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KR910002900A - 합성 펩티드 및 이를 함유하는 제약학적 조성물 - Google Patents

합성 펩티드 및 이를 함유하는 제약학적 조성물 Download PDF

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KR910002900A
KR910002900A KR1019890010373A KR890010373A KR910002900A KR 910002900 A KR910002900 A KR 910002900A KR 1019890010373 A KR1019890010373 A KR 1019890010373A KR 890010373 A KR890010373 A KR 890010373A KR 910002900 A KR910002900 A KR 910002900A
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ala
cys
arg
peptide
leu
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KR0138907B1 (ko
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에드워어드 프레드릭 리비어 지인
로어 리비어 캐서린
워어커 베일 쥬니어 와일리
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원본 미기재
더 솔크 인스티튜트 훠 바이올로지칼 스터디이즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract

내용 없음.
도 1

Description

합성 펩티드 및 이를 함유하는 제약학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (21)

  1. 하기 서열을 갖는 합성 펩티드 또는 그의 무독성염;
  2. (B)R1-R2-R3-Ala-Ile-Phe-Thr-R8-Ser-R10-Arg-R12-R13-Leu-R15-Gin-Leu-R18-Ala-Arg-R21-R22-Leu-R24-Gln-Gln-Gly-Glu-R34-Asn-Gln-Glu-R38-R39-R40-Arg-R42-R43-R43이 식에서 R1은 Tyr, D-Try, Met, D-Met, Phe, D-Phe, Pcl-Phe, Leu, His 또는 D-His; B는 H, CaMe, NaMe, 데스아미노, Ac 또는 For; R2는 Ala, D-Ala, NMA 또는 D-NMA; R3은 Asp 또는 D-Asp; R8은 Ser, Asn, Lys, Arg, Asp 또는 Gln; R10은 Tyr, D-Try 또는 Phe; R12는 Arg또는 Lys; R13은 Ile, Val, Leu 또는 Ala; R15는 Gly, Ala 또는 β-Ala; R18은 Ser 또는 Tyr; R21은 Lys, D-Lys; Arg 또는 D-Arg, R22는 Leu, Ile, Ala 또는 Val; R22는 Gln 또는 His; R25는 cys, abu, asq, glu, orn lys, dab 또는 dap; R27은 Met, D-Met, Ala, Nle, Ile, Leu, Nva, 또는 Val; R28은 Asn 또는 Ser;; R29는 cys, abu, asp, glu, orn. lys, dab 또는 dap; R34는 Ser 또는 Arg; R38은 arg 또는 Gln; R39는 Gly 또는 Arg; R40은 Ala 또는 Ser; R42는 Phe 또는 Arg; R43은 Asn 또는 Ala; R44는 천연 아미노산이고; 단, R44에서 시작되어 R29까지 뻗어있는 잔기의 C-말단 서열은 삭제될 수 있다.
  3. 제1항에 있어서, R1이 NaMeTyr인 펩티드.
  4. 제1항 또는 제2항에 있어서, R25가 D-Cys인 펩티드.
  5. 제3항에있어서, R29가 Cys인 펩티드.
  6. 제1항 또는 제2항에 있어서, R25이 Asp인 펩티드.
  7. 제5항에 있어서, R29가 Orn인 펩티드.
  8. 제1항 또는 제2항에 있어서, R25가 D-Glu이고, R29가 daP인 펩티드.
  9. 제1항 또는 제2항에 있어서, R25가 Cys이고, R29가 D-Cys인 펩티드.
  10. 제1항 또는 제8항에 어느 한 항에 있어서, R22가 Ala인 펩티드.
  11. 제1항 또는 제9항에 어느 한 항에 있어서, R17가 Nle인 펩티드.
  12. 제1항 또는 제10항에 어느 한 항에 있어서, R15가 Ala인 펩티드.
  13. 제1항 또는 제11항에 어느 한 항에 있어서, R28가 Asn인 펩티드.
  14. 제1항 또는 제11항에 어느 한 항에 있어서, 하기식을 갖는 펩티드; (B) R1-R2-R3-Ala-Ile-Phe-Thr-Ser-Ser-Tyr-Arg-R13-Leu-R15-Gln-Leu-Tyr-Ala-R21-Arg-R22-Leu-His- -NH2,
  15. 제1항에 있어서, 하기 식을 갖는 펩티드; 〔NaMeTyr1, Ala15, D-Cys25, Nle27, Cys29〕-rGRF(1-29)-NH2.
  16. 제1항에 있어서, 하기 식을 갖는 펩티드; 〔NaMeTyr1, Lys8, Ala15, D-Cys25, Nle27, Asn28, Cys29〕-hGRF(1-29)-NHEt.
  17. 제1항에 있어서, 하기 식을 갖는 펩티드; 〔NaMeTyr1, D-Cys25, daP29〕-rGRF(1-29)-NH2.
  18. 제1항에 있어서, 하기 식을 갖는 펩티드; 〔NaMeTyr1, Ala15, Cys2, Nle27, D-Cys25,〕-rGRF(1-29)-NH2.
  19. 제1항에 있어서, R25가 D-Cys25이고, R27이 Nle이고, R29가 Cys이며 30-44의 잔기가 삭제된 펩티드.
  20. 동물에 있어서, 제1항 내지 제18항중 어느 한 항의 펩티드 또는 그의 무독성염과, 그의 제약학적으로 또는 수의학적으로 허용 가능한 액체 또는 고체 담체로 구성되는 GH의 방출을 자극하는 제약학적 조성물.
  21. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890010373A 1988-07-22 1989-07-21 합성 펩티드 Expired - Fee Related KR0138907B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US223,277 1988-07-12
US07/223,277 US5043322A (en) 1988-07-22 1988-07-22 Cyclic GRF analogs
US233,277 1988-07-22

Publications (2)

Publication Number Publication Date
KR910002900A true KR910002900A (ko) 1991-02-26
KR0138907B1 KR0138907B1 (ko) 1998-04-30

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KR1019890010373A Expired - Fee Related KR0138907B1 (ko) 1988-07-22 1989-07-21 합성 펩티드

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US (1) US5043322A (ko)
EP (1) EP0352014B1 (ko)
JP (1) JP2739910B2 (ko)
KR (1) KR0138907B1 (ko)
AT (1) ATE103609T1 (ko)
DE (1) DE68914205T2 (ko)
DK (1) DK355889A (ko)
ES (1) ES2055792T3 (ko)
FI (1) FI91074C (ko)
IE (1) IE892378L (ko)
IL (1) IL90766A0 (ko)
NO (1) NO892970L (ko)
ZA (1) ZA895050B (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK49093A3 (en) * 1990-11-14 1993-10-06 Upjohn Co Stabilized active analogues of factors releasing of growth hormone
WO1992018531A1 (en) * 1991-04-09 1992-10-29 F. Hoffmann-La Roche Ag Growth hormone releasing factor analogs
US5262519A (en) * 1991-05-15 1993-11-16 The Salk Institute For Biological Studies GRF analogs XI
US5371070A (en) * 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
US6008058A (en) * 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity
CA2375502A1 (en) * 1999-06-23 2000-12-28 The Wistar Institute Of Anatomy & Biology Novel pyrrhocoricin-derived peptides, and methods of use thereof
US7015309B1 (en) 1999-06-23 2006-03-21 The Wistar Institute Of Anatomy And Biology Pyrrhocoricin-derived peptides, and methods of use thereof
WO2008095063A1 (en) 2007-01-31 2008-08-07 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
CN103282510A (zh) 2010-08-13 2013-09-04 爱勒让治疗公司 拟肽大环化合物
JP6100699B2 (ja) 2010-12-22 2017-03-22 ザ ソルク インスティテュート フォー バイオロジカル スタディーズ 環状ｃｒｆアンタゴニストペプチド及びその薬学的に許容される塩
KR20140100937A (ko) * 2011-10-18 2014-08-18 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2025128794A1 (en) 2023-12-15 2025-06-19 Neurocrine Biosciences, Inc. Fatty acid conjugated cyclic peptides

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
US4595676A (en) * 1983-04-26 1986-06-17 The Salk Institute For Biological Studies Rat hypothalamic GRF
US4518586A (en) * 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
US4626523A (en) * 1983-09-13 1986-12-02 The Salk Institute For Biological Studies GRF analogs II
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
US4661472A (en) * 1985-05-09 1987-04-28 The Salk Institute For Biological Studies GnRH antagonists IX
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
IL84758A (en) * 1987-01-13 1992-03-29 Salk Inst For Biological Studi Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
US4784987A (en) * 1987-01-13 1988-11-15 The Salk Institute For Biological Studies GRF analogs VI
EP0307860B1 (en) * 1987-09-18 1994-06-08 F. Hoffmann-La Roche Ag Cyclic GRF-analogs

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DE68914205D1 (de) 1994-05-05
ES2055792T3 (es) 1994-09-01
ZA895050B (en) 1990-04-25
EP0352014B1 (en) 1994-03-30
US5043322A (en) 1991-08-27
IE892378L (en) 1990-01-22
FI91074C (fi) 1994-05-10
FI893532L (fi) 1990-01-23
DE68914205T2 (de) 1994-07-07
FI91074B (fi) 1994-01-31
ATE103609T1 (de) 1994-04-15
DK355889A (da) 1990-01-23
NO892970D0 (no) 1989-07-20
JP2739910B2 (ja) 1998-04-15
EP0352014A2 (en) 1990-01-24
JPH0269499A (ja) 1990-03-08
DK355889D0 (da) 1989-07-18
FI893532A0 (fi) 1989-07-21
IL90766A0 (en) 1990-01-18
NO892970L (no) 1990-01-23
KR0138907B1 (ko) 1998-04-30
EP0352014A3 (en) 1991-07-03

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