LT4083038T - Piridazinilo tiazolkarboksamido junginys - Google Patents
Piridazinilo tiazolkarboksamido junginysInfo
- Publication number
- LT4083038T LT4083038T LTEPPCT/JP2020/048337T LTJP2020048337T LT4083038T LT 4083038 T LT4083038 T LT 4083038T LT JP2020048337 T LTJP2020048337 T LT JP2020048337T LT 4083038 T LT4083038 T LT 4083038T
- Authority
- LT
- Lithuania
- Prior art keywords
- pyridazinyl
- thiazolecarboxamide compound
- thiazolecarboxamide
- compound
- pyridazinyl thiazolecarboxamide
- Prior art date
Links
- -1 Pyridazinyl thiazolecarboxamide compound Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233673 | 2019-12-25 | ||
| PCT/JP2020/048337 WO2021132422A1 (ja) | 2019-12-25 | 2020-12-24 | ピリダジニルチアアゾールカルボキシアミド化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT4083038T true LT4083038T (lt) | 2024-12-27 |
Family
ID=76574296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/JP2020/048337T LT4083038T (lt) | 2019-12-25 | 2020-12-24 | Piridazinilo tiazolkarboksamido junginys |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US12227517B2 (lt) |
| EP (1) | EP4083038B1 (lt) |
| JP (1) | JP6948659B1 (lt) |
| KR (1) | KR20220119702A (lt) |
| CN (3) | CN115626919B (lt) |
| AR (1) | AR120896A1 (lt) |
| AU (1) | AU2020413997B2 (lt) |
| BR (1) | BR112022012637A2 (lt) |
| CA (1) | CA3165889A1 (lt) |
| CL (1) | CL2022001752A1 (lt) |
| CO (1) | CO2022009124A2 (lt) |
| CR (1) | CR20220328A (lt) |
| DK (1) | DK4083038T3 (lt) |
| DO (1) | DOP2022000137A (lt) |
| EC (1) | ECSP22057324A (lt) |
| ES (1) | ES2995459T3 (lt) |
| FI (1) | FI4083038T3 (lt) |
| HR (1) | HRP20241588T1 (lt) |
| HU (1) | HUE069173T2 (lt) |
| IL (1) | IL294136B2 (lt) |
| JO (1) | JOP20220163A1 (lt) |
| LT (1) | LT4083038T (lt) |
| MX (1) | MX2022007993A (lt) |
| MY (1) | MY206825A (lt) |
| PE (1) | PE20230163A1 (lt) |
| PH (1) | PH12022551569A1 (lt) |
| PL (1) | PL4083038T3 (lt) |
| PT (1) | PT4083038T (lt) |
| SA (1) | SA522433129B1 (lt) |
| SI (1) | SI4083038T1 (lt) |
| TW (3) | TW202413376A (lt) |
| UA (1) | UA129628C2 (lt) |
| WO (1) | WO2021132422A1 (lt) |
| ZA (1) | ZA202207543B (lt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL4081305T3 (pl) | 2019-12-24 | 2025-02-10 | Carna Biosciences, Inc. | Związki modulujące kinazę diacyloglicerolową |
| AR120896A1 (es) | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| CA3180819A1 (en) | 2020-04-24 | 2021-10-28 | Bayer Aktiengesellschaft | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
| AU2021389180A1 (en) | 2020-11-30 | 2023-06-29 | Astellas Pharma Inc. | Heteroaryl carboxamide compound |
| WO2022271684A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| EP4359411A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN117396478A (zh) | 2021-06-23 | 2024-01-12 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| JP7686086B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリエルコール（ｄｉａｃｙｌｇｌｙｅｒｃｏｌ）キナーゼ調節化合物 |
| CN114621214B (zh) * | 2022-04-25 | 2024-04-26 | 宜春学院 | 一种抗菌席夫碱n-酰化物及其制备方法和应用 |
| TW202428272A (zh) * | 2022-11-18 | 2024-07-16 | 美商英塞特公司 | 作為ｄｇｋ抑制劑之雜芳基氟烯烴 |
| US20240270739A1 (en) * | 2023-01-12 | 2024-08-15 | Incyte Corporation | Heteroaryl Fluoroalkenes As DGK Inhibitors |
| EP4661870A1 (en) | 2023-02-06 | 2025-12-17 | Bayer Aktiengesellschaft | Combinations of dgk (diacylglycerol kinase) inhibitors |
| WO2024199387A1 (zh) * | 2023-03-30 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
| CN120826393A (zh) * | 2023-04-06 | 2025-10-21 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的噻唑类化合物 |
| WO2025067360A1 (zh) * | 2023-09-27 | 2025-04-03 | 海思科医药集团股份有限公司 | 一种DGKzeta拮抗剂及其在医药上的应用 |
| WO2025082460A1 (zh) * | 2023-10-20 | 2025-04-24 | 上海先祥医药科技有限公司 | 二酰基甘油激酶抑制剂化合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381401B2 (en) * | 2004-01-08 | 2008-06-03 | The University Of Chicago | T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase |
| ZA200707125B (en) | 2005-01-25 | 2008-11-26 | Synta Pharmaceuticals Corp | Compounds for inflammation and immune-related uses |
| US8455658B2 (en) * | 2006-01-25 | 2013-06-04 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| JP5182088B2 (ja) * | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
| KR20090075873A (ko) | 2006-10-31 | 2009-07-09 | 쉐링 코포레이션 | 아닐리노피페라진 유도체 및 이의 사용방법 |
| AU2018328768A1 (en) | 2017-09-06 | 2020-03-12 | Propellon Therapeutics Inc. | Inhibitors of WDR5 protein-protein binding |
| FI3814348T3 (fi) * | 2018-06-27 | 2023-09-22 | Bristol Myers Squibb Co | Substituoituja naftyridinoniyhdisteitä, jotka ovat käyttökelpoisia t-solun aktivoijina |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| CA3180819A1 (en) | 2020-04-24 | 2021-10-28 | Bayer Aktiengesellschaft | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
| AU2021389180A1 (en) | 2020-11-30 | 2023-06-29 | Astellas Pharma Inc. | Heteroaryl carboxamide compound |
-
2020
- 2020-12-23 AR ARP200103641A patent/AR120896A1/es unknown
- 2020-12-24 LT LTEPPCT/JP2020/048337T patent/LT4083038T/lt unknown
- 2020-12-24 TW TW112145680A patent/TW202413376A/zh unknown
- 2020-12-24 MX MX2022007993A patent/MX2022007993A/es unknown
- 2020-12-24 IL IL294136A patent/IL294136B2/en unknown
- 2020-12-24 CA CA3165889A patent/CA3165889A1/en active Pending
- 2020-12-24 PL PL20906466.6T patent/PL4083038T3/pl unknown
- 2020-12-24 BR BR112022012637A patent/BR112022012637A2/pt unknown
- 2020-12-24 PT PT209064666T patent/PT4083038T/pt unknown
- 2020-12-24 SI SI202030542T patent/SI4083038T1/sl unknown
- 2020-12-24 TW TW109146029A patent/TWI881008B/zh active
- 2020-12-24 FI FIEP20906466.6T patent/FI4083038T3/fi active
- 2020-12-24 US US17/427,426 patent/US12227517B2/en active Active
- 2020-12-24 JO JOP/2022/0163A patent/JOP20220163A1/ar unknown
- 2020-12-24 PH PH1/2022/551569A patent/PH12022551569A1/en unknown
- 2020-12-24 DK DK20906466.6T patent/DK4083038T3/da active
- 2020-12-24 CR CR20220328A patent/CR20220328A/es unknown
- 2020-12-24 PE PE2022001161A patent/PE20230163A1/es unknown
- 2020-12-24 AU AU2020413997A patent/AU2020413997B2/en active Active
- 2020-12-24 CN CN202211308277.1A patent/CN115626919B/zh active Active
- 2020-12-24 UA UAA202202632A patent/UA129628C2/uk unknown
- 2020-12-24 WO PCT/JP2020/048337 patent/WO2021132422A1/ja not_active Ceased
- 2020-12-24 TW TW112145679A patent/TW202413375A/zh unknown
- 2020-12-24 HR HRP20241588TT patent/HRP20241588T1/hr unknown
- 2020-12-24 ES ES20906466T patent/ES2995459T3/es active Active
- 2020-12-24 HU HUE20906466A patent/HUE069173T2/hu unknown
- 2020-12-24 CN CN202080011114.XA patent/CN113365994B/zh active Active
- 2020-12-24 JP JP2021531562A patent/JP6948659B1/ja active Active
- 2020-12-24 MY MYPI2022003381A patent/MY206825A/en unknown
- 2020-12-24 KR KR1020227025714A patent/KR20220119702A/ko active Pending
- 2020-12-24 CN CN202211308268.2A patent/CN115590854B/zh active Active
- 2020-12-24 EP EP20906466.6A patent/EP4083038B1/en active Active
-
2022
- 2022-06-23 SA SA522433129A patent/SA522433129B1/ar unknown
- 2022-06-24 CL CL2022001752A patent/CL2022001752A1/es unknown
- 2022-06-24 DO DO2022000137A patent/DOP2022000137A/es unknown
- 2022-06-30 CO CONC2022/0009124A patent/CO2022009124A2/es unknown
- 2022-07-07 ZA ZA2022/07543A patent/ZA202207543B/en unknown
- 2022-07-21 EC ECSENADI202257324A patent/ECSP22057324A/es unknown
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