LT2820000T - Dihidrochinazolino darinio bezilato ir tozilato druskos ir jų, kaip antivirusinių agentų, panaudojimas - Google Patents
Dihidrochinazolino darinio bezilato ir tozilato druskos ir jų, kaip antivirusinių agentų, panaudojimasInfo
- Publication number
- LT2820000T LT2820000T LTEP13709345.6T LT13709345T LT2820000T LT 2820000 T LT2820000 T LT 2820000T LT 13709345 T LT13709345 T LT 13709345T LT 2820000 T LT2820000 T LT 2820000T
- Authority
- LT
- Lithuania
- Prior art keywords
- besylate
- antiviral agents
- tosylate salts
- dihydroquinazoline derivative
- dihydroquinazoline
- Prior art date
Links
- NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical class C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 title 1
- 125000005490 tosylate group Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012101673A DE102012101673A1 (de) | 2012-02-29 | 2012-02-29 | Salze eines Dihydrochinazolinderivats |
| PCT/EP2013/054109 WO2013127968A1 (de) | 2012-02-29 | 2013-02-28 | Besylat- und tosylatsalze eines dihydrochinazolinderivates und ihre verwendung als antivirale mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2820000T true LT2820000T (lt) | 2016-11-10 |
Family
ID=47884256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13709345.6T LT2820000T (lt) | 2012-02-29 | 2013-02-28 | Dihidrochinazolino darinio bezilato ir tozilato druskos ir jų, kaip antivirusinių agentų, panaudojimas |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9512085B2 (lt) |
| EP (1) | EP2820000B1 (lt) |
| JP (1) | JP6235493B2 (lt) |
| CN (1) | CN104144916B (lt) |
| CA (1) | CA2865534C (lt) |
| CY (1) | CY1118284T1 (lt) |
| DE (1) | DE102012101673A1 (lt) |
| DK (1) | DK2820000T3 (lt) |
| ES (1) | ES2583360T3 (lt) |
| HR (1) | HRP20160886T1 (lt) |
| HU (1) | HUE027751T2 (lt) |
| LT (1) | LT2820000T (lt) |
| PL (1) | PL2820000T3 (lt) |
| PT (1) | PT2820000T (lt) |
| RS (1) | RS54989B1 (lt) |
| SI (1) | SI2820000T1 (lt) |
| SM (1) | SMT201600343B (lt) |
| WO (1) | WO2013127968A1 (lt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2855695B2 (ja) | 1989-09-22 | 1999-02-10 | 東洋紡績株式会社 | 特殊捲縮加工糸 |
| DE10319612A1 (de) | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE102012101673A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| DE102012101659A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| JP6445546B2 (ja) * | 2013-06-19 | 2018-12-26 | アイキュリス アンチ−インフェクティブ キュアズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非晶質レテルモビル及び経口投与のためのその固形医薬製剤 |
| US9890128B2 (en) | 2013-12-12 | 2018-02-13 | Merck Sharp & Dohme Corp. | Process for making substituted quinazoline compounds |
| US10392353B2 (en) | 2015-11-24 | 2019-08-27 | Merck Sharp & Dohme Corp. | Processes for making substituted quinazoline compounds using hydrogen bonding catalysts |
| AU2019218150B2 (en) * | 2018-02-08 | 2021-05-13 | Phaeno Therapeutics Co., Ltd. | Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor |
| IT202000017617A1 (it) | 2020-07-21 | 2022-01-21 | Olon Spa | Procedimento per la preparazione di un intermedio utilizzato nella sintesi del letermovir |
| US20230312485A1 (en) | 2020-08-17 | 2023-10-05 | Lupin Limited | A precipitation process for amorphous letermovir |
| CN113880776B (zh) * | 2021-11-16 | 2023-06-16 | 山东诚创蓝海医药科技有限公司 | 一种莱特莫韦中间体的制备方法 |
| CN117229223A (zh) * | 2022-06-08 | 2023-12-15 | 苏州远智医药科技有限公司 | 一种杂环衍生物及其药物组合物、应用 |
| CN119731157A (zh) * | 2022-08-15 | 2025-03-28 | 上海迪赛诺化学制药有限公司 | 一种来特莫韦无定形的制备方法 |
| TW202535393A (zh) | 2023-12-21 | 2025-09-16 | 德商Ａｉｃ246股份兩合公司 | 2-[(4r,s)-8-氟-2-[4-(3-甲氧基苯基)哌嗪-1-基]-3-[2-甲氧基-5-(三氟甲基)苯基]-3,4-二氫喹唑啉-4-基]乙酸之非鏡像異構物胺基醇鹽及胺基醚鹽及其於鏡像異構物分離之用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10319612A1 (de) * | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE10352499A1 (de) * | 2003-11-11 | 2005-06-09 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline II |
| DE102005027517A1 (de) | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| DE102011101446A1 (de) | 2011-05-10 | 2012-11-15 | Aicuris Gmbh & Co. Kg | Herstellung von "Dense Bodies" (DB) |
| DE102012101673A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| DE102012101659A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| JP6445546B2 (ja) | 2013-06-19 | 2018-12-26 | アイキュリス アンチ−インフェクティブ キュアズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非晶質レテルモビル及び経口投与のためのその固形医薬製剤 |
-
2012
- 2012-02-29 DE DE102012101673A patent/DE102012101673A1/de not_active Ceased
-
2013
- 2013-02-28 HU HUE13709345A patent/HUE027751T2/en unknown
- 2013-02-28 PL PL13709345T patent/PL2820000T3/pl unknown
- 2013-02-28 SI SI201330242A patent/SI2820000T1/sl unknown
- 2013-02-28 CA CA2865534A patent/CA2865534C/en active Active
- 2013-02-28 PT PT137093456T patent/PT2820000T/pt unknown
- 2013-02-28 WO PCT/EP2013/054109 patent/WO2013127968A1/de not_active Ceased
- 2013-02-28 CN CN201380011791.1A patent/CN104144916B/zh active Active
- 2013-02-28 ES ES13709345.6T patent/ES2583360T3/es active Active
- 2013-02-28 RS RS20160574A patent/RS54989B1/sr unknown
- 2013-02-28 US US14/381,625 patent/US9512085B2/en active Active
- 2013-02-28 EP EP13709345.6A patent/EP2820000B1/de active Active
- 2013-02-28 HR HRP20160886TT patent/HRP20160886T1/hr unknown
- 2013-02-28 JP JP2014559231A patent/JP6235493B2/ja active Active
- 2013-02-28 LT LTEP13709345.6T patent/LT2820000T/lt unknown
- 2013-02-28 DK DK13709345.6T patent/DK2820000T3/en active
-
2016
- 2016-07-18 CY CY20161100699T patent/CY1118284T1/el unknown
- 2016-09-30 SM SM201600343T patent/SMT201600343B/it unknown
- 2016-10-31 US US15/338,984 patent/US10287254B2/en not_active Ceased
-
2017
- 2017-07-03 US US15/640,661 patent/US20170362186A1/en not_active Abandoned
-
2021
- 2021-05-14 US US17/320,587 patent/USRE49897E1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150045371A1 (en) | 2015-02-12 |
| HK1205511A1 (zh) | 2015-12-18 |
| CA2865534C (en) | 2019-04-02 |
| PL2820000T3 (pl) | 2017-07-31 |
| SI2820000T1 (sl) | 2016-08-31 |
| CY1118284T1 (el) | 2017-06-28 |
| HRP20160886T1 (hr) | 2016-09-23 |
| SMT201600343B (lt) | 2016-11-10 |
| US20170362186A1 (en) | 2017-12-21 |
| US10287254B2 (en) | 2019-05-14 |
| PT2820000T (pt) | 2016-07-20 |
| CN104144916A (zh) | 2014-11-12 |
| RS54989B1 (sr) | 2016-11-30 |
| ES2583360T3 (es) | 2016-09-20 |
| JP6235493B2 (ja) | 2017-11-22 |
| HUE027751T2 (en) | 2016-10-28 |
| JP2015508800A (ja) | 2015-03-23 |
| EP2820000B1 (de) | 2016-04-20 |
| DK2820000T3 (en) | 2016-07-25 |
| DE102012101673A1 (de) | 2013-08-29 |
| EP2820000A1 (de) | 2015-01-07 |
| US20170114026A1 (en) | 2017-04-27 |
| US9512085B2 (en) | 2016-12-06 |
| USRE49897E1 (en) | 2024-04-02 |
| CA2865534A1 (en) | 2013-09-06 |
| CN104144916B (zh) | 2016-08-24 |
| WO2013127968A1 (de) | 2013-09-06 |
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