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LT2275441T - Dideliu afiniškumu pasižymintys živ t ląstelių receptoriai - Google Patents

Dideliu afiniškumu pasižymintys živ t ląstelių receptoriai

Info

Publication number
LT2275441T
LT2275441T LTEP10008612.3T LT10008612T LT2275441T LT 2275441 T LT2275441 T LT 2275441T LT 10008612 T LT10008612 T LT 10008612T LT 2275441 T LT2275441 T LT 2275441T
Authority
LT
Lithuania
Prior art keywords
high affinity
cell receptors
affinity hiv
hiv
receptors
Prior art date
Application number
LTEP10008612.3T
Other languages
English (en)
Inventor
Bent Karsten Jakobsen
Peter Eamon Molloy
Yi Li
Steven Mark Dunn
Original Assignee
Immunocore Ltd.
Adaptimmune Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0506760A external-priority patent/GB0506760D0/en
Priority claimed from GB0516487A external-priority patent/GB0516487D0/en
Application filed by Immunocore Ltd., Adaptimmune Limited filed Critical Immunocore Ltd.
Publication of LT2275441T publication Critical patent/LT2275441T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
LTEP10008612.3T 2005-04-01 2006-03-29 Dideliu afiniškumu pasižymintys živ t ląstelių receptoriai LT2275441T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0506760A GB0506760D0 (en) 2005-04-01 2005-04-01 High affinity HIV TCRS
GB0516487A GB0516487D0 (en) 2005-08-10 2005-08-10 High affinity HIV T cell receptors

Publications (1)

Publication Number Publication Date
LT2275441T true LT2275441T (lt) 2016-12-12

Family

ID=37053744

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP10008612.3T LT2275441T (lt) 2005-04-01 2006-03-29 Dideliu afiniškumu pasižymintys živ t ląstelių receptoriai

Country Status (16)

Country Link
US (2) US8378074B2 (lt)
EP (4) EP2275441B8 (lt)
JP (3) JP2008535826A (lt)
CN (2) CN103059128B (lt)
AU (1) AU2006228308B2 (lt)
CA (1) CA2602463C (lt)
CY (1) CY1118160T1 (lt)
DK (1) DK2275441T3 (lt)
ES (2) ES2599010T3 (lt)
HU (1) HUE032037T2 (lt)
LT (1) LT2275441T (lt)
NZ (2) NZ561338A (lt)
PL (1) PL2275441T3 (lt)
PT (1) PT2275441T (lt)
SI (1) SI2275441T1 (lt)
WO (1) WO2006103429A2 (lt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
CA2476625A1 (en) 2002-02-20 2003-08-28 Dyax Corp. Mhc-peptide complex binding ligands
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
WO2008042814A2 (en) * 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
JP5292550B2 (ja) * 2007-03-23 2013-09-18 静岡県 T細胞レセプターβ鎖遺伝子及びα鎖遺伝子
WO2009125394A1 (en) * 2008-04-09 2009-10-15 Technion Research & Development Foundation Ltd. Anti human immunodeficiency antibodies and uses thereof
GB0816096D0 (en) * 2008-09-04 2008-10-15 Medigene Ltd Diabetes t cell receptors
EP2411545B1 (en) * 2009-03-25 2017-03-08 Altor BioScience Corporation Hiv vpr-specific t cell receptors
CA2777053A1 (en) * 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
GB201016672D0 (en) 2010-10-04 2010-11-17 Electronic Shipping Solutions Ltd Secure exchange/authentication of electronic documents
EP2502934B1 (en) 2011-03-24 2018-01-17 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
JP6389166B2 (ja) 2012-05-07 2018-09-12 トラスティーズ・オブ・ダートマス・カレッジ 抗b7−h6抗体、融合タンパク質、及びこれらを使用する方法
SG10201700442QA (en) 2012-07-27 2017-03-30 Univ Illinois Engineering t-cell receptors
CN113150112B (zh) * 2014-05-29 2024-02-06 美国卫生和人力服务部 抗人乳头瘤病毒16 e7的t细胞受体
US10526391B2 (en) 2014-07-22 2020-01-07 The University Of Notre Dame Du Lac Molecular constructs and uses thereof
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
GB201516277D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
GB201516272D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
EP3211003A1 (en) * 2016-02-24 2017-08-30 Institut Pasteur T cell receptors from the hiv-specific repertoire, means for their production and therapeutic uses thereof
GB201604953D0 (en) * 2016-03-23 2016-05-04 Immunocore Ltd T cell receptors
KR102473964B1 (ko) 2016-04-08 2022-12-06 이뮤노코어 리미티드 T 세포 수용체
KR102833184B1 (ko) 2017-07-14 2025-07-10 이매틱스 바이오테크놀로지스 게엠베하 향상된 이중 특이성 폴리펩티드 분자
DE102017115966A1 (de) * 2017-07-14 2019-01-17 Immatics Biotechnologies Gmbh Polypeptidmolekül mit verbesserter zweifacher Spezifität
EP4252759B1 (en) * 2018-05-11 2025-08-06 Memorial Sloan Kettering Cancer Center T cell receptors targeting pik3ca mutations and uses thereof
WO2020028595A2 (en) * 2018-07-31 2020-02-06 Janux Therapeutics, Inc. Inhibitory t cell receptor peptides and discovery methods
US12234473B2 (en) 2020-12-31 2025-02-25 Immatics US, Inc. CD8 polypeptides, compositions, and methods of using thereof
JP2025508738A (ja) * 2022-02-20 2025-04-10 イムノコア リミテッド Hiv特異的結合分子及びtcr
US12103971B2 (en) 2022-02-20 2024-10-01 Immunocore Limited HIV specific binding molecules
AR130241A1 (es) 2022-08-18 2024-11-20 Immunocore Ltd Receptores de linfocitos t y proteínas de fusión de estos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
NZ507887A (en) * 1998-05-19 2002-12-20 Avidex Ltd Soluble T cell receptor
NZ531208A (en) * 2001-08-31 2005-08-26 Avidex Ltd Multivalent soluble T cell receptor (TCR) complexes
US7751825B2 (en) 2002-06-27 2010-07-06 Qualcomm Incorporated Controlling geographic location information of devices operating in wireless communication systems
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
PT1558643E (pt) * 2002-11-09 2009-08-24 Immunocore Ltd Apresentação de um receptor das células t
NZ550815A (en) * 2004-05-19 2009-04-30 Immunocore Ltd Method of improving T cell receptors

Also Published As

Publication number Publication date
WO2006103429A2 (en) 2006-10-05
CY1118160T1 (el) 2017-06-28
EP2275441A1 (en) 2011-01-19
CA2602463A1 (en) 2006-10-05
JP5885220B2 (ja) 2016-03-15
NZ584523A (en) 2010-11-26
DK2275441T3 (en) 2016-12-12
PL2275441T3 (pl) 2017-07-31
NZ561338A (en) 2010-04-30
JP2014205671A (ja) 2014-10-30
EP1863842A2 (en) 2007-12-12
EP2985291B1 (en) 2018-09-19
EP2985291A1 (en) 2016-02-17
EP2301964A1 (en) 2011-03-30
JP2008535826A (ja) 2008-09-04
EP2275441A9 (en) 2011-09-14
SI2275441T1 (sl) 2016-11-30
ES2599010T3 (es) 2017-01-31
US8378074B2 (en) 2013-02-19
US20090214551A1 (en) 2009-08-27
US9255135B2 (en) 2016-02-09
JP2012144543A (ja) 2012-08-02
WO2006103429A3 (en) 2007-03-15
JP5612623B2 (ja) 2014-10-22
EP2275441B1 (en) 2016-08-24
EP2275441B8 (en) 2016-10-19
CN103059128B (zh) 2016-01-20
US20130295063A1 (en) 2013-11-07
PT2275441T (pt) 2016-11-18
CN105461802A (zh) 2016-04-06
CA2602463C (en) 2018-09-04
AU2006228308B2 (en) 2012-05-17
AU2006228308A1 (en) 2006-10-05
CN103059128A (zh) 2013-04-24
HUE032037T2 (en) 2017-08-28
ES2699320T3 (es) 2019-02-08

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