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KR960703566A - 비등성 입자와 이의 제조공정(effervescent granulated material and method for its preparation) - Google Patents

비등성 입자와 이의 제조공정(effervescent granulated material and method for its preparation) Download PDF

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Publication number
KR960703566A
KR960703566A KR1019960700956A KR19960700956A KR960703566A KR 960703566 A KR960703566 A KR 960703566A KR 1019960700956 A KR1019960700956 A KR 1019960700956A KR 19960700956 A KR19960700956 A KR 19960700956A KR 960703566 A KR960703566 A KR 960703566A
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South Korea
Prior art keywords
acid
calcium carbonate
citric acid
compound
effervescent
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KR1019960700956A
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KR100351748B1 (ko
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게하르트 게르겔리
토마스 게르겔리
이름가르트 게르겔리
스테판 게르겔리
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게하르트 게르겔리
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

탄산칼슘과 시트르산을 포함하는 제약학적 준비물의 비등성 입상제에 있어서 탄산칼슘과 반응하는 산의 총 중량비의 5~20중량비는 말린산, 글루코닌산, 라틱산과 이의 염으로 된 화합물적 적어도 하나로 대체한다. 시트르산과 탄산칼슘은 부분반응에 의해 입상화시키고 각 경우 화합물의 일부는 시트르산으로 대체하여, 시트르산과 탄산칼슘과 함께 고형분말형으로 입상화시키고 입상화액 또는 완충액에 용해시킨다.

Description

비등성 입자와 이의 제조공정(EFFERVESCENT GRANULATED MATERIAL AND METHOD FOR ITS PREPARATION)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 탄산칼슘, 시트르산과 고형의 식용 유기산과 이의 염을 포함하는 제약학적 제제의 준비를 위한 비등성 입자에 있어서 탄산칼슘과 반응하는 경향이 있는 유기산 또는 염의 총량에 5~20, 적절하게는 10 내지 15wt%는 말린산, 글루코닌산과 라틱산 그리고 이의 염 적절하게는 산 중에서 적어도 하나와 대체되는 것을 특징으로하는 비등성 입자.
  2. 제1항에 있어서, 유기산은 탄산칼슘 일부에 의해 피복되고 그리고 부분적으로 반응된 형으로 있을 수 있고 입상화 것을 특징으로 하는 비등성 입자.
  3. 제1항 또는 2항에 있어서, 적어도 하나의 폴로오르 화합물의 제약학적으로 효과적이고 허용가능한 양을 추가로 포함하는 것을 특징으로 하는 비등성 입자.
  4. 제1항 또는 제2항에 따른 비등성 입자를 만드는 공정에 있어서 시트르산과 탄산칼슘은 부분반응으로 입상화되고 화합물의 일부가 시트르산으로 대체된 화합물은 시트르산과 고형 분말형으로 혼합되고, 탄산칼슘과 물질은 습기와 함께 입상화되는 것을 특징으로 하는 공정.
  5. 제1항에 따른 비등성 입자의 준비를 위한 공정에 있어서, 시트르산과 탄산칼슘은 부분반응으로 입상화되고 시트르산이 부분적으로 대체된 화합물은 입상화액 적절하게는 완충액에 용해되는 것을 특징으로 하는 공정.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960700956A 1993-09-09 1994-09-09 비등정및이의제조공정 Expired - Fee Related KR100351748B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH2700/93-0 1993-09-09
CH270093 1993-09-09
PCT/EP1994/003018 WO1995007070A1 (de) 1993-09-09 1994-09-09 Brausegranulat und verfahren zu seiner herstellung

Publications (2)

Publication Number Publication Date
KR960703566A true KR960703566A (ko) 1996-08-31
KR100351748B1 KR100351748B1 (ko) 2002-12-26

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KR1019960700956A Expired - Fee Related KR100351748B1 (ko) 1993-09-09 1994-09-09 비등정및이의제조공정

Country Status (17)

Country Link
US (1) US5759575A (ko)
EP (1) EP0717614B1 (ko)
KR (1) KR100351748B1 (ko)
CN (1) CN1060037C (ko)
AT (1) ATE173614T1 (ko)
AU (1) AU677432B2 (ko)
BR (1) BR9407444A (ko)
CA (1) CA2171435C (ko)
CZ (1) CZ285475B6 (ko)
DE (1) DE59407351D1 (ko)
ES (1) ES2126147T3 (ko)
FI (1) FI116449B (ko)
HU (1) HU221814B1 (ko)
PL (1) PL176005B1 (ko)
RU (1) RU2153330C2 (ko)
SK (1) SK280055B6 (ko)
WO (1) WO1995007070A1 (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814257A1 (de) 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
DE19822036A1 (de) * 1998-05-15 1999-11-18 Bayer Ag Brausezubereitungen
EP1004292B1 (en) * 1998-11-23 2003-08-13 E-PHARMA TRENTO S.p.A. Method for preparing an effervescent granulate
US6264984B1 (en) 1999-12-06 2001-07-24 Bristol-Myers Squibb Company Effervescent histamine H2 antagonist composition
EP1417958A1 (en) * 2002-11-08 2004-05-12 Pari GmbH Wet granulation process
US8216610B2 (en) * 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
JP2008500288A (ja) * 2004-05-28 2008-01-10 イメイジノット ピーティーワイ エルティーディー 経口治療用化合物の供給系
US20070003611A1 (en) * 2005-06-29 2007-01-04 Sung-Tsuen Liu Novel method of granulating calcium carbonate and products provided therefrom
CN1292756C (zh) * 2005-08-08 2007-01-03 李海涛 一种补充人体营养元素的泡腾片制剂及其制备方法
EP3449928A1 (en) * 2005-11-28 2019-03-06 Imaginot Pty Ltd. Oral therapeutic compound delivery system
US7273521B1 (en) 2006-04-28 2007-09-25 J.M. Huber Corporation Method of producing granulated calcium carbonate/calcium phosphate composite materials with very high calcium to phosphate mole ratios
TR200908237A2 (tr) 2009-11-02 2011-05-23 Bi̇lgi̇ç Mahmut Kalsiyum ve D vitamini içeren farmasötik bileşimler.
CN101721387B (zh) * 2009-12-24 2013-01-02 山东达因海洋生物制药股份有限公司 一种碳酸钙泡腾剂及其制备方法
FR2992219B1 (fr) * 2012-06-22 2014-07-11 Aditec Lab Composition pour le traitement de l'hypocalcemie chez les ruminants
WO2014065890A1 (en) * 2012-10-25 2014-05-01 Otc Nutrition Llc Fast dissolving solid calcium mineral supplement compositions and process of making
CH710361B1 (de) * 2014-11-12 2018-12-28 Laboratoires Biofar Sarl Natrium-Ion-freie Brausetablette oder Brausepulver mit hohem Calcium-Ion-Gehalt (CaCO3).
IT201700099690A1 (it) * 2017-09-06 2019-03-06 Abiogen Pharma Spa Composizione per l’integrazione di calcio
IT201700099708A1 (it) * 2017-09-06 2019-03-06 Abiogen Pharma Spa Composizione per l’integrazione di calcio

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678661A (en) * 1983-09-28 1987-07-07 Gerhard Gergely Effervescent composition and method of making same
FR2552308B1 (fr) * 1983-09-28 1991-07-05 Gergely Gerhard Melange effervescent convenant en particulier pour des comprimes effervescents, comprimes effervescents prepares a l'aide de ce melange et procede pour sa preparation
DE3627475A1 (de) * 1986-06-26 1988-01-14 Gergely Gerhard Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung
US4783331A (en) * 1987-06-29 1988-11-08 Miles Inc. Method for solubilization of aspartame in effervescent aqueous systems; and composition
CA2009326C (en) * 1989-05-09 1998-01-27 Lawrence J. Daher Aqueous granulation solution and a method of tablet granulation
ES2079743T3 (es) * 1991-07-01 1996-01-16 Gergely Gerhard Tableta para chupar o masticar.
AU4597293A (en) * 1992-06-30 1994-01-24 Procter & Gamble Company, The Effervescent calcium supplements
WO1994008473A1 (en) * 1992-10-21 1994-04-28 The Procter & Gamble Company Storage stable calcium-supplemented beverage premix concentrates and syrups
RU2065300C1 (ru) * 1994-12-22 1996-08-20 Анатолий Евгеньевич Добротворский Фармацевтическая композиция в форме шипучих таблеток

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Publication number Publication date
ES2126147T3 (es) 1999-03-16
HUT74520A (en) 1997-01-28
CZ65296A3 (en) 1996-06-12
EP0717614B1 (de) 1998-11-25
BR9407444A (pt) 1996-04-09
AU677432B2 (en) 1997-04-24
FI961093A0 (fi) 1996-03-08
SK33096A3 (en) 1997-03-05
KR100351748B1 (ko) 2002-12-26
CA2171435C (en) 2005-04-05
ATE173614T1 (de) 1998-12-15
CN1060037C (zh) 2001-01-03
WO1995007070A1 (de) 1995-03-16
PL313479A1 (en) 1996-07-08
HU9600588D0 (en) 1996-05-28
CN1130865A (zh) 1996-09-11
FI116449B (fi) 2005-11-30
SK280055B6 (sk) 1999-07-12
HU221814B1 (hu) 2003-01-28
AU7696094A (en) 1995-03-27
CZ285475B6 (cs) 1999-08-11
FI961093L (fi) 1996-03-08
CA2171435A1 (en) 1995-03-16
PL176005B1 (pl) 1999-03-31
RU2153330C2 (ru) 2000-07-27
EP0717614A1 (de) 1996-06-26
DE59407351D1 (de) 1999-01-07
US5759575A (en) 1998-06-02

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