LT2918603T - Antikūnas, galintis specifiškai atpažinti transferino receptorių - Google Patents
Antikūnas, galintis specifiškai atpažinti transferino receptoriųInfo
- Publication number
- LT2918603T LT2918603T LTEP13853637.0T LT13853637T LT2918603T LT 2918603 T LT2918603 T LT 2918603T LT 13853637 T LT13853637 T LT 13853637T LT 2918603 T LT2918603 T LT 2918603T
- Authority
- LT
- Lithuania
- Prior art keywords
- transferrin receptor
- antibody capable
- specifically recognizing
- recognizing transferrin
- specifically
- Prior art date
Links
- 102000007238 Transferrin Receptors Human genes 0.000 title 1
- 108010033576 Transferrin Receptors Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012246215 | 2012-11-08 | ||
| PCT/JP2013/080249 WO2014073641A1 (ja) | 2012-11-08 | 2013-11-08 | トランスフェリン受容体を特異的に認識できる抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2918603T true LT2918603T (lt) | 2018-10-25 |
Family
ID=50684735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13853637.0T LT2918603T (lt) | 2012-11-08 | 2013-11-08 | Antikūnas, galintis specifiškai atpažinti transferino receptorių |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9593165B2 (lt) |
| EP (1) | EP2918603B1 (lt) |
| JP (1) | JP6212497B2 (lt) |
| CN (1) | CN104797600A (lt) |
| AU (1) | AU2013342432A1 (lt) |
| CA (1) | CA2893794C (lt) |
| CY (1) | CY1121158T1 (lt) |
| DK (1) | DK2918603T3 (lt) |
| ES (1) | ES2689782T3 (lt) |
| HK (1) | HK1213582A1 (lt) |
| HR (1) | HRP20181453T1 (lt) |
| HU (1) | HUE039920T2 (lt) |
| LT (1) | LT2918603T (lt) |
| PL (1) | PL2918603T3 (lt) |
| PT (1) | PT2918603T (lt) |
| RS (1) | RS57696B1 (lt) |
| SI (1) | SI2918603T1 (lt) |
| WO (1) | WO2014073641A1 (lt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL310251A (en) | 2015-05-04 | 2024-03-01 | Cytomx Therapeutics Inc | Anti-cd71 antibodies, activatable anti-cd71 antibodies, compositions comprising same and uses thereof |
| JP6858185B2 (ja) * | 2015-07-22 | 2021-04-14 | イナサリス | 増殖性および炎症性疾患の処置における抗ＴｆＲ抗体およびその使用 |
| SG11202105163UA (en) * | 2018-11-20 | 2021-06-29 | Perseus Proteomics Inc | Agent for inhibiting iron uptake into cells |
| EP3772518A1 (en) * | 2019-08-07 | 2021-02-10 | Merus N.V. | Modified human variable domains |
| JP7560815B2 (ja) * | 2019-09-04 | 2024-10-03 | 株式会社ペルセウスプロテオミクス | 多血症治療薬 |
| CN114502781B (zh) * | 2019-09-20 | 2025-06-17 | 纳维再生科技股份有限公司 | 个人化癌症免疫治疗 |
| JP7622926B2 (ja) | 2019-11-27 | 2025-01-28 | 株式会社ペルセウスプロテオミクス | 癌性腹膜炎の治療薬 |
| JPWO2022075439A1 (lt) | 2020-10-08 | 2022-04-14 | ||
| EP4393509A4 (en) * | 2021-08-26 | 2025-11-19 | Perseus Proteomics Inc | PROMOTER OF REACTIVE OXYGEN SPECIES (ROS) PRODUCTION |
| AU2022340568A1 (en) | 2021-09-01 | 2024-03-28 | Biogen Ma Inc. | Anti-transferrin receptor antibodies and uses thereof |
| WO2023204181A1 (ja) | 2022-04-19 | 2023-10-26 | 学校法人東海大学 | Ｎｋ細胞腫瘍の治療剤 |
| CN119285763B (zh) * | 2023-07-10 | 2025-08-08 | 东莞市朋志生物科技有限公司 | 抗铁蛋白抗体、检测铁蛋白的试剂和试剂盒 |
| WO2025024334A1 (en) | 2023-07-21 | 2025-01-30 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
| WO2025095058A1 (ja) * | 2023-10-31 | 2025-05-08 | 株式会社ペルセウスプロテオミクス | 多血症治療薬 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5589211A (en) | 1985-06-24 | 1996-12-31 | Cox; James P. | Methods for processing poultry shell eggs |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1991014452A1 (en) | 1990-03-27 | 1991-10-03 | The Salk Institute For Biological Studies | Method for inhibiting cell growth and compositions useful therefor |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5165424A (en) | 1990-08-09 | 1992-11-24 | Silverman Harvey N | Method and system for whitening teeth |
| DE69127627T2 (de) | 1990-08-29 | 1998-02-19 | Genpharm Int | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
| CA2119930C (en) | 1991-09-23 | 2002-10-01 | Hendricus R. J. M. Hoogenboom | Production of chimeric antibodies - a combinatorial approach |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5777085A (en) | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
| WO1993016043A1 (en) | 1992-02-18 | 1993-08-19 | Otsuka Kagaku Kabushiki Kaisha | β-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| CA2131151A1 (en) | 1992-03-24 | 1994-09-30 | Kevin S. Johnson | Methods for producing members of specific binding pairs |
| EP0652950B1 (en) | 1992-07-24 | 2007-12-19 | Amgen Fremont Inc. | Generation of xenogeneic antibodies |
| EP0754225A4 (en) | 1993-04-26 | 2001-01-31 | Genpharm Int | HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| JPH09506508A (ja) | 1993-12-03 | 1997-06-30 | メディカル リサーチ カウンシル | 組換え結合タンパク質およびペプチド |
| KR100654645B1 (ko) | 1995-04-27 | 2007-04-04 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE69633973T2 (de) | 1995-09-11 | 2005-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Antikörper gegen die alpha-kette von humanem interleukin 5 rezeptor |
| JP4870348B2 (ja) | 2003-12-04 | 2012-02-08 | 株式会社ペルセウスプロテオミクス | 細胞表面抗原に対する抗体取得とその抗原同定 |
| PT1740616E (pt) | 2004-04-30 | 2012-03-23 | Inst Nat Sante Rech Med | Anticorpo anti-rtf |
| BRPI0516284A (pt) | 2004-09-23 | 2008-09-02 | Genentech Inc | anticorpo construìdo com cisteìna, método de selecionar anticorpos, compostos conjugados de droga-anticorpo, composição farmacêutica, método para matar ou inibir a proliferação de células de tumor, métodos de inibir a proliferação celular e o crescimento de células de tumor, artigo manufaturado e método para produzir um composto |
| WO2006090750A1 (ja) | 2005-02-28 | 2006-08-31 | Institute For Antibodies Co., Ltd. | 抗IgSF4抗体及びその利用 |
| EP2078732B1 (en) | 2006-07-10 | 2015-09-16 | Fujita Health University | Method of identifying a candidate diagnostic or therapeutic antibody using flow cytometry |
| CN101245107B (zh) | 2007-02-14 | 2010-10-13 | 中国人民解放军军事医学科学院生物工程研究所 | 抗人转铁蛋白受体人源抗体及其应用 |
| US7973019B1 (en) | 2007-10-03 | 2011-07-05 | Alcon Research, Ltd. | Transferrin/transferrin receptor-mediated siRNA delivery |
| FR2953841B1 (fr) | 2009-12-16 | 2011-12-30 | Centre Nat Rech Scient | Anticorps diriges contre le recepteur de la transferrine et leurs utilisations pour l'immunotherapie des tumeurs qui dependent du fer |
| JP5980202B2 (ja) * | 2011-05-09 | 2016-08-31 | 株式会社ペルセウスプロテオミクス | トランスフェリン受容体を特異的に認識できる抗体 |
| JP5990523B2 (ja) * | 2011-08-26 | 2016-09-14 | 学校法人藤田学園 | 抗ヒトトランスフェリン受容体抗体を含む画像用腫瘍診断剤 |
| JP5939855B2 (ja) * | 2012-03-23 | 2016-06-22 | 国立大学法人 宮崎大学 | トランスフェリン受容体抗体 |
-
2013
- 2013-11-08 SI SI201331165T patent/SI2918603T1/sl unknown
- 2013-11-08 HU HUE13853637A patent/HUE039920T2/hu unknown
- 2013-11-08 JP JP2014545766A patent/JP6212497B2/ja active Active
- 2013-11-08 WO PCT/JP2013/080249 patent/WO2014073641A1/ja not_active Ceased
- 2013-11-08 ES ES13853637.0T patent/ES2689782T3/es active Active
- 2013-11-08 US US14/441,307 patent/US9593165B2/en active Active
- 2013-11-08 AU AU2013342432A patent/AU2013342432A1/en not_active Abandoned
- 2013-11-08 PL PL13853637T patent/PL2918603T3/pl unknown
- 2013-11-08 LT LTEP13853637.0T patent/LT2918603T/lt unknown
- 2013-11-08 CN CN201380058622.3A patent/CN104797600A/zh active Pending
- 2013-11-08 EP EP13853637.0A patent/EP2918603B1/en active Active
- 2013-11-08 PT PT13853637T patent/PT2918603T/pt unknown
- 2013-11-08 HK HK16101588.8A patent/HK1213582A1/en unknown
- 2013-11-08 DK DK13853637.0T patent/DK2918603T3/en active
- 2013-11-08 HR HRP20181453TT patent/HRP20181453T1/hr unknown
- 2013-11-08 CA CA2893794A patent/CA2893794C/en active Active
- 2013-11-08 RS RS20181120A patent/RS57696B1/sr unknown
-
2018
- 2018-10-05 CY CY20181101031T patent/CY1121158T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1213582A1 (en) | 2016-07-08 |
| WO2014073641A1 (ja) | 2014-05-15 |
| CA2893794A1 (en) | 2014-05-15 |
| CY1121158T1 (el) | 2020-05-29 |
| PL2918603T3 (pl) | 2019-01-31 |
| RS57696B1 (sr) | 2018-12-31 |
| US9593165B2 (en) | 2017-03-14 |
| AU2013342432A1 (en) | 2015-07-02 |
| HRP20181453T1 (hr) | 2018-12-14 |
| US20150291697A1 (en) | 2015-10-15 |
| ES2689782T3 (es) | 2018-11-15 |
| SI2918603T1 (sl) | 2018-12-31 |
| JPWO2014073641A1 (ja) | 2016-09-08 |
| EP2918603A1 (en) | 2015-09-16 |
| CA2893794C (en) | 2021-11-09 |
| JP6212497B2 (ja) | 2017-10-11 |
| PT2918603T (pt) | 2018-10-30 |
| DK2918603T3 (en) | 2018-10-15 |
| CN104797600A (zh) | 2015-07-22 |
| EP2918603B1 (en) | 2018-08-29 |
| HUE039920T2 (hu) | 2019-02-28 |
| EP2918603A4 (en) | 2016-06-29 |
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