KR900701174A - 인지질-함유 조성물, 이의 제조방법 및 이의 약제학적 물질용 부형제로서의 용도 - Google Patents
인지질-함유 조성물, 이의 제조방법 및 이의 약제학적 물질용 부형제로서의 용도Info
- Publication number
- KR900701174A KR900701174A KR1019900700733A KR900700733A KR900701174A KR 900701174 A KR900701174 A KR 900701174A KR 1019900700733 A KR1019900700733 A KR 1019900700733A KR 900700733 A KR900700733 A KR 900700733A KR 900701174 A KR900701174 A KR 900701174A
- Authority
- KR
- South Korea
- Prior art keywords
- phospholipid
- containing composition
- sugar
- excipients
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003904 phospholipids Chemical class 0.000 title claims 11
- 239000000203 mixture Substances 0.000 title claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 title claims 2
- 239000000126 substance Substances 0.000 title claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims 1
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 229940042880 natural phospholipid Drugs 0.000 claims 1
- 239000008347 soybean phospholipid Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (6)
- 당으로서 인지질 : 팔라티니트의 중량비가 1:20 내지 20:1인 글루코피라노시도-1,6-만나톨과 글리코피라노시도-1,6-솔비통(팔라티니트)과의 1:1혼합물을 사용함을 특징으로 하는, 고형화 물질로서의 상기 당 및 통상의 보조제를 함유하는 인지질-함유 조성물.
- 제1항에 있어서, 인지질로서 천연 또는 합성 인지질을 함유함을 특징으로 하는 인지질-함유 조성물.
- 제1항 또는 2항에 있어서, 천연 인지질로서 콩 레시틴 또는 난황 레시틴, 또는 이의 매우 정제된 분획을 함유함을 특징으로 하는 인지질-함유 조성물.
- 인지질을 열 작용하에 팔라티니트의 용융물과 함께 균질해질때가지 혼합시키고 이 생성물을 냉각시킨후, 분쇄시킴으로써 상기 팔라티니트를 1:20내지 20:1의 인지질 : 팔라티니트 중량비로 도입시킴을 특징으로 하여, 고형화제로서의 당 및 통상의 보조제를 함유하는 인지질-함유 조성물을 제조하는 방법.
- 경구 표시 형태로서의 제1항 내지 4항중 어느 한 항에 따른 인지질-함유 조성물의 용도.
- 제6항에 있어서, 조성물이 경구투여용 약제학적 활성의 물질에 대한 부형제로서 작용함을 특징으로 하는 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3826946.5 | 1988-08-09 | ||
| DE3826946A DE3826946C1 (ko) | 1988-08-09 | 1988-08-09 | |
| PCT/EP1989/000898 WO1990001269A1 (en) | 1988-08-09 | 1989-08-01 | Phospholipid-containing composition, a process for its preparation and its use as an excipient for pharmaceutical substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR900701174A true KR900701174A (ko) | 1990-12-01 |
| KR930003882B1 KR930003882B1 (ko) | 1993-05-15 |
Family
ID=6360482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900700733A Expired - Lifetime KR930003882B1 (ko) | 1988-08-09 | 1989-08-01 | 인지질-함유 조성물, 이의 제조방법 및 약제학적 물질용 부형제로서의 용도 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5114928A (ko) |
| EP (2) | EP0354442A1 (ko) |
| JP (1) | JPH02504397A (ko) |
| KR (1) | KR930003882B1 (ko) |
| CN (1) | CN1037149C (ko) |
| CA (1) | CA1336957C (ko) |
| DE (2) | DE3826946C1 (ko) |
| ES (1) | ES2043117T3 (ko) |
| GR (1) | GR3004892T3 (ko) |
| WO (1) | WO1990001269A1 (ko) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041581A (en) * | 1985-10-18 | 1991-08-20 | The University Of Texas System Board Of Regents | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
| US4971798A (en) * | 1989-11-30 | 1990-11-20 | Miles Inc. | Hard confections containing hydrogenated isomaltulose and medicinally active ingredient |
| SG65599A1 (en) * | 1993-03-24 | 1999-06-22 | Collaborative Lab Inc | Cosmetic delivery system for salicylic acid and process for preparation of same |
| EP0650669B1 (en) * | 1993-10-29 | 2002-01-09 | Dsm N.V. | Baking improver compositions |
| DE19536394A1 (de) | 1995-09-29 | 1997-04-03 | Basf Ag | Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze |
| DE19629167C2 (de) * | 1996-07-19 | 2000-05-04 | Einhorn Apotheke Dr Guenther H | Feste orale, antikariogene Zusammensetzung in Form einer Lutschtablette zum Reinigen der Mundhöhle und Zähne |
| US6312703B1 (en) * | 1998-02-06 | 2001-11-06 | Lecigel, Llc | Compressed lecithin preparations |
| DE19818842C1 (de) * | 1998-04-28 | 2000-01-05 | Suedzucker Ag | Erkältungsmittel |
| DE29923766U1 (de) * | 1998-05-27 | 2001-06-07 | Euroceltique S.A., Luxemburg/Luxembourg | Wirkstoffapplikationssystem umfassend einen hochverdichteten festen Arzneimittelvorrat |
| GB9828013D0 (en) * | 1998-12-18 | 1999-02-10 | Lovesgrove Res Ltd | Specific phospholipid-lipid mixtures for inclusion in animal feed |
| US7300667B1 (en) | 1999-05-27 | 2007-11-27 | Euro-Celtique, S.A. | Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract |
| HU229598B1 (en) | 1999-05-27 | 2014-02-28 | Euro Celtique Sa | Preparations for the application of anti-inflammatory agents |
| US7297344B1 (en) | 1999-05-27 | 2007-11-20 | Euro-Celtique, S.A. | Preparations for the promotion of wound healing in the upper respiratory tract and/or ear |
| AU5428800A (en) * | 1999-06-29 | 2001-01-31 | Takeda Chemical Industries Ltd. | Tablets quickly disintegrating in mouth |
| DE10340741A1 (de) * | 2003-09-04 | 2005-03-31 | Degussa Food Ingredients Gmbh | Formulierung auf Phospholipidbasis |
| TW200524541A (en) * | 2003-11-17 | 2005-08-01 | Cargill Inc | Lecithin-containing granular compositions and methods of their preparation |
| WO2005099681A1 (ja) * | 2004-04-14 | 2005-10-27 | Kyowa Hakko Kogyo Co., Ltd. | 分岐鎖アミノ酸を含有する錠剤およびその製造方法 |
| CN1305881C (zh) * | 2004-08-13 | 2007-03-21 | 河南工业大学 | 磷脂酰胆碱的制备方法 |
| US8535750B2 (en) | 2005-05-17 | 2013-09-17 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
| US20140072617A1 (en) * | 2007-09-26 | 2014-03-13 | Lvmh Recherche | Method for preventing or slowing down the appearance of the effects of skin ageing using a tocopheryl phosphate in liposomes |
| RU2376011C1 (ru) * | 2008-05-19 | 2009-12-20 | Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" | Средство для ухода за областью периферических суставов и позвоночника |
| PL2545150T3 (pl) * | 2010-03-12 | 2019-01-31 | Dupont Nutrition Biosciences Aps | Sposób |
| BR112012029040A2 (pt) * | 2010-05-14 | 2016-08-02 | Archer Daniels Midland Co | composição de organogel de fosfolipideo estruturado termorreversível comestível para uso em produto alimentício, método de estruturar uma fase orgânica comestível, produto ou ingrediente alimentício, composição, método de carregar um organogel de fosfolipídeo estruturado termorreversível comestível, método de revestir um alimento e composição de organogel de fosfolipídeo estruturado termorreversivel comestível para uso em um produto alimentício |
| US11253531B2 (en) | 2011-08-11 | 2022-02-22 | Nutritional Therapeutics, Inc. | Lipid supplements for reducing nerve action potentials |
| US10117885B2 (en) * | 2011-08-11 | 2018-11-06 | Allergy Research Group, Llc | Chewable lipid supplements for treating pain and fibromyalgia |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2057695A (en) * | 1933-12-13 | 1936-10-20 | American Lecithin Co | Method for the production of vegetable phosphatide preparations |
| US2447726A (en) * | 1945-09-21 | 1948-08-24 | Wilber J Allingham | Lecithin composition |
| US2430553A (en) * | 1946-11-02 | 1947-11-11 | Frank E Bigelow | Lecithinated sugar |
| US2708631A (en) * | 1952-10-21 | 1955-05-17 | Sadie Neiman | Lecithin composition and method of producing the same |
| US3012888A (en) * | 1959-04-13 | 1961-12-12 | Central Soya Co | Method for preparing a granular oilfree phosphatide product |
| US4374082A (en) * | 1981-08-18 | 1983-02-15 | Richard Hochschild | Method for making a pharmaceutical and/or nutritional dosage form |
-
1988
- 1988-08-09 DE DE3826946A patent/DE3826946C1/de not_active Expired - Lifetime
-
1989
- 1989-08-01 WO PCT/EP1989/000898 patent/WO1990001269A1/en not_active Ceased
- 1989-08-01 EP EP89114144A patent/EP0354442A1/en active Pending
- 1989-08-01 ES ES89908999T patent/ES2043117T3/es not_active Expired - Lifetime
- 1989-08-01 JP JP1508457A patent/JPH02504397A/ja active Granted
- 1989-08-01 US US07/499,524 patent/US5114928A/en not_active Expired - Lifetime
- 1989-08-01 EP EP89908999A patent/EP0428582B1/en not_active Expired - Lifetime
- 1989-08-01 KR KR1019900700733A patent/KR930003882B1/ko not_active Expired - Lifetime
- 1989-08-01 DE DE8989908999T patent/DE68901771T2/de not_active Expired - Lifetime
- 1989-08-07 CN CN89105572A patent/CN1037149C/zh not_active Expired - Lifetime
- 1989-08-08 CA CA000607750A patent/CA1336957C/en not_active Expired - Lifetime
-
1992
- 1992-06-11 GR GR920401237T patent/GR3004892T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE68901771D1 (de) | 1992-07-16 |
| CN1037149C (zh) | 1998-01-28 |
| JPH0571596B2 (ko) | 1993-10-07 |
| CA1336957C (en) | 1995-09-12 |
| EP0428582B1 (en) | 1992-06-10 |
| DE3826946C1 (ko) | 1990-03-15 |
| CN1040144A (zh) | 1990-03-07 |
| JPH02504397A (ja) | 1990-12-13 |
| DE68901771T2 (de) | 1992-12-17 |
| WO1990001269A1 (en) | 1990-02-22 |
| KR930003882B1 (ko) | 1993-05-15 |
| US5114928A (en) | 1992-05-19 |
| GR3004892T3 (ko) | 1993-04-28 |
| ES2043117T3 (es) | 1993-12-16 |
| EP0354442A1 (en) | 1990-02-14 |
| EP0428582A1 (en) | 1991-05-29 |
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