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KR970006299A - Method for preparing lansoprazole - Google Patents

Method for preparing lansoprazole Download PDF

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Publication number
KR970006299A
KR970006299A KR1019950021417A KR19950021417A KR970006299A KR 970006299 A KR970006299 A KR 970006299A KR 1019950021417 A KR1019950021417 A KR 1019950021417A KR 19950021417 A KR19950021417 A KR 19950021417A KR 970006299 A KR970006299 A KR 970006299A
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KR
South Korea
Prior art keywords
compound
formula
vii
reacting
alkoxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019950021417A
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Korean (ko)
Inventor
양태선
탁희천
김학형
허영부
Original Assignee
박해룡
고려제약 주식회사
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Application filed by 박해룡, 고려제약 주식회사 filed Critical 박해룡
Priority to KR1019950021417A priority Critical patent/KR970006299A/en
Publication of KR970006299A publication Critical patent/KR970006299A/en
Ceased legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 구조식 ⑵의 화합물을 유기용매에 용해시키고 여기에 티오닐클로라이드를 가하여 반응시키고 이 반응혼합물에 구조식 ⑴의 화합물을 알칼리금속의 알콕사이드의 알카놀 용액과 반응시켜서 구조식 ⑶의 화합물을 제조하고, 이 얻어진 구조식 ⑶의 화합물을 유기과산으로 산화시켜서 제조된 구조식 ⑷의 화합물을 2,2,2-트리풀루오로에탄올과 반응시켜서 구조식 (Ⅰ)의 화합물을 제조하는 방법에 관한 것이며, 본 발명의 방법으로 목적화합물을 간단하게 높은 수율로 제조할 수 있다.The present invention prepares a compound of formula (VII) by dissolving a compound of formula (VII) in an organic solvent and adding thionyl chloride to the reaction mixture and reacting the compound of formula (VII) with an alkoxide solution of an alkoxide of an alkali metal to the reaction mixture, The present invention relates to a method for preparing a compound of formula (I) by reacting a compound of formula (VII) prepared by oxidizing the obtained compound of formula (VII) with organic peracid with 2,2,2-trifluorourool. By the method, the target compound can be easily produced in high yield.

Description

란소프라졸의 제조방법Method for preparing lansoprazole

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

구조식 ⑵의 화합물을 유기용매에 용해시키고 여기에 티오닐클로라이드를 가하여 반응시키고, 혼합물을 농축한 다음 여기에 구조식 ⑴의 화합물을 알칼리금속의 알콕사이드의 알카놀 용액과 함께 반응시켜서 얻어진 구조식 ⑶의 화합물을 유기용매 중에서 유기과산으로 산화시켜서 구조식 ⑷의 화합물을 제조하고 여기에 2,2,2-트리풀루오로에탄올을 반응시켜서 구조식 (Ⅰ)의 화합물을 제조하는 방법.The compound of formula (VII) obtained by dissolving the compound of formula (VII) in an organic solvent and adding thionyl chloride to it, concentrating the mixture, and then reacting the compound of formula (VII) with an alkoxide solution of an alkoxide of alkali metal. A method for preparing a compound of formula (I) by oxidizing with organic peracid in an organic solvent to produce a compound of formula (VII) and reacting 2,2,2-trifluorourool thereto. 상기 식에서 X는 할로겐원자 또는 니트로기이다.Wherein X is a halogen atom or a nitro group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950021417A 1995-07-20 1995-07-20 Method for preparing lansoprazole Ceased KR970006299A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950021417A KR970006299A (en) 1995-07-20 1995-07-20 Method for preparing lansoprazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950021417A KR970006299A (en) 1995-07-20 1995-07-20 Method for preparing lansoprazole

Publications (1)

Publication Number Publication Date
KR970006299A true KR970006299A (en) 1997-02-19

Family

ID=66541496

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950021417A Ceased KR970006299A (en) 1995-07-20 1995-07-20 Method for preparing lansoprazole

Country Status (1)

Country Link
KR (1) KR970006299A (en)

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