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LT4003532T - 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos - Google Patents

7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos

Info

Publication number
LT4003532T
LT4003532T LTEPPCT/US2020/043178T LTUS2020043178T LT4003532T LT 4003532 T LT4003532 T LT 4003532T LT US2020043178 T LTUS2020043178 T LT US2020043178T LT 4003532 T LT4003532 T LT 4003532T
Authority
LT
Lithuania
Prior art keywords
methyl
methoxyazetidin
dioxol
dihydropyridine
methylthio
Prior art date
Application number
LTEPPCT/US2020/043178T
Other languages
English (en)
Inventor
Alamelu Banda
Victor GEHLING
Original Assignee
Constellation Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals, Inc. filed Critical Constellation Pharmaceuticals, Inc.
Publication of LT4003532T publication Critical patent/LT4003532T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LTEPPCT/US2020/043178T 2019-07-24 2020-07-23 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos LT4003532T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962878012P 2019-07-24 2019-07-24
PCT/US2020/043178 WO2021016414A1 (en) 2019-07-24 2020-07-23 Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide

Publications (1)

Publication Number Publication Date
LT4003532T true LT4003532T (lt) 2024-11-11

Family

ID=72047059

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2020/043178T LT4003532T (lt) 2019-07-24 2020-07-23 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos

Country Status (29)

Country Link
US (1) US12516040B2 (lt)
EP (2) EP4003532B1 (lt)
JP (2) JP7603653B2 (lt)
KR (1) KR20220041129A (lt)
CN (2) CN114450279B (lt)
AU (1) AU2020316073A1 (lt)
BR (1) BR112022001161A2 (lt)
CA (1) CA3148447A1 (lt)
CL (1) CL2022000175A1 (lt)
CO (1) CO2022001482A2 (lt)
DK (1) DK4003532T3 (lt)
ES (1) ES2997972T3 (lt)
FI (1) FI4003532T3 (lt)
HR (1) HRP20241443T1 (lt)
HU (1) HUE069127T2 (lt)
IL (1) IL289972A (lt)
LT (1) LT4003532T (lt)
MA (1) MA56661B1 (lt)
MD (1) MD4003532T2 (lt)
MX (2) MX2022000931A (lt)
MY (1) MY207951A (lt)
PE (1) PE20220562A1 (lt)
PH (1) PH12022550188A1 (lt)
PL (1) PL4003532T3 (lt)
PT (1) PT4003532T (lt)
RS (1) RS66244B1 (lt)
SI (1) SI4003532T1 (lt)
SM (1) SMT202400485T1 (lt)
WO (1) WO2021016414A1 (lt)

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US20250059180A1 (en) * 2022-01-14 2025-02-20 Dong Wha Pharm. Co., Ltd. 1,3-benzodioxole derivative compound and pharmaceutical composition comprising same
KR20250023481A (ko) 2022-06-13 2025-02-18 트리라인 바이오사이언시스, 인크. 1,8-나프티리딘-2-온 이종이작용성 bcl6 분해제
CA3258325A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. BIFUNCTIONAL QUINOLONE DEGRADING AGENTS BCL6
JP2025523114A (ja) 2022-07-15 2025-07-17 コンステレーション・ファーマシューティカルズ・インコーポレイテッド Ａｔリッチ相互作用ドメイン含有タンパク質１ａ（ａｒｉｄ１ａ）突然変異癌を処置するためのｅｚｈ２阻害療法
CN115403040B (zh) * 2022-08-11 2023-08-01 中国地质大学（北京） 一种可通过光辐射调控导热系数的偶氮苯聚合物表面修饰的金刚石纳米粒子及其制备方法
JP2025528837A (ja) 2022-08-17 2025-09-02 インサイト・コーポレイション 抗ｃｄ１９抗体及びｅｚｈ２モジュレーターを含む治療
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