LT2599774T - Kondensuoti piridino junginiai kaip kanabinoidų cb2 receptoriaus ligandai - Google Patents
Kondensuoti piridino junginiai kaip kanabinoidų cb2 receptoriaus ligandaiInfo
- Publication number
- LT2599774T LT2599774T LTEP11812552.5T LT11812552T LT2599774T LT 2599774 T LT2599774 T LT 2599774T LT 11812552 T LT11812552 T LT 11812552T LT 2599774 T LT2599774 T LT 2599774T
- Authority
- LT
- Lithuania
- Prior art keywords
- receptor ligands
- cannabinoid receptor
- pyridine compounds
- condensed pyridine
- condensed
- Prior art date
Links
- 102000009135 CB2 Cannabinoid Receptor Human genes 0.000 title 1
- 108010073376 CB2 Cannabinoid Receptor Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010170338 | 2010-07-29 | ||
| PCT/JP2011/067222 WO2012014963A1 (ja) | 2010-07-29 | 2011-07-28 | 縮環ピリジン化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2599774T true LT2599774T (lt) | 2016-10-10 |
Family
ID=45530163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP11812552.5T LT2599774T (lt) | 2010-07-29 | 2011-07-28 | Kondensuoti piridino junginiai kaip kanabinoidų cb2 receptoriaus ligandai |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8791106B2 (lt) |
| EP (1) | EP2599774B1 (lt) |
| JP (1) | JP5776691B2 (lt) |
| KR (1) | KR101760158B1 (lt) |
| CN (1) | CN103038218B (lt) |
| AU (1) | AU2011283563C1 (lt) |
| BR (1) | BR112013003481A8 (lt) |
| CA (1) | CA2806821C (lt) |
| CY (1) | CY1118049T1 (lt) |
| DK (1) | DK2599774T3 (lt) |
| EA (1) | EA024353B1 (lt) |
| ES (1) | ES2592161T3 (lt) |
| HR (1) | HRP20161111T1 (lt) |
| HU (1) | HUE031639T2 (lt) |
| IL (1) | IL224342A (lt) |
| LT (1) | LT2599774T (lt) |
| MX (1) | MX341394B (lt) |
| PH (1) | PH12013500150A1 (lt) |
| PL (1) | PL2599774T3 (lt) |
| PT (1) | PT2599774T (lt) |
| RS (1) | RS55186B1 (lt) |
| SI (1) | SI2599774T1 (lt) |
| TW (1) | TWI482622B (lt) |
| UA (1) | UA109550C2 (lt) |
| WO (1) | WO2012014963A1 (lt) |
| ZA (1) | ZA201300572B (lt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI610916B (zh) * | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| PL3417851T3 (pl) | 2013-09-09 | 2020-12-14 | Peloton Therapeutics, Inc. | Etery arylowe i ich zastosowanie |
| WO2016145045A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating glioblastoma |
| US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
| US10278942B2 (en) | 2015-03-11 | 2019-05-07 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
| WO2016144826A1 (en) * | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
| WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| KR20190070985A (ko) * | 2016-11-01 | 2019-06-21 | 에프. 호프만-라 로슈 아게 | RORc 조절제로서의 피리다진 유도체 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2342240T3 (es) * | 1998-08-11 | 2010-07-02 | Novartis Ag | Derivados de isoquinolina con actividad que inhibe la angiogenia. |
| WO2003064369A1 (en) * | 2002-01-30 | 2003-08-07 | Kissei Pharmaceutical Co., Ltd. | Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof |
| JP2005539036A (ja) * | 2002-08-21 | 2005-12-22 | グラクソ グループ リミテッド | ピリミジン化合物 |
| UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| GB0412908D0 (en) * | 2004-06-09 | 2004-07-14 | Glaxo Group Ltd | Compounds |
| TW200611695A (en) | 2004-06-09 | 2006-04-16 | Glaxo Group Ltd | Pyrrolopyridine derivatives |
| JP2009504587A (ja) | 2005-08-09 | 2009-02-05 | グラクソ グループ リミテッド | ナンナビノイド受容体リガンドとしてのイミダゾピリジン誘導体 |
| GB0516379D0 (en) | 2005-08-09 | 2005-09-14 | Glaxo Group Ltd | Compounds |
| GB0516380D0 (en) * | 2005-08-09 | 2005-09-14 | Glaxo Group Ltd | Compounds |
| CN101296699B (zh) * | 2005-10-21 | 2013-01-02 | 田边三菱制药株式会社 | 吡唑并[1,5-a]嘧啶化合物 |
| JP4847275B2 (ja) * | 2005-10-21 | 2011-12-28 | 田辺三菱製薬株式会社 | ピラゾロ[1,5−a]ピリミジン化合物 |
| US7935715B2 (en) | 2006-07-28 | 2011-05-03 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| CN101573339A (zh) * | 2006-11-03 | 2009-11-04 | 格兰马克药品股份有限公司 | 作为大麻素受体配体的桥接二环吲唑 |
| GB0705803D0 (en) | 2007-03-28 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
| US8338623B2 (en) * | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US7943658B2 (en) * | 2007-07-23 | 2011-05-17 | Bristol-Myers Squibb Company | Indole indane amide compounds useful as CB2 agonists and method |
| EP2226323A1 (en) * | 2009-02-27 | 2010-09-08 | Almirall, S.A. | New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives |
-
2011
- 2011-07-28 PL PL11812552T patent/PL2599774T3/pl unknown
- 2011-07-28 HU HUE11812552A patent/HUE031639T2/en unknown
- 2011-07-28 EP EP11812552.5A patent/EP2599774B1/en active Active
- 2011-07-28 SI SI201130928A patent/SI2599774T1/sl unknown
- 2011-07-28 LT LTEP11812552.5T patent/LT2599774T/lt unknown
- 2011-07-28 MX MX2013001202A patent/MX341394B/es active IP Right Grant
- 2011-07-28 ES ES11812552.5T patent/ES2592161T3/es active Active
- 2011-07-28 HR HRP20161111TT patent/HRP20161111T1/hr unknown
- 2011-07-28 EA EA201390180A patent/EA024353B1/ru not_active IP Right Cessation
- 2011-07-28 UA UAA201302507A patent/UA109550C2/uk unknown
- 2011-07-28 DK DK11812552.5T patent/DK2599774T3/en active
- 2011-07-28 KR KR1020137004977A patent/KR101760158B1/ko not_active Expired - Fee Related
- 2011-07-28 JP JP2012526539A patent/JP5776691B2/ja not_active Expired - Fee Related
- 2011-07-28 PT PT118125525T patent/PT2599774T/pt unknown
- 2011-07-28 AU AU2011283563A patent/AU2011283563C1/en not_active Ceased
- 2011-07-28 TW TW100126743A patent/TWI482622B/zh not_active IP Right Cessation
- 2011-07-28 BR BR112013003481A patent/BR112013003481A8/pt not_active Application Discontinuation
- 2011-07-28 WO PCT/JP2011/067222 patent/WO2012014963A1/ja not_active Ceased
- 2011-07-28 RS RS20160820A patent/RS55186B1/sr unknown
- 2011-07-28 CN CN201180037334.0A patent/CN103038218B/zh not_active Expired - Fee Related
- 2011-07-28 CA CA2806821A patent/CA2806821C/en not_active Expired - Fee Related
- 2011-07-28 PH PH1/2013/500150A patent/PH12013500150A1/en unknown
-
2013
- 2013-01-21 IL IL224342A patent/IL224342A/en active IP Right Grant
- 2013-01-22 ZA ZA2013/00572A patent/ZA201300572B/en unknown
- 2013-01-29 US US13/753,005 patent/US8791106B2/en active Active
-
2016
- 2016-10-04 CY CY20161100987T patent/CY1118049T1/el unknown
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