LT2575884T - Panaudojimai ir kompozicijos, skirti pūlingo hidradenito (hs) gydymui - Google Patents
Panaudojimai ir kompozicijos, skirti pūlingo hidradenito (hs) gydymuiInfo
- Publication number
- LT2575884T LT2575884T LTEP11790495.3T LT11790495T LT2575884T LT 2575884 T LT2575884 T LT 2575884T LT 11790495 T LT11790495 T LT 11790495T LT 2575884 T LT2575884 T LT 2575884T
- Authority
- LT
- Lithuania
- Prior art keywords
- compositions
- treatment
- hidradenitis suppurativa
- suppurativa
- hidradenitis
- Prior art date
Links
- 208000002557 hidradenitis Diseases 0.000 title 1
- 201000007162 hidradenitis suppurativa Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35112510P | 2010-06-03 | 2010-06-03 | |
| US201161430645P | 2011-01-07 | 2011-01-07 | |
| US201161474764P | 2011-04-13 | 2011-04-13 | |
| PCT/US2011/039135 WO2011153477A2 (en) | 2010-06-03 | 2011-06-03 | Uses and compositions for treatment of hidradenitis suppurativa (hs) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2575884T true LT2575884T (lt) | 2018-09-25 |
Family
ID=45064648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP11790495.3T LT2575884T (lt) | 2010-06-03 | 2011-06-03 | Panaudojimai ir kompozicijos, skirti pūlingo hidradenito (hs) gydymui |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8747854B2 (lt) |
| EP (1) | EP2575884B1 (lt) |
| JP (2) | JP5944382B2 (lt) |
| CN (2) | CN103079594B (lt) |
| CA (1) | CA2801917C (lt) |
| CY (1) | CY1120664T1 (lt) |
| DK (1) | DK2575884T3 (lt) |
| ES (1) | ES2685607T3 (lt) |
| HR (1) | HRP20181598T1 (lt) |
| HU (1) | HUE039740T2 (lt) |
| LT (1) | LT2575884T (lt) |
| MX (1) | MX2012014080A (lt) |
| PL (1) | PL2575884T3 (lt) |
| PT (1) | PT2575884T (lt) |
| RS (1) | RS57543B1 (lt) |
| SI (1) | SI2575884T1 (lt) |
| SM (1) | SMT201800428T1 (lt) |
| WO (1) | WO2011153477A2 (lt) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US6258562B1 (en) | 1996-02-09 | 2001-07-10 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| CA2385745C (en) | 2001-06-08 | 2015-02-17 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| TWI556829B (zh) | 2004-04-09 | 2016-11-11 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| MX2007014440A (es) | 2005-05-16 | 2008-02-11 | Abbott Biotech Ltd | Uso de inhibidor de tnf para tratamiento de poliartritis erosiva. |
| HRP20131112T1 (hr) | 2005-11-01 | 2014-01-03 | Abbvie Biotechnology Ltd | Postupak za odreä�ivanje uäśinkovitosti adalimumaba kod subjekata koji pate od ankilozantnog spondilitisa pomoä†u ctx-ii i mmp3 kao biomarkera |
| SG170837A1 (en) | 2006-04-05 | 2011-05-30 | Abbott Biotech Ltd | Antibody purification |
| WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
| EP2010214A4 (en) * | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS |
| US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| CN107243099A (zh) | 2006-06-30 | 2017-10-13 | 艾伯维生物技术有限公司 | 自动注射装置 |
| JP2010507670A (ja) | 2006-10-27 | 2010-03-11 | アボツト・バイオテクノロジー・リミテツド | 結晶性抗hTNFα抗体 |
| EP2171451A4 (en) * | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| US20090110679A1 (en) * | 2007-07-13 | 2009-04-30 | Luk-Chiu Li | Methods and compositions for pulmonary administration of a TNFa inhibitor |
| MX2010001488A (es) * | 2007-08-08 | 2010-03-01 | Abbott Lab | Composiciones y metodos para cristalizar anticuerpos. |
| KR20210049186A (ko) * | 2007-11-30 | 2021-05-04 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| CN103079594B (zh) * | 2010-06-03 | 2016-04-13 | 艾伯维生物技术有限公司 | 用于治疗化脓性汗腺炎(hs)的用途和组合物 |
| ES2703774T3 (es) | 2010-06-18 | 2019-03-12 | Xbiotech Inc | Tratamiento para la artritis |
| KR102314003B1 (ko) | 2010-08-23 | 2021-10-19 | 얀센 바이오테크 인코포레이티드 | 종양성 질병들에 대한 치료 |
| AU2011325974B2 (en) | 2010-11-11 | 2016-10-27 | Abbvie Biotechnology Ltd. | Improved high concentration anti-TNFalpha antibody liquid formulations |
| WO2012103141A1 (en) | 2011-01-24 | 2012-08-02 | Abbott Biotechnology Ltd. | Automatic injection devices having overmolded gripping surfaces |
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| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| EP2890782A1 (en) | 2012-09-02 | 2015-07-08 | AbbVie Inc. | Methods to control protein heterogeneity |
| EP2934587A4 (en) | 2012-12-18 | 2016-08-03 | Merck Sharp & Dohme | Liquid formulations for an anti-TNF-alpha-antibody |
| EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US10376582B2 (en) | 2013-10-16 | 2019-08-13 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| US10696735B2 (en) | 2015-01-21 | 2020-06-30 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| EP3078675A1 (en) | 2015-04-10 | 2016-10-12 | Ares Trading S.A. | Induction dosing regimen for the treatment of tnf alpha mediated disorders |
| US11285210B2 (en) | 2016-02-03 | 2022-03-29 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| PE20190622A1 (es) | 2016-06-02 | 2019-04-26 | Abbvie Inc | Agonista del receptor de glucocorticoides e inmunoconjugados del mismo |
| EP3538118B1 (en) | 2016-11-11 | 2021-03-03 | Sjaellands Universitetshospital Dermatologisk Afdeling | Saprophytic live bacteria for use in treatment of hidradenitis suppurativa |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| SG11201907159SA (en) | 2017-02-16 | 2019-09-27 | Xbiotech Inc | Treatment of hidradenitis suppurativa |
| US20200277369A1 (en) * | 2017-11-20 | 2020-09-03 | Novartis Ag | Method of treating hidradentitis suppurativa with il-17 antagonists |
| HUE054428T2 (hu) | 2017-12-01 | 2021-09-28 | Abbvie Inc | Glükokortikoid receptor agonista és annak immunkonjugátumai |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019130215A1 (en) * | 2017-12-27 | 2019-07-04 | To Pharmaceuticals Llc | Cannabis compositions for the treatment of inflammatory skin disorders |
| IL277215B2 (en) | 2018-03-14 | 2025-10-01 | Boehringer Ingelheim Int | Use of anti-IL-36R antibodies for the treatment of generalized pustular psoriasis |
| TWI737000B (zh) * | 2018-10-22 | 2021-08-21 | 美商美國禮來大藥廠 | 用於治療化膿性汗腺炎之泛-elr+cxc趨化介素抗體 |
| TW202031265A (zh) | 2018-11-15 | 2020-09-01 | 美商艾伯維有限公司 | 用於皮下投藥之醫藥調配物 |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| JP2023509366A (ja) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス, インコーポレイテッド | Irak分解剤およびそれらの使用 |
| CA3182561A1 (en) * | 2020-06-17 | 2021-12-23 | Veronica CAMPBELL | Irak degraders and uses thereof |
| CN116745315A (zh) | 2020-07-17 | 2023-09-12 | 勃林格殷格翰国际有限公司 | 用于治疗嗜中性皮肤病的抗il-36r抗体 |
| WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
| TW202241891A (zh) | 2020-12-30 | 2022-11-01 | 美商凱麥拉醫療公司 | Irak降解劑及其用途 |
| MX2023009178A (es) | 2021-02-15 | 2023-08-21 | Kymera Therapeutics Inc | Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos. |
| US20240294626A1 (en) * | 2021-06-22 | 2024-09-05 | Novartis Ag | Bispecific antibodies for use in treatment of hidradenitis suppurativa |
| AR127505A1 (es) | 2021-10-29 | 2024-01-31 | Kymera Therapeutics Inc | Degradadores irak-4 y síntesis de los mismos |
| WO2023147594A2 (en) | 2022-01-31 | 2023-08-03 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| KR20250031013A (ko) * | 2023-08-23 | 2025-03-06 | (주)셀트리온 | TNFα 관련 질환을 치료하는 방법 |
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2011
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- 2011-06-03 RS RS20180883A patent/RS57543B1/sr unknown
- 2011-06-03 HU HUE11790495A patent/HUE039740T2/hu unknown
- 2011-06-03 CA CA2801917A patent/CA2801917C/en active Active
- 2011-06-03 JP JP2013513388A patent/JP5944382B2/ja active Active
- 2011-06-03 EP EP11790495.3A patent/EP2575884B1/en active Active
- 2011-06-03 CN CN201510560983.9A patent/CN105056232A/zh active Pending
- 2011-06-03 PT PT11790495T patent/PT2575884T/pt unknown
- 2011-06-03 US US13/153,131 patent/US8747854B2/en active Active
- 2011-06-03 LT LTEP11790495.3T patent/LT2575884T/lt unknown
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- 2011-06-03 MX MX2012014080A patent/MX2012014080A/es active IP Right Grant
- 2011-06-03 PL PL11790495T patent/PL2575884T3/pl unknown
- 2011-06-03 SI SI201131570T patent/SI2575884T1/sl unknown
- 2011-06-03 DK DK11790495.3T patent/DK2575884T3/en active
- 2011-06-03 ES ES11790495.3T patent/ES2685607T3/es active Active
- 2011-06-03 WO PCT/US2011/039135 patent/WO2011153477A2/en not_active Ceased
- 2011-06-04 SM SM20180428T patent/SMT201800428T1/it unknown
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- 2014-05-28 US US14/289,115 patent/US9334320B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| PL2575884T3 (pl) | 2018-12-31 |
| ES2685607T3 (es) | 2018-10-10 |
| WO2011153477A2 (en) | 2011-12-08 |
| DK2575884T3 (en) | 2018-09-03 |
| EP2575884A2 (en) | 2013-04-10 |
| US8747854B2 (en) | 2014-06-10 |
| EP2575884B1 (en) | 2018-07-18 |
| MX2012014080A (es) | 2013-05-01 |
| CN103079594B (zh) | 2016-04-13 |
| SMT201800428T1 (it) | 2018-09-13 |
| SI2575884T1 (sl) | 2018-10-30 |
| WO2011153477A3 (en) | 2012-03-15 |
| CA2801917C (en) | 2017-04-25 |
| RS57543B1 (sr) | 2018-10-31 |
| EP2575884A4 (en) | 2013-12-04 |
| CN105056232A (zh) | 2015-11-18 |
| US20150147335A1 (en) | 2015-05-28 |
| US9334320B2 (en) | 2016-05-10 |
| JP2013533858A (ja) | 2013-08-29 |
| US20110300151A1 (en) | 2011-12-08 |
| CY1120664T1 (el) | 2019-12-11 |
| HRP20181598T1 (hr) | 2018-11-30 |
| HUE039740T2 (hu) | 2019-01-28 |
| US20170101465A1 (en) | 2017-04-13 |
| PT2575884T (pt) | 2018-10-31 |
| JP5944382B2 (ja) | 2016-07-05 |
| JP2016193916A (ja) | 2016-11-17 |
| CA2801917A1 (en) | 2011-12-08 |
| CN103079594A (zh) | 2013-05-01 |
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