LT2943579T - Molekulių bibliotekos ir molekulių generavimo būdai - Google Patents
Molekulių bibliotekos ir molekulių generavimo būdaiInfo
- Publication number
- LT2943579T LT2943579T LTEP14737758.4T LT14737758T LT2943579T LT 2943579 T LT2943579 T LT 2943579T LT 14737758 T LT14737758 T LT 14737758T LT 2943579 T LT2943579 T LT 2943579T
- Authority
- LT
- Lithuania
- Prior art keywords
- libraries
- methods
- generating molecules
- molecules
- generating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751157P | 2013-01-10 | 2013-01-10 | |
| PCT/US2014/010428 WO2014110006A1 (en) | 2013-01-10 | 2014-01-07 | Templates, libraries, kits and methods for generating molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2943579T true LT2943579T (lt) | 2018-11-12 |
Family
ID=51167313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP14737758.4T LT2943579T (lt) | 2013-01-10 | 2014-01-07 | Molekulių bibliotekos ir molekulių generavimo būdai |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9988625B2 (lt) |
| EP (1) | EP2943579B1 (lt) |
| AU (1) | AU2014205648B2 (lt) |
| CA (1) | CA2897390A1 (lt) |
| LT (1) | LT2943579T (lt) |
| WO (1) | WO2014110006A1 (lt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| WO2015026853A2 (en) | 2013-08-19 | 2015-02-26 | Abbott Molecular Inc. | Next-generation sequencing libraries |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US10584358B2 (en) | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri |
| US20150166985A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting von willebrand factor point mutations |
| US10787654B2 (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting |
| KR102496984B1 (ko) | 2014-02-11 | 2023-02-06 | 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | Crispr 이용의 다중화된 게놈 조작 |
| JP2017512481A (ja) | 2014-04-08 | 2017-05-25 | ノースカロライナ ステート ユニバーシティーＮｏｒｔｈ Ｃａｒｏｌｉｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ | Ｃｒｉｓｐｒ関連遺伝子を用いた、ｒｎａ依存性の転写抑制のための方法および組成物 |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3186375A4 (en) | 2014-08-28 | 2019-03-13 | North Carolina State University | Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING |
| CN104357443B (zh) * | 2014-11-25 | 2017-03-15 | 中国科学院生物物理研究所 | 一种用于膀胱癌筛查的长链非编码rna的检测及其应用 |
| EA035378B1 (ru) | 2015-01-15 | 2020-06-04 | Юниверсити Оф Копенгаген | Вирусоподобная частица с эффективным экспонированием эпитопов |
| CA2983023A1 (en) | 2015-05-29 | 2016-12-08 | North Carolina State University | Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids |
| US11279926B2 (en) | 2015-06-05 | 2022-03-22 | The Regents Of The University Of California | Methods and compositions for generating CRISPR/Cas guide RNAs |
| WO2016205276A1 (en) | 2015-06-15 | 2016-12-22 | North Carolina State University | Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials |
| EP3356533A1 (en) | 2015-09-28 | 2018-08-08 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| EP3368068B1 (en) | 2015-10-30 | 2020-11-18 | University of Copenhagen | Virus like particle with efficient epitope display |
| DK3386550T3 (da) * | 2015-12-07 | 2021-04-26 | Arc Bio Llc | Fremgangsmåder til fremstilling og anvendelse af guide nukleinsyrer |
| WO2017112620A1 (en) | 2015-12-22 | 2017-06-29 | North Carolina State University | Methods and compositions for delivery of crispr based antimicrobials |
| US12049625B2 (en) | 2016-01-14 | 2024-07-30 | The Brigham And Women's Hospital, Inc. | Genome editing for treating glioblastoma |
| CN109688820B (zh) | 2016-06-24 | 2023-01-10 | 科罗拉多州立大学董事会（法人团体） | 用于生成条形码化组合文库的方法 |
| US10774328B2 (en) * | 2016-07-11 | 2020-09-15 | University Of North Texas Health Science Center At Fort Worth | Treatment for glaucoma and other eye diseases |
| EP3494215A1 (en) | 2016-08-03 | 2019-06-12 | President and Fellows of Harvard College | Adenosine nucleobase editors and uses thereof |
| EP3494229B1 (en) * | 2016-08-03 | 2023-10-25 | Meiragtx UK II Limited | High throughput cell-based screening for aptamers |
| CN109804066A (zh) | 2016-08-09 | 2019-05-24 | 哈佛大学的校长及成员们 | 可编程cas9-重组酶融合蛋白及其用途 |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| IL269458B2 (en) | 2017-03-23 | 2024-02-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CN108359720A (zh) * | 2018-04-16 | 2018-08-03 | 浙江省农业科学院 | 突变体的检测方法及其应用 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020072253A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for screening for variant cells |
| WO2020072250A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression |
| WO2020072248A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system |
| WO2020072254A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for killing target cells |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| AU2020242032A1 (en) | 2019-03-19 | 2021-10-07 | Massachusetts Institute Of Technology | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| WO2025072262A1 (en) * | 2023-09-26 | 2025-04-03 | Instance, Inc. | Ultra-high capacity dna synthesis to power functionally generative biological design |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US6511803B1 (en) | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| WO2000023610A1 (en) * | 1998-10-21 | 2000-04-27 | Chugai Seiyaku Kabushiki Kaisha | Method for screening compound inhibiting signal transduction of inflammatory cytokine |
| US20020146723A1 (en) * | 2000-10-25 | 2002-10-10 | Krontiris Theodore G. | Candidate region mismatch scanning for genotyping and mutation detection |
| US20020192721A1 (en) | 2001-03-28 | 2002-12-19 | Engeneos, Inc. | Modular molecular clasps and uses thereof |
| US20030165859A1 (en) * | 2001-10-23 | 2003-09-04 | Invitrogen Corporation | Primers and methods for the detection and discrimination of nucleic acids |
| US20030228611A1 (en) | 2002-05-01 | 2003-12-11 | President And Fellows Of Harvard College | Nucleic acid memory device |
| JP2005529624A (ja) * | 2002-06-21 | 2005-10-06 | シノゲノマックス カンパニー リミテッド | ランダムｄｎａライブラリーと二本鎖ｒｎａライブラリー、その用途および生産方法 |
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| JP2004261002A (ja) | 2003-01-08 | 2004-09-24 | Tsutomu Suzuki | ｓｉＲＮＡの製造方法 |
| US8133670B2 (en) | 2003-06-13 | 2012-03-13 | Cold Spring Harbor Laboratory | Method for making populations of defined nucleic acid molecules |
| WO2005024068A2 (en) * | 2003-09-05 | 2005-03-17 | Sequenom, Inc. | Allele-specific sequence variation analysis |
| US7387876B2 (en) | 2004-02-27 | 2008-06-17 | President And Fellows Of Harvard College | Amplification of trace amounts of nucleic acids |
| WO2005089110A2 (en) | 2004-02-27 | 2005-09-29 | President And Fellows Of Harvard College | Polynucleotide synthesis |
| CA2584984A1 (en) | 2004-10-18 | 2006-04-27 | Codon Devices, Inc. | Methods for assembly of high fidelity synthetic polynucleotides |
| WO2006127423A2 (en) | 2005-05-18 | 2006-11-30 | Codon Devices, Inc. | Methods of producing polynucleotide libraries using scarless ligation |
| WO2007005053A1 (en) | 2005-06-30 | 2007-01-11 | Codon Devices, Inc. | Hierarchical assembly methods for genome engineering |
| US20070172839A1 (en) * | 2006-01-24 | 2007-07-26 | Smith Douglas R | Asymmetrical adapters and methods of use thereof |
| WO2007136874A2 (en) | 2006-05-18 | 2007-11-29 | President And Fellows Of Harvard College | Genomic library construction |
| WO2008052101A2 (en) | 2006-10-25 | 2008-05-02 | President And Fellows Of Harvard College | Multiplex automated genome engineering |
| US20090075840A1 (en) | 2007-09-18 | 2009-03-19 | Joel Myerson | Methods And Compositions For Generating Mixtures Of Nucleic Acid Molecules |
| JP2010022262A (ja) | 2008-07-18 | 2010-02-04 | Univ Of Tokyo | 高活性ｓｈＲＮＡ及びその製造方法 |
| WO2010011346A1 (en) * | 2008-07-24 | 2010-01-28 | Rxi Pharmaceuticals Corporation | Rnai constructs and uses therof |
| US20100047876A1 (en) | 2008-08-08 | 2010-02-25 | President And Fellows Of Harvard College | Hierarchical assembly of polynucleotides |
| US8808986B2 (en) | 2008-08-27 | 2014-08-19 | Gen9, Inc. | Methods and devices for high fidelity polynucleotide synthesis |
| US20120185177A1 (en) | 2009-02-20 | 2012-07-19 | Hannon Gregory J | Harnessing high throughput sequencing for multiplexed specimen analysis |
| US20100304994A1 (en) | 2009-06-02 | 2010-12-02 | President And Fellows Of Havard College | Oligonucleotide Paints |
| US20110039304A1 (en) | 2009-08-12 | 2011-02-17 | President And Fellows Of Harvard College | Methods to Generate Oligonucleotide Pools and Enrich Target Nucleic Acid Sequences |
| WO2012018881A2 (en) | 2010-08-03 | 2012-02-09 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for the regulation of rna |
| US9410206B2 (en) | 2011-11-30 | 2016-08-09 | John Wayne Cancer Institute | Long noncoding RNA (lncRNA) as a biomarker and therapeutic marker in cancer |
-
2014
- 2014-01-07 CA CA2897390A patent/CA2897390A1/en not_active Abandoned
- 2014-01-07 WO PCT/US2014/010428 patent/WO2014110006A1/en not_active Ceased
- 2014-01-07 EP EP14737758.4A patent/EP2943579B1/en not_active Not-in-force
- 2014-01-07 US US14/758,391 patent/US9988625B2/en not_active Expired - Fee Related
- 2014-01-07 AU AU2014205648A patent/AU2014205648B2/en not_active Ceased
- 2014-01-07 LT LTEP14737758.4T patent/LT2943579T/lt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9988625B2 (en) | 2018-06-05 |
| US20150353927A1 (en) | 2015-12-10 |
| EP2943579A1 (en) | 2015-11-18 |
| EP2943579B1 (en) | 2018-09-12 |
| EP2943579A4 (en) | 2016-10-19 |
| AU2014205648B2 (en) | 2017-05-04 |
| AU2014205648A1 (en) | 2015-08-20 |
| WO2014110006A1 (en) | 2014-07-17 |
| CA2897390A1 (en) | 2014-07-17 |
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