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KR970006287A - Improved method of preparing barbituric acid - Google Patents

Improved method of preparing barbituric acid Download PDF

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Publication number
KR970006287A
KR970006287A KR1019950020130A KR19950020130A KR970006287A KR 970006287 A KR970006287 A KR 970006287A KR 1019950020130 A KR1019950020130 A KR 1019950020130A KR 19950020130 A KR19950020130 A KR 19950020130A KR 970006287 A KR970006287 A KR 970006287A
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KR
South Korea
Prior art keywords
barbituric acid
hydrochloric acid
sodium
preparing
improved method
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Application number
KR1019950020130A
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Korean (ko)
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KR100387695B1 (en
Inventor
권영칠
김석수
이인희
김창환
Original Assignee
이승웅
삼성정밀화학 주식회사
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Publication date
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Priority to KR1019950020130A priority Critical patent/KR100387695B1/en
Publication of KR970006287A publication Critical patent/KR970006287A/en
Application granted granted Critical
Publication of KR100387695B1 publication Critical patent/KR100387695B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/38—Malonic acid esters

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 말론산에스테르를 요소 및 소듐알콕사이드와 반응시켜 바비튜르산 나트륨염을 생성하고 이를 염산으로 중화시켜 바비튜르산을 제조하는 방법에 있어서, 염산 수용액은 5~10중량% 농도의 희석 염산수용액을 사용함을 특징으로 하는 고순도, 고수의 바비튜르산의 제조방법에 관한 것이다.The present invention relates to a method for producing barbituric acid by reacting malonic acid ester with urea and sodium alkoxide to produce sodium bibiturate and neutralizing it with hydrochloric acid. It relates to a method of producing high purity, high water barbituric acid characterized by using.

Description

개선된 바비튜르산의 제조방법Improved method of preparing barbituric acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

말론산에스테르를 요소 및 소듐알콕사이드와 반응시켜 바비튜르산 나트륨염을 생성하고 이를 염산으로 중화시켜 바비튜르산을 제조하는 방법에 있어서, 염산 수용액은 5~10중량% 농도의 희석 염산수용액을 사용함을 특징으로 하는 고순도, 고수율의 바비튜르산의 제조방법.In the method for producing barbituric acid by reacting malonic ester with urea and sodium alkoxide to produce sodium bibiturate and neutralizing it with hydrochloric acid, the aqueous hydrochloric acid solution is used in a dilute hydrochloric acid solution at a concentration of 5 to 10% by weight. A high purity, high yield barbituric acid production method characterized by the above-mentioned. 제1항에 있어서, 소듐알콕사이드의 농도는 14~30중량%임을 특징으로 하는 바비튜르산의 제조방법.The method for preparing barbituric acid according to claim 1, wherein the concentration of sodium alkoxide is 14 to 30 wt%. 제2항에 있어서, 소듐알콕사이드는 소듐메톡사이드임을 특징으로 하는 바비튜르산의 제조방법.The method for preparing barbituric acid according to claim 2, wherein the sodium alkoxide is sodium methoxide. 제1항에 있어서, 염산 수용액 첨가시 반응온도는 5~35℃임을 특징으로 하는 바비튜르산의 제조방법.The method of claim 1, wherein the reaction temperature is 5 ~ 35 ℃ when the aqueous solution of hydrochloric acid is added. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950020130A 1995-07-10 1995-07-10 Improved manufacturing method of barbituric acid Expired - Fee Related KR100387695B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950020130A KR100387695B1 (en) 1995-07-10 1995-07-10 Improved manufacturing method of barbituric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950020130A KR100387695B1 (en) 1995-07-10 1995-07-10 Improved manufacturing method of barbituric acid

Publications (2)

Publication Number Publication Date
KR970006287A true KR970006287A (en) 1997-02-19
KR100387695B1 KR100387695B1 (en) 2003-09-13

Family

ID=37421735

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950020130A Expired - Fee Related KR100387695B1 (en) 1995-07-10 1995-07-10 Improved manufacturing method of barbituric acid

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2680531C1 (en) * 2018-08-02 2019-02-22 Акционерное общество "Научно-исследовательский институт химии и технологии полимеров имени академика В.А. Каргина с опытным заводом" (АО "НИИ полимеров") Barbituric acid production method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2090594A (en) * 1936-01-24 1937-08-17 Du Pont Acyl ureas and process for the preparation thereof
JPS59112972A (en) * 1982-12-21 1984-06-29 Fuji Photo Film Co Ltd Preparation of barbituric acid derivative
GB8426101D0 (en) * 1984-10-16 1984-11-21 Bp Chem Int Ltd Preparation of barbiturates

Also Published As

Publication number Publication date
KR100387695B1 (en) 2003-09-13

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