KR920008036A - 3-피페라지노시드논 이민, 이의 제조방법 및 이의 용도 - Google Patents
3-피페라지노시드논 이민, 이의 제조방법 및 이의 용도 Download PDFInfo
- Publication number
- KR920008036A KR920008036A KR1019910017392A KR910017392A KR920008036A KR 920008036 A KR920008036 A KR 920008036A KR 1019910017392 A KR1019910017392 A KR 1019910017392A KR 910017392 A KR910017392 A KR 910017392A KR 920008036 A KR920008036 A KR 920008036A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- alkyl
- imine
- compound
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000002466 imines Chemical class 0.000 title claims 6
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- -1 ethoxy, pyridyl Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 일반식( I )의 3-아미노시드논 이민 및 약리학적으로 허용되는 이의 산 부가염.상기식에서, R1은 (C1-C4)-알킬 또는 디-(C1-C4)-알킬아미노를 나타내거나 (C1-C4)-알킬에 의해 임의로 치환될 수 있는 (C6-C12)-아릴을 나타내고, R2는 수소 또는 COR3를 나타내며, R3는 (C1-C4)-아킬, (C1-C4)-알콕시, (C1-C4)-알콕시-(C1-C4)-알킬 또는 아세톡시-(C1-C4)-알킬을 나타내거나 (C1-C4)-알킬 또는 (C1-C4)-알콕시에 의해 치환될 수 있는 (C6-C12)-아릴을 나타내고 피리딜, 피리딜(C1-C4)알킬, 또는 (C3-C8)-사이클로알킬을 나타낸다.
- 제1항에 있어서, R1이 메틸, p-톨릴 또는 디메틸아미노를 나타냄을 특징으로 하는 3-아미노시드논 이민.
- 제1항 및/또는 제2항에 있어서, R3가 에틸, i-프로필, 3급-부틸, 에톡시, 피리딜, p-메톡시페닐 또는 사이클로 헥실을 나타냄을 특징으로 하는 3-아미노시드논 이민.
- 일반식(Ⅱ)의 화합물을 폐환시켜 일반식( Ia )의 화합물을 수득하고, R2가 -COR3인 일반식( I )의 화합물을 제조하고자 할 경우에 이 화합물 또는 이의 산 부가염을 라디칼-COR3를 도입시키는 아실화제로 아실화시키고, 임의로 이와 같이 수득한 화합물을 약리학적으로 허용되는 이의 산 부가염으로 전환시킴을 특징으로 하여, 제1항 내지 제3항중 어느 한 항에 따른 일반식( I )의 3-아미노시드논 이민을 제조하는 방법.상기식에서, R1은 제1항에서 정의한 바와 같다.
- 제4항에 있어서, 폐환반응을 수용액 중에서 pH를 3이하로 조절하는 폐환제를 사용하여 -10 내지 40℃, 바람직하게는 0 내지 20℃의 온도에서 용매, 분산제 또는 희석제 속에서 수행함을 특징으로 하는 방법.
- 심혈관 질환의 치료 및 예방을 위한 제1항 내지 제3항중 어느 한 항에 따른 일반식( I )의 3-아미노시드논 이민 또는 약리학적으로 허용되는 이의 산 부가염의 용도.
- 약제학적으로 허용되는 부형제 및 첨가제 및, 경우에 따라, 하나 이상의 기타 약리학적으로 활성인 화합물과 함께 활성 성분으로서 제1항 내지 제3항중 어느 한 항에 일반식( I )의 3-아미노시드논 이민 또는 약리학적으로 허용되는 이의 산 부가염을 함유하는 특징으로 하는 약제학적 제제.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4031373A DE4031373A1 (de) | 1990-10-04 | 1990-10-04 | 3-piperazino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| DEP4031373.5 | 1990-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920008036A true KR920008036A (ko) | 1992-05-27 |
Family
ID=6415566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019910017392A Withdrawn KR920008036A (ko) | 1990-10-04 | 1991-10-02 | 3-피페라지노시드논 이민, 이의 제조방법 및 이의 용도 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5155109A (ko) |
| EP (1) | EP0480241A1 (ko) |
| JP (1) | JPH04273873A (ko) |
| KR (1) | KR920008036A (ko) |
| CA (1) | CA2052726A1 (ko) |
| DE (1) | DE4031373A1 (ko) |
| HU (1) | HUT61757A (ko) |
| IE (1) | IE913484A1 (ko) |
| PT (1) | PT99144A (ko) |
| ZA (1) | ZA917911B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4117249C2 (de) * | 1991-05-27 | 1998-05-14 | Christian Dr Stief | Linsidomin zur Behandlung erektiler Dysfunktionen |
| US5439938A (en) * | 1993-04-07 | 1995-08-08 | The Johns Hopkins University | Treatments for male sexual dysfunction |
| DE4337335A1 (de) * | 1993-11-02 | 1995-05-04 | Cassella Ag | Verfahren zur Herstellung von Sydnoniminium-hydrogensulfaten |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1695897C3 (de) * | 1966-07-04 | 1979-02-15 | Takeda Chemical Industries Ltd | N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE2930736A1 (de) * | 1979-07-28 | 1981-02-12 | Cassella Ag | Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| DE3107933A1 (de) * | 1981-03-02 | 1982-09-16 | Cassella Ag, 6000 Frankfurt | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| JPS5859977A (ja) * | 1981-10-06 | 1983-04-09 | Banyu Pharmaceut Co Ltd | 新規なｎ−アシルシドノンイミン誘導体およびその製法 |
| DE3240269C1 (de) * | 1982-10-30 | 1984-05-30 | Zeischegg, Walter, 7900 Ulm | Pflanzengefaess,insbesondere fuer Hydrokultur |
| DE3526068A1 (de) * | 1985-07-20 | 1987-01-22 | Cassella Ag | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische praeparate |
| DE3702083A1 (de) * | 1987-01-24 | 1988-08-04 | Cassella Ag | Allylmercaptoacetyl-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| DE3732174A1 (de) * | 1987-09-24 | 1989-04-06 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| DE3820210A1 (de) * | 1988-06-14 | 1989-12-21 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
-
1990
- 1990-10-04 DE DE4031373A patent/DE4031373A1/de not_active Withdrawn
-
1991
- 1991-07-16 US US07/730,491 patent/US5155109A/en not_active Expired - Fee Related
- 1991-09-25 EP EP91116291A patent/EP0480241A1/de not_active Withdrawn
- 1991-10-02 KR KR1019910017392A patent/KR920008036A/ko not_active Withdrawn
- 1991-10-03 JP JP3256736A patent/JPH04273873A/ja not_active Withdrawn
- 1991-10-03 IE IE348491A patent/IE913484A1/en not_active Application Discontinuation
- 1991-10-03 HU HU913159A patent/HUT61757A/hu unknown
- 1991-10-03 CA CA002052726A patent/CA2052726A1/en not_active Abandoned
- 1991-10-03 ZA ZA917911A patent/ZA917911B/xx unknown
- 1991-10-03 PT PT99144A patent/PT99144A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2052726A1 (en) | 1992-04-05 |
| US5155109A (en) | 1992-10-13 |
| IE913484A1 (en) | 1992-04-08 |
| DE4031373A1 (de) | 1992-04-09 |
| EP0480241A1 (de) | 1992-04-15 |
| PT99144A (pt) | 1993-10-29 |
| HU913159D0 (en) | 1992-01-28 |
| ZA917911B (en) | 1992-06-24 |
| JPH04273873A (ja) | 1992-09-30 |
| HUT61757A (en) | 1993-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE323687T1 (de) | Benzolsulfonamid-derivate und ihre anwendung als arzneimittel | |
| ATE87473T1 (de) | Arzneimittel zur inhibition von hautfalte. | |
| CA2463976A1 (en) | N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase | |
| RU94044436A (ru) | Способы подавления атрофии кожи и влагалища | |
| MX11031A (es) | Proceso para la preparacion de nuevas 1-fenil-3-naftaleniloxipropanaminas producto obtenido y composicion farmaceutica que lo incluye. | |
| CA2321188A1 (en) | Derivatives of azetidine and pyrrolidine | |
| AU669122B2 (en) | New pyrazine derivatives, their preparation and their use | |
| NO20044810L (no) | Farmasoytisk formulering med oyeblikkelig frigjoring | |
| KR940005274A (ko) | 쇼그렌(Sjoegren)증후군 치료제 | |
| RU2000122435A (ru) | Производные индола и фармацевтические композиции, включающие их | |
| AU3131684A (en) | New compounds derived from diphenyl-methylene-ethylamine | |
| UA37311C2 (uk) | Засіб для лікування статевої дисфункції і фармацевтичний препарат | |
| WO1999004770A3 (en) | A pharmaceutical composition active in reducing production of mcp-1 protein | |
| KR920008036A (ko) | 3-피페라지노시드논 이민, 이의 제조방법 및 이의 용도 | |
| YU5893A (sh) | Sulfonilkarbamid i postupak za njegovo dobijanje | |
| CA2202904A1 (en) | Pharmaceutical composition for prophylaxis and treatment of type i allergic diseases | |
| AU558261B2 (en) | Dialkylaminoalkyoxybenzylalcohol derivatives | |
| GB1289240A (ko) | ||
| RU94031479A (ru) | Новое применение производных аминокислот, способ лечения, фармацевтическая композиция | |
| DK0646110T3 (da) | N-substituerede 3-azabicyclo(3.2.0) heptanderivater som neuroleptika | |
| GB1457484A (en) | Acylamidocephalosporins | |
| CA2432138A1 (en) | New process for the preparation of eletriptan | |
| WO2001017955A3 (en) | Hydroxyacetamidobenzenesulphonamide derivatives | |
| TW349864B (en) | Use of N-(pyridinyl)-1H-indol-a-amines for the preparation of a medicament for the treatment of obsessive-compulsive disorders | |
| KR910000719A (ko) | 치환된 3-아미노시드논 이민, 이의 제조방법 및 이의 용도 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19911002 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |