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LT2001061A - Arilo ir heterociklilo pakaitus turintys pirimidino dariniai kaip antikoaguliantai - Google Patents

Arilo ir heterociklilo pakaitus turintys pirimidino dariniai kaip antikoaguliantai

Info

Publication number
LT2001061A
LT2001061A LT2001061A LT2001061A LT2001061A LT 2001061 A LT2001061 A LT 2001061A LT 2001061 A LT2001061 A LT 2001061A LT 2001061 A LT2001061 A LT 2001061A LT 2001061 A LT2001061 A LT 2001061A
Authority
LT
Lithuania
Prior art keywords
coagulants
aryl
pyrimidine derivatives
heterocyclyl substituted
substituted pyrimidine
Prior art date
Application number
LT2001061A
Other languages
English (en)
Other versions
LT4912B (lt
Inventor
D. David Davey
B. Gary Phillips
Original Assignee
Berlex Laboratories,Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories,Inc. filed Critical Berlex Laboratories,Inc.
Publication of LT2001061A publication Critical patent/LT2001061A/lt
Publication of LT4912B publication Critical patent/LT4912B/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LT2001061A 1998-12-04 2001-06-12 Arilo ir heterociklilo pakaitus turintys pirimidino dariniai kaip antikoaguliantai LT4912B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/205,498 US6127376A (en) 1998-12-04 1998-12-04 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Publications (2)

Publication Number Publication Date
LT2001061A true LT2001061A (lt) 2001-12-27
LT4912B LT4912B (lt) 2002-04-25

Family

ID=22762435

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2001061A LT4912B (lt) 1998-12-04 2001-06-12 Arilo ir heterociklilo pakaitus turintys pirimidino dariniai kaip antikoaguliantai

Country Status (26)

Country Link
US (2) US6127376A (lt)
EP (1) EP1135131A4 (lt)
JP (1) JP2002531506A (lt)
KR (1) KR20010093799A (lt)
CN (1) CN1329491A (lt)
AU (1) AU760370B2 (lt)
BG (1) BG105557A (lt)
BR (1) BR9915938A (lt)
CA (1) CA2354040A1 (lt)
CZ (1) CZ20011932A3 (lt)
EE (1) EE200100298A (lt)
HR (1) HRP20010499A2 (lt)
HU (1) HUP0104508A3 (lt)
IL (2) IL143347A0 (lt)
LT (1) LT4912B (lt)
LV (1) LV12783B (lt)
MX (1) MXPA01005656A (lt)
NO (1) NO20012701L (lt)
NZ (1) NZ512104A (lt)
PL (1) PL348034A1 (lt)
RO (1) RO120971B1 (lt)
RU (1) RU2001118466A (lt)
SI (1) SI20637A (lt)
SK (1) SK7632001A3 (lt)
WO (1) WO2000033844A1 (lt)
ZA (1) ZA200104235B (lt)

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US8877760B2 (en) 2011-11-23 2014-11-04 Portola Pharmaceuticals, Inc. Substituted pyrazine-2-carboxamide kinase inhibitors
JP6317320B2 (ja) 2012-03-15 2018-04-25 セルジーン シーエーアール エルエルシー 上皮成長因子受容体キナーゼ阻害剤の塩
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JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Egfr発動性がんの細胞増殖阻害用化合物
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Also Published As

Publication number Publication date
NO20012701L (no) 2001-07-25
KR20010093799A (ko) 2001-10-29
SI20637A (sl) 2002-02-28
NZ512104A (en) 2003-10-31
WO2000033844A1 (en) 2000-06-15
BR9915938A (pt) 2001-08-21
PL348034A1 (en) 2002-05-06
AU3107500A (en) 2000-06-26
CA2354040A1 (en) 2000-06-15
LV12783A (en) 2002-01-20
EP1135131A1 (en) 2001-09-26
SK7632001A3 (en) 2001-12-03
US6372751B1 (en) 2002-04-16
RO120971B1 (ro) 2006-10-30
IL143347A (en) 2006-12-10
HUP0104508A2 (hu) 2002-05-29
LV12783B (en) 2002-10-20
BG105557A (en) 2001-12-29
IL143347A0 (en) 2002-04-21
ZA200104235B (en) 2002-08-23
EE200100298A (et) 2002-12-16
MXPA01005656A (es) 2002-04-24
RU2001118466A (ru) 2003-04-20
HUP0104508A3 (en) 2002-07-29
US6127376A (en) 2000-10-03
LT4912B (lt) 2002-04-25
JP2002531506A (ja) 2002-09-24
AU760370B2 (en) 2003-05-15
HRP20010499A2 (en) 2003-04-30
CN1329491A (zh) 2002-01-02
EP1135131A4 (en) 2002-01-02
NO20012701D0 (no) 2001-06-01
CZ20011932A3 (cs) 2001-10-17

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Effective date: 20041203