Right Grant
- 2005-03-29 PE PE2014001477A patent/PE20142402A1/es not_active Application Discontinuation
- 2005-03-29 TW TW094109818A patent/TWI386212B/zh not_active IP Right Cessation
- 2005-03-29 NL NL1028639A patent/NL1028639C2/nl not_active IP Right Cessation
- 2005-03-30 AR ARP050101205A patent/AR049374A1/es active IP Right Grant
- 2005-03-30 UY UY28830A patent/UY28830A1/es active IP Right Grant
2006
- 2006-09-21 IL IL178250A patent/IL178250A/en active IP Right Grant
- 2006-09-22 CR CR8653A patent/CR8653A/es unknown
- 2006-10-18 ZA ZA200608689A patent/ZA200608689B/en unknown
- 2006-10-26 NO NO20064893A patent/NO338905B1/no unknown
- 2006-10-27 EC EC2006006960A patent/ECSP066960A/es unknown
2007
- 2007-01-08 NL NL1033190A patent/NL1033190C2/nl not_active IP Right Cessation
- 2007-01-08 NL NL1033189A patent/NL1033189C2/nl not_active IP Right Cessation
2010
- 2010-02-16 US US12/706,063 patent/US8283467B2/en not_active Expired - Lifetime
- 2010-04-09 CL CL2010000350A patent/CL2010000350A1/es unknown
- 2010-06-01 JP JP2010126333A patent/JP5414625B2/ja not_active Expired - Lifetime
2011
- 2011-09-23 DO DO2011000293A patent/DOP2011000293A/es unknown
- 2011-11-21 CY CY20111101122T patent/CY1112053T1/el unknown
2012
- 2012-05-17 IL IL219856A patent/IL219856A/en active IP Right Grant
- 2012-05-17 IL IL219853A patent/IL219853A/en active IP Right Grant
- 2012-09-14 US US13/615,894 patent/US20130005968A1/en not_active Abandoned
2013
- 2013-03-06 JP JP2013043972A patent/JP5894952B2/ja not_active Expired - Lifetime
- 2013-08-07 UY UY34969A patent/UY34969A/es not_active Application Discontinuation
2014
- 2014-03-06 US US14/199,265 patent/US20150038706A1/en not_active Abandoned
- 2014-04-08 HR HRP20140339TT patent/HRP20140339T1/hr unknown
- 2014-04-17 CY CY20141100297T patent/CY1115336T1/el unknown
- 2014-05-19 UY UY0001035578A patent/UY35578A/es not_active Application Discontinuation
- 2014-08-11 AR ARP140103013A patent/AR097310A2/es unknown
- 2014-08-11 AR ARP140103012A patent/AR097309A2/es active IP Right Grant
- 2014-08-25 CL CL2014002252A patent/CL2014002252A1/es unknown
2015
- 2015-11-30 JP JP2015232705A patent/JP6193960B2/ja not_active Expired - Lifetime
2016
- 2016-01-08 US US14/991,363 patent/US9862745B2/en not_active Expired - Lifetime
- 2016-08-24 NO NO20161350A patent/NO344610B1/no unknown
2017
- 2017-09-22 US US15/713,005 patent/US10000529B2/en not_active Expired - Lifetime
- 2017-12-05 NO NO20171939A patent/NO343966B1/no unknown
2018
- 2018-05-03 HK HK18105728.8A patent/HK1246300A1/zh unknown
- 2018-05-23 US US15/986,972 patent/US20180265546A1/en not_active Abandoned
- 2018-12-13 US US16/218,783 patent/US20190112334A1/en not_active Abandoned
2019
- 2019-07-11 US US16/508,706 patent/US20190330270A1/en not_active Abandoned
- 2019-09-04 NO NO20191065A patent/NO20191065A1/no not_active Application Discontinuation
2020
- 2020-01-24 US US16/751,374 patent/US20200157143A1/en not_active Abandoned
- 2020-08-13 US US16/992,353 patent/US20200369722A1/en not_active Abandoned
2021
- 2021-02-19 US US17/179,508 patent/US20210171574A1/en not_active Abandoned
- 2021-09-02 US US17/465,144 patent/US20210395301A1/en not_active Abandoned
- 2021-11-24 CY CY20211101021T patent/CY1124753T1/el unknown
2022
- 2022-03-14 US US17/694,545 patent/US20220204558A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DK4008721T3 (da)	2024-03-25
NO20171939A1 (no)	2006-12-22
HK1100004A1 (en)	2007-08-31
EP1756121B1 (en)	2011-08-24
RS62738B1 (sr)	2022-01-31
MX367324B (es)	2019-08-15
TW200616646A (en)	2006-06-01
US7714159B2 (en)	2010-05-11
US20050240047A1 (en)	2005-10-27
CN103396427B (zh)	2018-04-13
SI2377869T1 (sl)	2014-05-30
CN107474062A (zh)	2017-12-15
WO2005097809A2 (en)	2005-10-20
CA2560886A1 (en)	2005-10-20
AU2005230930B2 (en)	2011-09-29
NO343966B1 (no)	2019-07-29
ES2457593T3 (es)	2014-04-28
CA2738706A1 (en)	2005-10-20
US20210171574A1 (en)	2021-06-10
ZA200608689B (en)	2007-09-26
DK1756121T3 (da)	2012-01-09
SI1756121T1 (sl)	2012-03-30
IL219856A0 (en)	2012-06-28
HK1246300A1 (zh)	2018-09-07
JP2007530687A (ja)	2007-11-01
US20150038706A1 (en)	2015-02-05
EP4008721B1 (en)	2024-01-03
ES2371652T3 (es)	2012-01-05
KR100939598B1 (ko)	2010-02-01
HK1257298A1 (zh)	2019-10-18
UY35578A (es)	2016-01-08
IL219853A (en)	2015-05-31
ES2899606T3 (es)	2022-03-14
NL1033189C2 (nl)	2008-08-14
CA2738706C (en)	2014-10-14
DOP2011000293A (es)	2011-12-15
JP5414625B2 (ja)	2014-02-12
SI4008721T1 (sl)	2024-05-31
NO20064893L (no)	2006-12-22
NL1033190A1 (nl)	2007-04-23
JP6193960B2 (ja)	2017-09-06
NO338905B1 (no)	2016-10-31
FI4008721T3 (fi)	2024-03-19
IL178250A0 (en)	2006-12-31
EP2377869A1 (en)	2011-10-19
PL1756121T3 (pl)	2012-02-29
CL2014002252A1 (es)	2014-12-05
CN111925385A (zh)	2020-11-13
NO20191065A1 (no)	2006-12-22
JP2013100378A (ja)	2013-05-23
RS65253B1 (sr)	2024-03-29
AR097309A2 (es)	2016-03-02
HRP20212002T1 (hr)	2022-04-01
SG182998A1 (en)	2012-08-30
NL1028639C2 (nl)	2007-01-17
RS51983B (sr)	2012-02-29
US20130005968A1 (en)	2013-01-03
HUE065769T2 (hu)	2024-06-28
US20190330270A1 (en)	2019-10-31
US20200157143A1 (en)	2020-05-21
PE20142402A1 (es)	2015-02-04
NZ598172A (en)	2013-08-30
AR097310A2 (es)	2016-03-02
SG151322A1 (en)	2009-04-30
CL2010000350A1 (es)	2011-01-28
UY28830A1 (es)	2005-09-30
NL1033189A1 (nl)	2007-10-22
EP4008721A1 (en)	2022-06-08
US20220204558A1 (en)	2022-06-30
ME01975B (me)	2015-05-20
PL4008721T3 (pl)	2024-05-13
PT1756121E (pt)	2011-11-30
RS53259B (sr)	2014-08-29
CY1115336T1 (el)	2017-01-04
CN108329337B (zh)	2021-06-25
PE20110075A1 (es)	2011-02-17
EA012927B1 (ru)	2010-02-26
US10000529B2 (en)	2018-06-19
SI3385267T1 (sl)	2022-04-29
ECSP066960A (es)	2006-12-20
SG182999A1 (en)	2012-08-30
US20180044377A1 (en)	2018-02-15
KR20070007873A (ko)	2007-01-16
JP2010241816A (ja)	2010-10-28
PE20060162A1 (es)	2006-04-07
CN1960996A (zh)	2007-05-09
HRP20240307T3 (hr)	2024-05-10
NL1028639A1 (nl)	2005-10-20
CA2859119A1 (en)	2005-10-20
EP2377868A1 (en)	2011-10-19
EA200601795A1 (ru)	2007-04-27
JP4558039B2 (ja)	2010-10-06
TWI386212B (zh)	2013-02-21
AU2005230930A1 (en)	2005-10-20
EP2377869B1 (en)	2014-01-29
NZ586824A (en)	2012-03-30
US20210395301A1 (en)	2021-12-23
EP3385267A1 (en)	2018-10-10
CN111925385B (zh)	2023-11-21
PL3385267T3 (pl)	2022-02-14
JP2016056180A (ja)	2016-04-21
PT2377869E (pt)	2014-04-15
SG10201800972PA (en)	2018-03-28
US20190112334A1 (en)	2019-04-18
CR8653A (es)	2007-10-23
IL178250A (en)	2012-06-28
PT4008721T (pt)	2024-03-21
NO344610B1 (no)	2020-02-10
CY1112053T1 (el)	2015-11-04
IL219856A (en)	2015-05-31
HRP20110846T1 (hr)	2011-12-31
EP3385267B1 (en)	2021-09-29
NZ550522A (en)	2010-08-27
HRP20140339T1 (hr)	2014-05-09
UA90108C2 (uk)	2010-04-12
HK1164320A1 (en)	2012-10-19
IL219853A0 (en)	2012-06-28
SG10201600029PA (en)	2016-02-26
US9862745B2 (en)	2018-01-09
BRPI0509587A (pt)	2007-09-25
UY34969A (es)	2015-02-27
US8283467B2 (en)	2012-10-09
US20180265546A1 (en)	2018-09-20
WO2005097809A3 (en)	2006-02-16
NO20161350A1 (no)	2006-12-22
MY145427A (en)	2012-02-15
CA2853272A1 (en)	2005-10-20
CN103396427A (zh)	2013-11-20
CY1124753T1 (el)	2022-07-22
EP1756121A2 (en)	2007-02-28
CN108329337A (zh)	2018-07-27
DK2377869T3 (da)	2014-04-14
ATE521612T1 (de)	2011-09-15
AR049374A1 (es)	2006-07-26
CN1960996B (zh)	2016-04-20
HUE056859T2 (hu)	2022-03-28
PT3385267T (pt)	2021-11-23
DK3385267T3 (da)	2021-11-01
CA2560886C (en)	2014-08-12
PL2377869T3 (pl)	2014-07-31
US20200369722A1 (en)	2020-11-26
LT3385267T (lt)	2021-11-10
JP5894952B2 (ja)	2016-03-30
ES2974758T3 (es)	2024-07-01
NL1033190C2 (nl)	2007-11-27
US20100174072A1 (en)	2010-07-08
US20160362449A1 (en)	2016-12-15

Publication	Publication Date	Title
SG10201600029PA (en)	2016-02-26	Synthesis of boronic ester and acid compounds
EP1778618A4 (en)	2008-07-16	SYNTHESIS OF TRIETHYLENETETRAMINES
IL186297A0 (en)	2008-01-20	N-alkylcarbonyl-amino acid ester and n-alkylcarbonyl-amino lactone compounds and their use
SI1636190T1 (sl)	2012-09-28	Stabilni kristal 4-oksokinolinske spojine
ZA200801394B (en)	2009-12-30	Novel sulphonylpyrroles as inhibitors of HDAC S novel sulphonylpyrroles
IL176932A0 (en)	2006-12-10	Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
IL179538A0 (en)	2007-05-15	Synthesis of amino-alkoxy-heptanoic alkyl ester
ZA200609727B (en)	2008-02-27	Carbonylation of ester
EP1711484A4 (en)	2007-06-20	SYNTHESIS OF CYANOIMINO-BENZOIMIDAZOLES
PT1781145T (pt)	2018-11-29	Ferramenta para facilitar o consumo de substâncias ingeríveis
GB0410603D0 (en)	2004-06-16	Ester synthesis
ZA200900278B (en)	2010-02-24	Synthesis of 3-(5-nitrocyclohex-1-enyl)acrylic acid and esters thereof
PL1611083T3 (pl)	2008-01-31	Synteza estrów kwasu 2-chlorometylo-6-metylobenzoesowego
ZA200710408B (en)	2009-08-26	Synthesis of hydroquinone derivatives
IL178184A0 (en)	2006-12-31	Synthesis of pyrrole-2-carbonitriles
GB0421012D0 (en)	2004-10-20	Ester synthesis
SI1611083T1 (sl)	2008-02-29	Sinteza estrov 2-klorometil-6-metil-benzojske kisline
GB0428166D0 (en)	2005-01-26	Use of essentially fatty acid molecules
IL179151A0 (en)	2007-03-08	Synthesis of amino acid keto-epoxides
DOP2005000058A (es)	2006-10-31	Sintesis de compuestos de ester y acido borico
GB0428060D0 (en)	2005-01-26	Ester synthesis
SI1709057T1 (sl)	2008-06-30	Sinteza spongozina
HK1122013A (en)	2009-05-08	Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof
HK1094801A (en)	2007-04-13	Synthesis of pyrrole-2-carbonitriles
IL188075A0 (en)	2008-03-20	Synthesis of hydroquinone derivatives