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LT4056712T - Neinvazinis auglio metilomo nustatymas iš plazmos - Google Patents

Neinvazinis auglio metilomo nustatymas iš plazmos

Info

Publication number
LT4056712T
LT4056712T LTEP22171427.2T LT22171427T LT4056712T LT 4056712 T LT4056712 T LT 4056712T LT 22171427 T LT22171427 T LT 22171427T LT 4056712 T LT4056712 T LT 4056712T
Authority
LT
Lithuania
Prior art keywords
methylome
tumor
plasma
invasive determination
invasive
Prior art date
Application number
LTEP22171427.2T
Other languages
English (en)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee Chan
Yuk-Ming Dennis Lo
Miu Fan Lun
Peiyong Jiang
Wai Man Chan
Original Assignee
The Chinese University Of Hong Kong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4056712(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by The Chinese University Of Hong Kong filed Critical The Chinese University Of Hong Kong
Publication of LT4056712T publication Critical patent/LT4056712T/lt

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
LTEP22171427.2T 2012-09-20 2013-09-20 Neinvazinis auglio metilomo nustatymas iš plazmos LT4056712T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03

Publications (1)

Publication Number Publication Date
LT4056712T true LT4056712T (lt) 2024-09-10

Family

ID=50340462

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP22171427.2T LT4056712T (lt) 2012-09-20 2013-09-20 Neinvazinis auglio metilomo nustatymas iš plazmos
LTEP17202149.5T LT3354747T (lt) 2012-09-20 2013-09-20 Neinvazinis naviko metilomos nustatymas iš plazmos

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP17202149.5T LT3354747T (lt) 2012-09-20 2013-09-20 Neinvazinis naviko metilomos nustatymas iš plazmos

Country Status (28)

Country Link
EP (6) EP3839065A1 (lt)
JP (6) JP6317354B2 (lt)
KR (5) KR102390711B1 (lt)
CN (2) CN104781422B (lt)
AU (5) AU2013317708C1 (lt)
BR (3) BR122021021825B1 (lt)
CA (2) CA2884066C (lt)
CY (1) CY1124139T1 (lt)
DK (4) DK2898100T4 (lt)
EA (1) EA201500327A1 (lt)
ES (4) ES2969567T3 (lt)
FI (2) FI3536807T3 (lt)
HR (3) HRP20241142T1 (lt)
HU (3) HUE053822T2 (lt)
IL (4) IL313451A (lt)
LT (2) LT4056712T (lt)
MX (1) MX360034B (lt)
MY (2) MY187444A (lt)
NZ (2) NZ706269A (lt)
PH (2) PH12022552061A1 (lt)
PL (4) PL4056712T3 (lt)
PT (4) PT4056712T (lt)
SG (2) SG10201705198UA (lt)
SI (1) SI4056712T1 (lt)
SM (1) SMT202100256T1 (lt)
TW (5) TWI640634B (lt)
WO (1) WO2014043763A1 (lt)
ZA (1) ZA201501772B (lt)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335354B (en) 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
BR122021021825B1 (pt) * 2012-09-20 2022-05-24 The Chinese University Of Hong Kong Método para estimar um nível de metilação de dna em uma amostra biológica de um organismo, e, meio de armazenamento de memória
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10017824B2 (en) * 2013-07-30 2018-07-10 Bgi Genomics Co., Limited Method for determining nucleic acid composition of nucleic acid mixture
US10174375B2 (en) * 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
CN106029909B (zh) * 2014-02-18 2021-02-02 生物纳米基因公司 测定核酸结构信息的改进方法
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3134541B1 (en) * 2014-04-21 2020-08-19 Natera, Inc. Detecting copy number variations (cnv) of chromosomal segments in cancer
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
EP3140421B8 (en) 2014-05-09 2020-05-06 Eurofins LifeCodexx GmbH Detection of dna that originates from a specific cell-type and related methods
US11062789B2 (en) * 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
EP4358097A1 (en) 2014-07-25 2024-04-24 University of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
AU2015374259B2 (en) * 2014-12-31 2020-08-13 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
EP3256605B1 (en) 2015-02-10 2022-02-09 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
WO2017012544A1 (en) 2015-07-20 2017-01-26 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
CA2993362A1 (en) * 2015-07-23 2017-01-26 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free dna
CA2995422A1 (en) 2015-08-12 2017-02-16 The Chinese University Of Hong Kong Single-molecule sequencing of plasma dna
TWI767888B (zh) 2015-09-22 2022-06-21 香港中文大學 藉由母體血漿ｄｎａ之淺深度測序以準確定量胎兒ｄｎａ含量
US10260088B2 (en) * 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
WO2017083366A1 (en) * 2015-11-09 2017-05-18 Progenity, Inc. Methods for determining the origin of dna molecules
HUE050491T2 (hu) 2015-11-10 2020-12-28 Eurofins Lifecodexx Gmbh Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között
CN109072300B (zh) 2015-12-17 2023-01-31 伊路敏纳公司 区分复杂生物样品中的甲基化水平
SG11201806609TA (en) * 2016-02-02 2018-09-27 Guardant Health Inc Cancer evolution detection and diagnostic
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
EP4425178A3 (en) 2016-05-03 2024-12-18 University Health Network Methods of capturing cell-free methylated dna and uses of same
US12300356B2 (en) 2016-05-04 2025-05-13 Queen's University At Kingston Cell-free detection of methylated tumour DNA
CN115161390B (zh) * 2016-05-30 2025-12-05 香港中文大学 使用血液中的无细胞dna检测血液病症
ES2897550T3 (es) * 2016-06-16 2022-03-01 Univ Johns Hopkins Métodos y sistema de análisis epigenético
WO2018036537A1 (zh) * 2016-08-24 2018-03-01 中国科学院上海生命科学研究院 Cmd1酶催化的5-甲基胞嘧啶核酸的新修饰及其应用
CN109890984B (zh) * 2016-10-19 2024-03-29 香港中文大学 通过母体血浆dna的甲基化和大小谱分析进行胎龄评估
CN110100013A (zh) 2016-10-24 2019-08-06 香港中文大学 用于肿瘤检测的方法和系统
IL266347B2 (en) * 2016-11-30 2025-01-01 Univ Hong Kong Chinese Analysis of cell-free DNA in urine and other samples
WO2018112100A2 (en) * 2016-12-13 2018-06-21 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
CA3049442A1 (en) * 2017-01-11 2018-07-19 Quest Diagnostics Investments Llc Method for non-invasive prenatal screening for aneuploidy
RS65618B1 (sr) * 2017-01-24 2024-07-31 Bgi Genomics Co Ltd Postupak za utvrđivanje frakcije nukleinskih kiselina bez ćelija iz prethodno određenog izvora u biološkom uzorku
CN110291212A (zh) 2017-01-25 2019-09-27 香港中文大学 使用核酸片段的诊断应用
CN107247873B (zh) * 2017-03-29 2020-04-14 电子科技大学 一种差异甲基化位点识别方法
US12195802B2 (en) 2017-05-12 2025-01-14 President And Fellows Of Harvard College Universal early cancer diagnostics
CN118600004A (zh) * 2017-07-12 2024-09-06 大学健康网络 使用甲基化组分析进行癌症检测和分类
AU2018300157A1 (en) * 2017-07-12 2020-02-27 Ande Corporation Pattern recognition system
US12227737B2 (en) 2017-07-12 2025-02-18 University Health Network Cancer detection and classification using methylome analysis
AU2018305609B2 (en) * 2017-07-26 2023-01-19 The Chinese University Of Hong Kong Enhancement of cancer screening using cell-free viral nucleic acids
WO2019055819A1 (en) 2017-09-14 2019-03-21 Grail, Inc. METHODS FOR PREPARING A SEQUENCING LIBRARY FROM SINGLE STRANDED DNA
EP4269583B1 (en) 2017-09-28 2025-12-31 Grail, Inc. ENRICHEMENT OF SHORT NUCLEIC ACID FRAGMENTS IN SEQUENCING BANK PREPARATION
US11168356B2 (en) 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
CN111989407B (zh) 2018-03-13 2024-10-29 格里尔公司 异常的片段检测及分类
TWI848941B (zh) * 2018-03-15 2024-07-21 美商格瑞爾有限責任公司 組織特異性甲基化標記
CA3094717A1 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
WO2019200410A1 (en) * 2018-04-13 2019-10-17 Freenome Holdings, Inc. Machine learning implementation for multi-analyte assay of biological samples
CN112218957B (zh) * 2018-04-16 2025-08-08 格里尔公司 用于确定在无细胞核酸中的肿瘤分数的系统及方法
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US11932899B2 (en) * 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN109448789A (zh) * 2018-09-17 2019-03-08 上海派森诺生物科技股份有限公司 一种基于perl语言的种群特异SNP位点的自动化分析方法
AU2019351130B2 (en) 2018-09-27 2025-10-23 Grail, Inc. Methylation markers and targeted methylation probe panel
CN109295230A (zh) * 2018-10-24 2019-02-01 福建翊善生物科技有限公司 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法
AU2019384154B2 (en) 2018-11-21 2025-11-20 Agilent Technologies, Inc. Methods for targeted nucleic acid library formation
WO2020125709A1 (en) * 2018-12-19 2020-06-25 The Chinese University Of Hong Kong Cell-free dna end characteristics
EP3899953A1 (en) 2018-12-21 2021-10-27 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
EP4485464A3 (en) 2019-02-05 2025-02-19 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
WO2020163410A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
CN114072527B (zh) 2019-03-25 2025-03-04 香港中文大学 确定循环核酸的线性和环状形式
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
JP2022530920A (ja) * 2019-05-03 2022-07-04 コーネル ユニバーシティー 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
US20230178182A1 (en) * 2019-08-19 2023-06-08 Green Cross Genome Corporation Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments
GB201915469D0 (en) 2019-10-24 2019-12-11 Univ London Cancer detection methods
AU2020391488A1 (en) * 2019-11-27 2022-06-09 Grail, Inc. Systems and methods for evaluating longitudinal biological feature data
GB2612412B (en) 2020-01-31 2025-10-10 Agilent Technologies Inc Systems and methods for targeted nucleic acid capture
CN115398007A (zh) * 2020-02-10 2022-11-25 帕洛根公司 纳米孔装置和使用其检测和分类带电粒子的方法
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
EP4111457A1 (en) * 2020-02-28 2023-01-04 Grail, LLC Identifying methylation patterns that discriminate or indicate a cancer condition
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测11种癌症的探针组合物
RU2738675C1 (ru) * 2020-07-28 2020-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов
JP2023550141A (ja) * 2020-11-19 2023-11-30 ニュークレイクス リミテッド 制限酵素及びハイスループット配列決定を用いたｄｎａ試料におけるメチル化変化の検出
CA3205667A1 (en) * 2020-12-17 2022-06-23 President And Fellows Of Harvard College Methods of cancer detection using extraembryonically methylated cpg islands
CN112813148A (zh) * 2021-02-02 2021-05-18 博淼生物科技（北京）有限公司 飞行时间质谱检测5-羟甲基胞嘧啶的方法
TWI832443B (zh) * 2021-09-28 2024-02-11 香港商行動基因（智財）有限公司 甲基化生物標記選擇裝置及方法
KR20230059423A (ko) * 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
US20230138633A1 (en) * 2021-11-04 2023-05-04 Universal Diagnostics, S.L. Systems and methods for preparing biological samples for genetic sequencing
KR20240144954A (ko) 2022-02-07 2024-10-04 센터 포 노보스틱스 메틸화 및 질환을 측정하기 위한 단편화
US20240150840A1 (en) * 2022-02-22 2024-05-09 Flagship Pioneering Innovations Vi, Llc Intra-individual analysis for presence of health conditions
CN115064211B (zh) * 2022-08-15 2023-01-24 臻和(北京)生物科技有限公司 一种基于全基因组甲基化测序的ctDNA预测方法及装置
CN115612723B (zh) * 2022-09-26 2023-07-14 广州女娲生命科技有限公司 植入前胚胎的筛选方法
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
CN116555426B (zh) * 2023-05-04 2024-07-12 杭州圣庭医疗科技有限公司 一种鉴定肿瘤组织来源的试剂盒及数据分析方法
CN117025753A (zh) * 2023-08-15 2023-11-10 广州女娲生命科技有限公司 检测染色体变异的方法和装置
CN117079822B (zh) * 2023-10-17 2024-01-02 北京大学第三医院（北京大学第三临床医学院） 一种妊娠早中期四因子预测胎儿脑损伤的系统

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
DE60207979T2 (de) † 2002-03-05 2006-09-28 Epigenomics Ag Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten
AU2003294315A1 (en) * 2002-11-19 2004-06-15 Amgen Inc. Amplified genes involved in cancer
US20060183128A1 (en) † 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
CA2902980A1 (en) * 2004-03-08 2005-09-29 Rubicon Genomics, Inc. Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation
WO2006128192A2 (en) 2005-05-27 2006-11-30 John Wayne Cancer Institute Use of free circulating dna for diagnosis, prognosis, and treatment of cancer
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
TWI335354B (en) * 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
WO2008155549A2 (en) 2007-06-19 2008-12-24 Oncomethylome Sciences Sa Improved urine sample collecting and processing
HRP20140009T4 (hr) 2007-07-23 2019-03-08 The Chinese University Of Hong Kong Dijagnosticiranje fetalne kromosomske aneuploidije uporabom genomskog sekvencijskog postupka
JP4347372B2 (ja) 2007-08-10 2009-10-21 トヨタ自動車株式会社 静電塗装装置
US20110028333A1 (en) 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
WO2011038507A1 (en) * 2009-10-02 2011-04-07 Centre For Addiction And Mental Health Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids
SI3241914T1 (sl) * 2009-11-05 2019-07-31 The Chinese University Of Hong Kong Fetalna genomska analiza materinskega biološkega vzorca
ES3026544T3 (en) 2009-11-06 2025-06-11 Univ Hong Kong Chinese Size-based genomic analysis for prenatal diagnosis
EP2513341B1 (en) * 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
KR20120107512A (ko) † 2010-01-26 2012-10-02 엔아이피디 제네틱스 리미티드 태아 이수성의 비침해성 출생전 진단을 위한 방법과 조성물
JP6073217B2 (ja) † 2010-04-29 2017-02-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ゲノムモデルに関するデータ統合を用いたパスウェイ認識アルゴリズム（ｐａｒａｄｉｇｍ）
GB201007944D0 (en) 2010-05-12 2010-06-30 Univ Aberystwyth Methods
DK2576832T3 (en) 2010-05-25 2016-06-20 Univ Johns Hopkins CONFIGURATIONS AND METHODS FOR DETECTION OF neoplasia
CA2806291C (en) * 2010-07-23 2023-08-29 President And Fellows Of Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
SG186787A1 (en) * 2010-07-23 2013-02-28 Esoterix Genetic Lab Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
WO2012031329A1 (en) * 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
EA038374B1 (ru) † 2010-11-30 2021-08-17 Те Чайниз Юниверсити Ов Гонконг Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком
BR122021021825B1 (pt) * 2012-09-20 2022-05-24 The Chinese University Of Hong Kong Método para estimar um nível de metilação de dna em uma amostra biológica de um organismo, e, meio de armazenamento de memória

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